PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NAB2	2	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
AES	2	TRAF1	0	two hybrid	Rolland T (2014)	1
GOLGA2	2	TUBGCP4	3	two hybrid	Rual JF (2005)	1
DGCR6	0	PRDM14	1	two hybrid	Corominas R (2014)	1
DGCR6	0	TRAF2	1	two hybrid	Corominas R (2014)	1
ENKD1	3	SPERT	0	two hybrid	Rolland T (2014)	1
DGCR6	0	ZNF398	1	two hybrid	Corominas R (2014)	1
HGS	5	NUP54	1	two hybrid	Rolland T (2014)	1
DGCR6	0	DEUP1	0	two hybrid	Corominas R (2014)	1
DGCR6	0	SS18L1	2	two hybrid	Corominas R (2014)	1
MEOX2	2	DOCK8	10	two hybrid	Rolland T (2014)	1
AES	2	REL	5	two hybrid	Rolland T (2014)	1
PDLIM7	0	ENKD1	3	two hybrid	Rual JF (2005)	1
DGCR6	0	HGS	5	two hybrid	Corominas R (2014)	1
DGCR6	0	CEP126	0	two hybrid	Corominas R (2014)	1
ARNT2	5	APP	1	pull down	Olah J (2011)	1
DGCR6	0	EFHC2	0	two hybrid	Corominas R (2014)	1
TRIM27	2	FBF1	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
DGCR6	0	C1orf94	1	two hybrid	Corominas R (2014)	1
DGCR6	0	ZC4H2	3	two hybrid	Corominas R (2014)	1
VCP	6	NUP62	1	affinity chromatography technology	Yu CC (2013)	1
ZNF446	1	LZTS2	4	two hybrid	Rolland T (2014)	1
TRAF2	1	FBF1	2	two hybrid	Rual JF (2005)	1
DGCR6	0	MEIS2	7	two hybrid	Corominas R (2014)	1
DGCR6	0	HOMEZ	2	two hybrid	Corominas R (2014)	1
AES	2	GOLGA2	2	two hybrid	Rolland T (2014)	1
CCDC33	3	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
DGCR6	0	KLHL12	4	two hybrid	Corominas R (2014)	1
DGCR6	0	TRAF1	0	two hybrid	Corominas R (2014)	1
AES	2	IKZF3	1	two hybrid	Rolland T (2014)	1
ENKD1	3	MIPOL1	1	two hybrid	Rolland T (2014)	1
TRIM27	2	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
ARNT2	5	RIMBP3	0	two hybrid	Corominas R (2014)	1
TUBGCP4	3	TRIM27	2	two hybrid	Venkatesan K (2009)	1
HGS	5	APP	1	pull down, pull down, pull down	Pridgeon JW (2009), Olah J (2011), Virok DP (2011)	3
NAB2	2	CCDC33	3	two hybrid	Rolland T (2014)	1
MEOX2	2	FBF1	2	two hybrid	Rolland T (2014)	1
DGCR6	0	MBIP	0	two hybrid	Corominas R (2014)	1
MID2	1	FBF1	2	two hybrid	Rolland T (2014)	1
TRAF2	1	SPRY2	4	two hybrid	Rual JF (2005)	1
ARNT2	5	MIPOL1	1	two hybrid	Corominas R (2014)	1
TCF4	26	TCF12	14	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
DGCR6	0	C3orf62	0	two hybrid	Corominas R (2014)	1
DGCR6	0	GSE1	14	two hybrid	Corominas R (2014)	1
DGCR6	0	FBF1	2	two hybrid	Corominas R (2014)	1
DGCR6	0	ARNT2	5	two hybrid	Corominas R (2014)	1
SS18L1	2	RFX6	3	two hybrid	Rual JF (2005)	1
IKZF3	1	FBF1	2	two hybrid	Rolland T (2014)	1
ARNT2	5	TRIM27	2	two hybrid	Corominas R (2014)	1
DGCR6	0	AGTRAP	1	two hybrid	Corominas R (2014)	1
VCP	6	APP	1	affinity chromatography technology	Jang JK (2017)	1
DGCR6	0	GOLGA2	2	two hybrid	Corominas R (2014)	1
DGCR6	0	TRIM27	2	two hybrid	Corominas R (2014)	1
DGCR6	0	DOCK8	10	two hybrid	Corominas R (2014)	1
DGCR6	0	REL	5	two hybrid	Corominas R (2014)	1
PDLIM7	0	TRAF2	1	protein complementation assay, protein complementation assay	Talaty P (2011), Talaty P (2011)	2
