PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CSNK1A1	1	LRP5	8	affinity chromatography technology	Huttlin EL (2017)	1
AXIN1	1	DAXX	5	two hybrid, affinity chromatography technology, affinity chromatography technology	Li Q (2007), Li Q (2007), Li Q (2007)	3
PML	7	DAXX	5	two hybrid, two hybrid, affinity chromatography technology, imaging technique, two hybrid, affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique	Ishov AM (1999), Li H (2000), Li H (2000), Li H (2000), Lehembre F (2001), Zhong S (2000), Cuchet-Lourenco D (2011), Chu Y (2011), Meinecke I (2007), Jang MS (2002), Chang CC (2011), Wethkamp N (2011), Ferguson BJ (2007), Delbarre E (2013), Delbarre E (2013), Sahin U (2014), Lin DY (2006), Lin DY (2006), Lin DY (2006), Lin DY (2006), Torii S (1999)	21
DVL1	5	DVL3	7	two hybrid, affinity chromatography technology, pull down	Kishida S (1999), Kishida S (1999), Kishida S (1999)	3
TRIM25	5	JUP	7	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
APC	5	XPO1	8	affinity chromatography technology, pull down	Tickenbrock L (2002), Tickenbrock L (2002)	2
TP53	0	TRIM65	1	affinity chromatography technology	Li Y (2016)	1
CSNK1E	0	DVL2	5	two hybrid, affinity chromatography technology	Rual JF (2005), Varjosalo M (2013)	2
MYC	2	XPO1	8	affinity chromatography technology, affinity chromatography technology	Koch HB (2007), Kirli K (2015)	2
SMAD7	1	CTNNB1	30	affinity chromatography technology, imaging technique, affinity chromatography technology	Edlund S (2005), Edlund S (2005), Tang Y (2008)	3
PML	7	PIN1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Reineke EL (2008), Reineke EL (2008), Reineke EL (2010), Reineke EL (2010), Lim JH (2011), El Asmi F (2014)	6
EGLN3	0	USP7	14	affinity chromatography technology	Rodriguez J (2016)	1
ANP32A	3	XPO1	8	affinity chromatography technology	Gallouzi IE (2001)	1
APC	5	CSNK1D	3	affinity chromatography technology	Novellasdemunt L (2017)	1
FOXM1	3	GSK3B	1	affinity chromatography technology	Chen Y (2016)	1
MYC	2	GSK3B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Gregory MA (2003), Gregory MA (2003), Arnold HK (2009), Zhou Z (2014)	4
XPO1	8	CSNK1E	0	affinity chromatography technology	Kirli K (2015)	1
TRIM25	5	MAP3K2	1	affinity chromatography technology	Choudhury NR (2017)	1
MAPRE1	0	CTNNB1	30	affinity chromatography technology	Hein MY (2015)	1
EGLN3	0	AXIN1	1	affinity chromatography technology	Rodriguez J (2016)	1
AXIN1	1	PRMT1	3	two hybrid, affinity chromatography technology, pull down, enzymatic study	Cha B (2011), Cha B (2011), Cha B (2011), Cha B (2011)	4
PPP1CA	3	MAPRE1	0	affinity chromatography technology	Boldt K (2016)	1
SMURF2	3	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fukunaga E (2008), Fukunaga E (2008), Lee YS (2011), Huttlin EL (2017)	4
SMURF2	3	DAB2	1	two hybrid	Colland F (2004)	1
AMER1	0	BTRC	1	pull down, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Major MB (2007), Kim TY (2014), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017)	5
SMURF1	4	XPO1	8	affinity chromatography technology	Tajima Y (2003)	1
AXIN1	1	CTNNA1	7	affinity chromatography technology	Hein MY (2015)	1
CSNK1A1	1	APC	5	enzymatic study	Godin KS (2009)	1
TRIM25	5	MYC	2	affinity chromatography technology	Choudhury NR (2017)	1
GSK3A	1	AXIN2	1	affinity chromatography technology	Varjosalo M (2013)	1
ARRB1	2	MAP3K1	4	affinity chromatography technology	Xiao K (2007)	1
AXIN1	1	MAP3K2	1	affinity chromatography technology	Greenblatt MB (2016)	1
GSK3A	1	CTNNA1	7	affinity chromatography technology	Hein MY (2015)	1
SKIL	3	PML	7	affinity chromatography technology	Pan D (2009)	1
CTNNB1	30	CARM1	0	pull down	Koh SS (2002)	1
APC	5	CTNNB1	30	affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, unspecified method, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Su LK (1993), Su LK (1993), Kucerova D (2001), Tickenbrock L (2003), Davies G (2001), Ryo A (2001), Homma MK (2002), Tickenbrock L (2003), Davies G (2001), Satoh K (1997), Eklof Spink K (2001), Eklof Spink K (2001), Sierra J (2006), Choi J (2004), Huang X (2009), Brocardo MG (2011), Xing Y (2004), Xing Y (2004), Xing Y (2004), Hamada F (2004), Hamada F (2004), Schneikert J (2013), Hsi LC (1999), Hein MY (2015), Hein MY (2015), Chen TC (2014), Kuslansky Y (2016), Novellasdemunt L (2017), Novellasdemunt L (2017)	29
UBC	7	NCK2	2	unspecified method, x-ray crystallography	Kang J (2008), Kang J (2008)	2
CSNK1E	0	GAPVD1	6	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
APC	5	AMER1	0	affinity chromatography technology	Hein MY (2015)	1
TRIM25	5	GNAS	9	affinity chromatography technology	Choudhury NR (2017)	1
SMURF1	4	UBC	7	affinity chromatography technology, enzymatic study, pull down	Xie Y (2013), Kristariyanto YA (2015), Zhang Y (2017)	3
DAB2	1	DVL3	7	pull down, affinity chromatography technology	Hocevar BA (2003), Hocevar BA (2003)	2
