PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TP53	0	DOT1L	7	genetic interference	Xie L (2013)	1
CAND1	2	UBC	7	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	CUL1	7	affinity chromatography technology, affinity chromatography technology, biochemical	Bennett EJ (2010), Bennett EJ (2010), Wan C (2015)	3
TP53	0	IFI16	1	affinity chromatography technology	Johnstone RW (2000)	1
CUL3	17	RPL11	3	affinity chromatography technology	Bennett EJ (2010)	1
CDT1	2	GRWD1	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique	Sugimoto N (2008), Sugimoto N (2008), Sugimoto N (2008), Sugimoto N (2015), Sugimoto N (2015), Sugimoto N (2015)	6
MOV10	6	NOC2L	5	affinity chromatography technology	Castello A (2012)	1
DDX56	0	GRWD1	3	biochemical	Wan C (2015)	1
BCCIP	1	GRWD1	3	biochemical	Havugimana PC (2012)	1
DDX56	0	NOC2L	5	biochemical	Wan C (2015)	1
COPS5	0	NPM1	0	affinity chromatography technology	Bennett EJ (2010)	1
IFI16	1	WDR36	0	affinity chromatography technology	Diner BA (2015)	1
COPS5	0	ESR1	0	affinity chromatography technology	Callige M (2005)	1
CAND1	2	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
ESR1	0	WDR5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mo R (2006), Mo R (2006), Shi L (2011), Shi L (2011)	4
CCNB1	3	CDC6	0	enzymatic study	Jiang W (1999)	1
ESR1	0	VCP	6	pull down	Nalvarte I (2010)	1
CUL1	7	GRWD1	3	affinity chromatography technology	Bennett EJ (2010)	1
VHL	0	NCL	1	pull down	Lai Y (2012)	1
CAND1	2	DDX24	1	affinity chromatography technology	Bennett EJ (2010)	1
XPO1	8	DDX56	0	affinity chromatography technology	Kirli K (2015)	1
CUL4B	8	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Jin J (2006), Wang H (2006), Higa LA (2006), Higa LA (2006), Kawajiri K (2009), Bennett EJ (2010), Havugimana PC (2012), Ji Q (2014), Wan C (2015), Hein MY (2015), Mo Y (2017), Mo Y (2017), Yang Y (2015), Yang Y (2015), Yang Y (2015), Higa LA (2006), Higa LA (2006), Ohtake F (2007), Ohtake F (2007), Ohtake F (2007)	23
CUL4A	2	TP53	0	affinity chromatography technology	Banks D (2006)	1
COPS5	0	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
METTL18	4	GRWD1	3	affinity chromatography technology	Cloutier P (2013)	1
EWSR1	2	NPM1	0	affinity chromatography technology	Elzi DJ (2014)	1
DDX18	2	NOL10	3	biochemical	Wan C (2015)	1
ESR1	0	RPL11	3	affinity chromatography technology	Tarallo R (2011)	1
NXF1	0	GRWD1	3	affinity chromatography technology	Castello A (2012)	1
EWSR1	2	HDGF	0	bioid	Elzi DJ (2014)	1
IFI16	1	GRWD1	3	affinity chromatography technology	Diner BA (2015)	1
CDT1	2	DDB1	6	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology	Hu J (2004), Hu J (2004), Hu J (2004), Hu J (2004), Zhang Y (2012)	5
UBC	7	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhong X (2006), Dai RM (2001), Bish RA (2007), Lim JJ (2016), Zhang X (2017)	6
NPM1	0	DDX24	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
CUL4B	8	RPL11	3	affinity chromatography technology	Bennett EJ (2010)	1
DDB1	6	UBC	7	affinity chromatography technology, affinity chromatography technology	Angers S (2006), Matsumoto M (2005)	2
CUL3	17	DDX18	2	affinity chromatography technology	Bennett EJ (2010)	1
TP53	0	NPM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dhar SK (2006), Kurki S (2004), Kurki S (2004), Lambert B (2006), Colombo E (2002), Colombo E (2002), Colombo E (2002), Fogeron ML (2013), Li J (2005)	9
LNX1	7	GRWD1	3	affinity chromatography technology	Lenihan JA (2017)	1
MOV10	6	NPM1	0	affinity chromatography technology	Castello A (2012)	1
