PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FZD4	1	PDZRN3	3	affinity chromatography technology, imaging technique, biochemical	Sewduth RN (2014), Sewduth RN (2014), Sewduth RN (2014)	3
FZD4	1	BAG6	2	two hybrid	Vinayagam A (2011)	1
NDP	0	FZD4	1	affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique	Xu Q (2004), Xu Q (2004), Qin M (2008), Xu Q (2004)	4
FZD4	1	ZNRF3	2	affinity chromatography technology	Hao HX (2012)	1
FZD4	1	RAB5A	0	affinity chromatography technology	Sewduth RN (2014)	1
DLG4	11	FZD4	1	two hybrid	Hering H (2002)	1