PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MOB1B	0	RASSF5	2	bioid	Couzens AL (2013)	1
ITCH	1	RASSF5	2	affinity chromatography technology, affinity chromatography technology, pull down	Suryaraja R (2013), Suryaraja R (2013), Suryaraja R (2013)	3
BTRC	1	RASSF1	3	two hybrid, affinity chromatography technology, bioid, affinity chromatography technology	Vinayagam A (2011), Zhou X (2012), Coyaud E (2015), Huttlin EL (2017)	4
STK4	1	RASSF2	2	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Varjosalo M (2013), Huttlin EL (2015), Hauri S (2013), Hauri S (2013), Huttlin EL (2017)	10
MAP1LC3B	1	STK4	1	affinity chromatography technology	Behrends C (2010)	1
MAP1S	3	MAP1B	5	affinity chromatography technology	Hauri S (2013)	1
BTRC	1	REL	5	affinity chromatography technology, bioid	Coyaud E (2015), Coyaud E (2015)	2
TRAF1	0	RASSF5	2	two hybrid	Rolland T (2014)	1
RASSF5	2	STK3	1	affinity chromatography technology, two hybrid, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Wang J (2011), Couzens AL (2013), Couzens AL (2013), Varjosalo M (2013), Hauri S (2013), Hauri S (2013)	7
STK3	1	MOB1A	2	enzymatic study, affinity chromatography technology, bioid, affinity chromatography technology	Hirabayashi S (2008), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013)	4
STK3	1	MOB1B	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, bioid	Bao Y (2009), Bao Y (2009), Couzens AL (2013), Couzens AL (2013)	4
ADH6	1	KRAS	1	two hybrid	Wang J (2011)	1
BTRC	1	MAP1S	3	bioid, affinity chromatography technology	Coyaud E (2015), Huttlin EL (2017)	2
MAP1LC3B	1	RASSF5	2	affinity chromatography technology	Behrends C (2010)	1
STK3	1	TRAF1	0	two hybrid	Rolland T (2014)	1
RASSF5	2	RAP2A	0	pull down, two hybrid	Ortiz-Vega S (2002), Ortiz-Vega S (2002)	2
VPS28	2	RASSF5	2	two hybrid	Rolland T (2014)	1
MDM2	2	MAP1LC3A	0	enzymatic study	Guo Z (2013)	1
AMOTL2	5	KRTAP4-2	0	two hybrid	Rolland T (2014)	1
MAP1LC3B	1	MAP1B	5	affinity chromatography technology	Behrends C (2010)	1
KRAS	1	KCTD12	0	genetic interference	Luo J (2009)	1
RASSF5	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, two hybrid	Schmidt ML (2014), Schmidt ML (2014), Rolland T (2014)	3
MOB1B	0	RASSF2	2	affinity chromatography technology	Couzens AL (2013)	1
BTRC	1	MDM2	2	affinity chromatography technology, affinity chromatography technology, pull down	Inuzuka H (2010), Inuzuka H (2010), Inuzuka H (2010)	3
RASSF5	2	KRT40	0	two hybrid	Rolland T (2014)	1
HIPK1	1	RASSF5	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Lee D (2012), Lee D (2012), Lee D (2012)	3
RASSF1	3	MAP1B	5	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dallol A (2004), Dallol A (2004), Huttlin EL (2015), Hauri S (2013), Huttlin EL (2017)	5
MAP1LC3A	0	MAP1S	3	affinity chromatography technology, affinity chromatography technology, pull down	Xie R (2011), Xie R (2011), Xie R (2011)	3
HRAS	2	BTRC	1	pull down, affinity chromatography technology, affinity chromatography technology	Kim SE (2009), Kim SE (2009), Kim SE (2009)	3
SMAD4	9	RASSF5	2	two hybrid	Rolland T (2014)	1
RASSF1	3	ITCH	1	affinity chromatography technology	Pefani DE (2016)	1
UBQLN1	1	MAP1LC3A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rothenberg C (2010), Rothenberg C (2010), Lee DY (2013)	3
