PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MCM5	1	ORC1	3	pull down	Ramachandran N (2004)	1
XPO1	8	PAF1	6	affinity chromatography technology	Kirli K (2015)	1
CDK2	0	CDC7	2	enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Martin L (2007), Martin L (2007), Martin L (2007), Masai H (2000)	4
MCM3	2	DBF4	2	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
MCM7	5	ORC6	0	pull down	Ramachandran N (2004)	1
DBF4	2	MCM2	3	two hybrid, enzymatic study	Kneissl M (2003), Masai H (2000)	2
CDKN1A	1	CDK2	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology	Ono T (2000), McKenzie PP (2003), McKenzie PP (2003), Law BK (2002), Harper JW (1993), Harper JW (1993), Yam CH (1999), Selma Dagtas A (2010), Naderi S (2005), Varshochi R (2005), Jeong JH (2010), Hsu SP (2008), Scholz A (2003), Peiretti A (2003), Peiretti A (2003), Derjuga A (2001), Kim YB (2000), Park US (2000), Kim WH (2000), Kokontis JM (1998), Orend G (1998), Wu G (1997), Liu J (1997), Bendjennat M (2003), Zheleva DI (2002), Mandal M (1998), Bao GC (2006), Mattock H (2001), Chen Z (2002), Chen J (1996), Chen J (1996), Levkau B (1998), Levkau B (1998), Ramachandran N (2004), Lacy ER (2005), Akagi M (1996), Zhao J (1998), Zhang Y (1999), Poon RY (1998), Gorospe M (1996), Varjosalo M (2013), Varjosalo M (2013), Fogeron ML (2013), Huttlin EL (2015), Hall JR (2014), Hein MY (2015), Hein MY (2015), Chen TC (2014), Hukkelhoven E (2012), Huttlin EL (2017), Roessig L (2001)	51
MCM4	3	ORC5	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CDC7	2	MCM2	3	two hybrid, two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study	Kneissl M (2003), Kneissl M (2003), Gerard A (2006), Martin L (2007), Martin L (2007), Montagnoli A (2006), Suzuki T (2012), Masai H (2000)	8
CDC7	2	MCM6	5	enzymatic study	Masai H (2000)	1
RIPK4	0	CDC7	2	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	CDKN2A	1	affinity chromatography technology	Rodriguez J (2016)	1
TOB1	1	APP	1	pull down	Olah J (2011)	1
MCM2	3	MCM7	5	pull down, pull down, two hybrid, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), You Z (1999), Fujita M (1997), You Z (2002), Havugimana PC (2012), Ramachandran N (2004), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Drissi R (2015), Boldt K (2016)	14
CDKN1A	1	ING5	3	two hybrid	Vinayagam A (2011)	1
MCM10	2	CDKN2A	1	pull down	Ramachandran N (2004)	1
MCM5	1	ORC5	0	pull down	Ramachandran N (2004)	1
EGLN3	0	MCM5	1	affinity chromatography technology	Rodriguez J (2016)	1
DBF4	2	ORC1	3	two hybrid	Kneissl M (2003)	1
RAD18	3	DBF4	2	affinity chromatography technology, affinity chromatography technology	Yamada M (2013), Yamada M (2013)	2
CDKN1A	1	CDK4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Selma Dagtas A (2010), Guidoboni M (2005), Santiago FS (2007), Santiago FS (2007), Hsu SP (2008), Kehn K (2004), Kokontis JM (1998), Orend G (1998), Zheleva DI (2002), Mandal M (1998), Chen J (1996), Chen J (1996), Ramachandran N (2004), Gorospe M (1996), Fogeron ML (2013), Hukkelhoven E (2012), Hukkelhoven E (2012), Hukkelhoven E (2012), Huttlin EL (2017), Roessig L (2001)	20
MCM4	3	MCM7	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, biochemical, biochemical, affinity chromatography technology	Yabuta N (2003), Fujita M (1997), Ishimi Y (1996), You Z (2002), Havugimana PC (2012), Ramachandran N (2004), Kristensen AR (2012), Wan C (2015), Boldt K (2016)	9
MCM3	2	MCM2	3	two hybrid, two hybrid, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004), Wan C (2015), Drissi R (2015), Huttlin EL (2017), Lossaint G (2013), Mulvaney KM (2016)	8
TOB1	1	CHAF1A	1	affinity chromatography technology	Ezzeddine N (2007)	1
CDC7	2	RAD18	3	enzymatic study, affinity chromatography technology	Day TA (2010), Day TA (2010)	2
MCM5	1	CDC7	2	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