SMAD7	1	SMURF2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Asano Y (2004), Kavsak P (2000), Lee YS (2008), Komuro A (2004), Chong PA (2010), Chong PA (2010), Chong PA (2010), Cai Y (2012), Cai Y (2012), Chong PA (2006), Al-Salihi MA (2012), Ogunjimi AA (2005), Aragon E (2012), Aragon E (2012), Colland F (2004), Zhang L (2013), Chandhoke AS (2015), Iyengar PV (2015), Elkouris M (2016)	19
TRIM25	5	AXIN1	1	affinity chromatography technology	Choudhury NR (2017)	1
TP53	0	PRMT1	3	pull down	An W (2004)	1
DVL1	5	CTNNB1	30	affinity chromatography technology, imaging technique	Song DH (2000), Chen TC (2014)	2
PIN1	0	PPP2CA	7	biochemical	Havugimana PC (2012)	1
AXIN1	1	USP7	14	affinity chromatography technology	Novellasdemunt L (2017)	1
DAXX	5	TP53	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, unspecified method	Tang J (2006), Kim EJ (2003), Kim EJ (2003), Kim EJ (2003), Ohiro Y (2003), Ohiro Y (2003), Ohiro Y (2003), Ohiro Y (2003), Wethkamp N (2011), Zhao LY (2004), Zhao LY (2004), Zhao LY (2004), Gostissa M (2004), Gostissa M (2004), Gostissa M (2004), Gostissa M (2004), Gostissa M (2004), Zhao LY (2004), Zhao LY (2004), Zhang H (2013), Zhang H (2013), Chen TC (2014), Li Z (2017)	23
CSNK1D	3	DVL3	7	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
AXIN1	1	GAPVD1	6	affinity chromatography technology	Hein MY (2015)	1
USP15	4	GAPVD1	6	affinity chromatography technology	Boldt K (2016)	1
PPP2R5A	2	AXIN1	1	affinity chromatography technology, pull down, affinity chromatography technology	Yamamoto H (2001), Yamamoto H (2001), Arnold HK (2009)	3
FBXW11	2	CTNNA1	7	affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Coyaud E (2015)	2
SMURF2	3	UBC	7	enzymatic study, affinity chromatography technology, enzymatic study, pull down, pull down	Maspero E (2013), Zhang L (2013), Kristariyanto YA (2015), Mari S (2014), Zhang Y (2017)	5
TRIM25	5	PRMT1	3	affinity chromatography technology	Choudhury NR (2017)	1
CSNK1E	0	FBXW11	2	two hybrid	Wallach T (2013)	1
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
APC	5	ARHGAP21	5	affinity chromatography technology	Hein MY (2015)	1
FBXW11	2	AXIN1	1	affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Coyaud E (2015)	2
WDYHV1	0	AXIN1	1	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	CTNNB1	30	affinity chromatography technology	Choudhury NR (2017)	1
TNFAIP3	3	AXIN1	1	affinity chromatography technology, affinity chromatography technology	Shao L (2013), Shao L (2013)	2
GSK3B	1	TSC1	4	affinity chromatography technology	Mak BC (2003)	1
DAXX	5	PRMT1	3	two hybrid	Weimann M (2013)	1
TRIM25	5	PPP2CA	7	affinity chromatography technology	Choudhury NR (2017)	1
AXIN1	1	DVL2	5	affinity chromatography technology	Zhang Y (2000)	1
PIN1	0	TP53	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down	Wulf GM (2002), Wulf GM (2002), Zacchi P (2002), Zacchi P (2002), Vinayagam A (2011), Mantovani F (2007)	6
CTNNB1	30	FOXM1	3	affinity chromatography technology	Chen Y (2016)	1
AXIN1	1	ANP32A	3	two hybrid	Stelzl U (2005)	1
EGLN3	0	PPP1CA	3	affinity chromatography technology	Rodriguez J (2016)	1
AXIN1	1	CSNK1D	3	affinity chromatography technology	Hein MY (2015)	1
GSK3B	1	AXIN1	1	two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Mak BC (2003), Hino S (2005), Oosterveen T (2007), Kim MJ (2008), Kitagawa M (1999), Cha B (2011), Cha B (2011), Arnold HK (2009), Kashikar ND (2011), Kashikar ND (2011), Zhou F (2012), Yan D (2012), Zhang YG (2012), Sue Ng S (2010), Kim JW (2003), Tang Y (2008), Luo W (2007), Li VS (2012), Rosano L (2009), Yamamoto H (2006), Fei C (2013), Wang J (2011), Varjosalo M (2013), Gao C (2014), Varjosalo M (2013), Castellone MD (2005), Hein MY (2015), Chen TC (2014), Chen Y (2016), Novellasdemunt L (2017)	36
GSK3B	1	MAP3K4	1	enzymatic study	Abell AN (2007)	1
TRIM25	5	TNKS	12	affinity chromatography technology	Choudhury NR (2017)	1
AXIN1	1	CSNK1A1	1	genetic interference, affinity chromatography technology, affinity chromatography technology	Zhang Y (2002), Zhang Y (2002), Hein MY (2015)	3
USP15	4	USP7	14	enzymatic study	Loch CM (2012)	1
ARRB1	2	DVL1	5	affinity chromatography technology	Chen W (2001)	1
FBXW11	2	AXIN2	1	affinity chromatography technology	Kim TY (2014)	1
GAK	5	DAB2	1	affinity chromatography technology	Hein MY (2015)	1
SKI	3	SKIL	3	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Cohen SB (1999), Cohen SB (1999), Tan R (2006), He J (2003), Ikeuchi Y (2014)	5
CRMP1	0	HTT	14	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
DAXX	5	USP7	14	pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang J (2006), Tang J (2006), Tang J (2006), Tang J (2006), Song MS (2008), Giovinazzi S (2013), Giovinazzi S (2013), Giovinazzi S (2013), Kumar N (2013)	9
AXIN1	1	DVL3	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hocevar BA (2003), Sue Ng S (2010), Li VS (2012)	3
