PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CASP6	0	CASP8	1	enzymatic study, enzymatic study, enzymatic study	Cowling V (2002), Guo Y (2002), Srinivasula SM (1996)	3
CASP8	1	CRYAB	0	affinity chromatography technology	Lee JS (2012)	1
CASP8	1	RB1	2	enzymatic study	Lemaire C (2005)	1
CASP6	0	XIAP	0	affinity chromatography technology	Lee JS (2012)	1
CASP3	0	SP1	0	enzymatic study	Rickers A (1999)	1
CASP6	0	UBE4A	2	enzymatic study	Mahoney JA (2002)	1
CASP6	0	CRYAB	0	affinity chromatography technology	Lee JS (2012)	1
XIAP	0	CASP10	1	two hybrid, affinity chromatography technology	Rolland T (2014), McDonald ER (2004)	2
CASP8	1	XIAP	0	genetic interference, affinity chromatography technology, affinity chromatography technology	Guo Y (2002), Lee JS (2012), McDonald ER (2004)	3
CASP10	1	CASP8	1	biochemical, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Micheau O (2003), Guo Y (2002), Srinivasula SM (1996), Srinivasula SM (1996), Sinha SK (2004), Lee EW (2012), Feoktistova M (2011)	9
PIN1	0	CASP6	0	two hybrid	Vinayagam A (2011)	1
CASP10	1	CASP6	0	enzymatic study	Srinivasula SM (1996)	1
SP1	0	RB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Singh J (2002), Chang YC (2001), Opitz OG (2000)	3
IKBKG	0	TRAF1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Greenfeld H (2015), Greenfeld H (2015), Abdul-Sater AA (2017)	3
MAPK6	1	CASP6	0	two hybrid	Vinayagam A (2011)	1
CASP3	0	TRAF1	0	imaging technique	Chen TC (2014)	1
CASP6	0	RB1	2	enzymatic study	Lemaire C (2005)	1
CASP6	0	IKBKG	0	two hybrid	Wang J (2011)	1
CASP10	1	TRAF1	0	enzymatic study	Leo E (2001)	1
CASP8	1	CHD3	19	two hybrid	Stelzl U (2005)	1
CASP3	0	APP	1	imaging technique	Chen TC (2014)	1
CASP6	0	COPS6	0	enzymatic study	da Silva Correia J (2007)	1
SP1	0	PIN1	0	affinity chromatography technology, affinity chromatography technology	Yang HC (2014), Yang HC (2014)	2
TAB1	1	CASP6	0	two hybrid	Vinayagam A (2011)	1
CASP6	0	CASP6	0	enzymatic study, two hybrid, two hybrid	Cowling V (2002), Wang J (2011), Rolland T (2014)	3
CASP6	0	SP1	0	enzymatic study	Rickers A (1999)	1
CRYAB	0	CASP3	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Stegh AH (2008), Stegh AH (2008), Stegh AH (2008), Lee JS (2012), Jeong WJ (2012)	5
CASP8	1	CASP3	0	enzymatic study, enzymatic study, enzymatic study	Guo Y (2002), Srinivasula SM (1996), Chandra D (2004)	3
CASP6	0	TRAF1	0	enzymatic study	Leo E (2001)	1
CASP10	1	RB1	2	enzymatic study	Lemaire C (2005)	1
CASP10	1	CASP3	0	enzymatic study	Srinivasula SM (1996)	1
CASP6	0	CHD3	19	two hybrid	Stelzl U (2005)	1
CASP3	0	CASP6	0	enzymatic study, enzymatic study, imaging technique	Srinivasula SM (1996), Walsh JG (2008), Chen TC (2014)	3
CASP8	1	TRAF1	0	affinity chromatography technology, enzymatic study	Micheau O (2003), Leo E (2001)	2
SATB1	1	CASP6	0	affinity chromatography technology, affinity chromatography technology	Tan JA (2008), Tan JA (2008)	2
CASP3	0	COPS6	0	enzymatic study	da Silva Correia J (2007)	1
SATB1	1	CHD3	19	affinity chromatography technology, biochemical	Yasui D (2002), Yasui D (2002)	2
XIAP	0	CRYAB	0	affinity chromatography technology	Lee JS (2012)	1
XIAP	0	CASP3	0	affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Suzuki Y (2001), Suzuki Y (2001), Silke J (2002), Riedl SJ (2001), Riedl SJ (2001), Roy N (1997), Deveraux QL (1997), Deveraux QL (1997), Suzuki Y (2001), Bartke T (2004), Nakhaei P (2012), Qiu XB (2005), Nomura T (2003), Paulsen M (2008), Scott FL (2005), Mufti AR (2006), Rajalingam K (2006), Dudich E (2006), Chai J (2001), Checinska A (2007), Sun M (2009), Takahashi R (1998), Conde C (2012), Walsh JG (2008), Lee JS (2012), Lin YF (2013), Huttlin EL (2015), Chen TC (2014), Huttlin EL (2017), Hou Y (2017)	30
CASP6	0	APP	1	imaging technique	Chen TC (2014)	1
TAB1	1	XIAP	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yamaguchi K (1999), Yamaguchi K (1999), Yamaguchi K (1999), Sanna MG (2002), Sanna MG (2002), Caballero-Lopez MJ (2017)	6
MAPK6	1	COPS6	0	two hybrid, affinity chromatography technology	Vinayagam A (2011), Rodriguez J (2016)	2
CASP6	0	PRKAB2	0	two hybrid	Wang J (2011)	1
CASP8	1	COPS6	0	enzymatic study	da Silva Correia J (2007)	1
CASP3	0	RB1	2	enzymatic study, enzymatic study	Lemaire C (2005), Fattman CL (2001)	2
PIN1	0	TRAF1	0	two hybrid	Rolland T (2014)	1
CRYAB	0	APP	1	pull down, pull down, unspecified method, x-ray crystallography, pull down	Raman B (2005), Narayanan S (2006), Shammas SL (2011), Mainz A (2015), Narayan P (2012)	5
IKBKG	0	TAB1	1	pull down	Emmerich CH (2013)	1