PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CUL3	17	PCNA	0	affinity chromatography technology	Bennett EJ (2010)	1
UBE2D2	0	STAM2	0	enzymatic study	Hoeller D (2007)	1
TP53	0	TP73	2	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Stindt MH (2015), Puca R (2011), De Laurenzi V (1998), Di Como CJ (1999)	4
ERBB4	5	ITCH	1	affinity chromatography technology, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, pull down	Sundvall M (2008), Sundvall M (2008), Sundvall M (2008), Omerovic J (2007), Omerovic J (2007), Omerovic J (2007)	6
CYLD	2	SLC3A2	5	affinity chromatography technology	Elliott PR (2016)	1
SMAD2	5	USP9X	15	affinity chromatography technology	Dupont S (2009)	1
ELAVL1	0	TP53	0	affinity chromatography technology	Galban S (2003)	1
SMAD3	1	NCOA1	6	affinity chromatography technology	Li G (2006)	1
LATS1	3	USP9X	15	affinity chromatography technology, biochemical	Toloczko A (2017), Toloczko A (2017)	2
ELAVL1	0	UBE2D3	1	affinity chromatography technology	Abdelmohsen K (2009)	1
TRAF6	0	TAX1BP1	3	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Ling L (2000), Ling L (2000), Ling L (2000), Wang J (2011)	4
DVL2	5	ITCH	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique	Wei W (2012), Wei W (2012), Wei W (2012), Mund T (2015), Mund T (2015), Mund T (2015)	6
DVL1	5	DVL3	7	two hybrid, affinity chromatography technology, pull down	Kishida S (1999), Kishida S (1999), Kishida S (1999)	3
NOTCH1	25	CBL	7	affinity chromatography technology, affinity chromatography technology	Jehn BM (2002), Platonova N (2015)	2
SH3GL1	3	SH3GLB1	2	biochemical	Kristensen AR (2012)	1
TNFRSF10B	1	CBL	7	affinity chromatography technology, affinity chromatography technology	Song JJ (2010), Xu L (2017)	2
RASSF1	3	LATS1	3	affinity chromatography technology	Guo C (2007)	1
STAM	3	ITCH	1	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Malik R (2012), Malik R (2012), Malik R (2012), OConnor HF (2015)	4
UBE2E3	0	DTX3L	1	two hybrid	Markson G (2009)	1
MAP3K7	2	SMAD6	9	affinity chromatography technology, affinity chromatography technology	Kimura N (2000), Yanagisawa M (2001)	2
TXNIP	2	ITCH	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, x-ray crystallography, pull down, bioid	Zhang P (2010), Zhang P (2010), Zhang P (2010), Liu Y (2016), Liu Y (2016), Forred BJ (2016)	6
GLI1	3	SMAD2	5	affinity chromatography technology	Nye MD (2014)	1
USP13	2	UBC	7	enzymatic study, pull down, pull down, pull down, pull down	Zhang YH (2012), Nathan JA (2013), Zhang YH (2012), Zhang X (2017), Kwasna D (2018)	5
CUL3	17	KPNA2	0	affinity chromatography technology	Bennett EJ (2010)	1
CSNK2A1	15	MDM2	2	enzymatic study, enzymatic study	Goetz C (1999), Hjerrild M (2001)	2
ITCH	1	RASSF5	2	affinity chromatography technology, affinity chromatography technology, pull down	Suryaraja R (2013), Suryaraja R (2013), Suryaraja R (2013)	3
TRAF6	0	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Muroi M (2011), Park S (2013), Sun L (2004), Kanayama A (2004), Sakamoto H (2015), Yu J (2016), Middleton AJ (2017)	7
POLR2E	0	RPAP2	3	affinity chromatography technology	Huttlin EL (2017)	1
TP53	0	STAM2	0	genetic interference	Xie L (2013)	1
NUMB	1	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Colaluca IN (2008), Colaluca IN (2008), Amson R (2011), Sheng W (2013), Liu D (2016), Liu D (2016), Sheng W (2017)	7
SMAD6	9	SMAD7	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Topper JN (1997), Topper JN (1997), Topper JN (1997), Yan X (2016)	4
YAP1	0	WBP2	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid	Couzens AL (2013), Hauri S (2013), Schuchardt BJ (2014), Lim SK (2016), Lim SK (2016)	5
WWP2	7	POLR2C	0	affinity chromatography technology	Chaudhary N (2014)	1
ITCH	1	PACSIN1	0	fluorescent resonance energy transfe, affinity chromatography technology, far western blotting, pull down, unspecified method	Desrochers G (2015), Desrochers G (2015), Desrochers G (2015), Desrochers G (2015), Desrochers G (2017)	5
IKBKB	1	MAP3K7	2	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hofer-Warbinek R (2000), Wu ZH (2010), Wu ZH (2010), Prickett TD (2008), Fan YH (2011), Neil JR (2008), Wu X (2007), Shambharkar PB (2007), Shambharkar PB (2007), Niu J (2013), Yao F (2015), Yao F (2015), Mei ZZ (2016), Zheng C (2015)	14
WWP2	7	WWP1	3	affinity chromatography technology, affinity chromatography technology	Chaudhary N (2014), Chaudhary N (2014)	2
HDAC6	0	USP9X	15	affinity chromatography technology	Joshi P (2013)	1
NDFIP2	2	EGFR	5	affinity chromatography technology	Mund T (2010)	1
ATN1	2	WWP2	7	two hybrid, pull down, two hybrid	Wood JD (1998), Wood JD (1998), Lim J (2006)	3
HDAC6	0	ERBB4	5	protein complementation assay	Deribe YL (2009)	1
NEDD9	3	ITCH	1	two hybrid, affinity chromatography technology, pull down, pull down, two hybrid, affinity chromatography technology	Feng L (2004), Feng L (2004), Feng L (2004), Feng L (2004), Feng L (2004), Feng L (2004)	6
UBC	7	PCBP2	3	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
ITCH	1	RPAP3	1	pull down	Ingham RJ (2005)	1
SF1	9	HNRNPUL1	1	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
CDC34	3	CUL3	17	pull down	Plafker KS (2009)	1
WWP2	7	UBE2K	0	pull down	Sheng Y (2012)	1
TP53	0	WWOX	3	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Chang NS (2001), Chang NS (2001), Chang NS (2005), Chang NS (2005), Chang NS (2005)	5
MDM2	2	SMARCE1	1	unspecified method	Nicholson J (2014)	1
HNRNPL	3	SNX9	1	affinity chromatography technology	Fei T (2017)	1
NDFIP2	2	ITCH	1	affinity chromatography technology	Ohzono C (2010)	1
SMAD7	1	TGFBR1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mochizuki T (2004), Asano Y (2004), Koinuma D (2003), Kavsak P (2000), Hayashi H (1997), Hayashi H (1997), Datta PK (2000), Wicks SJ (2005), Lallemand F (2005), Seong HA (2007), Yan X (2011), Cai Y (2012), Cai Y (2012), Seo SR (2004), Zhu L (2012), Zhu L (2012), Nakao A (1997), Yan X (2009), Kamiya Y (2010), Suzuki C (2002), Hsu HY (2014)	21
ADRB2	0	ARRDC1	4	protein complementation assay, affinity chromatography technology	Kittanakom S (2014), Patwari P (2011)	2
ITCH	1	SMARCC1	5	pull down	Ingham RJ (2005)	1
WWP2	7	NUDT21	0	affinity chromatography technology	Chaudhary N (2014)	1
CFTR	5	POLR2E	0	affinity chromatography technology	Pankow S (2015)	1
LRRK2	5	GNAI2	1	affinity chromatography technology	Meixner A (2011)	1
ATXN3	2	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study	Liu H (2016), Liu H (2016), Liu H (2016), Liu H (2016), Liu H (2016)	5
TGFBR1	2	CAV1	0	biochemical, affinity chromatography technology	Razani B (2001), Razani B (2001)	2
USP9X	15	DDX20	4	affinity chromatography technology, affinity chromatography technology	Han KJ (2012), Han KJ (2012)	2
ITCH	1	RIPK1	2	affinity chromatography technology	Shembade N (2009)	1
HGS	5	ITCH	1	affinity chromatography technology, affinity chromatography technology	Marchese A (2003), OConnor HF (2015)	2
MAP3K7	2	ITCH	1	affinity chromatography technology	Kathania M (2015)	1
ARRDC1	4	YAP1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2K	0	ITSN1	5	two hybrid	Vinayagam A (2011)	1
TOLLIP	3	TRAF6	0	affinity chromatography technology	Lee JY (2009)	1
ITCH	1	PDCD6IP	3	affinity chromatography technology	OConnor HF (2015)	1
CYLD	2	ELAVL1	0	affinity chromatography technology	Elliott PR (2016)	1
HNRNPL	3	ARRB1	2	affinity chromatography technology	Fei T (2017)	1
CFTR	5	SFN	1	affinity chromatography technology	Pankow S (2015)	1
HNRNPL	3	UBE2E3	0	affinity chromatography technology	Fei T (2017)	1
CUL3	17	PRKACA	2	affinity chromatography technology	Bennett EJ (2010)	1
UBE2D3	1	HDAC6	0	enzymatic study	Hoeller D (2007)	1
URI1	2	PCBP2	3	affinity chromatography technology	Mita P (2016)	1
CFTR	5	HNRNPUL1	1	affinity chromatography technology	Pankow S (2015)	1
SMAD7	1	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lallemand F (2005), Lallemand F (2005), Al-Salihi MA (2012), Gen Y (2017), Gen Y (2017)	5
IKBKB	1	ITCH	1	affinity chromatography technology	Agarwal NK (2016)	1
ELAVL1	0	DTX3L	1	affinity chromatography technology	Abdelmohsen K (2009)	1
TRAF6	0	TAB1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takaesu G (2000), Ninomiya-Tsuji J (1999), Walsh MC (2008)	3
CUL3	17	KPNB1	3	affinity chromatography technology	Bennett EJ (2010)	1
CSNK2A1	15	UBE2D3	1	enzymatic study	Gao Z (2014)	1
TRAF6	0	WWP1	3	affinity chromatography technology	Lin XW (2013)	1
SCNN1B	1	ITCH	1	far western blotting	Harvey KF (2001)	1
RIPK1	2	CYLD	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wright A (2007), Nagabhushana A (2011), ODonnell MA (2012), Wu GR (2017)	4
CSNK2A1	15	SCNN1A	1	enzymatic study	Edinger RS (2009)	1
TP53	0	PABPC1	5	affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Horikawa I (2014)	2
SMAD2	5	DVL1	5	pull down	Warner DR (2003)	1
ELAVL1	0	EWSR1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
WBP2	0	WWP2	7	unspecified method, affinity chromatography technology, two hybrid, pull down	Pirozzi G (1997), Chaudhary N (2014), Lim SK (2016), Lim SK (2016)	4
ELAVL1	0	UBE2G1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
UBC	7	TOLLIP	3	pull down, pull down, pull down, biochemical, pull down, pull down, pull down, pull down	Fenner BJ (2009), Nathan JA (2013), Mitra S (2013), Mitra S (2013), Shih SC (2003), Lu K (2014), Lu K (2014), Zhang X (2017)	8
TRAF6	0	TP53	0	enzymatic study, affinity chromatography technology	Zhang X (2016), Zhang X (2016)	2
ELAVL1	0	SMARCC1	5	affinity chromatography technology	Abdelmohsen K (2009)	1
HNRNPL	3	UBA6	4	affinity chromatography technology	Fei T (2017)	1
POU5F1	0	WWP2	7	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study	Xu H (2009), Xu H (2009), Xu H (2009), Qian YW (2012), Liao B (2010)	5
UBE2E1	1	CUL3	17	pull down	Plafker KS (2009)	1
ITCH	1	UBAP2	5	pull down	Ingham RJ (2005)	1
ARRB2	5	MAP2K4	3	affinity chromatography technology, unspecified method	McDonald PH (2000), Li X (2009)	2
WWP2	7	DAZAP1	1	affinity chromatography technology	Chaudhary N (2014)	1
ATXN3	2	USP13	2	affinity chromatography technology	Sowa ME (2009)	1
ERBB4	5	TP53	0	affinity chromatography technology	Gilmore-Hebert M (2010)	1
CYLD	2	HDAC6	0	affinity chromatography technology, pull down, affinity chromatography technology	Wickstroem SA (2010), Wickstroem SA (2010), Sun L (2010)	3
HNRNPL	3	RPAP2	3	affinity chromatography technology	Fei T (2017)	1
GGA3	6	UBC	7	pull down, pull down, pull down, two hybrid, x-ray crystallography, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, pull down	Shiba Y (2004), Shiba Y (2004), Kang EL (2010), Kametaka S (2005), Kawasaki M (2005), Kawasaki M (2005), Kawasaki M (2005), Prag G (2005), Prag G (2005), Bilodeau PS (2004), Zhang X (2017)	11
ARRDC3	0	ARRB2	5	affinity chromatography technology, affinity chromatography technology	Shea FF (2012), Han SO (2012)	2
GRB2	2	5430	0	two hybrid	Wang J (2008)	1
EGFR	5	ITCH	1	affinity chromatography technology	Tong J (2014)	1
CFTR	5	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye S (2010), Ye S (2010), Bomberger JM (2012), Arora K (2016)	4
EGFR	5	SLC3A2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu SL (2006), Wu SL (2006), Tong J (2014), Li J (2013)	4
WDR48	2	TP53	0	affinity chromatography technology	Sowa ME (2009)	1
SCAMP3	0	WWP2	7	two hybrid	Aoh QL (2009)	1
UBE2K	0	DTX3L	1	two hybrid	Markson G (2009)	1
SFN	1	MDM2	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Yang HY (2007), Yang HY (2007), Yang HY (2007), Wood NT (2009)	4
OCLN	1	TGFBR1	2	affinity chromatography technology, affinity chromatography technology	Barrios-Rodiles M (2005), Barrios-Rodiles M (2005)	2
ERBB4	5	YAP1	0	two hybrid, pull down, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, pull down	Omerovic J (2004), Omerovic J (2004), Omerovic J (2004), Komuro A (2003), Komuro A (2003), Feng SM (2009), Schuchardt BJ (2014)	7
MDM2	2	ARRB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Wang P (2003), Shenoy SK (2008), Girnita L (2005), Girnita L (2005), Nogues L (2011), Shenoy SK (2001), Ahmed MR (2011)	7
MAVS	1	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	You F (2009), You F (2009), Choi YB (2017)	3
AMOT	6	YAP1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Wang C (2012), Wang C (2012), Adler JJ (2013), Couzens AL (2013), Adler JJ (2013), Chan SW (2013), Dai X (2013), Hauri S (2013)	9
CUL3	17	RPAP3	1	affinity chromatography technology	Bennett EJ (2010)	1
MAP3K7	2	MAP2K4	3	enzymatic study, affinity chromatography technology	Ge B (2003), Li MG (2003)	2
UBA6	4	UBE2L3	1	pull down, enzymatic study	Jin J (2007), Huang DT (2009)	2
ARRB2	5	HGS	5	affinity chromatography technology, affinity chromatography technology	Han SO (2012), Malik R (2010)	2
WDR48	2	PCNA	0	pull down	Cohn MA (2007)	1
SNX18	1	ITCH	1	affinity chromatography technology	Baumann C (2010)	1
HGS	5	STAM2	0	two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Rual JF (2005), Bache KG (2003), Bache KG (2003), Mizuno E (2004), Kanazawa C (2003), Kanazawa C (2003), Stuible M (2010), Havugimana PC (2012), Hoeller D (2006), Wan C (2015)	10
EGFR	5	USP9X	15	affinity chromatography technology	Foerster S (2013)	1
CPSF6	1	ITCH	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Ingham RJ (2005), Ingham RJ (2005), Ingham RJ (2005), OConnor HF (2015), Huttlin EL (2017)	5
LATS1	3	YAP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Zhang J (2008), Zhang J (2008), Ho KC (2011), Vigneron AM (2010), Vigneron AM (2010), Huntoon CJ (2010), Hao Y (2008), Hao Y (2008), Hao Y (2008), Hao Y (2008), Matallanas D (2007), Matallanas D (2007), Oka T (2008), Oka T (2008), Oka T (2008), Yu FX (2012), Yu FX (2012), Chiyoda T (2012), Couzens AL (2013), Ho KC (2011), Salah Z (2013), Hauri S (2013), Schuchardt BJ (2014), Mei L (2017), Enzo E (2015), Si Y (2017), Guo PD (2016)	27
ELAVL1	0	NDFIP2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
WWOX	3	SMARCC1	5	pull down, affinity chromatography technology	Ingham RJ (2005), Abu-Odeh M (2014)	2
UBC	7	IKBKB	1	pull down	Zhang X (2017)	1
SMAD3	1	SMARCC1	5	affinity chromatography technology	Xi Q (2008)	1
POLR2B	3	POLR2E	0	pull down, pull down, biochemical, biochemical	Acker J (1997), Acker J (1997), Havugimana PC (2012), Wan C (2015)	4
EWSR1	2	WWP2	7	two hybrid	Rual JF (2005)	1
ITCH	1	CDC34	3	pull down	Sheng Y (2012)	1
SMAD6	9	WWP2	7	affinity chromatography technology	Herhaus L (2014)	1
ITCH	1	LAPTM5	3	affinity chromatography technology, enzymatic study	Ishihara T (2011), Ishihara T (2011)	2
CUL3	17	ARID1A	16	affinity chromatography technology	Bennett EJ (2010)	1
ERBB4	5	GRB2	2	affinity chromatography technology, affinity chromatography technology	Schulze WX (2006), Kiuchi T (2014)	2
HNRNPL	3	DAZAP1	1	affinity chromatography technology	Fei T (2017)	1
ITCH	1	UBE2G1	2	pull down, pull down	Gallagher E (2006), Wei W (2012)	2
JUN	0	CSNK2A1	15	pull down, far western blotting, enzymatic study	Yamaguchi Y (1998), Yamaguchi Y (1998), Uhle S (2003)	3
YAP1	0	SMAD2	5	affinity chromatography technology	Pefani DE (2016)	1
ITCH	1	USP5	2	affinity chromatography technology	OConnor HF (2015)	1
MAP2K4	3	ITCH	1	affinity chromatography technology, pull down, enzymatic study	Ahn YH (2009), Ahn YH (2009), Ahn YH (2009)	3
WWP2	7	UBE2J2	1	pull down	Sheng Y (2012)	1
WWOX	3	RPAP3	1	affinity chromatography technology	Abu-Odeh M (2014)	1
ITCH	1	PABPC1	5	pull down	Ingham RJ (2005)	1
MDM2	2	UBC	7	pull down, enzymatic study, enzymatic study	Higashitsuji H (2005), Luo J (2013), Poyurovsky MV (2007)	3
ADRB2	0	SLC1A5	1	affinity chromatography technology	Roy SJ (2013)	1
EWSR1	2	SMARCC2	9	bioid	Elzi DJ (2014)	1
HNRNPL	3	WWP1	3	affinity chromatography technology	Fei T (2017)	1