SMAD7	1	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Asano Y (2004), Yamaguchi T (2006), Komuro A (2004), Ebisawa T (2001), Ebisawa T (2001), Al-Salihi MA (2012), Suzuki C (2002), Aragon E (2012), Aragon E (2012), Tajima Y (2003), Fei C (2013), Fei C (2014), Wan L (2011), Elkouris M (2016)	14
SMAD7	1	TP53	0	affinity chromatography technology	Zhang S (2006)	1
PRMT1	3	SMURF2	3	enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology	Cha B (2015), Cha B (2015), Cha B (2015), Cha B (2015)	4
GSK3A	1	CTNNB1	30	enzymatic study, affinity chromatography technology	Koo J (2015), Hein MY (2015)	2
TRIM25	5	CSNK1A1	1	affinity chromatography technology	Choudhury NR (2017)	1
MYC	2	PIN1	0	affinity chromatography technology, affinity chromatography technology	Arnold HK (2009), Yeh E (2004)	2
UBC	7	CAV1	0	affinity chromatography technology, imaging technique	Luo X (2017), Luo X (2017)	2
MYC	2	PPP1CA	3	affinity chromatography technology	Koch HB (2007)	1
AXIN1	1	TSC1	4	affinity chromatography technology	Mak BC (2003)	1
GSK3B	1	APC	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Davies G (2001), Varjosalo M (2013), Novellasdemunt L (2017)	3
HTT	14	PPP2CA	7	unspecified method	Krauss S (2013)	1
MAP3K1	4	DVL2	5	affinity chromatography technology	Zhang Y (2000)	1
EGLN3	0	DVL3	7	affinity chromatography technology	Rodriguez J (2016)	1
USP15	4	SMURF2	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Eichhorn PJ (2012), Iyengar PV (2015), Iyengar PV (2015)	3
STRAP	2	AXIN1	1	affinity chromatography technology	Kashikar ND (2011)	1
TNFAIP3	3	UBC	7	x-ray crystallography, enzymatic study, pull down, pull down, x-ray crystallography, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, x-ray crystallography, pull down	Bosanac I (2010), Bremm A (2010), Fenner BJ (2009), Tokunaga F (2012), Tokunaga F (2012), Verhelst K (2012), Mevissen TE (2013), Komander D (2009), Evans PC (2004), Skaug B (2011), Bohgaki M (2008), Boone DL (2004), Mevissen TE (2016), Mevissen TE (2016)	14
XPO1	8	STRAP	2	affinity chromatography technology	Kirli K (2015)	1
TRIM25	5	CSNK1D	3	affinity chromatography technology	Choudhury NR (2017)	1
PRMT1	3	CARM1	0	genetic interference	Koh SS (2001)	1
AXIN1	1	JUP	7	affinity chromatography technology	Hein MY (2015)	1
AXIN2	1	MAP3K2	1	affinity chromatography technology	Greenblatt MB (2016)	1
CTNNB1	30	JUP	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Hazan RB (1998), Kucerova D (2001), Hein MY (2015), Chen TC (2014)	4
XPO1	8	ARHGAP21	5	affinity chromatography technology	Kirli K (2015)	1
TNKS	12	AXIN1	1	affinity chromatography technology	Li N (2015)	1
AXIN1	1	GAK	5	two hybrid	Stelzl U (2005)	1
APC	5	DVL2	5	affinity chromatography technology	Hein MY (2015)	1
GSK3B	1	MAP3K2	1	affinity chromatography technology	Greenblatt MB (2016)	1
MYC	2	CARM1	0	affinity chromatography technology	Covic M (2005)	1
XPO1	8	DAXX	5	affinity chromatography technology	Kirli K (2015)	1
MYC	2	PPP2R5A	2	affinity chromatography technology	Arnold HK (2009)	1
CTNNB1	30	SMURF1	4	affinity chromatography technology, pull down	Boonanantanasarn K (2015), Boonanantanasarn K (2015)	2
MAPRE1	0	CTNNA1	7	affinity chromatography technology	Hein MY (2015)	1
FBXW11	2	TP53	0	affinity chromatography technology	Low TY (2014)	1
SMURF1	4	PPP2CA	7	affinity chromatography technology	Xie Y (2013)	1
MAP3K2	1	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Greenblatt MB (2016), Greenblatt MB (2016), Greenblatt MB (2016), Greenblatt MB (2016)	4
TP53	0	CSNK1A1	1	affinity chromatography technology, affinity chromatography technology	Huart AS (2009), Wei X (2016)	2
AXIN2	1	APC	5	affinity chromatography technology	von Kries JP (2000)	1
TRIM25	5	DVL3	7	affinity chromatography technology	Choudhury NR (2017)	1
DAXX	5	UBC	7	two hybrid	Bandyopadhyay S (2010)	1
ARRB1	2	UBC	7	affinity chromatography technology	Xiao K (2007)	1
LRP5	8	AXIN1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mao J (2001), Mao J (2001), Kim MJ (2008), Ding Y (2008)	4
APC	5	USP7	14	affinity chromatography technology, affinity chromatography technology	Novellasdemunt L (2017), Novellasdemunt L (2017)	2
CSNK1A1	1	PPP2CA	7	affinity chromatography technology	Dubois T (2002)	1
CTNNB1	30	GSK3B	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Davies G (2001), Kishida S (1999), Fischer L (2002), Kitagawa M (1999), Hart M (1999), Su Y (2008), Huang X (2009), Ding Q (2005), Piao S (2008), Varjosalo M (2013), Gao C (2014), Koo J (2015), Chen TC (2014), Lu D (2012), Kuslansky Y (2016), Novellasdemunt L (2017), Lu WJ (2015)	17
PPP1CA	3	AXIN1	1	affinity chromatography technology	Luo W (2007)	1
PPP1CA	3	GSK3B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tanji C (2002), Varjosalo M (2013), St-Denis N (2016)	3
AXIN1	1	PPP2CA	7	affinity chromatography technology	Arnold HK (2009)	1
EGLN3	0	CARM1	0	affinity chromatography technology	Rodriguez J (2016)	1
TRIM25	5	FOXM1	3	affinity chromatography technology	Choudhury NR (2017)	1
HTT	14	CTNNB1	30	affinity chromatography technology	Godin JD (2010)	1