DBF4	2	ORC6	0	two hybrid, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003)	2
MCM4	3	CDC7	2	two hybrid, two hybrid, enzymatic study	Kneissl M (2003), Kneissl M (2003), Masai H (2000)	3
CDK9	3	ING5	3	genetic interference	Srivas R (2016)	1
MCM6	5	ING5	3	two hybrid, affinity chromatography technology	Rual JF (2005), Doyon Y (2006)	2
CDK4	2	CDKN2A	1	affinity chromatography technology, unspecified method, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, two hybrid, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Ewing RM (2007), Fahraeus R (1996), Li J (2004), Sugimoto M (1999), Serrano M (1993), Serrano M (1993), Serrano M (1993), Coleman KG (1997), Zhang Y (1998), Haddad MM (1999), Li J (2002), Li J (2002), Lal G (2000), Yarbrough WG (1999), Della Torre G (2001), Jones R (2007), Jones R (2007), Ramachandran N (2004), Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Hein MY (2015), Fei HJ (2017), Huttlin EL (2017), Ivanov AA (2017)	25
EGLN3	0	CDK4	2	affinity chromatography technology	Rodriguez J (2016)	1
MAPK6	1	CDC7	2	affinity chromatography technology	Rodriguez J (2016)	1
MCM10	2	APP	1	pull down, affinity chromatography technology	Olah J (2011), Huttlin EL (2017)	2
CDKN2A	1	MCM2	3	pull down	Ramachandran N (2004)	1
MCM6	5	ORC6	0	pull down	Ramachandran N (2004)	1
ING5	3	MCM2	3	affinity chromatography technology	Doyon Y (2006)	1
KMT2E	7	MCM3	2	affinity chromatography technology	Ding X (2015)	1
CDC7	2	GPT	2	two hybrid	Wang J (2011)	1
MCM3	2	MCM4	3	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017), Mulvaney KM (2016)	4
CDK2	0	MCM6	5	affinity chromatography technology	Neganova I (2011)	1
CLSPN	1	CDC7	2	affinity chromatography technology, pull down	Kim JM (2008), Kim JM (2008)	2
XPO1	8	DBF4	2	affinity chromatography technology	Kirli K (2015)	1
MCM5	1	MCM6	5	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	DaFonseca CJ (2001), Havugimana PC (2012), Wan C (2015), Drissi R (2015)	4
DBF4B	1	CDC7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Montagnoli A (2002), Huttlin EL (2015), Huttlin EL (2017)	3
EGLN3	0	MAPK6	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang J (2011), Rodriguez J (2016), Rodriguez J (2016), Rodriguez J (2016), Rodriguez J (2016)	5
ORC1	3	MCM2	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
MCM7	5	ORC1	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CDC7	2	MCM3	2	enzymatic study, pull down	Sato N (1997), Ramachandran N (2004)	2
CDC7	2	ING5	3	genetic interference	Srivas R (2016)	1
EGLN3	0	XPO1	8	affinity chromatography technology	Rodriguez J (2016)	1
MAPK6	1	MCM3	2	two hybrid	Vinayagam A (2011)	1
ORC5	0	MCM2	3	two hybrid, two hybrid, pull down	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	3
MCM4	3	ORC6	0	two hybrid, two hybrid, pull down	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	3
ORC5	0	ORC6	0	two hybrid	Kneissl M (2003)	1
DBF4	2	ORC5	0	two hybrid	Kneissl M (2003)	1
CDC7	2	CDK9	3	two hybrid	Wang J (2011)	1
CDK9	3	RPS11	0	genetic interference	Srivas R (2016)	1
CDC7	2	CDC7	2	enzymatic study	Masai H (2000)	1
CDC7	2	GRHPR	1	two hybrid	Wang J (2011)	1
MCM5	1	MCM4	3	affinity chromatography technology, biochemical, biochemical	DaFonseca CJ (2001), Havugimana PC (2012), Wan C (2015)	3
MCM5	1	ORC6	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
MCM3	2	CDK2	0	affinity chromatography technology, pull down, pull down	Li J (2011), Li J (2011), Ramachandran N (2004)	3
ORC6	0	APP	1	pull down	Olah J (2011)	1
MCM3	2	ORC5	0	two hybrid, two hybrid, pull down	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	3
KMT2E	7	CDK2	0	affinity chromatography technology	Ding X (2015)	1
MAPK6	1	MCM4	3	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	CENPJ	6	affinity chromatography technology	Rodriguez J (2016)	1