TRAF2	1	ENKD1	3	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
NUP62	1	NUP54	1	two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Rual JF (2005), Rolland T (2014), Pante N (1994), Yu H (2011), Huttlin EL (2017)	5
DGCR6	0	TCF12	14	two hybrid	Corominas R (2014)	1
TRAF2	1	CCDC33	3	two hybrid	Rual JF (2005)	1
CCDC33	3	MIPOL1	1	two hybrid	Rolland T (2014)	1
DGCR6	0	SPRY2	4	two hybrid	Corominas R (2014)	1
ZNF446	1	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
VCP	6	FBF1	2	affinity chromatography technology	Fogeron ML (2013)	1
DGCR6	0	DNPEP	2	two hybrid	Corominas R (2014)	1
ARNT2	5	MEOX2	2	two hybrid	Corominas R (2014)	1
DGCR6	0	MEOX2	2	two hybrid	Corominas R (2014)	1
TRIM27	2	MID2	1	two hybrid	Rolland T (2014)	1
DGCR6	0	IKZF3	1	two hybrid	Corominas R (2014)	1
DGCR6	0	CBLL1	6	two hybrid	Corominas R (2014)	1
SPERT	0	MBIP	0	affinity chromatography technology	Huttlin EL (2017)	1
ARNT2	5	IKZF3	1	two hybrid	Corominas R (2014)	1
AES	2	RFX6	3	two hybrid	Rolland T (2014)	1
DGCR6	0	MIA2	5	two hybrid	Corominas R (2014)	1
DGCR6	0	LZTS2	4	two hybrid	Corominas R (2014)	1
TRAF1	0	FBF1	2	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
ARNT2	5	GOLGA2	2	two hybrid	Corominas R (2014)	1
ARNT2	5	LZTS2	4	two hybrid	Corominas R (2014)	1
DGCR6	0	AES	2	two hybrid	Corominas R (2014)	1
TUBGCP4	3	ADAMTSL4	6	two hybrid	Venkatesan K (2009)	1
DGCR6	0	ADAMTSL4	6	two hybrid	Corominas R (2014)	1
DGCR6	0	NOTCH2NL	1	two hybrid	Corominas R (2014)	1
C3orf62	0	APP	1	pull down	Olah J (2011)	1
DGCR6	0	RIMBP3	0	two hybrid	Corominas R (2014)	1
ARNT2	5	REL	5	two hybrid	Corominas R (2014)	1
DGCR6	0	EFEMP2	0	two hybrid	Corominas R (2014)	1
TUBGCP4	3	SPERT	0	two hybrid	Rual JF (2005)	1
ARNT2	5	CTBP1	2	two hybrid	Corominas R (2014)	1
SPRY2	4	ADAMTSL4	6	two hybrid	Rual JF (2005)	1
DGCR6	0	NUP54	1	two hybrid	Corominas R (2014)	1
DGCR6	0	ZBED1	0	two hybrid	Corominas R (2014)	1
CTBP1	2	TCF4	26	two hybrid, two hybrid	Ravasi T (2010), Corominas R (2014)	2
RABGEF1	1	TRAF2	1	affinity chromatography technology	Huttlin EL (2017)	1
AES	2	HGS	5	biochemical	Kristensen AR (2012)	1
TUBGCP4	3	EFHC2	0	two hybrid	Venkatesan K (2009)	1
MIA2	5	SS18L1	2	two hybrid	Rolland T (2014)	1
ARNT2	5	RFX6	3	two hybrid	Corominas R (2014)	1
TRAF2	1	LZTS2	4	two hybrid	Rual JF (2005)	1
DGCR6	0	TCF4	26	two hybrid	Corominas R (2014)	1
TRIM27	2	ZNF446	1	two hybrid	Rolland T (2014)	1
DGCR6	0	SPERT	0	two hybrid	Corominas R (2014)	1
HGS	5	CCDC33	3	two hybrid	Rual JF (2005)	1
GOLGA2	2	GSE1	14	two hybrid	Rolland T (2014)	1
DGCR6	0	VCP	6	two hybrid	Corominas R (2014)	1
AES	2	HOMEZ	2	two hybrid	Rolland T (2014)	1
FBF1	2	MIPOL1	1	two hybrid	Rolland T (2014)	1
AES	2	C1orf94	1	two hybrid	Rolland T (2014)	1
AES	2	MIA2	5	two hybrid	Rolland T (2014)	1
SPRY2	4	MID2	1	two hybrid	Rolland T (2014)	1
NECAB2	1	CCDC33	3	two hybrid	Rual JF (2005)	1
FBF1	2	CTBP1	2	bioid	Gupta GD (2015)	1
