PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
IQGAP1	1	DBN1	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
CAMK2G	4	GRIN1	13	enzymatic study	Wechsler A (1998)	1
CAMK2A	6	CAMK2G	4	affinity chromatography technology	So J (2015)	1
THOC2	4	CAMK2G	4	affinity chromatography technology	Hein MY (2015)	1
BCL10	0	CAMK2G	4	affinity chromatography technology	Oruganti SR (2011)	1
HSP90AA1	7	USP19	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Gano JJ (2010), Lee JG (2014), Lee JG (2014), Lee JG (2014), He WT (2016), He WT (2016), He WT (2016)	7
SYNPO	5	CAPZA2	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
CAMK2G	4	SMAD3	1	imaging technique	Chen TC (2014)	1
CAMK2A	6	SMAD2	5	imaging technique	Chen TC (2014)	1
THOC2	4	SMAD4	9	affinity chromatography technology	Cheng H (2006)	1
CAMK2G	4	PDLIM5	0	biochemical	Wan C (2015)	1
SMAD4	9	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Moren A (2003), Wotton D (1999), Mori N (2001), Wu JW (2002), Wu JW (2002), Nakao A (1997), Wicks SJ (2000), Wu JW (2001), Chen X (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Razani B (2001), Razani B (2001), Wang B (2008), Moren A (2005), Kurisaki K (2003), Prunier C (2003), Kato Y (2002), Xu J (2000), Wang L (2011), He W (2006), He W (2006), Dupont S (2009), Brown JD (1999), Pardali K (2000), Fu G (2011), Chen W (2007), Gao S (2009), Lin X (2003), Seo SR (2006), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Barrios-Rodiles M (2005), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Ali A (2013), Yamakawa N (2002), Yamakawa N (2002), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Zhou F (2017)	56
CALM1	0	HSP90AA1	7	pull down	Ning YM (1995)	1
CAPZA2	1	CAMK2G	4	affinity chromatography technology	Hein MY (2015)	1
HSP90AA1	7	MYC	2	affinity chromatography technology	Carystinos GD (2003)	1
TUBG1	2	CAMK2G	4	affinity chromatography technology	Hein MY (2015)	1
DACT2	1	CAMK2D	3	affinity chromatography technology	Huttlin EL (2015)	1
HSP90AA1	7	CAMK2G	4	affinity chromatography technology	Taipale M (2012)	1
FLNA	10	CALM1	0	affinity chromatography technology	Hein MY (2015)	1
CAMK2G	4	RRAD	2	pull down, enzymatic study, enzymatic study	Moyers JS (1997), Moyers JS (1997), Moyers JS (1998)	3
SYNPO	5	CAMK2G	4	affinity chromatography technology	Hein MY (2015)	1
CAMK2A	6	RCHY1	0	enzymatic study	Duan S (2007)	1
CAMK2G	4	STMN1	0	enzymatic study	Li N (2011)	1
CAMK2G	4	FLNA	10	imaging technique	Chen TC (2014)	1
RCHY1	0	CALM1	0	affinity chromatography technology	Duan S (2007)	1
ANLN	2	SYNPO	5	affinity chromatography technology	Hein MY (2015)	1
IQGAP1	1	CAPZA2	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
CAMK2G	4	BECN1	2	affinity chromatography technology	Li X (2017)	1
ZNF488	0	CAMK2G	4	affinity chromatography technology	Huttlin EL (2017)	1
HSP90AA1	7	CAMK2A	6	affinity chromatography technology	Taipale M (2012)	1
RBM42	0	CAMK2G	4	affinity chromatography technology	Huttlin EL (2017)	1
NDUFA8	1	CAMK2D	3	affinity chromatography technology	Huttlin EL (2015)	1
ANLN	2	CAMK2G	4	affinity chromatography technology	Hein MY (2015)	1
ANLN	2	CALM1	0	affinity chromatography technology	Hein MY (2015)	1
SYNPO	5	FLNA	10	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
GRIN1	13	GRIN2B	30	affinity chromatography technology	Al-Hallaq RA (2002)	1
DBN1	1	FLNA	10	biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Hein MY (2015), Hein MY (2015)	3
BECN1	2	SMAD2	5	fluorescent resonance energy transfe	Ivanov AA (2017)	1
IGBP1	1	CAMK2G	4	affinity chromatography technology	Hein MY (2015)	1
MYC	2	SMAD2	5	affinity chromatography technology, pull down, two hybrid, fluorescent resonance energy transfe	Feng XH (2002), Feng XH (2002), Feng XH (2002), Ivanov AA (2017)	4
CAMK2G	4	SMAD2	5	enzymatic study	Wicks SJ (2000)	1
MYC	2	CAMK2D	3	genetic interference, affinity chromatography technology	Toyoshima M (2012), Agrawal P (2010)	2
SIVA1	0	CAMK2G	4	affinity chromatography technology	Li N (2011)	1