MCM3	2	MCM5	1	two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), DaFonseca CJ (2001), Havugimana PC (2012), Ramachandran N (2004), Kristensen AR (2012), Wan C (2015), Drissi R (2015), Huttlin EL (2017), Chen YH (2015), Lossaint G (2013), Lossaint G (2013), Mulvaney KM (2016)	13
EGLN3	0	MCM7	5	affinity chromatography technology	Rodriguez J (2016)	1
MCM4	3	MCM2	3	pull down, two hybrid, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), You Z (1999), Ishimi Y (1996), Tan BC (2006), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Drissi R (2015), Boldt K (2016)	11
MCM2	3	MCM6	5	two hybrid, pull down, pull down, two hybrid, two hybrid, two hybrid, biochemical, affinity chromatography technology, biochemical, biochemical, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Yabuta N (2003), Yabuta N (2003), Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), You Z (1999), You Z (2002), Havugimana PC (2012), Kristensen AR (2012), Rolland T (2014), Wan C (2015), Hein MY (2015), Drissi R (2015), Boldt K (2016)	15
ING5	3	MCM4	3	affinity chromatography technology	Doyon Y (2006)	1
CDK2	0	MCM2	3	enzymatic study, affinity chromatography technology	Montagnoli A (2006), Neganova I (2011)	2
MCM5	1	APP	1	pull down	Olah J (2011)	1
MCM3	2	MCM6	5	biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Mulvaney KM (2016)	6
EGLN3	0	CDK2	0	affinity chromatography technology	Rodriguez J (2016)	1
ORC1	3	CDC7	2	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
MCM2	3	MCM10	2	pull down	Ramachandran N (2004)	1
MCM10	2	CDKN1A	1	pull down	Ramachandran N (2004)	1
XPO1	8	CLSPN	1	affinity chromatography technology	Kirli K (2015)	1
DBF4	2	MCM6	5	enzymatic study	Masai H (2000)	1
CDC7	2	DBF4	2	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Kneissl M (2003), Kumagai H (1999), Jiang W (1999), Jiang W (1999), Jiang W (1999), Kumagai H (1999), Kumagai H (1999), Liu P (2006), Masai H (2000), Masai H (2000), Huttlin EL (2017)	11
MCM10	2	MCM7	5	biochemical, pull down, affinity chromatography technology, affinity chromatography technology	Izumi M (2000), Ramachandran N (2004), Huttlin EL (2015), Huttlin EL (2017)	4
CDC7	2	BRD4	8	genetic interference	Srivas R (2016)	1
MCM6	5	MCM10	2	two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Ramachandran N (2004), Rolland T (2014), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	6
CDC7	2	CDKN2A	1	pull down	Ramachandran N (2004)	1
CDC7	2	IFT122	2	affinity chromatography technology	Boldt K (2016)	1
CDK9	3	PAF1	6	affinity chromatography technology, biochemical, biochemical	He N (2011), Wu L (2014), Wu L (2014)	3
MCM7	5	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
MCM6	5	MCM7	5	pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), Fujita M (1997), You Z (2002), Havugimana PC (2012), Ryu MJ (2006), Wan C (2015), Hein MY (2015), Boldt K (2016)	10
CDK4	2	CDC7	2	pull down	Ramachandran N (2004)	1
RPS11	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
CDK9	3	CLSPN	1	affinity chromatography technology	Yu DS (2010)	1
XPO1	8	RAD18	3	affinity chromatography technology	Kirli K (2015)	1
BRD4	8	CDK9	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Jang MK (2005), Jang MK (2005), He N (2006), Yang Z (2008), Jeronimo C (2007), Zippo A (2009), Rahman S (2011), Bisgrove DA (2007), Bisgrove DA (2007), Yang Z (2005), Yang Z (2005), Lu H (2014), Srivas R (2016)	13
MCM2	3	APP	1	pull down	Olah J (2011)	1
CDK2	0	CHAF1A	1	pull down, enzymatic study	Gerard A (2006), Gerard A (2006)	2
MCM5	1	MCM7	5	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology	Kneissl M (2003), Fujita M (1997), DaFonseca CJ (2001), Havugimana PC (2012), Ramachandran N (2004), Wan C (2015), Lossaint G (2013)	7
CDC7	2	MCM10	2	pull down	Ramachandran N (2004)	1
MAPK6	1	CDKN2A	1	affinity chromatography technology	Rodriguez J (2016)	1