EWSR1	2	DDB1	6	bioid	Elzi DJ (2014)	1
WDR36	0	DDX56	0	biochemical	Wan C (2015)	1
CUL4A	2	CUL3	17	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	DDB1	6	affinity chromatography technology	Bennett EJ (2010)	1
GRK5	7	GRWD1	3	affinity chromatography technology	Wu Z (2012)	1
UBC	7	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Matsumoto M (2005), Bennett EJ (2010), Bish RA (2007), Wu K (2016)	4
DDX18	2	NOC2L	5	biochemical	Wan C (2015)	1
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
CDT1	2	CDC6	0	pull down, pull down, imaging technique	Sugimoto N (2008), Ramachandran N (2004), Sugimoto N (2015)	3
COPS5	0	GRWD1	3	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	CDT1	2	biochemical	He YJ (2006)	1
NXF1	0	GRK5	7	affinity chromatography technology	Castello A (2012)	1
COPS5	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Min KW (2005), Min KW (2005), Chua YS (2011), Boh BK (2011), Emberley ED (2012), Emberley ED (2012), Choo YY (2011), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Enchev RI (2012), Birol M (2014), Pick E (2012), Sharon M (2009), Enchev RI (2012), Bornstein G (2015), Rockel B (2014), Schlierf A (2016), Reitsma JM (2017), Reitsma JM (2017)	23
XPO1	8	NPM1	0	unspecified method	Xu D (2012)	1
COPS5	0	CAND1	2	biochemical, affinity chromatography technology	Bornstein G (2006), Bennett EJ (2010)	2
XPO1	8	NOC2L	5	affinity chromatography technology	Kirli K (2015)	1
COPS5	0	MCM7	5	affinity chromatography technology	Bennett EJ (2010)	1
NCL	1	RPL11	3	biochemical, affinity chromatography technology	Havugimana PC (2012), Salvetti A (2016)	2
IFI16	1	NXF1	0	affinity chromatography technology	Diner BA (2015)	1
CUL4B	8	WDR5	2	affinity chromatography technology	Higa LA (2006)	1
NPM1	0	PPM1G	1	affinity chromatography technology	Chen R (2013)	1
UBC	7	NPM1	0	affinity chromatography technology, pull down	Matsumoto M (2005), Koike A (2010)	2
GTPBP4	2	DDX56	0	biochemical	Wan C (2015)	1
CUL4A	2	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Angers S (2006), Hu J (2004), Chua YS (2011), Tron AE (2012), Zheng J (2002), He YJ (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Gastaldello S (2012), Liu J (2002), Liu J (2002), Olma MH (2009), Olma MH (2009), Yang Y (2016), Yang Y (2016)	18
GRWD1	3	WDR5	2	affinity chromatography technology	Higa LA (2006)	1
CDT1	2	CUL1	7	affinity chromatography technology	Li X (2003)	1
COPS5	0	DDX56	0	affinity chromatography technology	Bennett EJ (2010)	1
NPM1	0	GRWD1	3	affinity chromatography technology	Chen R (2013)	1
GRWD1	3	POLR1E	3	biochemical	Wan C (2015)	1
CUL1	7	DDX18	2	affinity chromatography technology	Bennett EJ (2010)	1
DDX24	1	GTPBP4	2	biochemical	Wan C (2015)	1
CUL3	17	MOV10	6	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Angers S (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009), Olma MH (2009), Rao F (2014), Pick E (2012), Groisman R (2003), Groisman R (2003), Huttlin EL (2015), Cavadini S (2016), Scherer PC (2016), Scherer PC (2016), Huttlin EL (2017)	19
TOP1	1	NPM1	0	affinity chromatography technology	Czubaty A (2005)	1
CUL3	17	VCP	6	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Besten Wd (2012)	2
CCNB1	3	GRWD1	3	affinity chromatography technology	Lin Z (2015)	1
ESR1	0	TOP1	1	affinity chromatography technology	Tarallo R (2011)	1
CAND1	2	DDX56	0	affinity chromatography technology	Bennett EJ (2010)	1
NCL	1	GTPBP4	2	affinity chromatography technology	Salvetti A (2016)	1