HIPK2	0	DAXX	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hofmann TG (2003), Hofmann TG (2003), McDonough H (2009), Kumar N (2013)	4
EGLN3	0	XPO1	8	affinity chromatography technology	Rodriguez J (2016)	1
BTRC	1	JUP	7	affinity chromatography technology, bioid	Sadot E (2000), Coyaud E (2015)	2
XPO1	8	CTNNB1	30	affinity chromatography technology	Kirli K (2015)	1
AXIN1	1	TSC2	17	affinity chromatography technology, affinity chromatography technology	Mak BC (2003), Mak BC (2003)	2
FBXW11	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Suzuki H (2000), Suzuki H (2000), Sowa ME (2009), Sowa ME (2009), Coyaud E (2015), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017), Liu X (2017)	9
MAPRE1	0	DAB2	1	affinity chromatography technology	Hein MY (2015)	1
TP53	0	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li M (2002), Li M (2002), Li M (2002), Li M (2002), Brooks CL (2007), Brooks CL (2007), Becker K (2007), Hu M (2006), Hu M (2006), Sarkari F (2010), Marchenko ND (2007), Epping MT (2011), Qing P (2011), Tang J (2006), Ma J (2010), Dai C (2011), Holowaty MN (2003), Sheng Y (2006), Sheng Y (2006), Sheng Y (2006), Yi P (2013), Yi P (2013), Zhang J (2014), Fang Z (2013), Ye M (2015), Lim KH (2015), Lim KH (2015), Reddy BA (2014), Reddy BA (2014)	29
TRIM25	5	LRP5	8	affinity chromatography technology	Choudhury NR (2017)	1
BTRC	1	APC	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Kitagawa M (1999), Hart M (1999), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017), Novellasdemunt L (2017)	7
TRIM25	5	SKI	3	affinity chromatography technology	Choudhury NR (2017)	1
CSNK1D	3	GAPVD1	6	affinity chromatography technology	Huttlin EL (2017)	1
JUP	7	APC	5	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	Shibata T (1994), Daniel JM (1995), Bandyopadhyay S (2010), Hein MY (2015), Chen TC (2014)	5
XPO1	8	AXIN1	1	affinity chromatography technology	Kirli K (2015)	1
TP53	0	UTP14A	0	pull down, pull down, affinity chromatography technology	Hu L (2011), Hu L (2011), Hu L (2011)	3
DVL1	5	NCK2	2	two hybrid	Rolland T (2014)	1
PPP2CA	7	PPP2R5A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Goudreault M (2009), McCright B (1996), McCright B (1996), Widau RC (2010), Wan C (2015), Hein MY (2015), Craney A (2016), St-Denis N (2016), Yadav L (2017)	10
FBXW11	2	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Watanabe N (2005), Fuchs SY (1999), Gao D (2011), DAnnibale S (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014), Low TY (2014)	8
MAP3K1	4	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Islam MR (2010), Islam MR (2010), Chipps E (2015), Chipps E (2015), Chipps E (2015)	5
PPP2CA	7	TP53	0	affinity chromatography technology	Shouse GP (2011)	1
AXIN1	1	EEF1A1	0	two hybrid	Stelzl U (2005)	1
BTRC	1	MAP3K2	1	affinity chromatography technology	Greenblatt MB (2016)	1
EGLN3	0	CTNNA1	7	affinity chromatography technology	Rodriguez J (2016)	1
AXIN1	1	SKIL	3	affinity chromatography technology	Koinuma D (2011)	1
EGLN3	0	GNAS	9	affinity chromatography technology	Rodriguez J (2016)	1
APC	5	PPP2R5A	2	imaging technique	Galea MA (2001)	1
XPO1	8	DVL1	5	affinity chromatography technology	Kirli K (2015)	1
TRIM25	5	PPP1CA	3	affinity chromatography technology	Choudhury NR (2017)	1
HTT	14	TP53	0	pull down, affinity chromatography technology	Steffan JS (2000), Steffan JS (2000)	2
TRIM25	5	CTNNA1	7	affinity chromatography technology	Choudhury NR (2017)	1
AXIN1	1	CAV1	0	affinity chromatography technology	Yamamoto H (2006)	1
CSNK1E	0	DVL1	5	affinity chromatography technology	Gao ZH (2002)	1
PML	7	CTNNB1	30	affinity chromatography technology, pull down, affinity chromatography technology	Satow R (2012), Satow R (2012), Shtutman M (2002)	3
XPO1	8	DVL3	7	affinity chromatography technology	Kirli K (2015)	1
GSK3B	1	MAP3K1	4	affinity chromatography technology, pull down	Kim JW (2003), Kim JW (2003)	2
XPO1	8	GNAS	9	affinity chromatography technology	Kirli K (2015)	1
TP53	0	USP15	4	affinity chromatography technology, affinity chromatography technology	Liu WT (2016), Liu WT (2016)	2
JUP	7	WDYHV1	0	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
AXIN1	1	CSNK1E	0	genetic interference, affinity chromatography technology, two hybrid, affinity chromatography technology	Zhang Y (2002), Zhang Y (2002), Wang J (2011), Hein MY (2015)	4
CSNK1D	3	DVL1	5	affinity chromatography technology	Gao ZH (2002)	1
AXIN1	1	AXIN2	1	affinity chromatography technology	Sue Ng S (2010)	1
PML	7	SKI	3	affinity chromatography technology, pull down	Khan MM (2001), Khan MM (2001)	2
STRAP	2	SMAD7	1	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Datta PK (2000), Datta PK (2000), Datta PK (2000), Seong HA (2007)	4
XPO1	8	AMER1	0	affinity chromatography technology	Kirli K (2015)	1
TP53	0	HIPK2	0	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Hofmann TG (2002), Hofmann TG (2002), Hofmann TG (2002), Hofmann TG (2002), Kim EJ (2002), Sung KS (2005), Li Q (2011), Di Stefano V (2005), Rinaldo C (2007), Rinaldo C (2007), Lee MG (2014), Mancini F (2016)	12