WWOX	3	HNRNPUL1	1	affinity chromatography technology	Abu-Odeh M (2014)	1
ARRB2	5	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang Y (2006), Wang Y (2006), Xiao N (2015)	3
SMN1	0	EWSR1	2	affinity chromatography technology	Fuller HR (2010)	1
ITCH	1	TP73	2	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Oberst A (2007), Levy D (2007), Rossi M (2005), Rossi M (2005), Rossi M (2005), Rossi M (2005)	6
CAV1	0	CUL3	17	affinity chromatography technology, affinity chromatography technology	Dubiel D (2017), Dubiel D (2017)	2
IKBKB	1	JUN	0	enzymatic study	Orel L (2010)	1
PRKACA	2	ITCH	1	enzymatic study	Morales B (2007)	1
UBA1	1	UBE2D3	1	enzymatic study, pull down, enzymatic study, enzymatic study	Tokgoez Z (2012), Jin J (2007), Song AX (2014), Huguenin-Dezot N (2016)	4
ADRB2	0	GNAI2	1	fluorescent resonance energy transfe	Gales C (2005)	1
TOLLIP	3	ITCH	1	affinity chromatography technology	Li S (2011)	1
PRKACA	2	MAVS	1	affinity chromatography technology	Yan BR (2017)	1
CUL3	17	SNX9	1	affinity chromatography technology	Bennett EJ (2010)	1
CYLD	2	UBC	7	enzymatic study, enzymatic study, enzymatic study, pull down	Almeida S (2008), Bremm A (2010), Komander D (2009), Kwasna D (2018)	4
RIPK1	2	IKBKB	1	biochemical, pull down	Yang Y (2011), Poyet JL (2000)	2
SPART	0	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology	Milewska M (2009), Edwards TL (2009), Hooper C (2010), Eastman SW (2009), Ingham RJ (2005), Huttlin EL (2017)	6
KPNB1	3	SMAD3	1	pull down, affinity chromatography technology	Xiao Z (2000), Xiao Z (2000)	2
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
WWP2	7	UBC	7	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Sheng Y (2012), Maspero E (2013), Soond SM (2013), Kristariyanto YA (2015)	4
SCNN1B	1	HGS	5	affinity chromatography technology	Zhou R (2010)	1
AMOT	6	TP53BP2	5	bioid	Couzens AL (2013)	1
TP53	0	CYLD	2	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Fernandez-Majada V (2016), Fernandez-Majada V (2016), Fernandez-Majada V (2016), Fernandez-Majada V (2016)	4
CFTR	5	PCBP2	3	affinity chromatography technology	Pankow S (2015)	1
SMAD3	1	HGS	5	affinity chromatography technology	Miura S (2000)	1
BECN1	2	TRAF6	0	affinity chromatography technology, enzymatic study	Shi CS (2010), Shi CS (2010)	2
POLR2E	0	URI1	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gstaiger M (2003), Huttlin EL (2017), Cloutier P (2017), Mita P (2016)	4
YAP1	0	SMAD6	9	affinity chromatography technology	Ferrigno O (2002)	1
SPART	0	KPNB1	3	affinity chromatography technology	Milewska M (2009)	1
JUNB	0	JUN	0	affinity chromatography technology	Huttlin EL (2017)	1
TMEM255A	0	ITCH	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
WWOX	3	CPSF7	4	pull down, affinity chromatography technology	Ingham RJ (2005), Abu-Odeh M (2014)	2
CUL3	17	POLR2B	3	affinity chromatography technology	Bennett EJ (2010)	1
CPSF7	4	UBAP2L	4	biochemical	Havugimana PC (2012)	1
USP12	1	WDR48	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Joo HY (2011), Cohn MA (2009), Cohn MA (2009), Cohn MA (2009), Lehoux M (2014), Lehoux M (2014), Jahan AS (2016), McClurg UL (2015), Dharadhar S (2016), Cukras S (2016), Li H (2016), Li H (2016), Gangula NR (2013)	15
CBLC	1	UBE2D2	0	pull down, pull down	Ryan PE (2010), Kim M (2004)	2
ITCH	1	URI1	2	pull down	Ingham RJ (2005)	1
UBE2L3	1	ATXN3	2	pull down	Durcan TM (2011)	1
ELAVL1	0	LITAF	0	affinity chromatography technology	Abdelmohsen K (2009)	1
CBLC	1	EGFR	5	affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, x-ray crystallography	Kim M (1999), Keane MM (1999), Keane MM (1999), Takeshita K (2012), Takeshita K (2012), Takeshita K (2012)	6
TMEM171	1	WWOX	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2D3	1	WWP2	7	pull down, pull down, pull down	Maspero E (2013), Lv Y (2014), Kristariyanto YA (2015)	3
CPSF6	1	WWP1	3	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005), Xin X (2009), Huttlin EL (2017)	4
LDLRAD4	1	ITCH	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARRB2	5	SMARCC2	9	two hybrid	Stelzl U (2005)	1
TP53	0	SMARCC1	5	biochemical, affinity chromatography technology	Lee D (2002), Oh J (2008)	2
ITCH	1	NOTCH1	25	affinity chromatography technology	Puca L (2013)	1
WBP1	1	WWP2	7	unspecified method	Pirozzi G (1997)	1
WWP1	3	UBE2D2	0	pull down	Kristariyanto YA (2015)	1
CAV1	0	SMAD2	5	biochemical	Razani B (2001)	1
ELAVL1	0	CSNK2A1	15	affinity chromatography technology	Abdelmohsen K (2009)	1
WWOX	3	NUDT21	0	pull down	Ingham RJ (2005)	1
WWOX	3	SMAD3	1	pull down, affinity chromatography technology	Ferguson BW (2013), Ferguson BW (2013)	2
WWOX	3	POLR2C	0	affinity chromatography technology	Abu-Odeh M (2014)	1
UBA6	4	PDCD6IP	3	biochemical	Kristensen AR (2012)	1
IKBKB	1	MAVS	1	enzymatic study	Liu S (2015)	1
SMAD3	1	ARID1A	16	affinity chromatography technology	Xi Q (2008)	1
ARHGEF7	3	CBL	7	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Flanders JA (2003), Flanders JA (2003), Schmidt MH (2006), Schmidt MH (2006), Schmidt MH (2006), Wu WJ (2003), Singh VK (2012), Singh VK (2012), Chang CC (2012)	9
NOTCH1	25	KPNB1	3	affinity chromatography technology, affinity chromatography technology	Yatim A (2012), Mukherjee S (2016)	2
CFTR	5	SMARCC2	9	affinity chromatography technology	Pankow S (2015)	1
ADRB2	0	HDAC6	0	protein complementation assay	Kittanakom S (2014)	1
POLR2E	0	CSNK2A1	15	affinity chromatography technology	Huttlin EL (2017)	1
UBE2K	0	UBC	7	enzymatic study, x-ray crystallography, x-ray crystallography, pull down, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Flierman D (2006), Ko S (2010), Wilson RC (2011), Wilson RC (2011), Wilson RC (2011), Sheng Y (2012), Raasi S (2005), Bishop N (2002), Rajsbaum R (2014), Chong RA (2014), Whitby FG (1998), Singh RK (2012), Cook BW (2015)	13
USP12	1	GRB2	2	bioid	Jahan AS (2016)	1
SMN1	0	GEMIN8	1	affinity chromatography technology, affinity chromatography technology	Fuller HR (2010), Han KJ (2016)	2
TP53	0	HNRNPL	3	affinity chromatography technology	Horikawa I (2014)	1
SH3GL2	1	CBL	7	affinity chromatography technology	Soubeyran P (2002)	1
SMAD3	1	WWP1	3	affinity chromatography technology, affinity chromatography technology, two hybrid	Komuro A (2004), Seo SR (2004), Rolland T (2014)	3
WBP1	1	ITCH	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2E3	0	UBC	7	enzymatic study	Sheng Y (2012)	1
ITCH	1	TRPV4	2	affinity chromatography technology	Shukla AK (2010)	1
CSNK2A1	15	5430	0	enzymatic study, affinity chromatography technology	Moisan A (2004), Basnet H (2014)	2
NEDD9	3	FYN	1	affinity chromatography technology	Tachibana K (1997)	1
HDAC6	0	UBC	7	affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology	Pai MT (2007), Pozo FM (2011), Sekimoto T (2010), Kovacs JJ (2004), Hao R (2013), Lee JH (2013), Nakashima H (2014), Banerjee I (2014), Hao R (2013), Zhang X (2017), Yu Q (2018)	11
EGFR	5	KPNB1	3	affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Tong J (2014)	2
TP63	0	YAP1	0	pull down	Strano S (2001)	1
CYLD	2	PCBP2	3	affinity chromatography technology	Elliott PR (2016)	1
WWOX	3	ATN1	2	affinity chromatography technology	Abu-Odeh M (2014)	1
ARID1A	16	SMARCC1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Ryme J (2009), Ryme J (2009), Nagl NG (2005), Wang X (2004), Havugimana PC (2012), Wan C (2015), Dallas PB (1998)	7
TP53	0	SMN1	0	affinity chromatography technology, pull down, two hybrid	Young PJ (2002), Young PJ (2002), Vinayagam A (2011)	3
EGFR	5	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ettenberg SA (1999), Tvorogov D (2002), Pennock S (2008), Umebayashi K (2008), Ng C (2008), Ng C (2008), Povlsen GK (2008), Khan EM (2008), Su X (2007), Shtiegman K (2007), Han W (2006), Visser GD (2005), Tsacoumangos A (2005), Prasad NK (2005), Gur G (2004), Kowanetz K (2004), Feshchenko EA (2004), Wu WJ (2003), Schmidt MH (2003), Bao J (2003), Rubin C (2003), Waterman H (1999), Bonaccorsi L (2007), Dey N (2011), Miraoui H (2010), Guo HB (2009), Tong J (2009), Tong J (2009), Sun Q (2010), Sanada F (2009), Rafiq K (2011), Ravid T (2004), Ravid T (2004), Duan L (2011), Duan L (2011), Haglund K (2005), Oksvold MP (2003), Oksvold MP (2003), Gui A (2012), Yang S (2006), de Melker AA (2004), Crovello CS (1998), Graus-Porta D (1997), Oksvold MP (2001), Raguz J (2007), de Melker AA (2004), Thien CB (2001), Kassenbrock CK (2004), Tarcic G (2009), Schroeder B (2012), Adachi S (2009), Shen F (2007), Mitsushima M (2006), Choi JH (2003), Burke P (2001), Tanaka S (1995), Meisner H (1995), Meisner H (1995), Kumar EA (2012), Tong J (2008), Dou H (2012), Levkowitz G (1999), Levkowitz G (1999), Bode AM (2009), Thomas C (2012), Meijer IM (2013), Chang CC (2012), Chang CC (2012), Smith CJ (2013), Gan Y (2010), Scott RP (2005), Fukazawa T (1996), Fukazawa T (1996), Fukazawa T (1996), Wang L (2013), Hong SY (2013), Sigismund S (2013), Sigismund S (2013), Sigismund S (2013), Meisner H (1997), Odintsova E (2013), Kondratov KA (2010), He Z (2014), Tong J (2014), Balaji K (2012), Kiuchi T (2014), Zhang B (2005), Waterman H (1999), Ha Thi HT (2015), Yao S (2015), Kortuem F (2015), Igloi Z (2015), Song F (2016), Song F (2016), Lin TY (2017), Conte A (2017)	96
ARRB1	2	DVL1	5	affinity chromatography technology	Chen W (2001)	1
CBL	7	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jain SK (1997), Liu SK (1998), Ettenberg SA (1999), Wong A (2002), Wong A (2002), Robertson H (1997), Donovan JA (1994), Park RK (1999), Erdreich-Epstein A (1999), Gesbert F (1998), Gesbert F (1998), Gesbert F (1998), Husson H (1997), Saci A (2002), Odai H (1997), Ng C (2008), Khan EM (2008), Bandyopadhyay S (2010), Jiang X (2003), Waterman H (2002), Miraoui H (2010), Ravid T (2004), Ingham RJ (1996), Erdreich-Epstein A (1997), Rellahan BL (2003), Izadi KD (1998), Wang Y (1999), Chu J (1998), Bonita DP (1997), Boussiotis VA (1997), Meisner H (1995), Meisner H (1995), Barber DL (1997), Shishido T (2000), Bartkiewicz M (1999), Buday L (1996), Tarcic G (2009), Belleudi F (2007), Brizzi MF (1996), Brenner B (2001), Donovan JA (1996), Donovan JA (1996), Donovan JA (1996), Gaston I (2004), Gaston I (2004), Tsygankov AY (1996), Tsygankov AY (1996), Hunter S (1997), Jain SK (1997), Levkowitz G (1996), Liu YC (1997), Odai H (1995), Odai H (1995), Meisner H (1995), Huang JY (2000), Panchamoorthy G (1996), Panchamoorthy G (1996), Yokouchi M (1997), Oda A (1996), Fukazawa T (1995), Fukazawa T (1995), Selbach M (2006), Brehme M (2009), Brehme M (2009), Fukazawa T (1995), Cerboni C (1998), Cerboni C (1998), Fixman ED (1997), Anderson SM (1997), Houtman JC (2006), Brizzi MF (1996), Scott RP (2005), Scott RP (2005), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Umehara H (2002), Taipale M (2014), Taipale M (2014), Grossmann A (2015), Grossmann A (2015), Igloi Z (2015), Huttlin EL (2017)	83
RNF11	0	TNFRSF10B	1	affinity chromatography technology	Huttlin EL (2017)	1
TAX1BP1	3	FAM189A2	2	two hybrid	Rolland T (2014)	1
DAZAP1	1	PCBP2	3	biochemical	Wan C (2015)	1
CSNK2A1	15	SMARCC2	9	enzymatic study	Zhang M (2011)	1
ITCH	1	BIN1	2	fluorescent resonance energy transfe, affinity chromatography technology, far western blotting, unspecified method	Desrochers G (2015), Desrochers G (2015), Desrochers G (2015), Desrochers G (2017)	4
SMAD2	5	SMAD6	9	affinity chromatography technology	Topper JN (1997)	1
TP73	2	YAP1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Strano S (2001), Strano S (2001), Levy D (2007), Levy D (2007), Strano S (2005), Lapi E (2008), Lapi E (2008), Oka T (2008), Levy D (2008), Levy D (2008), Schuchardt BJ (2014), Pefani DE (2016)	12
CAV1	0	HDAC6	0	affinity chromatography technology	Li Y (2008)	1
CFTR	5	GSN	3	affinity chromatography technology	Pankow S (2015)	1
TMEM171	1	ITCH	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
YAP1	0	JUN	0	affinity chromatography technology	Enzo E (2015)	1
BID	1	TNFRSF10B	1	biochemical	Gajate C (2005)	1
ITCH	1	SMARCE1	1	pull down	Ingham RJ (2005)	1
UBE2J2	1	UBC	7	enzymatic study	Sheng Y (2012)	1
ELAVL1	0	DVL2	5	affinity chromatography technology	Abdelmohsen K (2009)	1
HGS	5	NOTCH1	25	affinity chromatography technology	Sjoeqvist M (2014)	1
CYLD	2	DVL1	5	affinity chromatography technology	Tauriello DV (2010)	1
CPSF6	1	CPSF7	4	biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Hein MY (2015), Huttlin EL (2017)	3
ERBB4	5	WWOX	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sundvall M (2012), Feng SM (2009), Abu-Odeh M (2014), Sundvall M (2010)	4
CPSF6	1	WWP2	7	two hybrid, affinity chromatography technology	Rual JF (2005), Huttlin EL (2017)	2
TP73	2	PRKACA	2	affinity chromatography technology	Katayama H (2012)	1
HGS	5	LITAF	0	two hybrid	Rolland T (2014)	1
CFTR	5	KPNB1	3	affinity chromatography technology, affinity chromatography technology	Wang X (2006), Pankow S (2015)	2
SMAD3	1	USP9X	15	affinity chromatography technology	Dupont S (2009)	1
RNF11	0	CSNK2A1	15	affinity chromatography technology	Poulsen SL (2013)	1
ARRB1	2	POLR2E	0	affinity chromatography technology	Xiao K (2007)	1
MAPK8	3	WWOX	3	affinity chromatography technology, two hybrid	Chang NS (2003), Chang NS (2003)	2
EGFR	5	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schulze WX (2006), Blagoev B (2003), Oneyama C (2002), Wong L (1999), Okutani T (1994), Okutani T (1994), Okutani T (1994), Tortora G (1997), Daly RJ (1996), Buday L (1994), Lowenstein EJ (1992), Lowenstein EJ (1992), Braverman LE (1999), Khan EM (2008), Bonaccorsi L (2007), Miraoui H (2010), Tong J (2009), Severe N (2011), Takahashi Y (1999), Tarcic G (2009), Thien CB (1997), Burke P (2001), Katayama H (1999), Meisner H (1995), Kurada BR (2009), Tong J (2008), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Sigismund S (2013), Foerster S (2013), Bisson N (2011), Gotoh N (1994), Wu SL (2006), Wu SL (2006), Tong J (2014), Oksvold MP (2001), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Song F (2016), Song F (2016), Ueno H (1995), Ueno H (1995), Ueno H (1995), Prigent SA (1996), Kapoor GS (2010), Kapoor GS (2010), Okamura T (2009)	51
UBC	7	HNRNPL	3	affinity chromatography technology	Matsumoto M (2005)	1
ELAVL1	0	KPNB1	3	affinity chromatography technology	Abdelmohsen K (2009)	1
ITCH	1	TAX1BP1	3	affinity chromatography technology, affinity chromatography technology	Shembade N (2008), Shembade N (2008)	2
MAPK8	3	NFE2	0	enzymatic study	Lee TL (2010)	1
LRRK2	5	SH3GL2	1	enzymatic study	Matta S (2012)	1
SMAD2	5	KPNB1	3	two hybrid	Colland F (2004)	1
SMAD7	1	WWP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Seo SR (2004), Seo SR (2004), Al-Salihi MA (2012)	4
ITCH	1	NUMB	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	McGill MA (2003), McGill MA (2003), McGill MA (2003), Chastagner P (2008), Di Marcotullio L (2011), Di Marcotullio L (2011)	6
UBE2D3	1	MGRN1	4	two hybrid	Markson G (2009)	1
SMAD2	5	SMAD7	1	genetic interference, pull down, affinity chromatography technology	Lebrun JJ (1999), Zhang S (2007), Yan X (2016)	3
ARRDC1	4	WWP1	3	pull down, two hybrid, affinity chromatography technology	Rauch S (2011), Rauch S (2011), Huttlin EL (2017)	3
HNRNPL	3	NUMB	1	affinity chromatography technology	Fei T (2017)	1
SMAD7	1	TP53	0	affinity chromatography technology	Zhang S (2006)	1
WBP1	1	WWOX	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ELAVL1	0	YAP1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
UBC	7	BIN1	2	pull down	Stamenova SD (2007)	1
HDAC6	0	BIN1	2	affinity chromatography technology	Watson GW (2016)	1
SMAD2	5	WWP1	3	affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Seo SR (2004)	2
ITCH	1	WWP1	3	affinity chromatography technology	OConnor HF (2015)	1
WWP1	3	FBXL15	0	affinity chromatography technology	Cui Y (2011)	1