VCP	6	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Yu CC (2013), Fogeron ML (2013)	3
NCL	1	NXF1	0	affinity chromatography technology, affinity chromatography technology	Salvetti A (2016), Salvetti A (2016)	2
UBC	7	GRWD1	3	affinity chromatography technology	Matsumoto M (2005)	1
CUL1	7	WDR5	2	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	NCL	1	affinity chromatography technology	Bennett EJ (2010)	1
NOL10	3	GRWD1	3	biochemical	Wan C (2015)	1
IFI16	1	RBM19	5	affinity chromatography technology	Diner BA (2015)	1
DDB1	6	NXF1	0	biochemical	Havugimana PC (2012)	1
NPM1	0	RPL11	3	affinity chromatography technology	Hein MY (2015)	1
TP53	0	TOP1	1	affinity chromatography technology, two hybrid, affinity chromatography technology	Gobert C (1999), Mao Y (2002), Restle A (2008)	3
CUL1	7	NXF1	0	affinity chromatography technology	Bennett EJ (2010)	1
ESR1	0	GTPBP4	2	affinity chromatography technology	Tarallo R (2011)	1
CDT1	2	NPM1	0	affinity chromatography technology, pull down	Sugimoto N (2008), Sugimoto N (2008)	2
DDX24	1	RPL11	3	biochemical	Wan C (2015)	1
TP53	0	DDB1	6	affinity chromatography technology	Fogeron ML (2013)	1
CAND1	2	DIMT1	0	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	8
POLR1D	4	GRWD1	3	biochemical	Wan C (2015)	1
DDX24	1	DDX56	0	biochemical	Wan C (2015)	1
CUL3	17	NCL	1	affinity chromatography technology	Bennett EJ (2010)	1
CDT1	2	TOP1	1	affinity chromatography technology, pull down, affinity chromatography technology	Sugimoto N (2008), Sugimoto N (2008), Sugimoto N (2008)	3
CDT1	2	CCNB1	3	affinity chromatography technology, pull down	Sugimoto N (2004), Sugimoto N (2004)	2
CUL3	17	TOP1	1	affinity chromatography technology	Bennett EJ (2010)	1
XPO1	8	WDR5	2	affinity chromatography technology	Kirli K (2015)	1
NXF1	0	XPO1	8	affinity chromatography technology	Bachi A (2000)	1
CUL4A	2	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
CAND1	2	DDX18	2	affinity chromatography technology	Bennett EJ (2010)	1
ESR1	0	CUL4B	8	affinity chromatography technology, affinity chromatography technology	Ohtake F (2007), Ohtake F (2007)	2
GRWD1	3	CDC6	0	affinity chromatography technology, affinity chromatography technology, pull down, imaging technique	Sugimoto N (2015), Sugimoto N (2015), Sugimoto N (2015), Sugimoto N (2015)	4
KMT2E	7	GRWD1	3	affinity chromatography technology	Ding X (2015)	1
PPM1G	1	GRWD1	3	affinity chromatography technology	Yadav L (2017)	1
HDGF	0	GRWD1	3	affinity chromatography technology	Zhao J (2011)	1
HDGF	0	WDR36	0	affinity chromatography technology	Zhao J (2011)	1
DDX18	2	BCCIP	1	biochemical	Wan C (2015)	1
CAND1	2	GTPBP4	2	affinity chromatography technology	Bennett EJ (2010)	1
CAND1	2	MOV10	6	affinity chromatography technology	Bennett EJ (2010)	1
DIMT1	0	GRWD1	3	biochemical	Wan C (2015)	1
MOV10	6	DDX24	1	affinity chromatography technology	Castello A (2012)	1
DDX24	1	BCCIP	1	biochemical	Wan C (2015)	1
CAND1	2	NXF1	0	affinity chromatography technology	Bennett EJ (2010)	1
VHL	0	GRWD1	3	affinity chromatography technology	Lai Y (2011)	1
COPS5	0	NXF1	0	affinity chromatography technology	Bennett EJ (2010)	1
DDX18	2	POLR1E	3	biochemical	Wan C (2015)	1
COPS5	0	DDX18	2	affinity chromatography technology	Bennett EJ (2010)	1
WDR36	0	NOC2L	5	biochemical	Wan C (2015)	1
TP53	0	GRWD1	3	affinity chromatography technology	Fogeron ML (2013)	1
CUL4B	8	NXF1	0	biochemical	Wan C (2015)	1
MOV10	6	HDGF	0	affinity chromatography technology	Castello A (2012)	1
CUL4A	2	WDR5	2	affinity chromatography technology	Higa LA (2006)	1
