PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MCPH1	4	ZMIZ2	1	two hybrid	Liu X (2017)	1
MVP	1	ZMIZ2	1	two hybrid	Corominas R (2014)	1
TRIM25	5	ZMIZ2	1	affinity chromatography technology	Choudhury NR (2017)	1
ZMIZ2	1	TP53	0	two hybrid	Lee J (2007)	1
SALL2	2	ZMIZ2	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
TRIM25	5	ASB13	0	affinity chromatography technology	Choudhury NR (2017)	1
BANP	1	ZMIZ2	1	two hybrid	Rolland T (2014)	1
MVP	1	BANP	1	two hybrid	Corominas R (2014)	1
AR	3	PIAS3	2	two hybrid	Kotaja N (2000)	1
PIN1	0	TP53	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down	Wulf GM (2002), Wulf GM (2002), Zacchi P (2002), Zacchi P (2002), Vinayagam A (2011), Mantovani F (2007)	6
TRIM25	5	C2orf88	0	affinity chromatography technology	Choudhury NR (2017)	1
PIAS1	4	ZMIZ2	1	affinity chromatography technology	Peng Y (2010)	1
ZMIZ2	1	342666	0	two hybrid	Rolland T (2014)	1
ASB13	0	ZMIZ2	1	two hybrid	Rolland T (2014)	1
ARSJ	2	ZMIZ2	1	two hybrid	Rolland T (2014)	1
TP53	0	PIAS4	5	two hybrid	Goehler H (2004)	1
BANP	1	TP53	0	pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pavithra L (2009), Pavithra L (2009), Sinha S (2010), Sinha S (2010), Sinha S (2010), Sinha S (2012), Pavithra L (2009)	7
CRCP	0	ZMIZ2	1	two hybrid	Rolland T (2014)	1
SCAMP1	3	ZMIZ2	1	two hybrid	Rolland T (2014)	1
AR	3	SMARCE1	1	pull down, pull down, bioid	Link KA (2008), Link KA (2005), Lempiaeinen JK (2017)	3
MCPH1	4	SMARCA4	19	affinity chromatography technology, affinity chromatography technology	Peng G (2009), Peng G (2009)	2
ZMIZ2	1	SMARCA4	19	affinity chromatography technology	Huang CY (2005)	1
TRIM25	5	BANP	1	affinity chromatography technology	Choudhury NR (2017)	1
AR	3	SMARCA4	19	affinity chromatography technology, two hybrid, affinity chromatography technology, bioid	Wang Q (2004), van de Wijngaart DJ (2009), Dai Y (2008), Lempiaeinen JK (2017)	4
AR	3	PIAS1	4	two hybrid, affinity chromatography technology	Kotaja N (2000), Toropainen S (2015)	2
AICDA	0	ZMIZ2	1	affinity chromatography technology	Delker RK (2013)	1
ZMIZ2	1	C2orf88	0	two hybrid	Rolland T (2014)	1
TP53	0	SCAMP1	3	two hybrid	Lim J (2006)	1
ZMIZ2	1	AR	3	affinity chromatography technology, two hybrid	Huang CY (2005), Huang CY (2005)	2
PIN1	0	ZMIZ2	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
SSX2	0	ZMIZ2	1	two hybrid	Rolland T (2014)	1
TP53	0	SMARCA4	19	pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee D (2002), Lee D (2002), Lee D (2002), Napolitano MA (2007), Guan B (2011), Oh J (2008)	6
ZMIZ2	1	SMARCE1	1	affinity chromatography technology	Huang CY (2005)	1
MVP	1	TP53	0	two hybrid	Corominas R (2014)	1
AR	3	TP53	0	genetic interference	Shenk JL (2001)	1
TRAPPC6A	0	ZMIZ2	1	two hybrid	Rolland T (2014)	1
SMARCA4	19	SMARCE1	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Wang W (1996), Zhao K (1998), Zhao K (1998), Hu K (2006), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Pal S (2003), Bultman SJ (2005), Battaglioli E (2002), ONeill DW (2000), Tando T (2010), Mak AB (2010), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	18
RANBP3	0	ZMIZ2	1	two hybrid	Rolland T (2014)	1
SOCS6	0	ZMIZ2	1	two hybrid	Wang J (2011)	1
TRIM25	5	SMARCA4	19	affinity chromatography technology	Choudhury NR (2017)	1
PIAS4	5	ZMIZ2	1	affinity chromatography technology	Peng Y (2010)	1
AR	3	PIAS4	5	pull down, pull down	Gross M (2001), Gross M (2004)	2
ZMIZ2	1	INTS4	2	two hybrid	Rolland T (2014)	1
TP53	0	PIAS1	4	two hybrid, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, imaging technique, pull down	Gallagher WM (1999), Kahyo T (2001), Kahyo T (2001), Schmidt D (2002), Pelisch F (2010), Schmidt D (2002), Chen TC (2014), Okubo S (2004)	8
NBL1	1	ZMIZ2	1	two hybrid	Rolland T (2014)	1
ZMIZ2	1	SELENOV	2	two hybrid	Rolland T (2014)	1
ZMIZ2	1	PIAS3	2	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Peng Y (2010), Peng Y (2010), Peng Y (2010), Peng Y (2010)	4