MCM4	3	ORC1	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CDK4	2	APP	1	pull down	Olah J (2011)	1
RIPK4	0	PAF1	6	affinity chromatography technology	Rodriguez J (2016)	1
XPO1	8	RPS11	0	affinity chromatography technology	Kirli K (2015)	1
EGLN3	0	MCM3	2	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	MCM4	3	affinity chromatography technology	Rodriguez J (2016)	1
MCM10	2	MCM4	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MCM7	5	DBF4	2	two hybrid, two hybrid, enzymatic study	Kneissl M (2003), Kneissl M (2003), Masai H (2000)	3
CDKN1A	1	APP	1	pull down	Olah J (2011)	1
EGLN3	0	CDK9	3	affinity chromatography technology	Rodriguez J (2016)	1
ICK	1	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
CDK2	0	MCM4	3	enzymatic study, enzymatic study	Ishimi Y (2000), Komamura-Kohno Y (2006)	2
EGLN3	0	CLSPN	1	affinity chromatography technology	Rodriguez J (2016)	1
CDC7	2	APP	1	pull down	Olah J (2011)	1
MAPK6	1	MCM7	5	affinity chromatography technology	Rodriguez J (2016)	1
MCM2	3	XPO1	8	affinity chromatography technology	Drissi R (2015)	1
MCM2	3	RPS11	0	affinity chromatography technology	Drissi R (2015)	1
ORC1	3	ORC5	0	two hybrid, two hybrid, pull down, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004), Hein MY (2015)	4
CDK2	0	MCM7	5	affinity chromatography technology	Neganova I (2011)	1
CDC7	2	RPS11	0	genetic interference	Srivas R (2016)	1
MCM6	5	ORC1	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CDK2	0	RPS11	0	affinity chromatography technology	Neganova I (2011)	1
MCM4	3	MCM6	5	pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), Ishimi Y (1996), You Z (2002), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Boldt K (2016)	10
ORC6	0	MCM2	3	pull down	Ramachandran N (2004)	1
MCM7	5	CDC7	2	two hybrid, two hybrid, enzymatic study	Kneissl M (2003), Kneissl M (2003), Masai H (2000)	3
PAF1	6	CDC7	2	biochemical	Wan C (2015)	1
ORC6	0	CDC7	2	two hybrid, two hybrid, pull down	Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	3
CDK4	2	MCM2	3	pull down	Ramachandran N (2004)	1
MCM3	2	MCM10	2	pull down	Ramachandran N (2004)	1
CDC7	2	CDKN1A	1	pull down	Ramachandran N (2004)	1
ORC5	0	CDC7	2	pull down	Ramachandran N (2004)	1
MCM7	5	ORC5	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
DBF4	2	MCM4	3	two hybrid, enzymatic study	Kneissl M (2003), Masai H (2000)	2
TOB1	1	CDC7	2	affinity chromatography technology, enzymatic study	Suzuki T (2012), Suzuki T (2012)	2
MCM3	2	MCM7	5	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Fujita M (1999), Fujita M (1997), Fujita M (2002), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017), Lossaint G (2013), Mulvaney KM (2016)	10
CDC7	2	CHAF1A	1	enzymatic study, affinity chromatography technology	Gerard A (2006), Gerard A (2006)	2
MCM5	1	MCM2	3	two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), DaFonseca CJ (2001), Havugimana PC (2012), Ramachandran N (2004), Wan C (2015), Drissi R (2015), Drissi R (2015), Huang J (2013), Lossaint G (2013)	10
CHAF1A	1	PAF1	6	affinity chromatography technology	Hoek M (2011)	1
ICK	1	CDC7	2	affinity chromatography technology	Fu Z (2006)	1
MCM5	1	CDKN2A	1	pull down	Ramachandran N (2004)	1
XPO1	8	CDC7	2	affinity chromatography technology	Kirli K (2015)	1
EGLN3	0	CDC7	2	affinity chromatography technology	Rodriguez J (2016)	1
ORC1	3	CDK2	0	affinity chromatography technology, enzymatic study	Mendez J (2002), Mendez J (2002)	2
CDK2	0	DBF4	2	enzymatic study	Masai H (2000)	1
CENPJ	6	CDC7	2	bioid	Firat-Karalar EN (2014)	1
KMT2E	7	CDC7	2	affinity chromatography technology	Ding X (2015)	1
RIPK4	0	XPO1	8	affinity chromatography technology	Rodriguez J (2016)	1
CDKN2A	1	MCM6	5	affinity chromatography technology, affinity chromatography technology, pull down	Souza-Rodrigues E (2007), Souza-Rodrigues E (2007), Souza-Rodrigues E (2007)	3