CUL4A	2	VCP	6	affinity chromatography technology	Besten Wd (2012)	1
COPS5	0	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology	Cayli S (2009), Cayli S (2009), Cayli S (2009), Cayli S (2009), Bennett EJ (2010)	5
CUL3	17	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Bennett EJ (2010), Olma MH (2009), Bish RA (2007), Wu K (2016)	4
KMT2E	7	TP53	0	affinity chromatography technology	Cheng F (2011)	1
CAND1	2	NCL	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL4B	8	GRWD1	3	affinity chromatography technology, affinity chromatography technology	Higa LA (2006), Higa LA (2006)	2
NOC2L	5	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu L (2011), Wu L (2011), Hublitz P (2005), Hublitz P (2005)	4
GRK5	7	CUL4A	2	affinity chromatography technology, affinity chromatography technology	Wu Z (2012), Wu Z (2012)	2
COPS5	0	VHL	0	affinity chromatography technology	Bemis L (2004)	1
DOT1L	7	GRWD1	3	affinity chromatography technology	Park G (2010)	1
CUL4A	2	CDT1	2	affinity chromatography technology, affinity chromatography technology, biochemical	Hu J (2004), Higa LA (2003), He YJ (2006)	3
NPM1	0	GTPBP4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
GRWD1	3	RBM19	5	biochemical	Wan C (2015)	1
CUL4A	2	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Angers S (2006), Jin J (2006), Wang H (2006), Kapetanaki MG (2006), Matsuda N (2005), Hu J (2004), Hu J (2004), Hu J (2004), Ahn J (2010), Maddika S (2009), Fischer ES (2011), Tan L (2007), He YJ (2006), He YJ (2006), He YJ (2006), McCall CM (2008), McCall CM (2008), Shiyanov P (1999), Bennett EJ (2010), Gastaldello S (2012), Kanei-Ishii C (2012), Hodgson AJ (2012), Kulaksiz G (2005), Wu Z (2012), Wu Z (2012), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Rao F (2014), Wan C (2015), Liu Y (2015), Zha Z (2015), Mouysset J (2015), Gao J (2015), Yang Y (2016), Yang Y (2016), Scherer PC (2016), Eichner R (2016), Mo Y (2017), Mo Y (2017), Peng Z (2016), Higa LA (2006), Ohtake F (2007)	46
RPL11	3	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2003), Zhang Y (2003), Dai MS (2004), Dai MS (2004), Bursac S (2012), Fogeron ML (2013)	6
PPM1G	1	CAND1	2	biochemical	Kristensen AR (2012)	1
CUL3	17	MCM7	5	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Rutz N (2015)	2
CUL4A	2	GRWD1	3	affinity chromatography technology, affinity chromatography technology	Higa LA (2006), He YJ (2006)	2
DDX18	2	GRWD1	3	biochemical	Wan C (2015)	1
CUL1	7	ESR1	0	affinity chromatography technology	Zhou W (2014)	1
VHL	0	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Roe JS (2006), Roe JS (2006), Roe JS (2006), Lai Y (2011), Lai Y (2011)	5
TOP1	1	CDC6	0	genetic interference	Srivas R (2016)	1
TP53	0	EWSR1	2	affinity chromatography technology	Li Y (2012)	1
ESR1	0	CUL3	17	affinity chromatography technology	Byun B (2008)	1
VHL	0	MCM7	5	pull down, affinity chromatography technology	Hubbi ME (2011), Hubbi ME (2011)	2
TP53	0	GTPBP4	2	affinity chromatography technology	Lunardi A (2010)	1
NPM1	0	BCCIP	1	affinity chromatography technology	Hein MY (2015)	1
CUL1	7	NPM1	0	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	TOP1	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL4B	8	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Min KW (2003), Bennett EJ (2010), Bennett EJ (2010), Hein MY (2015)	6
CUL1	7	RPL11	3	affinity chromatography technology	Bennett EJ (2010)	1
IFI16	1	DDX56	0	affinity chromatography technology	Diner BA (2015)	1