SMAD7	1	SMAD3	1	genetic interference, genetic interference, affinity chromatography technology, protein complementation assay	Datta PK (2000), Lebrun JJ (1999), Yan X (2016), Yan X (2016)	4
TOLLIP	3	CAV1	0	affinity chromatography technology	Ohnuma K (2005)	1
EGFR	5	SLC1A5	1	affinity chromatography technology	Tong J (2014)	1
UBC	7	CAV1	0	affinity chromatography technology, imaging technique	Luo X (2017), Luo X (2017)	2
SMARCE1	1	ARID1A	16	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Hu K (2006), Ryme J (2009), Kaeser MD (2008), Kaeser MD (2008), Mak AB (2010), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	9
UBE2M	0	CUL3	17	enzymatic study, pull down	Huang G (2011), Schumacher FR (2015)	2
TP63	0	CPSF6	1	affinity chromatography technology	Amoresano A (2010)	1
SMARCC2	9	SMARCC1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Ryme J (2009), Ryme J (2009), Kaeser MD (2008), Kaeser MD (2008), Nagl NG (2005), Mak AB (2010), Havugimana PC (2012), Wan C (2015), Dallas PB (1998), Huttlin EL (2017)	10
BECN1	2	TP53BP2	5	affinity chromatography technology	Behrends C (2010)	1
NUDT21	0	POLR2C	0	two hybrid	Vinayagam A (2011)	1
WWOX	3	DVL2	5	affinity chromatography technology, affinity chromatography technology	Abu-Odeh M (2014), Huttlin EL (2017)	2
MAP3K7	2	SMAD3	1	imaging technique	Chen TC (2014)	1
ILDR1	2	ITCH	1	affinity chromatography technology	Huttlin EL (2017)	1
NOTCH1	25	DTX1	2	affinity chromatography technology, affinity chromatography technology	Yamamoto N (2001), Zhang P (2010)	2
JUN	0	EWSR1	2	pull down, bioid	Fuchs B (2003), Elzi DJ (2014)	2
DTX3L	1	STAM	3	affinity chromatography technology	Holleman J (2014)	1
ATN1	2	WWP1	3	two hybrid, two hybrid	Wood JD (1998), Lim J (2006)	2
UBE2D1	0	DTX1	2	two hybrid	van Wijk SJ (2009)	1
SMAD3	1	TGFBR1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Yan X (2009), Tang Y (2003), Tang Y (2003), Herhaus L (2015)	4
SMAD6	9	KPNA2	0	affinity chromatography technology	Herhaus L (2014)	1
CUL3	17	SMARCC1	5	affinity chromatography technology	Bennett EJ (2010)	1
UBA1	1	PABPC1	5	biochemical	Kristensen AR (2012)	1
SH3GLB1	2	ITCH	1	affinity chromatography technology	Azakir BA (2009)	1
TP53	0	TP53BP2	5	two hybrid, pull down, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology	Iwabuchi K (1994), Iwabuchi K (1994), Iwabuchi K (1994), Naumovski L (1996), Naumovski L (1996), Naumovski L (1996), Gillotin S (2011)	7
USP5	2	CDC34	3	biochemical	Kristensen AR (2012)	1
PCNA	0	EGFR	5	affinity chromatography technology, affinity chromatography technology, enzymatic study	Wang SC (2006), Wang SC (2006), Wang SC (2006)	3
CYLD	2	TRAF6	0	enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Bremm A (2010), Wu J (2015), Wu J (2015)	4
RPAP2	3	POLR2C	0	affinity chromatography technology	Jeronimo C (2007)	1
USP13	2	DVL1	5	two hybrid	Stelzl U (2005)	1
LDLRAD4	1	SMAD3	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARRB2	5	TAB1	1	affinity chromatography technology	Xiao K (2007)	1
ITCH	1	UBA6	4	affinity chromatography technology	OConnor HF (2015)	1
MAP2K4	3	MAPK8	3	pull down, pull down, enzymatic study, genetic interference, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Lee CM (2002), Park HS (2002), Chen Z (2001), Tournier C (1997), Cheng J (2000), Deacon K (1997), Xia Y (1998), Xia Y (1998), Ho DT (2006), Song JJ (2005), Sundarrajan M (2003), Ho DT (2003), Ho DT (2003)	13
JUN	0	SMARCC2	9	affinity chromatography technology	Li X (2015)	1
CFLAR	1	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Abedini MR (2008), Saha A (2011), Saha A (2011), Panner A (2009), Panner A (2009), Murata E (2008)	6
SMAD3	1	JUN	0	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Verrecchia F (2000), Liberati NT (1999), Liberati NT (2001), Lee SY (2011)	7
ELAVL1	0	DAZAP1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ADRB2	0	ARRDC3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down	Nabhan JF (2010), Shea FF (2012), Qi S (2014), Patwari P (2011), Shea FF (2012), Tian X (2016), Tian X (2016), Tian X (2016)	8
EGFR	5	DDX20	4	affinity chromatography technology	Foerster S (2013)	1
UBC	7	MAP2K4	3	pull down	Zhang X (2017)	1
DVL3	7	CSNK2A1	15	affinity chromatography technology, affinity chromatography technology	Song DH (2000), Huttlin EL (2017)	2
BECN1	2	UBC	7	pull down	Shi CS (2010)	1
POU5F1	0	USP9X	15	affinity chromatography technology	Oliviero G (2015)	1
DVL1	5	ITCH	1	affinity chromatography technology	Wei W (2012)	1
YAP1	0	EGFR	5	affinity chromatography technology	Komuro A (2003)	1
DVL2	5	CPSF7	4	two hybrid	Rual JF (2005)	1
ARRB1	2	STAM	3	affinity chromatography technology, pull down, imaging technique, pull down	Malik R (2010), Malik R (2010), Malik R (2010), Malik R (2010)	4
GGA3	6	ITCH	1	affinity chromatography technology	Santonico E (2014)	1
SMAD3	1	JUNB	0	two hybrid, pull down	Liberati NT (1999), Liberati NT (1999)	2
ITCH	1	SMARCC2	9	pull down	Ingham RJ (2005)	1
ITCH	1	POLR2C	0	pull down	Ingham RJ (2005)	1
NOTCH1	25	TAB1	1	affinity chromatography technology	Yatim A (2012)	1
TP53	0	SMAD2	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Cordenonsi M (2003), Cordenonsi M (2003), Tateossian H (2009), Lu D (2013), Chen TC (2014)	5
MAPK8	3	JUN	0	enzymatic study, enzymatic study, enzymatic study, pull down, pull down, pull down, two hybrid, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, two hybrid, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study	Ishitani T (2003), Nishitoh H (1998), Derijard B (1994), Derijard B (1994), Yazgan O (2002), Tada K (2001), Meyer CF (1996), Cano E (1995), Cano E (1995), Trivedi AK (2007), Zhu F (2006), Zuniga A (1999), Zuniga A (1999), Higashimoto T (2008), Garcia-Guzman M (2000), Singhirunnusorn P (2005), Hofmann TG (2005), Lewis J (2004), Jeon YJ (2009), Yamashita M (2008), Ryoo K (2004), Abell AN (2005), Burns K (1998), Hirano T (2002), Gravestein LA (1998), Dadgostar H (2003), Han YH (2006), Kolluri SK (2003), Chen LY (2003), Manna SK (2010), Gallagher ED (2002), Liu HP (2011), Xia Y (1998), Funakoshi-Tago M (2005), Ho DT (2006), Wang J (2000), Choi HK (2011), Chang TS (2003), Yao K (2009), Chang TS (2003), Dai R (2000), Gupta S (1996), Gupta S (1996), Sundarrajan M (2003), Kallunki T (1994), Kallunki T (1994), Wasserman T (2010), Blonska M (2007), Lee KH (2005), Kadoya T (2005), Katagiri C (2006), Yao K (2007), Wu X (2007), Kato T (2008), Cavigelli M (1995), Katagiri C (2006), Choi BY (2005), Choi BY (2005), Yuan ZQ (2003), Phelan DR (2001), Eliopoulos AG (2006), Hayashi T (2007), Zhang J (2013), Li X (2002), Kendrick TS (2004), Holzberg D (2003), Grau R (2004), Hernandez M (2000), Hwang SG (2014), Larsson H (1999), Rausch O (1997), Morley SJ (2000), Ho JM (2002), Shkoda A (2012), Pop M (2004), Chang HY (1999)	76
ATXN3	2	ITCH	1	affinity chromatography technology, affinity chromatography technology	Chhangani D (2014), Chhangani D (2014)	2
HTT	14	UBE2K	0	two hybrid, two hybrid, pull down, two hybrid	Faber PW (1998), Kalchman MA (1996), Kalchman MA (1996), Suter B (2013)	4
UBE2D2	0	DTX1	2	two hybrid	van Wijk SJ (2009)	1
HDAC6	0	PCNA	0	affinity chromatography technology	New M (2013)	1
HNRNPL	3	SCNN1A	1	affinity chromatography technology	Fei T (2017)	1
UBE2D2	0	UBE2M	0	biochemical	Havugimana PC (2012)	1
TRAF6	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Ishitani T (2003), Takaesu G (2000), Ninomiya-Tsuji J (1999), Takaesu G (2001), Mochida Y (2000), Mochida Y (2000), Walsh MC (2008), Sorrentino A (2008), Frobose H (2006), Ishitani T (2003), Xia ZP (2009), Jiang Z (2003), Jiang Z (2003), Yamazaki K (2009), Yamazaki K (2009), Jiang Z (2002), Jiang Z (2002), Cui W (2012), Jiang Z (2003), Minoda Y (2009), Gao D (2009), Lee HJ (2012), Hirata Y (2006), Hu MM (2014), Fujikawa H (2013), Sun D (2011), Li W (2015), Lin J (2015), Lee Y (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016)	33
BECN1	2	TP53	0	affinity chromatography technology	Verma N (2017)	1
URI1	2	5430	0	affinity chromatography technology, affinity chromatography technology	Cloutier P (2017), Mita P (2016)	2
ARRB2	5	ITCH	1	affinity chromatography technology, affinity chromatography technology, pull down	Shenoy SK (2008), Bhandari D (2007), Bhandari D (2007)	3
EGFR	5	RIPK1	2	affinity chromatography technology	Habib AA (2001)	1
SARAF	0	ITCH	1	affinity chromatography technology	Huttlin EL (2017)	1
CUL3	17	SMARCC2	9	affinity chromatography technology	Bennett EJ (2010)	1
EGFR	5	ARHGEF7	3	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
LRRK2	5	RIPK1	2	affinity chromatography technology	Ho CC (2009)	1
WWP2	7	SCNN1A	1	pull down	McDonald FJ (2002)	1
UBE2D1	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
SMN1	0	ITCH	1	affinity chromatography technology, affinity chromatography technology, pull down	Han KJ (2016), Han KJ (2016), Han KJ (2016)	3
HNRNPUL1	1	SMN1	0	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
UBC	7	UBA1	1	affinity chromatography technology, unspecified method, x-ray crystallography, biochemical, affinity chromatography technology, pull down	Nicassio F (2007), Zhao B (2012), Schaefer A (2014), Schaefer A (2014), Bish RA (2007), Zhang X (2017)	6
RPAP2	3	RPAP3	1	affinity chromatography technology	Jeronimo C (2007)	1
TP53	0	SFN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Tian H (2002), Yang HY (2007), Yang HY (2003), Yang HY (2003), Choi HH (2011)	5
RNF11	0	USP5	2	two hybrid, affinity chromatography technology	Colland F (2004), Poulsen SL (2013)	2
TGFBR1	2	SMAD2	5	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Razani B (2001), Faresse N (2008), Bai Y (2004), Tang Y (2003), Tang Y (2003), Ding L (2009), Lu D (2013), Herhaus L (2015)	8
SH3GL2	1	ITCH	1	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, unspecified method	Angers A (2004), Desrochers G (2015), Desrochers G (2015), Desrochers G (2015), Desrochers G (2015), Desrochers G (2015), Desrochers G (2017)	7
UBC	7	AMOT	6	affinity chromatography technology	Matsumoto M (2005)	1
WWOX	3	WBP2	0	pull down, affinity chromatography technology	Ingham RJ (2005), Abu-Odeh M (2014)	2
MDM2	2	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, protein complementation assay, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, two hybrid, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, unspecified method, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, protein complementation assay, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, x-ray crystallography, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, far western blotting, affinity chromatography technology, x-ray crystallography, unspecified method, pull down, pull down, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, biochemical, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, protein complementation assay, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, fluorescent resonance energy transfe, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, imaging technique, enzymatic study, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, enzymatic study, pull down, pull down, unspecified method, fluorescent resonance energy transfe, two hybrid, pull down	Li M (2003), Latonen L (2001), Zhang Y (2003), Zhang Y (2003), Kurki S (2003), Kurki S (2003), Freeman DJ (2003), Ito A (2002), Ito A (2002), Grossman SR (1998), Fang S (2000), Liu G (2000), Zhang Y (1998), Zhang Y (1998), Chen J (1993), Thut CJ (1997), Leung KM (2002), Wawrzynow B (2009), Ochocka AM (2009), Chen D (2009), Hedstroem E (2009), Brenkman AB (2008), Qiu W (2008), Qiu W (2008), Zhang Z (2008), Muller P (2008), Colaluca IN (2008), Colaluca IN (2008), Colaluca IN (2008), Tang Y (2008), Tang Y (2008), Lu X (2007), Lukashchuk N (2007), Lukashchuk N (2007), Lee JH (2007), Carter S (2007), Sasaki M (2007), Brooks CL (2007), Li L (2007), Becker K (2007), Zhao BX (2006), Zhao BX (2006), Abida WM (2007), Yang WH (2006), Ma J (2006), Wallace M (2006), Shimizu H (2006), Andrews P (2006), Yang J (2009), Zhu Z (2009), Wang C (2005), Higashitsuji H (2005), Higashitsuji H (2005), Yan C (2005), Vega FM (2004), Dai MS (2004), Dai MS (2004), Groenroos E (2004), Ohkubo S (2006), Sui G (2004), Di Stefano V (2004), Brignone C (2004), Katayama H (2004), Linares LK (2003), OKeefe K (2003), Wang W (2003), Blattner C (2002), Matt T (2004), Matt T (2004), Eyckerman S (2005), Shimizu H (2002), Shimizu H (2002), Migliorini D (2002), Gu J (2001), Sengupta S (2001), Chernov MV (2001), Cross B (2011), Cross B (2011), Cross B (2011), Buschmann T (2001), Nakamura S (2000), Rodriguez MS (2000), Rodriguez MS (2000), Geyer RK (2000), Zaika A (1999), Maki CG (1999), Chen L (2010), Chen L (2010), Lin RK (2010), Fuchs SY (1998), Xirodimas DP (2001), Fuchs SY (1998), Inoue T (2001), Wu L (2011), Du W (2009), Li DQ (2009), Illuzzi JL (2011), Oliver TG (2011), Kim MM (2007), Marchenko ND (2007), Vaseva AV (2009), Vaseva AV (2009), Lai KP (2010), Naderi EH (2011), Zdzalik M (2010), Singh RK (2007), Meng L (2011), Moore L (2007), Kim S (2010), Inoue Y (2011), Fraser JA (2010), Worrall EG (2009), Wu H (2011), Wang KS (2011), Wang KS (2011), Wang KS (2011), Izumi T (2010), Huang YF (2009), Tang J (2006), Tang J (2006), Fu X (2010), Fu X (2010), Shloush J (2011), Yadavilli S (2009), Stevenson LF (2007), Suzuki T (2010), Cheng Q (2009), Kulikov R (2010), Kulikov R (2010), Li L (2010), Li L (2010), Cheng Q (2011), Li D (2011), Nie J (2010), Demma M (2010), Sun XX (2011), Jung CR (2010), Jung CR (2010), Jung CR (2010), Jung CR (2010), Nishida T (2011), Li M (2011), Li M (2011), Amson R (2011), Amson R (2011), Bhatt P (2011), David Y (2011), Zhang Y (2010), Liu J (2010), Liu J (2010), Song MS (2008), Cummins JM (2004), Kim CK (2010), Kim CK (2010), Yan C (2010), Wang X (2011), Phillips A (2010), Phillips A (2010), Kang HN (2011), Kang HN (2011), Wang X (2004), Sionov RV (2001), Wei S (2012), Camus S (2012), Ding B (2012), Yang Z (2012), Yang Z (2012), Tripathi V (2007), Tripathi V (2007), Dai C (2011), Chen S (2012), Honda R (1997), Kinyamu HK (2003), Zhan C (2012), Zhan C (2012), Lee CW (2010), Zhou X (2012), Bouska A (2008), Wade M (2012), Ferreon JC (2009), Domenici F (2011), Uldrijan S (2007), Uldrijan S (2007), Stad R (2000), Stad R (2000), Banks D (2006), Banks D (2006), Bernal F (2010), Bernal F (2010), Jain AK (2012), Kane SA (2000), Tan Z (2000), Yang Z (2012), Wawrzynow B (2007), Wawrzynow B (2007), Wawrzynow B (2007), Hiramatsu K (2006), Bao-Lei T (2006), Kulikov R (2005), Yang Y (2005), Lindstroem MS (2007), Bech-Otschir D (2001), Li Y (2012), Gillotin S (2010), Burch L (2004), Liu WL (2001), OHagan HM (2004), OHagan HM (2004), Funari G (2009), Candeias MM (2008), Brew CT (2006), Wang J (2011), Calabro V (2002), Burch L (2004), Iyappan S (2010), Poyurovsky MV (2010), Poyurovsky MV (2010), Poyurovsky MV (2010), Kurki S (2004), Tian LF (2006), Wang J (2006), Bae S (2012), Bae S (2012), Frazier DP (2012), Frazier DP (2012), Lew QJ (2012), Lew QJ (2012), Huart AS (2012), Li Z (2004), Balint E (1999), Balint E (1999), Funston G (2012), Dou X (2012), Sadagopan S (2012), Sadagopan S (2012), Dixit D (2012), Roxburgh P (2012), Xu L (2012), Drago-Ferrante R (2008), Li H (2009), Negorev D (2001), Wang X (2012), Wang X (2012), Wang X (2012), Boettger A (1997), Jung H (2008), Oliner JD (1992), Seemann S (2005), Kawai H (2007), Schuster K (2007), Dawson R (2003), DArcy P (2009), Schon O (2004), Schon O (2004), Hogan C (2008), Lottin-Divoux S (2005), Latini P (2011), Latini P (2011), Latini P (2011), McCoy MA (2003), Kussie PH (1996), Shieh SY (1997), Shieh SY (1997), Naski N (2009), Naski N (2009), Schon O (2002), Tamborini E (2001), Wade M (2006), Wade M (2006), Lohrum MA (2003), Garcia JF (2002), Garcia JF (2002), Kallen J (2009), Kulikov R (2006), Kulikov R (2006), Czarna A (2009), Czarna A (2009), Hu B (2007), Chi SW (2005), Yu GW (2006), Yu GW (2006), Saji S (2001), Chen L (1997), Zhang H (1998), Issaeva N (2004), Wade M (2008), Wade M (2008), Chen HF (2007), Chen HF (2007), Li HH (2004), Wang J (2011), Gu L (2009), Gu L (2009), Meng L (2008), Meng L (2008), Okamoto K (2006), Malaguarnera R (2008), Zhou M (2003), Zhou M (2003), Di Conza G (2012), Xirodimas DP (2004), Auger KR (2005), Li J (2011), Li J (2011), Li J (2011), Lee SJ (2007), Chau JF (2012), Lu X (2005), Mazars A (2010), Mazars A (2010), Mazars A (2010), Olson DC (1993), Picksley SM (1994), Issaeva N (2004), Issaeva N (2004), Zhang J (2012), Wen W (2013), Wen W (2013), Bursac S (2012), Yang Y (2013), Yang Y (2013), Landre V (2013), Pettersson S (2012), Thin TH (2007), Thin TH (2007), Piccinin S (2012), Shan B (2012), Caratozzolo MF (2012), Lui K (2013), Kobet E (2000), Lim KH (2010), Ranaweera RS (2013), Cui D (2013), Ebina M (2013), He Y (2013), He Y (2013), Siepe D (2009), Suh HW (2013), Zhan YA (2013), Wang J (2011), Hjerpe R (2010), Murray MF (2007), Jin L (2013), Jin L (2013), Zhang R (2013), Yan S (2013), Sun XX (2011), Heyne K (2014), Heyne K (2014), Bista M (2013), Jin J (2014), Mikawa T (2014), Qi M (2014), Cheng Q (2014), Zhang HH (2014), Perry ME (2000), Nishizaki M (2004), Sanchez-Aguilera A (2006), Chen YC (2013), Bertamino A (2013), Ding G (2013), Kubo N (2013), Kubo N (2013), Hsueh KW (2013), Kofod-Olsen E (2014), Fogeron ML (2013), Chang YS (2013), Gotoh T (2014), Gotoh T (2014), Oi N (2014), Corcoran CA (2009), Corcoran CA (2009), Ayroldi E (2014), Wu G (2014), Rajendra R (2004), Zhang J (2014), Lee MG (2014), Lee MG (2014), Freedman DA (1997), Freedman DA (1997), Saxena A (2006), Shi D (2009), Lohrum MA (2001), Lohrum MA (2001), Grossman SR (2003), Yan S (2013), Xirodimas DP (2004), Yasuhara T (2014), Yasuhara T (2014), Yasuhara T (2014), Yasuhara T (2014), Saville MK (2004), Rodriguez MS (1999), Lui K (2013), Wu PY (2003), Pavithra L (2009), He Y (2013), Tan BX (2014), Huttlin EL (2015), Marcar L (2015), Borcherds W (2014), Borcherds W (2014), Li YC (2014), Ayroldi E (2014), Ling X (2014), Batuello CN (2015), Zhu N (2006), Mo XL (2015), Chen TC (2014), Stindt MH (2015), Caratozzolo MF (2014), Li X (2015), Saxena R (2016), Reed SM (2014), Du C (2016), Du C (2016), Du C (2016), Fraser JA (2015), Fraser JA (2015), Wu B (2015), Qin JJ (2015), Raza S (2015), Raza S (2015), Yamauchi T (2014), Yamauchi T (2014), Yamauchi T (2014), Shi Y (2010), Ahn HJ (2015), Lim KH (2015), Kang JH (2016), Chen J (2015), Liu X (2016), Yang P (2016), Yang P (2016), Liu D (2016), Liu D (2016), Liu D (2016), Datta D (2015), Reddy BA (2014), He X (2016), Shostak K (2014), Liu LJ (2016), Liu LJ (2016), Stegh AH (2010), Liu XH (2005), Medina-Medina I (2016), Medina-Medina I (2016), Kayama K (2017), Singh AK (2016), Liu WT (2016), Yue X (2016), Soares J (2015), Mukhopadhyay R (2016), Mukhopadhyay R (2016), Zhou X (2016), Zhou X (2016), Xie X (2016), Leao M (2015), Luo H (2016), Luo H (2016), Xie N (2016), Maeda R (2017), Maeda R (2017), Maeda R (2017), Sheng W (2017), Sheng W (2017), Liu M (2010), Huttlin EL (2017), Chauhan KM (2016), Goetz C (1999), Zhang J (2017), Unger T (1999), Liu Z (2004), Wu W (2015), Tan G (2017), Nomura K (2017), Lu W (2017), Lu W (2017), Hjerrild M (2001), Landre V (2017), Landre V (2017), Landre V (2017), Landre V (2017), Shangary S (2008), Shangary S (2008), Du WW (2017), Du WW (2017), Bista M (2013), Bista M (2013), Jin M (2017), LaRusch GA (2007), LaRusch GA (2007), Kurokawa M (2013), Ivanov AA (2017), Wong JH (2017), Wong JH (2017)	496
TP53	0	SMAD3	1	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Cordenonsi M (2003), Cordenonsi M (2003), Lu D (2013), Ali A (2013)	4
SMAD2	5	SMARCC2	9	affinity chromatography technology, affinity chromatography technology	Xi Q (2008), He W (2006)	2
CUL3	17	HNRNPUL1	1	affinity chromatography technology	Bennett EJ (2010)	1
GRAP2	0	SNX18	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ERBB4	5	TAB1	1	two hybrid	Yao Z (2017)	1
PACSIN1	0	HTT	14	two hybrid, pull down	Modregger J (2002), Modregger J (2002)	2
SFN	1	TP63	0	affinity chromatography technology, affinity chromatography technology	Fomenkov A (2004), Fomenkov A (2004)	2
ARRB1	2	UBC	7	affinity chromatography technology	Xiao K (2007)	1
EWSR1	2	DAZAP1	1	bioid	Elzi DJ (2014)	1
TXNIP	2	WWP1	3	affinity chromatography technology	Huttlin EL (2017)	1
ITCH	1	SF1	9	pull down	Ingham RJ (2005)	1
FAM189A2	2	WWP1	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	3
HNRNPL	3	EGFR	5	affinity chromatography technology	Fei T (2017)	1
CBLC	1	FYN	1	affinity chromatography technology, pull down	Kim M (1999), Kim M (1999)	2
SMAD2	5	ARID1A	16	affinity chromatography technology	Xi Q (2008)	1
GRB2	2	PDCD6IP	3	two hybrid, two hybrid	Bandyopadhyay S (2010), Wang J (2011)	2
TRAF6	0	SMN1	0	affinity chromatography technology	Kim EK (2017)	1
HTT	14	EGFR	5	affinity chromatography technology	Liu YF (1997)	1
UBE2M	0	PCBP2	3	biochemical	Wan C (2015)	1
CUL3	17	SF1	9	affinity chromatography technology	Bennett EJ (2010)	1
RIPK1	2	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bertrand MJ (2008), Li H (2006), Yang Y (2011), Yang Y (2011), Yang Y (2011), Hu MM (2014)	6
HNRNPL	3	MGRN1	4	affinity chromatography technology	Fei T (2017)	1
ATN1	2	EWSR1	2	two hybrid, bioid	Lim J (2006), Elzi DJ (2014)	2
ELAVL1	0	MGRN1	4	affinity chromatography technology	Abdelmohsen K (2009)	1
ITCH	1	LRRK2	5	affinity chromatography technology	OConnor HF (2015)	1
GSN	3	ITCH	1	affinity chromatography technology	Abedini MR (2014)	1
GRB2	2	KPNA2	0	two hybrid	Wang J (2011)	1
FAM189A2	2	WWP2	7	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
WBP2	0	EGFR	5	affinity chromatography technology	Lim SK (2016)	1
MAPK8	3	JUNB	0	affinity chromatography technology	Fuchs SY (1997)	1
ARRB2	5	TRPV4	2	affinity chromatography technology	Xiao K (2007)	1
MAP2K4	3	JUN	0	enzymatic study	Sundarrajan M (2003)	1
RASSF1	3	ITCH	1	affinity chromatography technology	Pefani DE (2016)	1
CFLAR	1	SMAD3	1	two hybrid	Wang J (2011)	1
ITCH	1	ARID1A	16	pull down	Ingham RJ (2005)	1
HNRNPL	3	WWOX	3	affinity chromatography technology	Fei T (2017)	1
SFN	1	CSNK2A1	15	affinity chromatography technology	Benzinger A (2005)	1
RNF11	0	WWP1	3	affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, pull down, two hybrid	Chen C (2008), Chen C (2008), Chen C (2008), Chen C (2008), Chen C (2008), Colland F (2004)	6
CPSF6	1	UBAP2L	4	biochemical	Havugimana PC (2012)	1
ARRB2	5	ARRB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Xiao K (2007), Xiao K (2007), Huttlin EL (2017)	4
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
UBA6	4	UBE2D1	0	pull down	Jin J (2007)	1
EGFR	5	ARRB2	5	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
NCOA1	6	ITCH	1	affinity chromatography technology	Jung SY (2005)	1
ATXN3	2	MGRN1	4	affinity chromatography technology, affinity chromatography technology	Chhangani D (2014), Chhangani D (2014)	2
WWP2	7	UBE2E1	1	pull down	Xu H (2009)	1
EGFR	5	EWSR1	2	affinity chromatography technology	Tong J (2014)	1
USP9X	15	AMOT	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Thanh Nguyen H (2016), Thanh Nguyen H (2016), Toloczko A (2017)	3
LDLRAD3	4	ITCH	1	affinity chromatography technology	Noyes NC (2016)	1
UBE2J2	1	UBA1	1	enzymatic study	Huguenin-Dezot N (2016)	1
POU5F1	0	SMARCC2	9	affinity chromatography technology	Oliviero G (2015)	1
UBC	7	MAP3K7	2	pull down	Zhang X (2017)	1
EGFR	5	HDAC6	0	affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Gao YS (2010), Deribe YL (2009), Deribe YL (2009), Deribe YL (2009), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	7
ARRB2	5	CSNK2A1	15	affinity chromatography technology, enzymatic study	Xiao K (2007), Kim YM (2002)	2
UBE2D3	1	ITCH	1	pull down, pull down	Maspero E (2013), Kristariyanto YA (2015)	2
5430	0	POLR2C	0	pull down, pull down, pull down, biochemical, affinity chromatography technology, biochemical	Acker J (1997), Acker J (1997), Knuesel MT (2009), Havugimana PC (2012), Ayguen O (2008), Wan C (2015)	6
CUL3	17	N4BP1	3	affinity chromatography technology	Bennett EJ (2010)	1
NUDT21	0	CPSF6	1	two hybrid, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Havugimana PC (2012), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	5
UBC	7	TAB1	1	pull down	Zhang X (2017)	1
GLI1	3	TP53	0	affinity chromatography technology	Li X (2015)	1
STAM2	0	TP53BP2	5	biochemical	Wan C (2015)	1
SMAD7	1	MAP3K7	2	affinity chromatography technology	Edlund S (2003)	1
ARRDC3	0	ARRB1	2	affinity chromatography technology	Shea FF (2012)	1
EWSR1	2	KPNA2	0	bioid	Elzi DJ (2014)	1
TNFRSF10B	1	ITCH	1	affinity chromatography technology	Panner A (2009)	1
5430	0	EWSR1	2	affinity chromatography technology	Dutertre M (2010)	1
TP53	0	LAPTM5	3	genetic interference	Xie L (2013)	1
STAM	3	ARRDC3	0	affinity chromatography technology	Tian X (2016)	1
NUDT21	0	CPSF7	4	two hybrid, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Rolland T (2014), Wan C (2015), Hein MY (2015), Hein MY (2015)	5
EWSR1	2	UBE2M	0	bioid	Elzi DJ (2014)	1
HDAC6	0	ATXN3	2	pull down	Bonanomi M (2014)	1
HNRNPL	3	URI1	2	affinity chromatography technology	Fei T (2017)	1
EWSR1	2	PCNA	0	bioid	Elzi DJ (2014)	1
OCLN	1	ITCH	1	affinity chromatography technology	Murakami T (2009)	1
ITCH	1	CYLD	2	affinity chromatography technology, affinity chromatography technology, pull down	Ahmed N (2011), Ahmed N (2011), Ahmed N (2011)	3
CDC34	3	UBE2D3	1	affinity chromatography technology, affinity chromatography technology	Kuang P (2016), Kuang P (2016)	2
EGFR	5	UBAP2L	4	affinity chromatography technology	Yao Z (2017)	1
UBA1	1	UBE2L3	1	enzymatic study, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Tokgoez Z (2012), Ronchi VP (2012), Jin J (2007), Liu Z (2014), Nuber U (1996), Huang DT (2009), Kang D (2002), Wauer T (2015), Huguenin-Dezot N (2016)	9
GRB2	2	ARHGEF7	3	affinity chromatography technology	Bisson N (2011)	1
WWP2	7	POLR2E	0	affinity chromatography technology	Chaudhary N (2014)	1
DVL2	5	WWP1	3	affinity chromatography technology, affinity chromatography technology, imaging technique	Mund T (2015), Mund T (2015), Mund T (2015)	3
WWOX	3	POLR2E	0	affinity chromatography technology	Abu-Odeh M (2014)	1
ARRDC1	4	ITCH	1	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Rauch S (2011), Shea FF (2012), Puca L (2013), Huttlin EL (2015), Huttlin EL (2017)	5
UBE2G1	2	WWP2	7	biochemical	Havugimana PC (2012)	1
CUL3	17	SLC1A5	1	affinity chromatography technology	Bennett EJ (2010)	1
HDAC6	0	CFTR	5	affinity chromatography technology, affinity chromatography technology	Kawaguchi Y (2003), Ouyang H (2012)	2
LITAF	0	WWP2	7	affinity chromatography technology	Li W (2015)	1
ARRDC4	1	WWP2	7	affinity chromatography technology	Shea FF (2012)	1
ELAVL1	0	LDLRAD3	4	affinity chromatography technology	Abdelmohsen K (2009)	1
SMAD7	1	CBL	7	affinity chromatography technology, affinity chromatography technology, pull down	Ha Thi HT (2015), Ha Thi HT (2015), Ha Thi HT (2015)	3
WDR48	2	UBC	7	x-ray crystallography	Yin J (2015)	1
LRRK2	5	MAP2K4	3	enzymatic study	Gloeckner CJ (2009)	1
ITCH	1	UBC	7	enzymatic study, unspecified method, enzymatic study, enzymatic study	Sheng Y (2012), Ernst A (2013), Maspero E (2013), Kristariyanto YA (2015)	4
LITAF	0	STAM2	0	two hybrid	Rolland T (2014)	1
UBAP2	5	UBAP2L	4	biochemical	Havugimana PC (2012)	1
USP9X	15	YAP1	0	biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kim M (2016), Kim M (2016)	3
GRB2	2	UBC	7	two hybrid	Bandyopadhyay S (2010)	1
HTT	14	TP53	0	pull down, affinity chromatography technology	Steffan JS (2000), Steffan JS (2000)	2
BECN1	2	SMAD2	5	fluorescent resonance energy transfe	Ivanov AA (2017)	1
STAM	3	UBC	7	pull down, affinity chromatography technology, x-ray crystallography, pull down, pull down, pull down, unspecified method, pull down, pull down, x-ray crystallography, pull down	Kim MS (2006), Mizuno E (2006), Hong YH (2009), Nathan JA (2013), Nathan JA (2013), Stuible M (2010), Lim J (2011), Baiady N (2016), Kharitidi D (2015), Sundd M (2012), Zhang X (2017)	11
NCOA1	6	SF1	9	affinity chromatography technology	Kelly SN (2005)	1
HTT	14	ITCH	1	imaging technique, affinity chromatography technology, affinity chromatography technology	Chhangani D (2014), Chhangani D (2014), Chhangani D (2014)	3
UBE2D2	0	MGRN1	4	two hybrid	Markson G (2009)	1
ARRDC4	1	ITCH	1	affinity chromatography technology	Shea FF (2012)	1
WWP2	7	HNRNPUL1	1	two hybrid, two hybrid, affinity chromatography technology	Rolland T (2014), Yu H (2011), Chaudhary N (2014)	3
EGFR	5	SNX9	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
ATN1	2	DVL2	5	two hybrid	Lim J (2006)	1
EGFR	5	MAP2K4	3	affinity chromatography technology	Tong J (2014)	1
ARHGEF7	3	LRRK2	5	affinity chromatography technology, imaging technique, enzymatic study	Haebig K (2010), Haebig K (2010), Haebig K (2010)	3
HNRNPL	3	COL18A1	8	affinity chromatography technology	Fei T (2017)	1
ITCH	1	DDX20	4	affinity chromatography technology	Han KJ (2016)	1
CSNK2A1	15	CPSF6	1	enzymatic study	Zhang M (2011)	1
TAB1	1	MDM2	2	affinity chromatography technology	Zhu Y (2013)	1
UBE2L3	1	NCOA1	6	affinity chromatography technology	Verma S (2004)	1
CYLD	2	HNRNPUL1	1	affinity chromatography technology	Elliott PR (2016)	1
WWP2	7	PABPC1	5	affinity chromatography technology	Lv Y (2014)	1
USP9X	15	GEMIN8	1	affinity chromatography technology	Han KJ (2012)	1
ARRB2	5	MAP3K7	2	affinity chromatography technology	Xiao K (2007)	1
ARRDC4	1	ARRB2	5	affinity chromatography technology	Shea FF (2012)	1
CUL3	17	SLC3A2	5	affinity chromatography technology	Bennett EJ (2010)	1
WWOX	3	CPSF6	1	pull down, affinity chromatography technology	Ingham RJ (2005), Abu-Odeh M (2014)	2
WWP2	7	CDC34	3	pull down	Sheng Y (2012)	1
CUL3	17	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Bennett EJ (2010), Olma MH (2009), Bish RA (2007), Wu K (2016)	4
EGFR	5	PRKACA	2	affinity chromatography technology, enzymatic study	Tortora G (1997), Piiper A (2003)	2
WWP2	7	UBE2L3	1	pull down, pull down, pull down, pull down, pull down, pull down	Wiesner S (2007), Xu H (2009), Anindya R (2007), Kristariyanto YA (2015), Zhang W (2016), Chen Z (2016)	6
TP53	0	NCOA1	6	two hybrid, pull down	Lee SK (1999), Lee SK (1999)	2
WWOX	3	AMOT	6	affinity chromatography technology, affinity chromatography technology	Abu-Odeh M (2014), Abu-Odeh M (2014)	2
ITCH	1	POLR2B	3	pull down	Ingham RJ (2005)	1
ELAVL1	0	TXNIP	2	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2D1	0	MGRN1	4	two hybrid, pull down	Markson G (2009), Kim BY (2007)	2
EGFR	5	STAM2	0	affinity chromatography technology, pull down	Kong C (2007), Morino C (2004)	2
WWP2	7	USP9X	15	affinity chromatography technology	Chaudhary N (2014)	1
EWSR1	2	SMARCE1	1	bioid	Elzi DJ (2014)	1
GBA	2	CBL	7	affinity chromatography technology	Lu J (2010)	1
POU5F1	0	KPNB1	3	affinity chromatography technology	Oliviero G (2015)	1
USP5	2	PCNA	0	biochemical	Kristensen AR (2012)	1
MDM2	2	LATS1	3	affinity chromatography technology	Matallanas D (2011)	1
UBE2D2	0	UBE2L3	1	biochemical	Havugimana PC (2012)	1
CUL3	17	AMOT	6	affinity chromatography technology	Bennett EJ (2010)	1
ITCH	1	PCNA	0	affinity chromatography technology	OConnor HF (2015)	1
GSN	3	CFLAR	1	affinity chromatography technology, affinity chromatography technology	Abedini MR (2014), Abedini MR (2014)	2