MAP3K1	4	AXIN1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2002), Zhang Y (2000), Zhang Y (2000), Sue Ng S (2010), Sue Ng S (2010), Loke J (2014)	6
EGLN3	0	PML	7	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	PPP2CA	7	affinity chromatography technology	Rodriguez J (2016)	1
SMURF2	3	SKIL	3	affinity chromatography technology	Bonni S (2001)	1
PRMT1	3	WDYHV1	0	two hybrid	Rolland T (2014)	1
TP53	0	EEF1A1	0	affinity chromatography technology	Fogeron ML (2013)	1
EGLN3	0	AMER1	0	affinity chromatography technology	Rodriguez J (2016)	1
ARRB1	2	DVL2	5	two hybrid, affinity chromatography technology	Chen W (2001), Chen W (2001)	2
HIPK2	0	BTRC	1	affinity chromatography technology	Kanei-Ishii C (2008)	1
TP53	0	CSNK1E	0	imaging technique	Chen TC (2014)	1
AXIN1	1	HIPK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li Q (2011), He Y (2013), He Y (2013)	3
GSK3B	1	STRAP	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Kashikar ND (2011), Kashikar ND (2011)	3
GSK3B	1	ARRB1	2	enzymatic study	Lin FT (1999)	1
AXIN1	1	LMO2	2	two hybrid	Wang J (2011)	1
CSNK1A1	1	CSNK1E	0	affinity chromatography technology	Varjosalo M (2013)	1
FBXW11	2	APC	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Coyaud E (2015), Low TY (2014), Huttlin EL (2017)	3
SMURF1	4	CSNK1D	3	enzymatic study	Andrews PS (2010)	1
AXIN1	1	PUF60	16	affinity chromatography technology	Hein MY (2015)	1
MYC	2	GSK3A	1	affinity chromatography technology, affinity chromatography technology, pull down	Gregory MA (2003), Gregory MA (2003), Gregory MA (2003)	3
SMURF1	4	USP15	4	affinity chromatography technology	Xie Y (2013)	1
XPO1	8	UTP14A	0	affinity chromatography technology	Kirli K (2015)	1
AXIN1	1	APC	5	pull down, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Hino S (2005), Kitagawa M (1999), Sue Ng S (2010), Tran H (2012), Li VS (2012), Hein MY (2015), Hein MY (2015), Novellasdemunt L (2017)	12
TP53	0	PML	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Kurki S (2003), Kurki S (2003), Fogal V (2000), Fogal V (2000), Guo A (2000), Guo A (2000), Insinga A (2004), Chu Y (2011), Li Q (2011), Li Q (2011), Bernassola F (2005), Yang Q (2013), Yang Q (2013), Catalano A (2004), Chen TC (2014)	15
LRP6	3	GSK3B	1	affinity chromatography technology, enzymatic study, far western blotting	Yamamoto H (2006), Piao S (2008), Piao S (2008)	3
TP53	0	CARM1	0	pull down	An W (2004)	1
AMER1	0	AXIN1	1	pull down, affinity chromatography technology, affinity chromatography technology	Major MB (2007), Sue Ng S (2010), Hein MY (2015)	3
WDR26	6	AXIN1	1	affinity chromatography technology	Goto T (2016)	1
AXIN1	1	CRMP1	0	two hybrid	Stelzl U (2005)	1
SMURF1	4	TP53	0	affinity chromatography technology	Nie J (2010)	1
MAPRE1	0	AXIN1	1	affinity chromatography technology	Hein MY (2015)	1
USP7	14	MYC	2	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Tavana O (2016), Tavana O (2016), Tavana O (2016), Tavana O (2016)	4
PPP1CA	3	GSK3A	1	affinity chromatography technology	St-Denis N (2016)	1
AXIN1	1	GSK3A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Arnold HK (2009), Fei C (2013), Varjosalo M (2013), Hein MY (2015), Chen Y (2016)	5
TRIM25	5	XPO1	8	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	HIPK2	0	affinity chromatography technology	Choudhury NR (2017)	1
AXIN1	1	NCK2	2	affinity chromatography technology	Cowan CA (2001)	1
PML	7	HTT	14	pull down, pull down	Guo L (2014), Guo L (2014)	2
SMAD7	1	USP15	4	affinity chromatography technology	Eichhorn PJ (2012)	1
LMO2	2	MAPRE1	0	two hybrid	Rolland T (2014)	1
APC	5	CSNK1E	0	imaging technique, affinity chromatography technology	Chen TC (2014), Novellasdemunt L (2017)	2
TRIM25	5	EGLN3	0	affinity chromatography technology	Choudhury NR (2017)	1
XPO1	8	CSNK1D	3	affinity chromatography technology	Kirli K (2015)	1
SKI	3	HIPK2	0	pull down, pull down, affinity chromatography technology	Harada J (2003), Harada J (2003), Harada J (2003)	3
SMURF1	4	AXIN1	1	enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Fei C (2013), Fei C (2013), Fei C (2014), Fei C (2014), Fei C (2014)	5
SKI	3	SMURF2	3	affinity chromatography technology	Zhou F (2017)	1
AXIN1	1	FOXM1	3	affinity chromatography technology, affinity chromatography technology	Chen Y (2016), Chen Y (2016)	2
FBXW11	2	GSK3B	1	two hybrid	Wallach T (2013)	1
EGLN3	0	TP53	0	affinity chromatography technology	Rodriguez J (2016)	1