XPO1	8	ESR1	0	affinity chromatography technology	Castoria G (2012)	1
DDX24	1	NOC2L	5	biochemical	Wan C (2015)	1
CEP57	0	RPL11	3	affinity chromatography technology	Fogeron ML (2013)	1
COPS5	0	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang XC (2008), Zhang XC (2008), Zhang XC (2008), Wang J (2006), Bech-Otschir D (2001), Bech-Otschir D (2001), Oh W (2006), Bhansali M (2014), Bhansali M (2014)	9
CUL4B	8	CDT1	2	affinity chromatography technology	Higa LA (2003)	1
NXF1	0	NPM1	0	affinity chromatography technology	Castello A (2012)	1
CEP57	0	GRWD1	3	affinity chromatography technology	Fogeron ML (2013)	1
TP53	0	NCL	1	affinity chromatography technology, affinity chromatography technology, far western blotting, pull down	Daniely Y (2002), Daniely Y (2002), Daniely Y (2002), Lim KH (2015)	4
NOL10	3	WDR36	0	biochemical	Wan C (2015)	1
NCL	1	NPM1	0	affinity chromatography technology, pull down, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Li YP (1996), Li YP (1996), Park G (2010), Okuwaki M (2012), Havugimana PC (2012), Yu Y (2006), Huttlin EL (2017)	7
VCP	6	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Besten Wd (2012), Zhang Z (2015)	3
CUL3	17	NXF1	0	affinity chromatography technology	Bennett EJ (2010)	1
VHL	0	UBC	7	pull down	Lisztwan J (1999)	1
GRK5	7	CUL4B	8	affinity chromatography technology, affinity chromatography technology	Wu Z (2012), Wu Z (2012)	2
CUL1	7	TOP1	1	affinity chromatography technology	Bennett EJ (2010)	1
WDR36	0	GRWD1	3	biochemical	Wan C (2015)	1
CUL3	17	DDX24	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL1	7	DDB1	6	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Gastaldello S (2012)	2
DDX18	2	WDR36	0	biochemical	Wan C (2015)	1
CUL4A	2	NCL	1	affinity chromatography technology	Bennett EJ (2010)	1
UBC	7	NCL	1	affinity chromatography technology	Matsumoto M (2005)	1
ESR1	0	NCL	1	affinity chromatography technology, pull down	Tarallo R (2011), Nalvarte I (2010)	2
CUL4A	2	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Angers S (2006), Bennett EJ (2010), Olma MH (2009), Wu K (2016)	4
ESR1	0	NPM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Ambrosino C (2010), Ambrosino C (2010), Tarallo R (2011), Nalvarte I (2010)	4
KMT2E	7	DDX24	1	affinity chromatography technology	Ding X (2015)	1
CUL4B	8	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
NCL	1	DDX18	2	affinity chromatography technology	Salvetti A (2016)	1
DDB1	6	COPS5	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Angers S (2006), Jin J (2006), Emberley ED (2012), Bennett EJ (2010), Olma MH (2009), He F (2013)	6
NXF1	0	UBC	7	affinity chromatography technology	Castello A (2012)	1
TP53	0	POLR1D	4	genetic interference	Xie L (2013)	1
DDX18	2	POLR1D	4	biochemical	Wan C (2015)	1
XPO1	8	CCNB1	3	affinity chromatography technology	Kirli K (2015)	1
CUL4B	8	UBC	7	affinity chromatography technology, pull down	Bennett EJ (2010), Nathan JA (2013)	2
TP53	0	MOV10	6	affinity chromatography technology	Li X (2015)	1
CUL4A	2	NPM1	0	affinity chromatography technology	Bennett EJ (2010)	1
CAND1	2	WDR5	2	affinity chromatography technology	Bennett EJ (2010)	1
CAND1	2	GRWD1	3	affinity chromatography technology	Bennett EJ (2010)	1
GRWD1	3	NOC2L	5	biochemical	Wan C (2015)	1
EWSR1	2	GRWD1	3	bioid	Elzi DJ (2014)	1
TP53	0	ESR1	0	pull down, affinity chromatography technology, affinity chromatography technology	Liu G (2000), Duong V (2007), Saxena R (2016)	3
GTPBP4	2	NOC2L	5	biochemical	Wan C (2015)	1