CFLAR	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kataoka T (2000), Chaudhary PM (2000), Rebe C (2007), Feoktistova M (2011), Ranjan K (2016), Ranjan K (2016)	6
WWOX	3	MDM2	2	affinity chromatography technology, affinity chromatography technology	Chang NS (2005), Maroni P (2014)	2
FYN	1	CAV1	0	biochemical	Mastick CC (1997)	1
ELAVL1	0	5430	0	affinity chromatography technology	Abdelmohsen K (2009)	1
ITCH	1	GBA	2	affinity chromatography technology, affinity chromatography technology	Maor G (2013), Maor G (2013)	2
CBL	7	UBE2M	0	affinity chromatography technology, pull down	Oved S (2006), Zuo W (2013)	2
EGFR	5	ARRB1	2	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
WWP2	7	SMAD7	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Soond SM (2011), Soond SM (2011), Soond SM (2011), Al-Salihi MA (2012)	4
WWOX	3	SPART	0	affinity chromatography technology	Abu-Odeh M (2014)	1
PTCH1	8	ITCH	1	affinity chromatography technology, affinity chromatography technology	Chen XL (2014), Chen XL (2014)	2
ELAVL1	0	ITCH	1	affinity chromatography technology	Abdelmohsen K (2009)	1
MDM2	2	JUN	0	pull down	Miyamoto-Sato E (2010)	1
5430	0	POLR2E	0	pull down, pull down, pull down, biochemical, biochemical, affinity chromatography technology	Acker J (1997), Acker J (1997), Knuesel MT (2009), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	6
TNFRSF10B	1	CUL3	17	affinity chromatography technology	Gonzalvez F (2012)	1
MAPK8	3	MAP3K7	2	affinity chromatography technology, pull down	Sanna MG (2002), Sanna MG (2002)	2
POLR2B	3	POLR2C	0	pull down, pull down, biochemical, affinity chromatography technology, biochemical	Acker J (1997), Acker J (1997), Havugimana PC (2012), Ayguen O (2008), Wan C (2015)	5
MGRN1	4	ITCH	1	affinity chromatography technology	Gunn TM (2012)	1
UBA1	1	UBE2D2	0	enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Tokgoez Z (2012), Jin J (2007), Choi JS (2014), Huang DT (2009), Kang D (2002), Kumar B (2010), Liu X (2017), Huguenin-Dezot N (2016)	8
SARAF	0	WWP1	3	affinity chromatography technology	Huttlin EL (2017)	1
MAVS	1	NDFIP1	0	affinity chromatography technology, affinity chromatography technology	Wang Y (2012), Wang Y (2012)	2
CBLC	1	UBC	7	enzymatic study	Kim M (2004)	1
UBE2K	0	CBLC	1	two hybrid	Markson G (2009)	1
SH3GL2	1	ITSN1	5	two hybrid	Vinayagam A (2011)	1
MAVS	1	PCBP2	3	affinity chromatography technology, affinity chromatography technology	You F (2009), You F (2009)	2
YAP1	0	WBP1	1	unspecified method, pull down	Goldstrohm AC (2001), Schuchardt BJ (2014)	2
CFTR	5	TP53	0	affinity chromatography technology	Pankow S (2015)	1
WWOX	3	DAZAP1	1	affinity chromatography technology	Abu-Odeh M (2014)	1
ITCH	1	ITCH	1	enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Scialpi F (2008), Scialpi F (2008), Oberst A (2007), Mouchantaf R (2006), Gallagher E (2006), Sheng Y (2012), Ingham RJ (2005), Holleman J (2014), Anindya R (2007), Fang S (2001), Moessinger J (2012), Wiesner S (2007), Zhang W (2016), Liao B (2010), Chen Z (2017)	15
ITCH	1	N4BP1	3	affinity chromatography technology, pull down	Oberst A (2007), Oberst A (2007)	2
CUL3	17	UBA1	1	affinity chromatography technology	Bennett EJ (2010)	1
CYLD	2	TAB1	1	affinity chromatography technology	Elliott PR (2016)	1
ELAVL1	0	SMARCC2	9	affinity chromatography technology	Abdelmohsen K (2009)	1
ITCH	1	UBE2E3	0	pull down	Sheng Y (2012)	1
PTCH1	8	CPSF6	1	affinity chromatography technology	Yamaki Y (2016)	1
UBE2D1	0	RNF11	0	two hybrid, two hybrid, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Subramaniam V (2003), Markson G (2009)	4
CPSF7	4	WWP2	7	affinity chromatography technology	Hein MY (2015)	1
ARID1A	16	NCOA1	6	pull down	Flajollet S (2007)	1
GLIS3	6	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	ZeRuth GT (2015), ZeRuth GT (2015), ZeRuth GT (2015), ZeRuth GT (2015)	4
ARRB2	5	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid, two hybrid, affinity chromatography technology	Wang P (2003), Wang P (2003), Wang P (2003), Shenoy SK (2008), Shenoy SK (2001), Ahmed MR (2011), Yin C (2011), Yin C (2011), Yin C (2011), Girnita L (2005), Girnita L (2005), Nogues L (2011), Boularan C (2007), Boularan C (2007), Wang J (2011), Shenoy SK (2001), Zheng M (2015)	17
TGFBR1	2	NOTCH1	25	affinity chromatography technology, affinity chromatography technology	Gudey SK (2014), Gudey SK (2014)	2
ITCH	1	UBE2D2	0	pull down, pull down, pull down, pull down	Sheng Y (2012), Fang S (2001), Kristariyanto YA (2015), Riling C (2015)	4
ARHGEF7	3	ITCH	1	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, unspecified method, x-ray crystallography	Janz JM (2007), Janz JM (2007), Janz JM (2007), Janz JM (2007), Desrochers G (2015), Desrochers G (2017), Desrochers G (2017)	7
KPNB1	3	KPNA2	0	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Nagoshi E (2001), Koehler M (1999), Kutay U (1997), Hein MY (2015), Huttlin EL (2017)	5
POLR2C	0	POLR2E	0	pull down, pull down, biochemical, affinity chromatography technology, biochemical	Acker J (1997), Acker J (1997), Havugimana PC (2012), Ayguen O (2008), Wan C (2015)	5
SMAD6	9	TGFBR1	2	affinity chromatography technology, affinity chromatography technology	Hata A (1998), Kamiya Y (2010)	2
STAM	3	STAM2	0	imaging technique	Kanazawa C (2003)	1
TP53BP2	5	ITCH	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Gao K (2015), Gao K (2015), Gao K (2015), Gao K (2015), Gen Y (2017), Gen Y (2017)	6
ARRB1	2	DVL2	5	two hybrid, affinity chromatography technology	Chen W (2001), Chen W (2001)	2
WWP2	7	DVL1	5	affinity chromatography technology	Chaudhary N (2014)	1
MDM2	2	UBE2E3	0	pull down, pull down	David Y (2011), Yamauchi T (2014)	2
WWP2	7	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Soond SM (2011), Soond SM (2011), Brown KA (2008)	3
DVL2	5	USP5	2	two hybrid	Rual JF (2005)	1
SF1	9	UBE2L3	1	biochemical	Havugimana PC (2012)	1
SMAD3	1	PABPC1	5	affinity chromatography technology	Brown KA (2008)	1
TP53	0	EWSR1	2	affinity chromatography technology	Li Y (2012)	1
ELAVL1	0	SMAD2	5	affinity chromatography technology	Abdelmohsen K (2009)	1
LRRK2	5	DVL2	5	two hybrid, affinity chromatography technology	Sancho RM (2009), Sancho RM (2009)	2
ARRB1	2	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Wang Y (2006), Wang Y (2006)	2
MAPK8	3	ITCH	1	enzymatic study, affinity chromatography technology	Gallagher E (2006), Gallagher E (2006)	2
OCLN	1	HGS	5	affinity chromatography technology	Murakami T (2009)	1
PRKACA	2	GLI1	3	enzymatic study	Sheng T (2006)	1
ELAVL1	0	PABPC1	5	affinity chromatography technology	Abdelmohsen K (2009)	1
DTX3L	1	ITCH	1	affinity chromatography technology, pull down, pull down	Holleman J (2014), Holleman J (2014), Holleman J (2014)	3
ITCH	1	WDR48	2	affinity chromatography technology	Moretti J (2012)	1
MAP3K7	2	MAVS	1	affinity chromatography technology	Xu LG (2005)	1
ARRB1	2	CUL3	17	affinity chromatography technology	Skieterska K (2016)	1
HDAC6	0	SMAD7	1	affinity chromatography technology, affinity chromatography technology	Simonsson M (2005), Laganiere J (2005)	2
RIPK1	2	TAX1BP1	3	affinity chromatography technology, affinity chromatography technology	Shembade N (2009), Shembade N (2008)	2
FYN	1	CBL	7	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid	Taher TE (2002), Deckert M (1998), Deckert M (1998), Deckert M (1998), Ghosh AK (2004), Rellahan BL (2003), Boussiotis VA (1997), Andoniou CE (2000), Shishido T (2000), Okabe S (2006), Kaabeche K (2004), Tsygankov AY (1996), Tsygankov AY (1996), Tsygankov AY (1996), Tsygankov AY (1996), Tsygankov AY (1996), Tanaka S (1995), Reedquist KA (1996), Grossmann AH (2004), Panchamoorthy G (1996), Fukazawa T (1995), Fukazawa T (1995), Fukazawa T (1995), Nishio H (2002), Anderson SM (1997), Fukazawa T (1996), Grossmann A (2015)	27
WWP2	7	UBE2D2	0	pull down, pull down, pull down	Sheng Y (2012), Kristariyanto YA (2015), Chaudhary N (2014)	3
UBA1	1	UBE2E1	1	enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Tokgoez Z (2012), Jin J (2007), Nuber U (1996), Takeuchi T (2005), Wauer T (2015), Huguenin-Dezot N (2016)	6
ELAVL1	0	PCBP2	3	affinity chromatography technology, biochemical	Abdelmohsen K (2009), Wan C (2015)	2
ARRDC1	4	WWP2	7	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Rauch S (2011), Nabhan JF (2012), Shea FF (2012), Huttlin EL (2015), Yu H (2011), Huttlin EL (2017)	6
ARRDC3	0	TNFRSF10B	1	affinity chromatography technology	Huttlin EL (2017)	1
JUN	0	SMARCC1	5	affinity chromatography technology	Li X (2015)	1
ADRB2	0	ITCH	1	affinity chromatography technology	Shea FF (2012)	1
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
RPAP2	3	POLR2B	3	affinity chromatography technology	Jeronimo C (2007)	1
GNAI2	1	ITCH	1	pull down	Chandrasekaran P (2012)	1
SMN1	0	KPNB1	3	affinity chromatography technology, pull down	Narayanan U (2002), Narayanan U (2002)	2
ITCH	1	COL18A1	8	affinity chromatography technology	OConnor HF (2015)	1
SMN1	0	5430	0	affinity chromatography technology, affinity chromatography technology, pull down	Zhao DY (2016), Zhao DY (2016), Zhao DY (2016)	3
WWP1	3	ERBB4	5	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Li Y (2009), Li Y (2009), Li Y (2009), Feng SM (2009), Feng SM (2009)	5
POU5F1	0	SH3GL1	3	affinity chromatography technology	Oliviero G (2015)	1
ELAVL1	0	HDAC6	0	affinity chromatography technology, affinity chromatography technology	Scott GK (2008), Scott GK (2008)	2
LATS1	3	CAV1	0	unspecified method	Salah Z (2013)	1
UBE2K	0	TP53	0	affinity chromatography technology, affinity chromatography technology, protein complementation assay	Bae Y (2013), Bae Y (2013), Bae Y (2013)	3
ITSN1	5	SMARCC2	9	two hybrid	Stelzl U (2005)	1
ARRB2	5	KPNB1	3	affinity chromatography technology	Xiao K (2007)	1
CFTR	5	GNAI2	1	affinity chromatography technology	Wang X (2006)	1
USP9X	15	UBC	7	unspecified method, pull down	Ernst A (2013), Kwasna D (2018)	2
WWP2	7	RPAP3	1	affinity chromatography technology	Chaudhary N (2014)	1
EGFR	5	GRAP2	0	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
CUL3	17	CPSF6	1	affinity chromatography technology	Bennett EJ (2010)	1
FAM189A2	2	FAM189B	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NEDD9	3	SMAD3	1	two hybrid, pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Feng L (2004), Nourry C (2004), Feng L (2004), Feng L (2004), Liu X (2000), Liu X (2000)	6
UBE2D2	0	CBL	7	pull down, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Joazeiro CA (1999), Dou H (2012), Dou H (2012), Sehat B (2008), Kassenbrock CK (2004), Roxburgh P (2012), Tsukahara F (2010), Bulut GB (2013), Buetow L (2016), Conte A (2017)	10
EWSR1	2	HNRNPUL1	1	two hybrid	Wang J (2011)	1
UBE2D3	1	PCNA	0	enzymatic study	Hibbert RG (2012)	1
PTCH1	8	ARRB2	5	affinity chromatography technology	Yamaki Y (2016)	1
TP53	0	GSN	3	affinity chromatography technology	Horikawa I (2014)	1
USP5	2	TRAF6	0	enzymatic study	Bremm A (2010)	1
LDLRAD4	1	SMAD2	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
WWP2	7	UBE2E3	0	pull down	Sheng Y (2012)	1
UBE2L3	1	SMAD7	1	unspecified method	Ogunjimi AA (2005)	1
ITCH	1	SGK3	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Slagsvold T (2006), Slagsvold T (2006), Slagsvold T (2006)	3
UBE2E1	1	RNF11	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
YAP1	0	ITCH	1	affinity chromatography technology	Levy D (2007)	1
ERBB4	5	MDM2	2	affinity chromatography technology	Gilmore-Hebert M (2010)	1
SCNN1A	1	WWP1	3	two hybrid	Malbert-Colas L (2003)	1
EWSR1	2	SNX18	1	affinity chromatography technology	Elzi DJ (2014)	1
ITCH	1	SNX9	1	pull down, affinity chromatography technology, enzymatic study, pull down	Baumann C (2010), Baumann C (2010), Baumann C (2010), Baumann C (2010)	4
ITCH	1	CPSF7	4	pull down	Ingham RJ (2005)	1
ITCH	1	CBL	7	affinity chromatography technology	Azakir BA (2009)	1
CXCR4	0	MTSS1	1	affinity chromatography technology, affinity chromatography technology	Li L (2017), Li L (2017)	2
MTSS1	1	ITCH	1	affinity chromatography technology	Li L (2017)	1
ATXN3	2	SLC3A2	5	affinity chromatography technology	Hein MY (2015)	1
TP63	0	MDM2	2	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zdzalik M (2010), Zdzalik M (2010), Galli F (2010), Calabro V (2002), Calabro V (2002), Stindt MH (2015)	6
ITCH	1	WBP2	0	pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Ingham RJ (2005), OConnor HF (2015), Lim SK (2016), Lim SK (2016), Lim SK (2016), Lim SK (2016), Lim SK (2016)	7
CUL3	17	DVL2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jin X (2016), Jin X (2016), Jin X (2016)	3
IKBKB	1	HTT	14	enzymatic study	Thompson LM (2009)	1
UBA1	1	UBE2E3	0	enzymatic study, pull down	Tokgoez Z (2012), Jin J (2007)	2
TOLLIP	3	SMAD7	1	affinity chromatography technology, affinity chromatography technology, imaging technique	Zhu L (2012), Zhu L (2012), Zhu L (2012)	3
LAPTM5	3	GGA3	6	affinity chromatography technology	Pak Y (2006)	1
CUL3	17	UBAP2	5	affinity chromatography technology	Bennett EJ (2010)	1
WBP2	0	UBC	7	two hybrid	Lim SK (2016)	1
HNRNPL	3	UBE2K	0	affinity chromatography technology	Fei T (2017)	1
GRAP2	0	ITCH	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TNFRSF10B	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology	Chaudhary PM (1997), Bellail AC (2012)	2
USP13	2	ITCH	1	affinity chromatography technology	Sowa ME (2009)	1
ELAVL1	0	TOLLIP	3	affinity chromatography technology	Abdelmohsen K (2009)	1
EGFR	5	ERBB4	5	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Meijer IM (2013), Kiuchi T (2014), Kiuchi T (2014)	3
ITCH	1	UBE2L3	1	pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, pull down, enzymatic study, pull down, pull down	Wiesner S (2007), Ishihara T (2011), Scialpi F (2008), Bai Y (2004), Oberst A (2007), Mouchantaf R (2006), Rossi M (2005), Zhang P (2010), Anindya R (2007), Kathania M (2015), Kristariyanto YA (2015), Riling C (2015), Riling C (2015), Zhang W (2016)	14
ARRDC4	1	ARRB1	2	affinity chromatography technology	Shea FF (2012)	1
RPAP3	1	POLR2B	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Jeronimo C (2007), Cloutier P (2017)	3
CUL3	17	PCBP2	3	affinity chromatography technology	Bennett EJ (2010)	1
RPAP3	1	POLR2E	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Cloutier P (2009), Taipale M (2014), Taipale M (2014), Cloutier P (2017)	5
CFTR	5	SNX9	1	affinity chromatography technology	Wang X (2006)	1
EGFR	5	TAB1	1	affinity chromatography technology, two hybrid, protein complementation assay	Tong J (2008), Kotlyar M (2015), Petschnigg J (2014)	3
EGFR	5	SH3GL2	1	affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schmidt MH (2004), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Liu W (2014), Liu W (2014)	6
ITCH	1	SLC1A5	1	affinity chromatography technology	OConnor HF (2015)	1
ITCH	1	PCBP2	3	affinity chromatography technology, affinity chromatography technology	You F (2009), You F (2009)	2
CBLC	1	ITCH	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Courbard JR (2002), Courbard JR (2002), Courbard JR (2002), Courbard JR (2002)	4
CUL3	17	SMARCE1	1	affinity chromatography technology	Bennett EJ (2010)	1
CFTR	5	UBA1	1	affinity chromatography technology	Pankow S (2015)	1
SF1	9	WWP2	7	two hybrid	Rual JF (2005)	1
UBE2J2	1	EGFR	5	affinity chromatography technology	Chen S (2017)	1
DVL3	7	ITCH	1	affinity chromatography technology	Wei W (2012)	1
WBP2	0	WWP1	3	unspecified method, two hybrid	Pirozzi G (1997), Lim SK (2016)	2
PDCD6IP	3	ARRDC1	4	pull down, two hybrid, two hybrid	Rauch S (2011), Rauch S (2011), Rauch S (2011)	3
GRB2	2	SNX18	1	affinity chromatography technology, affinity chromatography technology	Bisson N (2011), Huttlin EL (2017)	2
ITCH	1	BID	1	affinity chromatography technology	Azakir BA (2010)	1