CTNNB1	30	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, protein complementation assay, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, enzymatic study, protein complementation assay, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang J (2006), Yang J (2006), Cong F (2003), Kitagawa M (1999), Kitagawa M (1999), Kitagawa M (1999), Hart M (1999), Hart M (1999), Hart M (1999), Su Y (2008), Winston JT (1999), Peschiaroli A (2010), Latres E (1999), Liu J (2004), Dorrello NV (2006), Godin JD (2010), Guardavaccaro D (2008), Evrard-Todeschi N (2008), Saha A (2008), Saha A (2008), Chen CH (2012), Wei S (2008), Dehan E (2009), Wang D (2011), Gao D (2011), Li VS (2012), Sahasrabuddhe AA (2014), Mbom BC (2014), Mbom BC (2014), Kovacev J (2014), Gao C (2014), Kluge SF (2013), Chong RA (2014), Herrero-Ruiz J (2014), Zhang L (2012), Coyaud E (2015), Loveless TB (2015), Low TY (2014), Coyaud E (2015), Tseng RC (2015), Wu K (2016), Villalobos V (2010), Pierce NW (2009), Shrestha H (2016), Gu JJ (2016), Vaid M (2011)	46
HIPK2	0	PML	7	affinity chromatography technology, enzymatic study, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, enzymatic study	de la Vega L (2011), Renner F (2010), Sung KS (2011), Sung KS (2011), Gresko E (2009), Gresko E (2009), Gresko E (2009)	7
AXIN1	1	PIN1	0	affinity chromatography technology	Arnold HK (2009)	1
AXIN1	1	ARHGAP21	5	affinity chromatography technology	Hein MY (2015)	1
EGLN3	0	APC	5	affinity chromatography technology	Rodriguez J (2016)	1
DVL2	5	CTNNB1	30	affinity chromatography technology	Song DH (2000)	1
TSC2	17	CAV1	0	biochemical	Yamamoto Y (2002)	1
AXIN1	1	UTP14A	0	two hybrid	Stelzl U (2005)	1
EGLN3	0	USP15	4	affinity chromatography technology	Rodriguez J (2016)	1
CSNK1A1	1	GAPVD1	6	affinity chromatography technology	Huttlin EL (2017)	1
XPO1	8	CSNK1A1	1	affinity chromatography technology	Kirli K (2015)	1
PML	7	CSNK1D	3	affinity chromatography technology, affinity chromatography technology	Alsheich-Bartok O (2008), Alsheich-Bartok O (2008)	2
XPO1	8	DAB2	1	affinity chromatography technology	Kirli K (2015)	1
GSK3B	1	TP53	0	affinity chromatography technology, two hybrid	Watcharasit P (2002), Vinayagam A (2011)	2
AXIN2	1	GSK3B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	von Kries JP (2000), Schwarz-Romond T (2002), Varjosalo M (2013), Varjosalo M (2013)	4
BTRC	1	AXIN1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Kitagawa M (1999), Kitagawa M (1999), Li VS (2012), Coyaud E (2015), Coyaud E (2015), Novellasdemunt L (2017)	6
AMER1	0	FBXW11	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Major MB (2007), Kim TY (2014), Coyaud E (2015), Low TY (2014), Huttlin EL (2017), Camp ND (2012)	6
HTT	14	UTP14A	0	two hybrid	Goehler H (2004)	1
LRP6	3	CAV1	0	affinity chromatography technology, affinity chromatography technology	Yamamoto H (2006), Yamamoto H (2006)	2
EGLN3	0	CTNNB1	30	affinity chromatography technology	Rodriguez J (2016)	1
CTNNB1	30	PIN1	0	pull down	Ryo A (2001)	1
DAB2	1	DVL2	5	pull down, affinity chromatography technology	Hocevar BA (2003), Hocevar BA (2003)	2
AXIN1	1	MYOT	0	two hybrid	Wang J (2011)	1
AXIN1	1	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, pull down	Li Q (2011), Li Q (2011), He Y (2013), He Y (2013), He Y (2013), He Y (2013)	6
CSNK1D	3	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, imaging technique	Kulikov R (2006), Alsheich-Bartok O (2008), Alsheich-Bartok O (2008), Wolff S (2006), Chen TC (2014)	5
APC	5	MAPRE1	0	pull down, pull down, affinity chromatography technology	Askham JM (2002), Xia P (2012), Hein MY (2015)	3
SKI	3	WDR26	6	affinity chromatography technology	Rashidian J (2015)	1
AXIN1	1	UBC	7	affinity chromatography technology	Li VS (2012)	1
CTNNB1	30	CTNNA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down	Oyama T (1994), Roe S (1998), Piedra J (2003), Aberle H (1994), Reuver SM (1998), Selbach M (2006), Tian Q (2004), Wan C (2015), Hein MY (2015), Ji H (2009), Ji H (2009)	11
EEF1A1	0	PPP2CA	7	affinity chromatography technology	Huttlin EL (2017)	1
LRP6	3	CTNNB1	30	affinity chromatography technology	Yamamoto H (2006)	1
XPO1	8	GAPVD1	6	affinity chromatography technology	Kirli K (2015)	1
TRIM25	5	USP7	14	affinity chromatography technology	Choudhury NR (2017)	1
AXIN2	1	SMAD7	1	affinity chromatography technology, pull down	Zhou F (2014), Elkouris M (2016)	2
MYC	2	CSNK1E	0	genetic interference	Toyoshima M (2012)	1
PPP1CA	3	XPO1	8	biochemical	Kristensen AR (2012)	1
CTNNB1	30	USP15	4	affinity chromatography technology, affinity chromatography technology	Greenblatt MB (2016), Greenblatt MB (2016)	2
USP15	4	BTRC	1	affinity chromatography technology	Greenblatt MB (2016)	1
EGLN3	0	PRMT1	3	affinity chromatography technology	Rodriguez J (2016)	1
AXIN1	1	SKI	3	affinity chromatography technology	Koinuma D (2011)	1
AXIN1	1	LRP6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology	Sue Ng S (2010), Li VS (2012), Yamamoto H (2006), Yamamoto H (2006), Piao S (2008), Fei C (2013)	6
USP15	4	UBC	7	pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Hetfeld BK (2005), Bremm A (2010), Komander D (2009), Loch CM (2012), Herhaus L (2014), Wauer T (2015), Das T (2017), Zhang X (2017), Kwasna D (2018)	9
EEF1A1	0	PUF60	16	biochemical	Havugimana PC (2012)	1
AXIN2	1	CTNNB1	30	affinity chromatography technology	von Kries JP (2000)	1