DDX18	2	RPL11	3	biochemical	Wan C (2015)	1
HDGF	0	WDR5	2	affinity chromatography technology	Zhao J (2011)	1
CAND1	2	NPM1	0	affinity chromatography technology	Bennett EJ (2010)	1
CEP57	0	MCM7	5	affinity chromatography technology	Fogeron ML (2013)	1
XPO1	8	CDT1	2	affinity chromatography technology	Kirli K (2015)	1
CUL3	17	CUL4B	8	affinity chromatography technology	Bennett EJ (2010)	1
NPM1	0	NOC2L	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GRK5	7	NCL	1	affinity chromatography technology	Wu Z (2012)	1
MOV10	6	UBC	7	affinity chromatography technology	Castello A (2012)	1
VCP	6	BCCIP	1	affinity chromatography technology	Yu CC (2013)	1
XPO1	8	GRWD1	3	affinity chromatography technology	Kirli K (2015)	1
VCP	6	CCNB1	3	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Fogeron ML (2013)	2
CUL1	7	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
ESR1	0	DDX18	2	affinity chromatography technology	Tarallo R (2011)	1
NXF1	0	MCM7	5	affinity chromatography technology	Castello A (2012)	1
COPS5	0	MOV10	6	affinity chromatography technology	Bennett EJ (2010)	1
HDGF	0	TOP1	1	affinity chromatography technology	Zhao J (2011)	1
CAND1	2	CCNB1	3	affinity chromatography technology	Bennett EJ (2010)	1
CUL4A	2	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guerrero-Santoro J (2008), Angers S (2006), Bennett EJ (2010), Bennett EJ (2010), Sertic S (2013)	5
NXF1	0	DDX24	1	affinity chromatography technology	Castello A (2012)	1
DDB1	6	ESR1	0	affinity chromatography technology	Ohtake F (2007)	1
CUL3	17	NPM1	0	affinity chromatography technology	Bennett EJ (2010)	1
GTPBP4	2	GRWD1	3	biochemical	Wan C (2015)	1
HDGF	0	NCL	1	affinity chromatography technology	Zhao J (2011)	1
COPS5	0	GTPBP4	2	affinity chromatography technology	Bennett EJ (2010)	1
ESR1	0	GRWD1	3	pull down	Nalvarte I (2010)	1
NCL	1	GRWD1	3	affinity chromatography technology	Salvetti A (2016)	1
NXF1	0	NOC2L	5	affinity chromatography technology	Castello A (2012)	1
DDX18	2	DDX56	0	biochemical	Wan C (2015)	1
CUL4A	2	RPL11	3	affinity chromatography technology	Bennett EJ (2010)	1
TP53	0	WDR5	2	pull down, pull down	Dou Y (2005), Tang Z (2013)	2
HDGF	0	DIMT1	0	affinity chromatography technology	Zhao J (2011)	1
RPL11	3	GRWD1	3	affinity chromatography technology, affinity chromatography technology, pull down	Kayama K (2017), Kayama K (2017), Kayama K (2017)	3
VCP	6	TOP1	1	affinity chromatography technology	Yu CC (2013)	1
NPM1	0	DDX56	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDC6	0	MCM7	5	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Fujita M (1999), Fujita M (1999), Sugimoto N (2015), Hubbi ME (2013)	7
CUL4A	2	CUL1	7	biochemical	He YJ (2006)	1
IFI16	1	DDX24	1	affinity chromatography technology	Diner BA (2015)	1
ESR1	0	EWSR1	2	affinity chromatography technology	Tarallo R (2011)	1
VCP	6	LNX1	7	two hybrid	Rolland T (2014)	1
MCM7	5	GRWD1	3	imaging technique	Sugimoto N (2015)	1
EWSR1	2	PPM1G	1	bioid	Elzi DJ (2014)	1
CUL1	7	DDX56	0	affinity chromatography technology	Bennett EJ (2010)	1
DDX24	1	GRWD1	3	biochemical	Wan C (2015)	1
CUL4B	8	TP53	0	affinity chromatography technology	Thirunavukarasou A (2014)	1
DDX18	2	DDX24	1	biochemical	Wan C (2015)	1
CUL3	17	WDR5	2	affinity chromatography technology	Bennett EJ (2010)	1
VHL	0	RPL11	3	biochemical	Zhao WT (2013)	1
KMT2E	7	DDX18	2	affinity chromatography technology	Ding X (2015)	1
CUL1	7	NCL	1	affinity chromatography technology	Bennett EJ (2010)	1
ESR1	0	WDR36	0	affinity chromatography technology	Tarallo R (2011)	1