UBC	7	TAX1BP1	3	pull down, x-ray crystallography, pull down, pull down	Fenner BJ (2009), Tumbarello DA (2015), Tumbarello DA (2015), Zhang X (2017)	4
MDM2	2	UBE2M	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Xirodimas DP (2004), Batuello CN (2015), Batuello CN (2015), Batuello CN (2015)	4
ARRB1	2	ARRDC1	4	affinity chromatography technology	Puca L (2013)	1
ATN1	2	DVL1	5	two hybrid	Okamura-Oho Y (1999)	1
CBLC	1	TP53	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
POU5F1	0	DDX20	4	affinity chromatography technology	Oliviero G (2015)	1
HGS	5	UBA1	1	pull down	Pridgeon JW (2009)	1
UBE2M	0	TP53	0	enzymatic study	Xirodimas DP (2004)	1
SFN	1	FAM189A2	2	two hybrid	Rual JF (2005)	1
5430	0	YAP1	0	affinity chromatography technology	Gavva NR (1997)	1
SPART	0	WWP2	7	two hybrid, affinity chromatography technology	Eastman SW (2009), Chaudhary N (2014)	2
ATXN3	2	EWSR1	2	two hybrid	Lim J (2006)	1
SMAD3	1	NOTCH1	25	pull down, affinity chromatography technology	Blokzijl A (2003), Blokzijl A (2003)	2
LRRK2	5	DVL1	5	two hybrid, affinity chromatography technology	Sancho RM (2009), Sancho RM (2009)	2
ITCH	1	USP12	1	affinity chromatography technology, affinity chromatography technology, bioid	Moretti J (2012), Moretti J (2012), Jahan AS (2016)	3
SMN1	0	DDX20	4	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Carnegie GK (2003), Meister G (2000), Meister G (2000), Mourelatos Z (2002), Charroux B (1999), Charroux B (1999), Charroux B (1999), Fuller HR (2010), Peter CJ (2011), Havugimana PC (2012), Joshi P (2013), Han KJ (2016)	12
WWP2	7	SMAD3	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, two hybrid	Soond SM (2011), Soond SM (2011), Soond SM (2011), Brown KA (2008), Soond SM (2013), Yu H (2011)	6
RPAP2	3	URI1	2	affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Cloutier P (2017)	2
WWP2	7	FBXL15	0	affinity chromatography technology	Cui Y (2011)	1
ADRB2	0	KPNB1	3	affinity chromatography technology	Roy SJ (2013)	1
DDX20	4	CPSF7	4	affinity chromatography technology	Huttlin EL (2017)	1
FAM189B	2	ITCH	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
WWP1	3	UBE2L3	1	pull down, pull down, pull down, pull down, pull down	Peschiaroli A (2010), Anindya R (2007), Kristariyanto YA (2015), Courivaud T (2015), Zhang W (2016)	5
ITCH	1	TP63	0	affinity chromatography technology, pull down, x-ray crystallography, pull down, x-ray crystallography, affinity chromatography technology, pull down	Rossi M (2006), Bellomaria A (2010), Bellomaria A (2010), Bellomaria A (2012), Bellomaria A (2012), Salah Z (2013), Melino S (2014)	7
TAB1	1	IKBKB	1	affinity chromatography technology	Neil JR (2008)	1
DTX3L	1	UBE2D3	1	affinity chromatography technology, two hybrid	Takeyama K (2003), Markson G (2009)	2
RNF11	0	RIPK1	2	affinity chromatography technology, affinity chromatography technology	Shembade N (2009), Shembade N (2009)	2
GBA	2	PCBP2	3	biochemical	Wan C (2015)	1
CFTR	5	EGFR	5	affinity chromatography technology	Pankow S (2015)	1
UBE2D3	1	STAM2	0	enzymatic study	Hoeller D (2007)	1
USP5	2	UBC	7	pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, unspecified method, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, pull down, enzymatic study, enzymatic study, pull down, pull down	Reyes-Turcu FE (2008), Nicassio F (2007), Zhang YH (2012), Bremm A (2010), Komander D (2009), Melandri F (1996), Sokratous K (2012), Fenner BJ (2009), Schulz S (2012), Raasi S (2005), Nathan JA (2013), Ernst A (2013), Bish RA (2007), Reyes-Turcu FE (2006), Reyes-Turcu FE (2006), Zhang YH (2012), Liu Y (2014), Scott D (2015), Flierman D (2016), Castaneda CA (2016), Zhang X (2017), Kwasna D (2018)	22
SCNN1A	1	ITCH	1	far western blotting	Harvey KF (2001)	1
5430	0	UBE2L3	1	pull down	Anindya R (2007)	1
CUL3	17	ITCH	1	affinity chromatography technology	Bennett EJ (2010)	1
SPART	0	WWP1	3	affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Milewska M (2009), Edwards TL (2009), Eastman SW (2009), Eastman SW (2009), Eastman SW (2009), Eastman SW (2009), Huttlin EL (2017)	7
RPAP3	1	URI1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Cloutier P (2009), Taipale M (2014), Taipale M (2014), Wan C (2015), Cloutier P (2017), Cloutier P (2017), Mita P (2016)	8
UBA6	4	UBE2D3	1	pull down	Jin J (2007)	1
UBE2L3	1	CBLC	1	two hybrid	Markson G (2009)	1
ITCH	1	NDFIP1	0	affinity chromatography technology, affinity chromatography technology, pull down	Kathania M (2015), Kathania M (2015), Riling C (2015)	3
MARVELD2	0	ITCH	1	affinity chromatography technology, pull down	Jennek S (2017), Jennek S (2017)	2
HGS	5	SCAMP3	0	affinity chromatography technology	Aoh QL (2009)	1
KPNB1	3	RASSF5	2	affinity chromatography technology	Suryaraja R (2013)	1
CFTR	5	DAZAP1	1	affinity chromatography technology	Pankow S (2015)	1
5430	0	ITCH	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Ingham RJ (2005), Ingham RJ (2005), Ingham RJ (2005), OConnor HF (2015)	4
TRAF6	0	UBE2E1	1	pull down	Markson G (2009)	1
SMAD2	5	NEDD9	3	affinity chromatography technology	Liu X (2000)	1
ITCH	1	DAZAP1	1	pull down	Ingham RJ (2005)	1
KLF10	1	ITCH	1	affinity chromatography technology, affinity chromatography technology	Venuprasad K (2008), Venuprasad K (2008)	2
HNRNPL	3	WWP2	7	affinity chromatography technology	Fei T (2017)	1
UBE2K	0	MDM2	2	two hybrid, pull down, pull down	Bae Y (2013), Saville MK (2004), David Y (2011)	3
LRRK2	5	SH3GL1	3	enzymatic study	Matta S (2012)	1
SFN	1	ITCH	1	affinity chromatography technology	Benzinger A (2005)	1
CFLAR	1	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Abedini MR (2008), Abedini MR (2008), Saha A (2011), Saha A (2011)	4
UBE2L3	1	USP9X	15	biochemical	Havugimana PC (2012)	1
MDM2	2	UBE2D3	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Yadavilli S (2009), Nie J (2010), Minsky N (2004), Wang X (2011), Sionov RV (2001), Oh W (2010), Zhu Y (2009), Latini P (2011), Jung CR (2010), David Y (2011), Ye B (2013), Cheng Q (2014), Saville MK (2004), Yamauchi T (2014), Jin M (2017)	15
TMEM92	0	NDFIP1	0	affinity chromatography technology	Huttlin EL (2015)	1
HNRNPL	3	SF1	9	biochemical	Wan C (2015)	1
PDCD6IP	3	SH3GL1	3	affinity chromatography technology, two hybrid	Usami Y (2007), Wang J (2011)	2
SCNN1A	1	HGS	5	affinity chromatography technology, affinity chromatography technology	Zhou R (2010), Zhou R (2010)	2
ARRDC3	0	HGS	5	affinity chromatography technology	Han SO (2012)	1
DTX1	2	GRB2	2	two hybrid	Matsuno K (1998)	1
FAM189B	2	WWOX	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MLANA	2	ITCH	1	affinity chromatography technology, pull down	Levy F (2005), Levy F (2005)	2
UBE2D2	0	USP9X	15	biochemical	Havugimana PC (2012)	1
ITCH	1	SLC3A2	5	affinity chromatography technology	OConnor HF (2015)	1
LATS1	3	WWP1	3	unspecified method	Salah Z (2013)	1
RNF11	0	WWP2	7	two hybrid	Colland F (2004)	1
WWP2	7	PCNA	0	affinity chromatography technology	Chaudhary N (2014)	1
DVL2	5	WWP2	7	affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology	Mund T (2015), Mund T (2015), Mund T (2015), Mund T (2015), Chaudhary N (2014)	5
ITCH	1	HNRNPUL1	1	pull down	Ingham RJ (2005)	1
TP73	2	IKBKB	1	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, enzymatic study	Accardi R (2011), Accardi R (2011), Accardi R (2011), Accardi R (2011)	4
PDCD6IP	3	ARRDC3	0	two hybrid	Rauch S (2011)	1
TRAF6	0	TGFBR1	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, imaging technique	Sorrentino A (2008), Yamashita M (2008), Yamashita M (2008), Yamashita M (2008), Zhang J (2014), Cao Q (2016), Sundar R (2015), Sundar R (2015), Sundar R (2015)	9
UBE2D1	0	USP9X	15	biochemical, biochemical	Havugimana PC (2012), You J (2001)	2
PTCH1	8	WWP2	7	affinity chromatography technology, affinity chromatography technology	Chen XL (2014), Chen XL (2014)	2
CSNK2A1	15	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, enzymatic study	Uhle S (2003), Fogeron ML (2013), Bhansali M (2014), Chen TC (2014), Walerych D (2004), Walerych D (2004)	6
UBC	7	UBE2L3	1	affinity chromatography technology	Bish RA (2007)	1
GNAI2	1	SLC3A2	5	biochemical	Wan C (2015)	1
ARID1A	16	SMARCC2	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Ryme J (2009), Ryme J (2009), Mak AB (2010), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	6
WWP2	7	SCNN1B	1	pull down, far western blotting	McDonald FJ (2002), Harvey KF (2001)	2
CXCR4	0	STAM	3	imaging technique, biochemical	Malik R (2010), Malik R (2012)	2
RASSF5	2	RASSF1	3	pull down, affinity chromatography technology	Ortiz-Vega S (2002), Ortiz-Vega S (2002)	2
HNRNPL	3	HTT	14	affinity chromatography technology	Fei T (2017)	1
CFTR	5	ITCH	1	affinity chromatography technology	Pankow S (2015)	1
TMEM255A	0	WWP2	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MDM2	2	TP73	2	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Balint E (1999), Zeng X (1999), Zeng X (1999), Chen L (2010), Zdzalik M (2010), Kim JW (2008), Balint E (1999), Balint E (1999), Wang J (2011), Ongkeko WM (1999), Ongkeko WM (1999), Ongkeko WM (1999), Ongkeko WM (1999), Wu H (2015), Stindt MH (2015), Zhou X (2015), Zhou X (2015)	17
TMEM51	2	WWP1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EWSR1	2	CPSF7	4	two hybrid, bioid	Rual JF (2005), Elzi DJ (2014)	2
PTCH1	8	EGFR	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMARCE1	1	SMARCC2	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Zhao K (1998), Hu K (2006), Lai D (2009), Ryme J (2009), Kaeser MD (2008), Kaeser MD (2008), Chen J (2005), Mak AB (2010), Mak AB (2010), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	13
CFTR	5	SARAF	0	affinity chromatography technology	Wang X (2006)	1
PRKACA	2	CAV1	0	affinity chromatography technology	Razani B (2001)	1
DTX1	2	DTX3L	1	affinity chromatography technology	Takeyama K (2003)	1
ARRB2	5	UBC	7	affinity chromatography technology, fluorescent resonance energy transfe	Xiao K (2007), Dalrymple MB (2011)	2
HNRNPL	3	ARID1A	16	affinity chromatography technology	Fei T (2017)	1
UBE2D3	1	DTX1	2	two hybrid	van Wijk SJ (2009)	1
CXCR4	0	CAV1	0	biochemical	Malik R (2012)	1
UBC	7	POLR2C	0	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
UBE2D1	0	MDM2	2	two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Singh RK (2007), Poyurovsky MV (2007), Li M (2003), Yogosawa S (2003), Honda R (1997), Sun XX (2011), Singh RK (2007), Taira N (2010), Fu X (2010), Wang KS (2011), Wang X (2004), Sehat B (2008), Wawrzynow B (2007), Burch L (2004), Frazier DP (2012), Huart AS (2012), Pettersson S (2009), Gama V (2009), Demma M (2010), Chymkowitch P (2011), Yan C (2010), Yang Y (2013), Ranaweera RS (2013), Siepe D (2009), Shi D (2009), Uchiki T (2009), Grossman SR (2003), Xirodimas DP (2004), Saville MK (2004), Liu T (2015), Batuello CN (2015), Fraser JA (2015), Yamauchi T (2014), Liu D (2016), McClurg UL (2016), Landre V (2017)	36
SMAD3	1	SMAD2	5	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Nakao A (1997), Lebrun JJ (1999), Dumont E (2003), Brown KA (2008), Brown KA (2008), Wu RY (1997), Wu RY (1997), Tang Y (2003), Tang Y (2003), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	12
NUMB	1	GLI1	3	pull down, affinity chromatography technology	Di Marcotullio L (2011), Di Marcotullio L (2011)	2
SMAD3	1	YAP1	0	affinity chromatography technology	Alarcon C (2009)	1
UBA1	1	UBE2G1	2	pull down	Jin J (2007)	1
ELAVL1	0	UBA6	4	affinity chromatography technology	Abdelmohsen K (2009)	1
SMAD3	1	SMARCC2	9	affinity chromatography technology, affinity chromatography technology	Xi Q (2008), Xi Q (2008)	2
EWSR1	2	SH3GL1	3	bioid	Elzi DJ (2014)	1
TRAF6	0	UBE2L3	1	pull down, pull down	Geetha T (2005), Babu JR (2005)	2
ITCH	1	JUN	0	pull down, affinity chromatography technology, affinity chromatography technology	Gao B (2006), Ahmed SU (2009), Xie M (2010)	3
CSNK2A1	15	HNRNPL	3	enzymatic study	Zhang M (2011)	1
UBC	7	FBXL15	0	pull down	Zhang X (2017)	1
CUL3	17	SMN1	0	affinity chromatography technology	Bennett EJ (2010)	1
YAP1	0	SFN	1	affinity chromatography technology	Enzo E (2015)	1
SF1	9	EWSR1	2	two hybrid, pull down	Zhang D (1998), Zhang D (1998)	2
LITAF	0	WWP1	3	affinity chromatography technology	Li W (2015)	1
TP53	0	PCNA	0	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Banks D (2006), Banks D (2006), Hampp S (2016), Hampp S (2016)	4
DTX3L	1	UBE2D1	0	affinity chromatography technology, two hybrid, pull down	Takeyama K (2003), Markson G (2009), Yan Q (2009)	3
ITCH	1	FBXL15	0	affinity chromatography technology	Cui Y (2011)	1
WBP1	1	WWP1	3	unspecified method, affinity chromatography technology, affinity chromatography technology	Pirozzi G (1997), Huttlin EL (2015), Huttlin EL (2017)	3
SCAMP3	0	YAP1	0	two hybrid	Aoh QL (2009)	1
GRB2	2	TAB1	1	affinity chromatography technology	Bisson N (2011)	1
YAP1	0	KPNA2	0	affinity chromatography technology	Enzo E (2015)	1
CAV1	0	BID	1	affinity chromatography technology, affinity chromatography technology	Zhang M (2011), Zhang M (2011)	2
CUL3	17	PDCD6IP	3	affinity chromatography technology	Bennett EJ (2010)	1
URI1	2	POLR2B	3	affinity chromatography technology	Cloutier P (2017)	1
ELAVL1	0	HNRNPL	3	affinity chromatography technology	Abdelmohsen K (2009)	1
GLI1	3	SMARCC2	9	affinity chromatography technology	Li X (2015)	1
TP53	0	KPNB1	3	affinity chromatography technology, pull down	Akakura S (2001), Akakura S (2001)	2
NOTCH1	25	CUL3	17	affinity chromatography technology, affinity chromatography technology	Ren K (2014), Ren K (2014)	2
ITCH	1	NUDT21	0	affinity chromatography technology, pull down	Ingham RJ (2005), Ingham RJ (2005)	2
EGFR	5	5430	0	affinity chromatography technology	Yao Z (2017)	1
TP53	0	TXNIP	2	affinity chromatography technology	Suh HW (2013)	1
LDLRAD4	1	WWP2	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMAD6	9	ITCH	1	affinity chromatography technology	Herhaus L (2014)	1
SMAD6	9	WWP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Seo SR (2004), Herhaus L (2014)	3
CUL3	17	POLR2C	0	affinity chromatography technology	Bennett EJ (2010)	1
ADRB2	0	PCBP2	3	affinity chromatography technology	Roy SJ (2013)	1
RPAP3	1	5430	0	affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Cloutier P (2017)	2
STAM	3	HGS	5	two hybrid, affinity chromatography technology, biochemical, pull down, imaging technique, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Asao H (1997), Bache KG (2003), Malik R (2010), Kanazawa C (2003), Kanazawa C (2003), Havugimana PC (2012), Sirisaengtaksin N (2014), Sirisaengtaksin N (2014), Holleman J (2014), Holleman J (2014), Wan C (2015), Berlin I (2010), Huttlin EL (2017)	14
WWP2	7	RPAP2	3	affinity chromatography technology	Chaudhary N (2014)	1
MDM2	2	UBE2L3	1	pull down, pull down	Hampe C (2006), Yamauchi T (2014)	2
CSNK2A1	15	TP73	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Lu H (2014), Lu H (2014), Lu H (2014)	3
ITCH	1	SCAMP3	0	affinity chromatography technology	OConnor HF (2015)	1
PDCD6IP	3	SH3GL2	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Schmidt MH (2004), Schmidt MH (2004), Ichioka F (2007), Ichioka F (2007)	4
FAM189B	2	WWP1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PRKACA	2	SH3GL1	3	biochemical	Kristensen AR (2012)	1
MGRN1	4	HTT	14	affinity chromatography technology	Chhangani D (2014)	1
LDLRAD4	1	WWOX	3	affinity chromatography technology	Huttlin EL (2015)	1
SMN1	0	IKBKB	1	affinity chromatography technology	Kim EK (2017)	1
CYLD	2	PABPC1	5	affinity chromatography technology	Elliott PR (2016)	1
USP12	1	NOTCH1	25	enzymatic study	Moretti J (2012)	1
UBA1	1	PDCD6IP	3	biochemical	Kristensen AR (2012)	1
ARRDC3	0	ITCH	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Shea FF (2012), Shea FF (2012), Huttlin EL (2017)	3
PTCH1	8	CUL3	17	affinity chromatography technology	Yamaki Y (2016)	1
FAM189B	2	YAP1	0	affinity chromatography technology	Huttlin EL (2015)	1