MAP3K2	1	SMURF1	4	affinity chromatography technology, enzymatic study	Crose LE (2009), Andrews PS (2010)	2
MYC	2	BTRC	1	affinity chromatography technology, enzymatic study	Popov N (2010), Popov N (2010)	2
BTRC	1	TP53	0	affinity chromatography technology, affinity chromatography technology	Xia Y (2009), Verma S (2011)	2
TRIM25	5	PPP2R5A	2	affinity chromatography technology	Choudhury NR (2017)	1
DVL2	5	TP53	0	two hybrid, two hybrid	Rual JF (2005), Lim J (2006)	2
EGLN3	0	WDR26	6	affinity chromatography technology	Rodriguez J (2016)	1
TSC2	17	GSK3B	1	affinity chromatography technology, enzymatic study, affinity chromatography technology	Mak BC (2003), Inoki K (2006), Mak BC (2003)	3
MYC	2	PML	7	affinity chromatography technology, affinity chromatography technology, pull down	Cairo S (2005), Buschbeck M (2007), Buschbeck M (2007)	3
TNFAIP3	3	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang M (2013), Wang M (2013), Liu J (2013), Liu J (2013)	4
SMURF1	4	PRMT1	3	affinity chromatography technology	Xie Y (2013)	1
SMURF1	4	EEF1A1	0	affinity chromatography technology	Xie Y (2013)	1
XPO1	8	GSK3B	1	affinity chromatography technology	Kirli K (2015)	1
SMURF2	3	XPO1	8	affinity chromatography technology, affinity chromatography technology, pull down	Kim DG (2016), Kim DG (2016), Kim DG (2016)	3
XPO1	8	DVL2	5	affinity chromatography technology	Kirli K (2015)	1
EGLN3	0	CSNK1A1	1	affinity chromatography technology	Rodriguez J (2016)	1
CAV1	0	PPP2CA	7	pull down, affinity chromatography technology	Li L (2003), Zhang X (2007)	2
CSNK1A1	1	CSNK1D	3	affinity chromatography technology	Varjosalo M (2013)	1
TRIM25	5	GAK	5	affinity chromatography technology	Choudhury NR (2017)	1
MYC	2	TP53	0	affinity chromatography technology, fluorescent resonance energy transfe	Agrawal P (2010), Ivanov AA (2017)	2
CARM1	0	AXIN1	1	enzymatic study	Cha B (2011)	1
SMURF1	4	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Cui Y (2011), Zhang Y (2017), Zhang Y (2017), Zhang Y (2017), Zhang Y (2017)	5
SMURF2	3	BTRC	1	enzymatic study, affinity chromatography technology	Shukla S (2014), Shukla S (2014)	2
EGLN3	0	ARHGAP21	5	affinity chromatography technology	Rodriguez J (2016)	1
MYC	2	TSC1	4	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TRIM25	5	BTRC	1	affinity chromatography technology	Choudhury NR (2017)	1
DAB2	1	AXIN1	1	pull down	Hocevar BA (2003)	1
PIN1	0	DAXX	5	affinity chromatography technology, affinity chromatography technology	Ryo A (2007), Ryo A (2007)	2
USP7	14	PPP2CA	7	affinity chromatography technology, affinity chromatography technology	Park JJ (2015), Park JJ (2015)	2
FBXW11	2	UTP14A	0	affinity chromatography technology	Low TY (2014)	1
MAP3K4	1	AXIN1	1	affinity chromatography technology	Abell AN (2007)	1
APC	5	TNKS	12	affinity chromatography technology	Tran H (2012)	1
DVL1	5	AXIN1	1	affinity chromatography technology, affinity chromatography technology	Li L (1999), Kim MJ (2008)	2
SMYD2	0	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Huang J (2006), Huang J (2006), Abu-Farha M (2008)	3
CSNK1A1	1	LRP6	3	affinity chromatography technology	Huttlin EL (2017)	1
TP53	0	MYOT	0	genetic interference	Xie L (2013)	1
EGLN3	0	GAPVD1	6	affinity chromatography technology	Rodriguez J (2016)	1
UBC	7	BTRC	1	affinity chromatography technology, enzymatic study	Matsumoto M (2005), Kumar KG (2007)	2
CTNNB1	30	USP7	14	affinity chromatography technology, affinity chromatography technology, enzymatic study, unspecified method	Novellasdemunt L (2017), Novellasdemunt L (2017), Novellasdemunt L (2017), Novellasdemunt L (2017)	4
UBC	7	APC	5	affinity chromatography technology	Matsumoto M (2005)	1
MYC	2	PPP2CA	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Arnold HK (2009), Junttila MR (2007), Cianfanelli V (2015), Cianfanelli V (2015)	4
SMYD2	0	GSK3B	1	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Ewing RM (2007)	2
GSK3B	1	EEF1A1	0	two hybrid	Vinayagam A (2011)	1
TSC2	17	TSC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dan HC (2002), Hodges AK (2001), Aicher LD (2001), van Slegtenhorst M (1998), Nellist M (2002), Li Y (2004), Mak BC (2003), van Slegtenhorst M (1998), van Slegtenhorst M (1998), Ma L (2005), Cai SL (2006), Cao Y (2006), Ma L (2005), Inoki K (2003), Nellist M (2005), Goncharova EA (2006), Astrinidis A (2006), Cao Y (2006), Astrinidis A (2003), Hodges AK (2001), Hodges AK (2001), Nellist M (2001), Aicher LD (2001), Murthy V (2000), van Slegtenhorst M (1998), Dan HC (2002), Miloloza A (2000), Nakashima A (2007), Nakashima A (2007), Benvenuto G (2000), Chong-Kopera H (2006), York B (2005), Vega-Rubin-de-Celis S (2010), Vega-Rubin-de-Celis S (2010), Lin Y (2011), Cloutier P (2017), Cloutier P (2017)	37
AXIN1	1	MYC	2	affinity chromatography technology, affinity chromatography technology, pull down	Arnold HK (2009), Arnold HK (2009), Arnold HK (2009)	3
BTRC	1	DVL1	5	bioid	Coyaud E (2015)	1