CUL4B	8	NCL	1	affinity chromatography technology	Bennett EJ (2010)	1
IFI16	1	NOC2L	5	affinity chromatography technology	Diner BA (2015)	1
UBC	7	WDR5	2	affinity chromatography technology	Matsumoto M (2005)	1
IFI16	1	GTPBP4	2	affinity chromatography technology	Diner BA (2015)	1
DDB1	6	GRWD1	3	affinity chromatography technology	He YJ (2006)	1
CAND1	2	RPL11	3	affinity chromatography technology	Bennett EJ (2010)	1
NCL	1	TOP1	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Haluska P (1998), Haluska P (1998), Bharti AK (1996), Bharti AK (1996), Czubaty A (2005)	5
CEP76	1	GRWD1	3	affinity chromatography technology	Fogeron ML (2013)	1
CUL1	7	KMT2E	7	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), He F (2013), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	9
TOP1	1	GRWD1	3	unspecified method	Trzcinska AM (2002)	1
MOV10	6	GRK5	7	affinity chromatography technology	Castello A (2012)	1
DOT1L	7	NPM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Park G (2010), Park G (2010), Hein MY (2015)	3
UBC	7	DDX18	2	affinity chromatography technology	Matsumoto M (2005)	1
CUL3	17	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
GTPBP4	2	WDR36	0	biochemical	Wan C (2015)	1
CUL3	17	GRWD1	3	affinity chromatography technology	Bennett EJ (2010)	1
VCP	6	GRWD1	3	affinity chromatography technology	Fogeron ML (2013)	1
DDX18	2	GTPBP4	2	biochemical	Wan C (2015)	1
CAND1	2	TOP1	1	affinity chromatography technology	Bennett EJ (2010)	1
NXF1	0	HDGF	0	affinity chromatography technology	Castello A (2012)	1
CUL1	7	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Min KW (2003), Menon S (2008), Chew EH (2007), Min KW (2005), Min KW (2005), Min KW (2005), Hwang JW (2003), Hwang JW (2003), Mao X (2011), Chua YS (2011), Chua YS (2011), Tron AE (2012), Zheng J (2002), Zheng J (2002), Bornstein G (2006), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), He YJ (2006), Emberley ED (2012), Choo YY (2011), Jonason JH (2007), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Liu J (2002), Liu J (2002), Liu J (2002), Liu J (2002), Korzeniewski N (2012), Pierce NW (2013), Kim AY (2008), Zhang S (2016), Tikhmyanova N (2017), Tikhmyanova N (2017), Reitsma JM (2017), Reitsma JM (2017)	41
GRK5	7	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu Z (2012), Wu Z (2012), Wu Z (2012)	3
DDX24	1	NCL	1	affinity chromatography technology	Yamauchi T (2014)	1
NOL10	3	RBM19	5	biochemical	Wan C (2015)	1
IFI16	1	CUL4A	2	affinity chromatography technology	Diner BA (2015)	1
IFI16	1	DDX18	2	affinity chromatography technology	Diner BA (2015)	1
CEP57	0	DDB1	6	affinity chromatography technology	Fogeron ML (2013)	1
COPS5	0	UBC	7	affinity chromatography technology	Bennett EJ (2010)	1
CUL4B	8	DDX56	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Chua YS (2011), Chua YS (2011), Tron AE (2012), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Schumacher FR (2015), Schumacher FR (2015), Lo SC (2006), Lo SC (2006)	12
MOV10	6	GRWD1	3	affinity chromatography technology	Castello A (2012)	1
DDB1	6	CAND1	2	affinity chromatography technology	Hu J (2004)	1
MCM7	5	CDT1	2	imaging technique	Sugimoto N (2015)	1
IFI16	1	NOL10	3	affinity chromatography technology	Diner BA (2015)	1
COPS5	0	RPL11	3	affinity chromatography technology	Bennett EJ (2010)	1
NPM1	0	VCP	6	affinity chromatography technology	Chen R (2013)	1
COPS5	0	WDR5	2	affinity chromatography technology	Bennett EJ (2010)	1
NXF1	0	RBM19	5	affinity chromatography technology	Castello A (2012)	1