CUL3	17	GRB2	2	affinity chromatography technology	Bennett EJ (2010)	1
ELAVL1	0	TGFBR1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
HTT	14	UBE2E3	0	two hybrid	Suter B (2013)	1
WWP1	3	UBC	7	enzymatic study	Kristariyanto YA (2015)	1
WWP1	3	NOTCH1	25	pull down, imaging technique	Flasza M (2006), Flasza M (2006)	2
ERBB4	5	CBL	7	affinity chromatography technology	Kiuchi T (2014)	1
DTX3L	1	UBE2D2	0	affinity chromatography technology, two hybrid, pull down	Takeyama K (2003), Markson G (2009), Yan Q (2009)	3
ELAVL1	0	HNRNPUL1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
ELAVL1	0	MARVELD2	0	affinity chromatography technology	Abdelmohsen K (2009)	1
LDLRAD4	1	WWP1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PRKACA	2	CFTR	5	enzymatic study	Goldstein RF (2007)	1
ITCH	1	GRB2	2	biochemical	Wan C (2015)	1
MDM2	2	RASSF5	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Lee D (2012), Lee D (2012), Lee D (2012)	3
ITCH	1	FYN	1	affinity chromatography technology, affinity chromatography technology, pull down	Yang C (2006), Yang C (2006), Yang C (2006)	3
SFN	1	PABPC1	5	biochemical	Wan C (2015)	1
MDM2	2	ADRB2	0	enzymatic study	Shenoy SK (2001)	1
CBLC	1	UBE2D1	0	pull down	Kim M (2004)	1
FYN	1	TNFRSF10B	1	affinity chromatography technology	Huttlin EL (2017)	1
SMARCC1	5	NCOA1	6	far western blotting, pull down	Hong CY (2005), Hong CY (2005)	2
CPSF6	1	SMARCC1	5	biochemical	Wan C (2015)	1
GLI1	3	IKBKB	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Agarwal NK (2016), Agarwal NK (2016), Agarwal NK (2016), Agarwal NK (2016), Agarwal NK (2016)	5
CBL	7	ITSN1	5	far western blotting, two hybrid, affinity chromatography technology, affinity chromatography technology	Martin NP (2006), Thalappilly S (2008), Dergai M (2011), Tsyba L (2008)	4
ITCH	1	POU5F1	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Liao B (2012), Liao B (2012), Liao B (2012), Liao B (2010)	4
ITCH	1	KPNA2	0	affinity chromatography technology	OConnor HF (2015)	1
ELAVL1	0	GRB2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
DVL2	5	TP53	0	two hybrid, two hybrid	Rual JF (2005), Lim J (2006)	2
DVL2	5	CSNK2A1	15	affinity chromatography technology	Song DH (2000)	1
CUL3	17	POLR2E	0	affinity chromatography technology	Bennett EJ (2010)	1
USP5	2	UBA1	1	affinity chromatography technology	Song AX (2014)	1
WWP2	7	UBE2D1	0	pull down, pull down	Kristariyanto YA (2015), Chen Z (2016)	2
TMEM92	0	WWOX	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
WWOX	3	DVL1	5	affinity chromatography technology, affinity chromatography technology	Abu-Odeh M (2014), Abu-Odeh M (2014)	2
MAPK8	3	SF1	9	affinity chromatography technology	Hein MY (2015)	1
SMAD3	1	CPSF7	4	two hybrid	Rolland T (2014)	1
WWOX	3	UBAP2	5	affinity chromatography technology	Abu-Odeh M (2014)	1
TMEM51	2	WWP2	7	affinity chromatography technology	Huttlin EL (2017)	1
HTT	14	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Zucchelli S (2011), Zucchelli S (2011)	2
TRAF6	0	ITCH	1	affinity chromatography technology	Shembade N (2008)	1
IKBKB	1	TP53	0	enzymatic study	Xia Y (2009)	1
UBC	7	N4BP1	3	pull down, affinity chromatography technology, pull down	Fenner BJ (2009), Fenner BJ (2009), Zhang X (2017)	3
UBE2E1	1	DTX1	2	two hybrid	van Wijk SJ (2009)	1
CAV1	0	PTCH1	8	affinity chromatography technology, affinity chromatography technology	Karpen HE (2001), Karpen HE (2001)	2
UBA1	1	UBE2D1	0	enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study	Tokgoez Z (2012), Jin J (2007), Kang D (2002), Wauer T (2015), Huguenin-Dezot N (2016)	5
RNF11	0	GGA3	6	two hybrid, unspecified method, imaging technique	Colland F (2004), Santonico E (2014), Santonico E (2014)	3
STAM2	0	UBC	7	x-ray crystallography, x-ray crystallography, pull down, pull down, pull down, pull down, pull down	Lange A (2010), Lange A (2012), Lange A (2012), Stuible M (2010), Baiady N (2016), Zhang X (2017), Hologne M (2016)	7
ELAVL1	0	UBAP2L	4	affinity chromatography technology	Abdelmohsen K (2009)	1
CUL3	17	UBE2D1	0	pull down	Sumara I (2007)	1
JUN	0	KPNA2	0	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
ITCH	1	UBE2K	0	pull down	Sheng Y (2012)	1
ITCH	1	HDAC6	0	affinity chromatography technology	OConnor HF (2015)	1
ITCH	1	ITSN1	5	fluorescent resonance energy transfe, affinity chromatography technology	Desrochers G (2015), Desrochers G (2015)	2
ARRDC3	0	WWP1	3	pull down, affinity chromatography technology	Rauch S (2011), Huttlin EL (2017)	2
ITCH	1	SH3GL1	3	unspecified method	Desrochers G (2017)	1
ITCH	1	UBE2J2	1	pull down	Sheng Y (2012)	1
EGFR	5	TNFRSF10B	1	affinity chromatography technology	Tong J (2014)	1
EGFR	5	HGS	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Umebayashi K (2008), Morino C (2004), Meijer IM (2013), Sun Y (2013), Ali N (2013), Tan X (2015)	6
UBA6	4	UBE2D2	0	pull down, pull down, enzymatic study, enzymatic study	Pelzer C (2007), Jin J (2007), Huang DT (2009), Liu X (2017)	4
CXCR4	0	ITCH	1	pull down, affinity chromatography technology, fluorescent resonance energy transfe, pull down, biochemical, affinity chromatography technology, affinity chromatography technology	Bhandari D (2009), Bhandari D (2009), Bhandari D (2009), Bhandari D (2009), Malik R (2012), Chandrasekaran P (2014), Li L (2017)	7
FAM189A2	2	ITCH	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ITCH	1	JUNB	0	enzymatic study	Li H (2016)	1
DVL3	7	CYLD	2	affinity chromatography technology	Tauriello DV (2010)	1
STAM2	0	ARRDC3	0	two hybrid	Rolland T (2014)	1
EGFR	5	SFN	1	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Wu SL (2006), Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014), Li J (2013)	5
EGFR	5	CAV1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, pull down, biochemical	Couet J (1997), Couet J (1997), Khan EM (2006), Feldman R (2009), Hua H (2003), Wu SL (2006), Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014), Park WY (2000), Abulrob A (2004), Abulrob A (2004)	12
LATS1	3	ITCH	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, unspecified method	Salah Z (2011), Salah Z (2011), Salah Z (2011), Ho KC (2011), Adler JJ (2013), Ho KC (2011), Ho KC (2011), Ho KC (2011), Salah Z (2013)	9
WWP2	7	ITCH	1	affinity chromatography technology	Chaudhary N (2014)	1
UBE2E1	1	HDAC6	0	enzymatic study	Hoeller D (2007)	1
POLR2C	0	SMARCC2	9	two hybrid	Stelzl U (2005)	1
UBE2M	0	ITCH	1	pull down, pull down	Li H (2016), Li H (2016)	2
TRPV4	2	FYN	1	affinity chromatography technology	Xu H (2003)	1
TRAF6	0	FYN	1	pull down	Liu A (2012)	1
ITCH	1	NFE2	0	enzymatic study, affinity chromatography technology, two hybrid, far western blotting	Lee TL (2008), Lee TL (2008), Chen X (2001), Chen X (2001)	4
PTCH1	8	WWP1	3	affinity chromatography technology	Chen XL (2014)	1
ITCH	1	EWSR1	2	pull down	Ingham RJ (2005)	1
SMAD3	1	TP63	0	affinity chromatography technology	Lu D (2013)	1
TGFBR1	2	TOLLIP	3	affinity chromatography technology, affinity chromatography technology	Zhu L (2012), Zhu L (2012)	2
CBL	7	UBC	7	x-ray crystallography, pull down, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, x-ray crystallography, pull down, pull down, enzymatic study	Peschard P (2007), Peschard P (2007), Davies GC (2004), Davies GC (2004), Kassenbrock CK (2004), Zhou ZR (2008), Kim M (2004), Dou H (2013), Liu N (2015), Buetow L (2016), Kliza K (2017)	11
MDM2	2	NUMB	1	pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yogosawa S (2003), Yogosawa S (2003), Yogosawa S (2003), Colaluca IN (2008), Colaluca IN (2008), Colaluca IN (2008), Sczaniecka M (2012), Tian LF (2006), Pettersson S (2012), Liu D (2016), Liu D (2016), Sheng W (2017)	12
CUL3	17	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
WWOX	3	DVL3	7	affinity chromatography technology	Abu-Odeh M (2014)	1
LRRK2	5	DVL3	7	two hybrid, affinity chromatography technology	Sancho RM (2009), Sancho RM (2009)	2
CBLC	1	UBE2D3	1	pull down	Kim M (2004)	1
ITCH	1	KPNB1	3	pull down	Suryaraja R (2013)	1
ITCH	1	LITAF	0	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Eaton HE (2011), Eaton HE (2011), Li W (2015)	3
WWP1	3	UBE2D3	1	pull down	Kristariyanto YA (2015)	1
TAB1	1	PDCD6IP	3	two hybrid	Vinayagam A (2011)	1
CBL	7	MAPK8	3	affinity chromatography technology, enzymatic study	Miao H (2002), Miao H (2002)	2
ARRB2	5	PABPC1	5	affinity chromatography technology	Xiao K (2007)	1
ELAVL1	0	UBE2L3	1	affinity chromatography technology	Abdelmohsen K (2009)	1
CUL3	17	PABPC1	5	affinity chromatography technology	Bennett EJ (2010)	1
SMAD2	5	HGS	5	affinity chromatography technology	Miura S (2000)	1
ATXN3	2	UBC	7	pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, pull down, x-ray crystallography, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, x-ray crystallography, pull down, imaging technique, enzymatic study, pull down	Winborn BJ (2008), Mao Y (2005), Berke SJ (2005), Matsumoto M (2005), Bremm A (2010), Nicastro G (2010), Nicastro G (2010), Donaldson KM (2003), Chai Y (2004), Chai Y (2004), Nathan JA (2013), Seki T (2013), Yang H (2014), Yang H (2014), Blount JR (2014), Evers MM (2013), Weeks SD (2011), Donaldson KM (2003), Winborn BJ (2008), Faggiano S (2015), Wauer T (2015), Satoh T (2014), Satoh T (2014), Zhang X (2017), Toonen LJA (2017), Toonen LJA (2017), Kwasna D (2018)	27
ITCH	1	TAB1	1	affinity chromatography technology, affinity chromatography technology, pull down	Theivanthiran B (2015), Theivanthiran B (2015), Theivanthiran B (2015)	3
FAM189A2	2	STAM2	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
USP5	2	USP13	2	affinity chromatography technology	Sowa ME (2009)	1
ADRB2	0	HGS	5	affinity chromatography technology	Shea FF (2012)	1
UBC	7	USP12	1	pull down	Cohn MA (2009)	1
NDFIP2	2	FYN	1	affinity chromatography technology	Mund T (2010)	1
HGS	5	UBC	7	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Mizuno E (2006), Raiborg C (2002), Raiborg C (2002), Nathan JA (2013), Nathan JA (2013), Bishop N (2002), Stuible M (2010), Oved S (2006), Hoeller D (2006), Kharitidi D (2015), Zhang X (2017)	11
CSNK2A1	15	CPSF7	4	enzymatic study	Zhang M (2011)	1
BID	1	MAPK8	3	biochemical	Gajate C (2005)	1
UBE2E1	1	DTX3L	1	two hybrid	Markson G (2009)	1
CUL3	17	DAZAP1	1	affinity chromatography technology	Bennett EJ (2010)	1
CBL	7	SMAD3	1	affinity chromatography technology, affinity chromatography technology	Kang JM (2012), Kang JM (2012)	2
ARRB1	2	MAP2K4	3	unspecified method	Li X (2009)	1
CFTR	5	TAX1BP1	3	affinity chromatography technology	Pankow S (2015)	1
EWSR1	2	ARID1A	16	bioid	Elzi DJ (2014)	1
ARRB1	2	HGS	5	affinity chromatography technology, affinity chromatography technology	Malik R (2010), Han SO (2012)	2
TP53	0	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Abedini MR (2008), Saha A (2011), Saha A (2011)	3
CBL	7	UBE2D3	1	pull down, pull down	Tsukahara F (2010), Sigismund S (2013)	2
LATS1	3	WWOX	3	unspecified method	Salah Z (2013)	1
GRB2	2	CYLD	2	affinity chromatography technology	Huttlin EL (2017)	1
UBE2K	0	UBE2D2	0	biochemical	Wan C (2015)	1
YAP1	0	ARID1A	16	bioid, affinity chromatography technology	Couzens AL (2013), Enzo E (2015)	2
EWSR1	2	CPSF6	1	two hybrid	Rual JF (2005)	1
SMARCC2	9	KPNA2	0	affinity chromatography technology	Mak AB (2010)	1
CBL	7	SNX18	1	affinity chromatography technology	Selbach M (2006)	1
FAM189A2	2	WWOX	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAVS	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Wang Y (2012), Xu LG (2005), Wang P (2013), Wang P (2013), Shi Z (2015), Shi Z (2015), Minassian A (2015), Khan M (2016), Fang R (2017), Fang R (2017)	11
WWOX	3	TP73	2	affinity chromatography technology	Abu-Odeh M (2014)	1
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
CFTR	5	CAV1	0	affinity chromatography technology	Pankow S (2015)	1
UBC	7	CSNK2A1	15	affinity chromatography technology	Matsumoto M (2005)	1
NDFIP1	0	EGFR	5	affinity chromatography technology	Mund T (2010)	1
MAP3K7	2	TAB1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cheung PC (2004), Cheung PC (2004), Channavajhala PL (2003), Ninomiya-Tsuji J (1999), Sakurai H (2000), Liu XY (2008), Li S (2011), Li S (2011), Ear T (2010), Singhirunnusorn P (2005), Prickett TD (2008), Kim SY (2012), Jiang Z (2002), Shibuya H (1996), Shibuya H (1996), Minoda Y (2009), Minoda Y (2009), Scholz R (2010), Scholz R (2010), Scholz R (2010), Kim SI (2009), Ge B (2003), Blonska M (2005), Kishimoto K (2000), Kishimoto K (2000), Zhu Y (2013), Liu R (2014), Chen TC (2014), Moon G (2015), Ninomiya-Tsuji J (2003), Min Y (2016), St-Denis N (2016), Zhang J (2017)	33
MDM2	2	GSN	3	affinity chromatography technology	Frum R (2007)	1
EWSR1	2	AMOT	6	bioid	Elzi DJ (2014)	1
ITCH	1	SMAD2	5	enzymatic study, affinity chromatography technology	Bai Y (2004), Bai Y (2004)	2
MAPK8	3	TP53	0	affinity chromatography technology, pull down, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down	Hu MC (1997), Yin ZM (2004), Yin ZM (2004), Fuchs SY (1998), Topisirovic I (2009), Drago-Ferrante R (2008), Wang J (2000), Chang NS (2003), Fuchs SY (1998)	9
ITCH	1	UBAP2L	4	pull down	Ingham RJ (2005)	1
MAPK8	3	TNFRSF10B	1	biochemical	Gajate C (2005)	1
RPAP2	3	5430	0	affinity chromatography technology	Jeronimo C (2007)	1
GLI1	3	ITCH	1	affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology	Di Marcotullio L (2011), Di Marcotullio L (2011), Di Marcotullio L (2011), Di Marcotullio L (2011), Di Marcotullio L (2011)	5
MAP3K7	2	NDFIP1	0	affinity chromatography technology, affinity chromatography technology	Kathania M (2015), Kathania M (2015)	2
YAP1	0	PTCH1	8	pull down	Schuchardt BJ (2014)	1
PTCH1	8	COL18A1	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SMAD2	5	SMARCC1	5	affinity chromatography technology, affinity chromatography technology	Xi Q (2008), He W (2006)	2
ITCH	1	UBA1	1	affinity chromatography technology	OConnor HF (2015)	1
UBC	7	SPART	0	affinity chromatography technology	Matsumoto M (2005)	1
WWP2	7	AMOT	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Chaudhary N (2014), Huttlin EL (2017)	3
5430	0	PCNA	0	affinity chromatography technology	Kang H (2011)	1
PCBP2	3	PABPC1	5	two hybrid, pull down, biochemical	Wang Z (1999), Wang Z (1999), Wan C (2015)	3
HNRNPL	3	UBAP2L	4	affinity chromatography technology	Fei T (2017)	1
CFTR	5	USP9X	15	affinity chromatography technology	Wang X (2006)	1
CDC34	3	UBC	7	pull down, x-ray crystallography, enzymatic study, enzymatic study, x-ray crystallography, pull down, fluorescent resonance energy transfe, affinity chromatography technology, enzymatic study, enzymatic study	Choi YS (2010), Choi YS (2010), Sheng Y (2012), Enchev RI (2012), Huang H (2014), Huang H (2014), Huang H (2014), Bish RA (2007), Chong RA (2014), Phillips AH (2013)	10
DTX3L	1	HGS	5	affinity chromatography technology	Holleman J (2014)	1
RNF11	0	STAM2	0	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down	Kostaras E (2012), Colland F (2004), Kostaras E (2014), Kostaras E (2012)	4
OCLN	1	CSNK2A1	15	affinity chromatography technology, pull down, enzymatic study	Doerfel MJ (2013), Doerfel MJ (2013), Doerfel MJ (2013)	3
UBE2D3	1	RNF11	0	two hybrid, two hybrid, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Subramaniam V (2003), Markson G (2009)	4
LDLRAD4	1	TAX1BP1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HNRNPL	3	PDCD6IP	3	affinity chromatography technology	Fei T (2017)	1
WWP1	3	TP63	0	affinity chromatography technology, enzymatic study, affinity chromatography technology	Peschiaroli A (2010), Peschiaroli A (2010), Li Y (2008)	3
UBE2L3	1	YAP1	0	biochemical	Havugimana PC (2012)	1
DDX20	4	GEMIN8	1	affinity chromatography technology	Huttlin EL (2017)	1