MOB1A	2	STK4	1	affinity chromatography technology, bioid, affinity chromatography technology	Couzens AL (2013), Couzens AL (2013), Couzens AL (2013)	3
RASSF5	2	KRTAP4-2	0	two hybrid	Rolland T (2014)	1
BTRC	1	STK3	1	affinity chromatography technology, bioid, affinity chromatography technology	Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017)	3
RABIF	0	REL	5	two hybrid	Rolland T (2014)	1
RAP1B	0	RASSF5	2	two hybrid	Rolland T (2014)	1
RASSF5	2	STK4	1	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Behrends C (2010), Couzens AL (2013), Varjosalo M (2013), Hauri S (2013), Hauri S (2013)	6
RASSF5	2	MAP1B	5	affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Hauri S (2013)	2
RABIF	0	RASSF5	2	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
RASSF5	2	AGL	4	affinity chromatography technology	Behrends C (2010)	1
MAP1LC3A	0	RASSF5	2	affinity chromatography technology	Behrends C (2010)	1
MOB1B	0	MOB1A	2	affinity chromatography technology, affinity chromatography technology	Hauri S (2013), Huttlin EL (2017)	2
RASSF1	3	STK3	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Guo C (2007), Guo C (2007), Liu L (2007), Matallanas D (2007), Romano D (2010), Romano D (2010), Couzens AL (2013), Varjosalo M (2013), Fenton SL (2004), Huttlin EL (2015), Hauri S (2013), Hauri S (2013), Huttlin EL (2017), Ivanov AA (2017)	14
UBQLN1	1	RASSF5	2	two hybrid, two hybrid	Lim J (2006), Rolland T (2014)	2
RASSF5	2	APPBP2	3	two hybrid, two hybrid	Venkatesan K (2009), Rolland T (2014)	2
BTRC	1	SMAD4	9	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wan M (2004), Wan M (2004), Yang L (2006), Yang L (2006), Wan M (2005), Liang M (2004), Demagny H (2014), Li D (2015)	8
MOB1A	2	RASSF2	2	affinity chromatography technology	Couzens AL (2013)	1
RASSF5	2	RRAS	2	pull down, affinity chromatography technology	Ortiz-Vega S (2002), Ortiz-Vega S (2002)	2
MOB1A	2	RASSF5	2	bioid	Couzens AL (2013)	1
STK3	1	MAP1S	3	bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Varjosalo M (2013), Hauri S (2013), Hauri S (2013)	4
TRAF2	1	RASSF5	2	two hybrid	Rolland T (2014)	1
STK3	1	RASSF2	2	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, bioid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Varjosalo M (2013), Rolland T (2014), Huttlin EL (2015), Hauri S (2013), Hauri S (2013), Huttlin EL (2017)	11
KRAS	1	MYLIP	1	genetic interference	Luo J (2009)	1
KPNB1	3	RASSF5	2	affinity chromatography technology	Suryaraja R (2013)	1
MAP1LC3A	0	STK4	1	affinity chromatography technology	Behrends C (2010)	1
RAP2B	0	RASSF5	2	two hybrid	Rolland T (2014)	1
MOB1B	0	STK4	1	affinity chromatography technology, affinity chromatography technology, bioid	Couzens AL (2013), Couzens AL (2013), Couzens AL (2013)	3
RASSF5	2	RASSF1	3	pull down, affinity chromatography technology	Ortiz-Vega S (2002), Ortiz-Vega S (2002)	2
RASSF5	2	ERP44	1	affinity chromatography technology	Behrends C (2010)	1
STK4	1	RASSF1	3	affinity chromatography technology, two hybrid, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, fluorescent resonance energy transfe	Behrends C (2010), Liu L (2007), Couzens AL (2013), Varjosalo M (2013), Huttlin EL (2015), Hauri S (2013), Hauri S (2013), Mo XL (2015), Huttlin EL (2017), Ivanov AA (2017)	10