TRAF1	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Takeuchi M (1996), Li S (2011), Li S (2011), Fries KL (1999), He L (2004), Zheng C (2010), Zheng C (2010), Relaix F (1998), Relaix F (1998), Jang HD (2001), Fotin-Mleczek M (2004), Pullen SS (1998), Wicovsky A (2009), Rothe M (1994), Rothe M (1994), Chen TC (2014), Greenfeld H (2015), Huttlin EL (2017)	19
ARNT2	5	TRAF2	1	two hybrid	Corominas R (2014)	1
DGCR6	0	CTBP1	2	two hybrid	Corominas R (2014)	1
GOLGA2	2	DEUP1	0	two hybrid	Rolland T (2014)	1
MEOX2	2	EFEMP2	0	two hybrid	Rolland T (2014)	1
DGCR6	0	NUP62	1	two hybrid	Corominas R (2014)	1
ARNT2	5	CCDC33	3	two hybrid	Corominas R (2014)	1
MEIS2	7	C1orf94	1	two hybrid	Rolland T (2014)	1
DGCR6	0	ZNF446	1	two hybrid	Corominas R (2014)	1
GOLGA2	2	FBF1	2	two hybrid	Rolland T (2014)	1
AES	2	NAB2	2	two hybrid	Rolland T (2014)	1
MEIS2	7	APP	1	pull down	Olah J (2011)	1
DGCR6	0	TFIP11	5	two hybrid	Corominas R (2014)	1
DGCR6	0	DLGAP2	4	two hybrid	Corominas R (2014)	1
ARNT2	5	MEIS2	7	two hybrid	Corominas R (2014)	1
DGCR6	0	TUBGCP4	3	two hybrid	Corominas R (2014)	1
DGCR6	0	RABGEF1	1	two hybrid	Corominas R (2014)	1
AES	2	TRIM27	2	two hybrid	Rolland T (2014)	1
ARNT2	5	ADAMTSL4	6	two hybrid	Corominas R (2014)	1
ARNT2	5	TFIP11	5	two hybrid	Corominas R (2014)	1
DGCR6	0	RFX6	3	two hybrid	Corominas R (2014)	1
DNPEP	2	ADAMTSL4	6	two hybrid	Rual JF (2005)	1
DGCR6	0	CCDC33	3	two hybrid	Corominas R (2014)	1
FBF1	2	APP	1	pull down	Olah J (2011)	1
DGCR6	0	CCDC36	1	two hybrid	Corominas R (2014)	1
VCP	6	NUP54	1	affinity chromatography technology	Fogeron ML (2013)	1
ARNT2	5	TRAF1	0	two hybrid	Corominas R (2014)	1
DGCR6	0	NAB2	2	two hybrid	Corominas R (2014)	1
DGCR6	0	DLX2	0	two hybrid	Corominas R (2014)	1
MEOX2	2	SPRY2	4	two hybrid	Rolland T (2014)	1
DGCR6	0	NECAB2	1	two hybrid	Corominas R (2014)	1
AES	2	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
TCF4	26	GSE1	14	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
TUBGCP4	3	FBF1	2	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
DGCR6	0	NQO2	0	two hybrid	Corominas R (2014)	1
GOLGA2	2	MID2	1	two hybrid	Rolland T (2014)	1
DGCR6	0	ENKD1	3	two hybrid	Corominas R (2014)	1
HGS	5	SPRY2	4	affinity chromatography technology	Kim HJ (2007)	1
MID2	1	ADAMTSL4	6	two hybrid	Rolland T (2014)	1
EFEMP2	0	CCDC33	3	two hybrid	Rolland T (2014)	1
DGCR6	0	MIPOL1	1	two hybrid	Corominas R (2014)	1
AES	2	FBF1	2	two hybrid	Rolland T (2014)	1
DGCR6	0	MID2	1	two hybrid	Corominas R (2014)	1
FBF1	2	DEUP1	0	two hybrid	Rolland T (2014)	1
DGCR6	0	PDLIM7	0	two hybrid	Corominas R (2014)	1
GSE1	14	C1orf94	1	two hybrid	Rolland T (2014)	1
AES	2	TCF4	26	two hybrid	Rolland T (2014)	1
LZTS2	4	FBF1	2	two hybrid, bioid	Rolland T (2014), Gupta GD (2015)	2
AES	2	RIMBP3	0	two hybrid	Rolland T (2014)	1
ENKD1	3	APP	1	pull down	Olah J (2011)	1
DGCR6	0	APP	1	pull down	Olah J (2011)	1
AES	2	TRAF2	1	two hybrid	Rolland T (2014)	1