PIN1	0	DAB2	1	affinity chromatography technology, pull down	He J (2003), He J (2003)	2
CTNNB1	30	AXIN1	1	pull down, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Nakamura T (1998), Hocevar BA (2003), Hino S (2005), Stoothoff WH (2002), Kim MJ (2008), Kitagawa M (1999), Kitagawa M (1999), Arnold HK (2009), Zhang YG (2012), Godin JD (2010), Godin JD (2010), Sue Ng S (2010), Sue Ng S (2010), Tang Y (2008), Li VS (2012), Yamamoto H (2006), Fei C (2013), Hein MY (2015), Kuslansky Y (2016), Novellasdemunt L (2017)	25
EGLN3	0	DVL2	5	affinity chromatography technology	Rodriguez J (2016)	1
XPO1	8	TNKS	12	affinity chromatography technology	Kirli K (2015)	1
AXIN1	1	GNAS	9	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Castellone MD (2005), Castellone MD (2005), Castellone MD (2005), Castellone MD (2005)	4
GSK3B	1	BTRC	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Kitagawa M (1999), Gao C (2014), Gao C (2014), Gao C (2014)	4
SMYD2	0	AXIN1	1	affinity chromatography technology	Ewing RM (2007)	1
FOXM1	3	GSK3A	1	affinity chromatography technology	Chen Y (2016)	1
DAXX	5	CARM1	0	two hybrid	Weimann M (2013)	1
XPO1	8	MAP3K1	4	affinity chromatography technology	Kirli K (2015)	1
CSNK1E	0	DVL3	7	two hybrid	Rolland T (2014)	1
PPP1CA	3	TP53	0	two hybrid	Colland F (2004)	1
DAB2	1	DVL1	5	pull down	Hocevar BA (2003)	1
USP15	4	AXIN1	1	affinity chromatography technology	Greenblatt MB (2016)	1
JUP	7	CTNNA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, biochemical, biochemical, imaging technique	Roe S (1998), Roe S (1998), Sacco PA (1995), Obama H (1997), Bandyopadhyay S (2010), Havugimana PC (2012), Wan C (2015), Chen TC (2014)	8
UBC	7	WDR26	6	affinity chromatography technology	Matsumoto M (2005)	1
SMAD7	1	DVL1	5	pull down	Warner DR (2003)	1
DVL1	5	DVL2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	de Groot RE (2014), Huttlin EL (2015), Huttlin EL (2017)	3
GSK3B	1	SMURF2	3	affinity chromatography technology	Wu Q (2009)	1
CSNK1E	0	CSNK1D	3	affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2017)	2
TRIM65	1	AXIN1	1	affinity chromatography technology	Yang YF (2017)	1
PPP1CA	3	CSNK1E	0	enzymatic study	Luo W (2007)	1
USP7	14	UBC	7	enzymatic study, enzymatic study, unspecified method, enzymatic study, pull down	Bremm A (2010), Faesen AC (2011), Ernst A (2013), Holowaty MN (2003), Kwasna D (2018)	5
AXIN1	1	HTT	14	affinity chromatography technology	Godin JD (2010)	1
BTRC	1	CSNK1A1	1	affinity chromatography technology, bioid	Coyaud E (2015), Coyaud E (2015)	2
TRIM25	5	UBC	7	enzymatic study	Sanchez JG (2016)	1
BTRC	1	CTNNA1	7	affinity chromatography technology, bioid	Coyaud E (2015), Coyaud E (2015)	2
CAV1	0	CTNNB1	30	affinity chromatography technology, affinity chromatography technology	Li Y (2008), Rodriguez DA (2009)	2
MAP3K1	4	HIPK2	0	affinity chromatography technology, imaging technique	Ritterhoff S (2010), Ritterhoff S (2010)	2
APC	5	TRIM25	5	two hybrid	Arroyo R (2015)	1
PML	7	AXIN1	1	affinity chromatography technology, affinity chromatography technology, pull down	Li Q (2011), Li Q (2011), Li Q (2011)	3
DVL2	5	DVL3	7	affinity chromatography technology, affinity chromatography technology	de Groot RE (2014), Huttlin EL (2017)	2
TRIM25	5	EEF1A1	0	biochemical	Wan C (2015)	1
TRIM25	5	GSK3A	1	affinity chromatography technology	Choudhury NR (2017)	1
ARRB1	2	AXIN1	1	affinity chromatography technology, affinity chromatography technology	Rosano L (2009), Rosano L (2009)	2
TRIM25	5	PML	7	affinity chromatography technology	Choudhury NR (2017)	1
APC	5	CTNNA1	7	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology	Su LK (1993), Daniel JM (1995), Bandyopadhyay S (2010), Hein MY (2015), Chen TC (2014), Novellasdemunt L (2017)	6
AXIN1	1	AXIN1	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Stelzl U (2005), Zhang Y (2002), Kim MJ (2008)	3
USP7	14	PML	7	affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Sivachandran N (2010), Sarkari F (2011), Sarkari F (2011), Hein MY (2015)	4
PIN1	0	TSC2	17	two hybrid	Vinayagam A (2011)	1
SMURF2	3	AXIN1	1	enzymatic study, affinity chromatography technology	Kim S (2010), Kim S (2010)	2
SKI	3	TP53	0	affinity chromatography technology	Inoue Y (2011)	1
EGLN3	0	GSK3B	1	affinity chromatography technology	Rodriguez J (2016)	1
SMAD7	1	AXIN1	1	affinity chromatography technology	Tang Y (2008)	1
TRIM25	5	USP15	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Pauli EK (2014), Pauli EK (2014), Pauli EK (2014), Pauli EK (2014)	4
SMAD7	1	MYC	2	affinity chromatography technology, affinity chromatography technology	Kim TA (2013), Kim TA (2013)	2
PPP1CA	3	CAV1	0	affinity chromatography technology, affinity chromatography technology, pull down	Li L (2003), Li L (2003), Li L (2003)	3
AMER1	0	CTNNB1	30	pull down, affinity chromatography technology	Major MB (2007), Hein MY (2015)	2
DVL3	7	CTNNB1	30	affinity chromatography technology	Song DH (2000)	1