TP53	0	TP63	0	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McDade SS (2011), Lu D (2013), Chae YS (2012), Chae YS (2012), Stindt MH (2015), Wei S (2014)	6
GRAP2	0	CBL	7	biochemical, affinity chromatography technology, two hybrid	Yankee TM (2003), Yankee TM (2003), Grossmann A (2015)	3
NOTCH1	25	SMARCC2	9	affinity chromatography technology	Yatim A (2012)	1
UBE2D2	0	RNF11	0	two hybrid, two hybrid, pull down, two hybrid, pull down	van Wijk SJ (2009), Markson G (2009), Subramaniam V (2003), Colland F (2004), Markson G (2009)	5
ELAVL1	0	SMAD6	9	affinity chromatography technology	Abdelmohsen K (2009)	1
SMAD7	1	TAB1	1	affinity chromatography technology, affinity chromatography technology	Edlund S (2003), Yanagisawa M (2001)	2
SFN	1	CBL	7	affinity chromatography technology	Subramanian RR (2001)	1
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
MAVS	1	TAX1BP1	3	affinity chromatography technology	Choi YB (2017)	1
CFTR	5	PABPC1	5	affinity chromatography technology	Pankow S (2015)	1
BECN1	2	ITCH	1	two hybrid	Platta HW (2012)	1
EWSR1	2	SMARCC1	5	bioid	Elzi DJ (2014)	1
UBE2D2	0	CUL3	17	pull down	Plafker KS (2009)	1
WWOX	3	ELAVL1	0	affinity chromatography technology	Abu-Odeh M (2014)	1
MDM2	2	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kubo N (2010), Kubo N (2010), Wu H (2015), Wu H (2015)	4
LRRK2	5	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Ho DH (2015), Ho DH (2015), Ho DH (2015)	3
ITCH	1	RNF11	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shembade N (2009), Santonico E (2010), Pranski EL (2012), Kitching R (2003)	4
ATXN3	2	TRAF6	0	enzymatic study	Bremm A (2010)	1
EWSR1	2	WWP1	3	two hybrid	Rual JF (2005)	1
ITCH	1	POLR2E	0	pull down	Ingham RJ (2005)	1
ARRB1	2	CSNK2A1	15	affinity chromatography technology	Ewing RM (2007)	1
TP63	0	HNRNPL	3	affinity chromatography technology	Amoresano A (2010)	1
LAPTM5	3	USP13	2	two hybrid	Colland F (2004)	1
GRB2	2	UBA1	1	two hybrid	Wang J (2011)	1
ELAVL1	0	BIN1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
UBA1	1	UBE2K	0	pull down, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Seufert W (1990), Jin J (2007), Whitby FG (1998), Whitby FG (1998), Pickart CM (1994), Huguenin-Dezot N (2016)	6
RNF11	0	PDCD6IP	3	two hybrid	Colland F (2004)	1
UBE2D2	0	DVL3	7	affinity chromatography technology	Boldt K (2016)	1
ITSN1	5	PDCD6IP	3	two hybrid	Wong KA (2012)	1
WWOX	3	PABPC1	5	pull down, affinity chromatography technology	Ingham RJ (2005), Abu-Odeh M (2014)	2
ITCH	1	UBE2E1	1	pull down, pull down	Bai Y (2004), Ahn YH (2009)	2
CFTR	5	KPNA2	0	affinity chromatography technology	Pankow S (2015)	1
JUN	0	ARRB1	2	two hybrid	Bandyopadhyay S (2010)	1
ADRB2	0	GRB2	2	affinity chromatography technology, pull down	Karoor V (1998), Karoor V (1998)	2
ITCH	1	CAV1	0	affinity chromatography technology	Malik R (2012)	1
LAPTM5	3	WWP1	3	two hybrid	Colland F (2004)	1
GBA	2	SCAMP3	0	affinity chromatography technology	Hein MY (2015)	1
EGFR	5	SCAMP3	0	affinity chromatography technology	Tong J (2014)	1
CUL3	17	UBAP2L	4	affinity chromatography technology	Bennett EJ (2010)	1
SMAD7	1	DVL1	5	pull down	Warner DR (2003)	1
TMEM92	0	ITCH	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SCNN1B	1	SCNN1A	1	protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Faria D (2012), Faria D (2012), Faria D (2012), Buck TM (2017)	4
UBA1	1	CDC34	3	enzymatic study, pull down, enzymatic study, pull down, enzymatic study	Tokgoez Z (2012), Jin J (2007), Chong RA (2014), Chong RA (2014), Wauer T (2015)	5
ARRB1	2	ITCH	1	affinity chromatography technology, affinity chromatography technology	Shenoy SK (2008), Bhandari D (2007)	2
EGFR	5	MAPK8	3	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
CPSF6	1	TOLLIP	3	two hybrid	Rolland T (2014)	1
WDR48	2	CSNK2A1	15	affinity chromatography technology	Sowa ME (2009)	1
SMARCE1	1	SMARCC1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Zhao K (1998), Hu K (2006), Ryme J (2009), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Chen J (2005), Chen J (2005), Keppler BR (2010), Mak AB (2010), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	15
NCOA1	6	SMARCE1	1	pull down, pull down, pull down	Belandia B (2002), Kiskinis E (2006), Flajollet S (2007)	3
DVL1	5	DVL2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	de Groot RE (2014), Huttlin EL (2015), Huttlin EL (2017)	3
ARRDC3	0	WWP2	7	two hybrid, affinity chromatography technology, affinity chromatography technology	Shea FF (2012), Shea FF (2012), Dores MR (2015)	3
EGFR	5	PDCD6IP	3	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Schmidt MH (2004), Schmidt MH (2003), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
ADRB2	0	UBC	7	affinity chromatography technology	Roy SJ (2013)	1
ARRB1	2	NOTCH1	25	affinity chromatography technology	Puca L (2013)	1
NDFIP2	2	WWP2	7	affinity chromatography technology	Ohzono C (2010)	1
HNRNPL	3	UBE2J2	1	affinity chromatography technology	Fei T (2017)	1
SH3GL2	1	SH3GL1	3	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Vinayagam A (2011), Ralser M (2005), Ralser M (2005), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	6
ADRB2	0	ARRB2	5	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Kittanakom S (2014), Tian X (2016), Tian X (2016)	3
JUN	0	SMARCE1	1	affinity chromatography technology	Li X (2015)	1
RNF11	0	TAX1BP1	3	affinity chromatography technology, two hybrid	Shembade N (2009), Colland F (2004)	2
UBE2D3	1	TRAF6	0	two hybrid, enzymatic study, pull down, pull down, pull down	Markson G (2009), Petroski MD (2007), Xia ZP (2009), Markson G (2009), Wauer T (2015)	5
ITCH	1	HNRNPL	3	pull down, affinity chromatography technology	Ingham RJ (2005), Fei T (2017)	2
LDLRAD4	1	YAP1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL3	17	HNRNPL	3	affinity chromatography technology	Bennett EJ (2010)	1
ARRB1	2	GSN	3	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Xiao K (2007)	2
UBE2D1	0	HDAC6	0	enzymatic study	Hoeller D (2007)	1
SMAD3	1	DVL1	5	pull down	Warner DR (2003)	1
ARRB2	5	GSN	3	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Xiao K (2007)	2
DAZAP1	1	UBE2L3	1	biochemical	Wan C (2015)	1
WWP2	7	TP73	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Chaudhary N (2014), Chaudhary N (2014), Chaudhary N (2014), Chaudhary N (2014), Chaudhary N (2014)	5
GRB2	2	TP53BP2	5	two hybrid	Rolland T (2014)	1
TXNIP	2	SLC3A2	5	bioid	Forred BJ (2016)	1
CUL3	17	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
TMEM255A	0	WWP1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TP63	0	WWOX	3	affinity chromatography technology, affinity chromatography technology	Salah Z (2013), Salah Z (2013)	2
SH3GLB1	2	PRKACA	2	biochemical	Kristensen AR (2012)	1
ILDR1	2	WWP1	3	affinity chromatography technology	Huttlin EL (2017)	1
WWOX	3	CSNK2A1	15	affinity chromatography technology	Abu-Odeh M (2014)	1
WWOX	3	POLR2B	3	pull down, affinity chromatography technology	Ingham RJ (2005), Abu-Odeh M (2014)	2
YAP1	0	TP53BP2	5	two hybrid, two hybrid, pull down, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, unspecified method, far western blotting, affinity chromatography technology	Espanel X (2001), Espanel X (2001), Espanel X (2001), Couzens AL (2013), Couzens AL (2013), Hauri S (2013), Gao K (2015), Espanel X (1999), Espanel X (1999), Enzo E (2015)	10
NDFIP1	0	UBE2L3	1	affinity chromatography technology	Kathania M (2015)	1
ARRDC3	0	WWOX	3	affinity chromatography technology	Huttlin EL (2017)	1
MAP3K7	2	HGS	5	pull down	Sasaki Y (2001)	1
STAM2	0	PLEKHB2	4	two hybrid	Rolland T (2014)	1
DVL2	5	DVL3	7	affinity chromatography technology, affinity chromatography technology	de Groot RE (2014), Huttlin EL (2017)	2
TRAF6	0	IKBKB	1	affinity chromatography technology	Bidere N (2006)	1
DVL1	5	CSNK2A1	15	affinity chromatography technology, imaging technique	Song DH (2000), Chen TC (2014)	2
TGFBR1	2	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sorrentino A (2008), Kim SI (2009), Kim SI (2009), Zhang L (2013)	4
ITCH	1	RPAP2	3	pull down	Ingham RJ (2005)	1
CYLD	2	PCNA	0	affinity chromatography technology	Elliott PR (2016)	1
UBE2D2	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
AMOT	6	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang C (2012), Wang C (2012), Adler JJ (2013), Adler JJ (2013), Adler JJ (2013)	5
TMEM51	2	ITCH	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CYLD	2	HNRNPL	3	affinity chromatography technology	Elliott PR (2016)	1
RNF11	0	HGS	5	affinity chromatography technology	Kostaras E (2012)	1
ITCH	1	GEMIN8	1	affinity chromatography technology	Han KJ (2016)	1
ELAVL1	0	ARID1A	16	affinity chromatography technology	Abdelmohsen K (2009)	1
SMAD2	5	JUN	0	affinity chromatography technology, pull down	Pessah M (2001), Miyamoto-Sato E (2010)	2
ARRB2	5	CUL3	17	affinity chromatography technology	Skieterska K (2016)	1
CBL	7	UBE2D1	0	pull down, pull down, pull down	Umebayashi K (2008), Sehat B (2008), Tsukahara F (2010)	3
PCBP2	3	HNRNPL	3	two hybrid, two hybrid, pull down, pull down	Kim JH (2000), Kim JH (2000), Kim JH (2000), Kim JH (2000)	4
RNF11	0	UBC	7	two hybrid, two hybrid	Li H (2004), Colland F (2004)	2
PCNA	0	MDM2	2	affinity chromatography technology, affinity chromatography technology	Groehler AL (2010), Banks D (2006)	2
PTCH1	8	KPNA2	0	affinity chromatography technology	Yamaki Y (2016)	1
TP53BP2	5	HNRNPUL1	1	two hybrid	Rolland T (2014)	1
UBE2D1	0	STAM2	0	enzymatic study	Hoeller D (2007)	1
MDM2	2	UBE2D2	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Iyappan S (2010), Dou H (2012), Brenkman AB (2008), Fang S (2000), Szypowska AA (2011), Okamoto K (2009), Busso CS (2009), Maguire M (2008), Sehat B (2008), Uldrijan S (2007), Yang Y (2005), Jin Y (2004), Roxburgh P (2012), Shloush J (2011), Rinaldo C (2007), Cheng Q (2009), Amson R (2011), Li X (2009), David Y (2011), Sosin AM (2012), Schumacher FR (2013), Bista M (2013), Mikawa T (2014), Lohrum MA (2001), Fang S (2001), Saville MK (2004), Rodriguez MS (1999), Auger KR (2005), Wu PY (2003), Wu H (2015), Yamauchi T (2014), Nomura K (2017), Kurokawa M (2013)	33
PLEKHB2	4	ITCH	1	affinity chromatography technology	Huttlin EL (2015)	1
TP53	0	EGFR	5	genetic interference, genetic interference	Xie L (2013), Ye H (2016)	2
ITCH	1	SMAD3	1	pull down	Feng L (2004)	1
TGFBR1	2	ITCH	1	affinity chromatography technology	Bai Y (2004)	1
WWP2	7	NDFIP1	0	affinity chromatography technology	Huttlin EL (2015)	1
UBC	7	LAPTM5	3	pull down	Pak Y (2006)	1
CUL3	17	IKBKB	1	affinity chromatography technology	Lee DF (2009)	1
TMEM171	1	CXCR4	0	affinity chromatography technology	Huttlin EL (2017)	1
NFE2	0	YAP1	0	far western blotting, two hybrid	Gavva NR (1997), Gavva NR (1997)	2
RIPK1	2	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao L (2015), Ding Z (2015), Varfolomeev E (2015)	3
UBE2E1	1	MGRN1	4	two hybrid	Markson G (2009)	1
CUL3	17	WDR48	2	affinity chromatography technology	Wimuttisuk W (2014)	1
WWP1	3	UBE2D1	0	pull down	Kristariyanto YA (2015)	1
SMAD6	9	TAB1	1	affinity chromatography technology	Yanagisawa M (2001)	1
USP13	2	CYLD	2	affinity chromatography technology	Sowa ME (2009)	1
UBE2J2	1	MGRN1	4	two hybrid	Markson G (2009)	1
SMAD7	1	YAP1	0	two hybrid, genetic interference, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down	Ferrigno O (2002), Ferrigno O (2002), Ferrigno O (2002), Aragon E (2012), Aragon E (2012), Aragon E (2012), Schuchardt BJ (2014)	7
MDM2	2	NOTCH1	25	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Lim SO (2011), Lim SO (2011), Pettersson S (2012), Pettersson S (2012), Pettersson S (2012)	5
UBE2D1	0	YAP1	0	biochemical	Havugimana PC (2012)	1
MAPK8	3	SMAD3	1	imaging technique	Chen TC (2014)	1
ITCH	1	UBE2D1	0	pull down	Kristariyanto YA (2015)	1
NOTCH1	25	SMARCC1	5	affinity chromatography technology	Yatim A (2012)	1
ATN1	2	ITCH	1	two hybrid, pull down	Wood JD (1998), Wood JD (1998)	2
WWP2	7	5430	0	affinity chromatography technology	Huttlin EL (2017)	1
HTT	14	GRB2	2	affinity chromatography technology, pull down	Liu YF (1997), Liu YF (1997)	2
WWOX	3	SMARCE1	1	affinity chromatography technology	Abu-Odeh M (2014)	1
WWOX	3	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Abu-Odeh M (2014), Abu-Odeh M (2014), Abu-Odeh M (2014)	3
MAP3K7	2	CYLD	2	affinity chromatography technology, affinity chromatography technology	Koga T (2008), Elliott PR (2016)	2
NOTCH1	25	NUMB	1	pull down, pull down	Zhong W (1996), Pettersson S (2012)	2
LATS1	3	AMOT	6	bioid, enzymatic study, affinity chromatography technology	Couzens AL (2013), Adler JJ (2013), Hauri S (2013)	3
UBC	7	PDCD6IP	3	pull down	Zhang X (2017)	1
TNFRSF10B	1	CFLAR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	MacFarlane M (1997), Kim Y (2002), Kaunisto A (2009), Gonzalvez F (2012)	4
POU5F1	0	KPNA2	0	affinity chromatography technology	Oliviero G (2015)	1
WWP2	7	PDCD6IP	3	affinity chromatography technology	Dores MR (2015)	1
GRB2	2	HGS	5	affinity chromatography technology	Bisson N (2011)	1
EGFR	5	NUMB	1	unspecified method	Jones RB (2006)	1
CPSF6	1	SMARCC2	9	biochemical	Wan C (2015)	1
ELAVL1	0	PDCD6IP	3	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2E3	0	RNF11	0	two hybrid	Markson G (2009)	1
CSNK2A1	15	ITCH	1	enzymatic study	Morales B (2007)	1
TNFRSF10B	1	NDFIP1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGFR	5	CSNK2A1	15	affinity chromatography technology	Tong J (2014)	1
HDAC6	0	SMARCC1	5	affinity chromatography technology	Joshi P (2013)	1
UBA6	4	UBC	7	pull down, enzymatic study, unspecified method, affinity chromatography technology	Gavin JM (2012), Gavin JM (2012), Zhao B (2012), Bish RA (2007)	4
ITCH	1	DTX1	2	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Chastagner P (2008), Chastagner P (2006), Chastagner P (2006), Chastagner P (2006)	4
TP53	0	ARID1A	16	affinity chromatography technology, pull down	Guan B (2011), Guan B (2011)	2
TMEM171	1	OCLN	1	affinity chromatography technology	Huttlin EL (2015)	1
RASSF1	3	TGFBR1	2	affinity chromatography technology	Pefani DE (2016)	1
SMAD2	5	CPSF7	4	affinity chromatography technology	Brown KA (2008)	1
STAM2	0	ITCH	1	pull down, pull down	Malik R (2012), Malik R (2012)	2
CBL	7	UBE2L3	1	pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography	Yokouchi M (1999), Zheng N (2000), Wong ES (2002), Wong ES (2002), Oved S (2006), Dominguez C (2004)	6
MDM2	2	RASSF1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Song MS (2008), Zhang H (2013), Zhang H (2013)	3
TP63	0	TP73	2	affinity chromatography technology	Huttlin EL (2017)	1
HNRNPL	3	ARRB2	5	affinity chromatography technology	Fei T (2017)	1
5430	0	POLR2B	3	pull down, biochemical, biochemical	Knuesel MT (2009), Havugimana PC (2012), Wan C (2015)	3
ARRB2	5	POLR2E	0	affinity chromatography technology	Xiao K (2007)	1
JUN	0	UBC	7	two hybrid, protein complementation assay	Bandyopadhyay S (2010), Fang D (2004)	2
WBP2	0	TOLLIP	3	two hybrid	Lim SK (2016)	1
UBE2E3	0	CUL3	17	pull down	Plafker KS (2009)	1
CUL3	17	NUDT21	0	affinity chromatography technology	Bennett EJ (2010)	1
ITCH	1	USP9X	15	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Mouchantaf R (2006), Mouchantaf R (2006), Azakir BA (2009), OConnor HF (2015)	4
IKBKB	1	TP63	0	affinity chromatography technology, affinity chromatography technology	Chatterjee A (2010), Chatterjee A (2010)	2
WWOX	3	5430	0	pull down, affinity chromatography technology	Ingham RJ (2005), Abu-Odeh M (2014)	2
GGA3	6	TOLLIP	3	pull down	Katoh Y (2004)	1
UBC	7	KPNB1	3	affinity chromatography technology	Matsumoto M (2005)	1
CUL3	17	USP9X	15	affinity chromatography technology	Bennett EJ (2010)	1
ARRDC4	1	ADRB2	0	affinity chromatography technology	Patwari P (2011)	1
NCOA1	6	JUN	0	pull down, pull down, two hybrid, pull down	Lee SK (1999), Lee SK (2000), Lee SK (1998), Lee SK (1998)	4