LSM7	0	RASSF5	2	two hybrid	Wang J (2011)	1
KPNB1	3	SMAD4	9	affinity chromatography technology	Xiao Z (2000)	1
AMOTL2	5	RASSF5	2	two hybrid	Rolland T (2014)	1
STK4	1	MAP1B	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Varjosalo M (2013), Hauri S (2013)	3
MDM2	2	RASSF5	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Lee D (2012), Lee D (2012), Lee D (2012)	3
TRAF1	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Takeuchi M (1996), Li S (2011), Li S (2011), Fries KL (1999), He L (2004), Zheng C (2010), Zheng C (2010), Relaix F (1998), Relaix F (1998), Jang HD (2001), Fotin-Mleczek M (2004), Pullen SS (1998), Wicovsky A (2009), Rothe M (1994), Rothe M (1994), Chen TC (2014), Greenfeld H (2015), Huttlin EL (2017)	19
KRAS	1	RASSF2	2	affinity chromatography technology, pull down	Vos MD (2003), Vos MD (2003)	2
MAP1LC3B	1	STK3	1	affinity chromatography technology	Behrends C (2010)	1
RASSF1	3	HRAS	2	pull down, affinity chromatography technology	Vos MD (2000), Vos MD (2000)	2
MAP1LC3A	0	MAP1B	5	affinity chromatography technology	Behrends C (2010)	1
STK3	1	STK4	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, fluorescent resonance energy transfe	Behrends C (2010), Behrends C (2010), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Varjosalo M (2013), Varjosalo M (2013), Hauri S (2013), Hauri S (2013), Wan C (2015), Ivanov AA (2017)	12
RASSF5	2	MAP1S	3	affinity chromatography technology, two hybrid, affinity chromatography technology	Behrends C (2010), Rolland T (2014), Hauri S (2013)	3
RASSF5	2	KRAS	1	pull down	Ortiz-Vega S (2002)	1
ITCH	1	KPNB1	3	pull down	Suryaraja R (2013)	1
REL	5	RASSF5	2	two hybrid	Rolland T (2014)	1
RASSF5	2	KCTD12	0	affinity chromatography technology	Behrends C (2010)	1
TRAF2	1	AMOTL2	5	two hybrid	Rolland T (2014)	1
RASSF5	2	RASSF5	2	pull down	Ortiz-Vega S (2002)	1
HRAS	2	RASSF5	2	pull down, two hybrid	Vavvas D (1998), Corominas R (2014)	2
MDM2	2	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kubo N (2010), Kubo N (2010), Wu H (2015), Wu H (2015)	4
RASSF5	2	MRAS	0	pull down, affinity chromatography technology	Ortiz-Vega S (2002), Ortiz-Vega S (2002)	2
ADH6	1	RASSF5	2	two hybrid	Wang J (2011)	1
RASSF5	2	FLNC	8	affinity chromatography technology	Behrends C (2010)	1
KRAS	1	BTRC	1	affinity chromatography technology	Shukla S (2014)	1
STK3	1	MAP1B	5	affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Hauri S (2013)	2
BTRC	1	STK4	1	affinity chromatography technology, bioid, affinity chromatography technology	Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017)	3
MAP1S	3	RASSF1	3	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu L (2005), Dallol A (2004), Dallol A (2004), Huttlin EL (2015), Hauri S (2013), Huttlin EL (2017)	6
RASSF5	2	RASSF2	2	pull down, two hybrid	Ortiz-Vega S (2002), Rolland T (2014)	2
STK4	1	MAP1S	3	bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Varjosalo M (2013), Hauri S (2013), Hauri S (2013)	4
MYLIP	1	RASSF5	2	two hybrid	Rolland T (2014)	1
MAP1LC3A	0	STK3	1	affinity chromatography technology	Behrends C (2010)	1
MDM2	2	RASSF1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Song MS (2008), Zhang H (2013), Zhang H (2013)	3
MAP1LC3B	1	MAP1LC3A	0	affinity chromatography technology	Behrends C (2010)	1