NDUFA8	1	CAMK2G	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HSP90AA1	7	CAMK2D	3	affinity chromatography technology	Taipale M (2012)	1
MYC	2	TUBG1	2	affinity chromatography technology	Koch HB (2007)	1
CAMK2A	6	CAMK2D	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), So J (2015), Huttlin EL (2017)	3
CAMK2G	4	SMAD4	9	enzymatic study	Wicks SJ (2000)	1
ARHGAP25	2	CAMK2D	3	affinity chromatography technology	Huttlin EL (2015)	1
SMAD3	1	FLNA	10	two hybrid	Colland F (2004)	1
IQGAP1	1	SYNPO	5	affinity chromatography technology	Hein MY (2015)	1
CAMK2D	3	CAMK2G	4	affinity chromatography technology	Huttlin EL (2017)	1
ANLN	2	DBN1	1	affinity chromatography technology	Hein MY (2015)	1
CAMK2G	4	RCHY1	0	enzymatic study	Duan S (2007)	1
ECHS1	2	CAMK2G	4	affinity chromatography technology	Huttlin EL (2015)	1
HSP90AA1	7	BECN1	2	affinity chromatography technology	Xu C (2011)	1
MALT1	1	CAMK2G	4	affinity chromatography technology	Oruganti SR (2011)	1
CUL3	17	SBDS	5	biochemical	Wan C (2015)	1
ANLN	2	FLNA	10	affinity chromatography technology	Hein MY (2015)	1
CAMK2G	4	DDX11	1	biochemical	Wan C (2015)	1
TIRAP	1	CAMK2G	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
USP19	1	FLNA	10	two hybrid	Velasco K (2013)	1
RCHY1	0	CAMK2D	3	affinity chromatography technology	Ma-Lauer Y (2016)	1
HSP90AA1	7	FLNA	10	affinity chromatography technology	Falsone SF (2005)	1
SIVA1	0	STMN1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Li N (2011), Li N (2011), Li N (2011), Li N (2011)	4
ANLN	2	CAPZA2	1	affinity chromatography technology	Hein MY (2015)	1
SMAD3	1	SMAD2	5	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Nakao A (1997), Lebrun JJ (1999), Dumont E (2003), Brown KA (2008), Brown KA (2008), Wu RY (1997), Wu RY (1997), Tang Y (2003), Tang Y (2003), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	12
CUL3	17	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Taipale M (2012)	2
CALM1	0	RRAD	2	pull down, pull down	Moyers JS (1998), Fischer R (1996)	2
USP19	1	CAMK2G	4	affinity chromatography technology	Sowa ME (2009)	1
TIRAP	1	CAMK2D	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RBM42	0	CAMK2D	3	affinity chromatography technology	Huttlin EL (2017)	1
CALM1	0	IQGAP1	1	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li Z (2003), Briggs MW (2002), Ren JG (2008), Hein MY (2015), Boldt K (2016)	5
DBN1	1	CALM1	0	affinity chromatography technology	Hein MY (2015)	1
SMAD3	1	SMAD4	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Seoane J (2004), Moren A (2003), Wu JW (2002), Nakao A (1997), Hanai J (1999), Lebrun JJ (1999), Poncelet AC (2001), Jablonska E (2010), Prunier C (2003), Kato Y (2002), Kaimori A (2010), Tang LY (2011), Tang LY (2011), Dupont S (2009), Dupont S (2009), Pardali K (2000), Kardassis D (2000), Xu L (2003), Fu G (2011), Chen W (2007), Kang JM (2012), Gao S (2009), Li H (2009), Li H (2009), Brown KA (2008), Brown KA (2008), Halder SK (2005), Barrios-Rodiles M (2005), Dai F (2007), Dai F (2007), Chacko BM (2004), Chacko BM (2004), Chacko BM (2004), Stroschein SL (1999), Stroschein SL (1999), Stroschein SL (1999), Wu RY (1997), Wu RY (1997), Wu RY (1997), Wu RY (1997), Tomita M (2004), Colland F (2004), Colland F (2004), Tang Y (2003), Ding L (2009), Fattet L (2013), Wang J (2011), Xue J (2014), Ali A (2013), Gao S (2009), Yamakawa N (2002), Yamakawa N (2002), Wang G (2005), Li X (2015), Zhou F (2014), Yang Y (2015), Yan X (2016), Yan X (2016), Wu Y (2017), Wu Y (2017)	60
ARHGAP25	2	CAMK2G	4	affinity chromatography technology	Huttlin EL (2015)	1
ECHS1	2	CAMK2D	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MYC	2	SMAD3	1	affinity chromatography technology, pull down, two hybrid	Feng XH (2002), Feng XH (2002), Feng XH (2002)	3
DBN1	1	CAMK2G	4	affinity chromatography technology	Hein MY (2015)	1
FLNA	10	CAPZA2	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
IQGAP1	1	CAMK2G	4	affinity chromatography technology	Hein MY (2015)	1
CUL3	17	CALM1	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	CAMK2G	4	affinity chromatography technology	Bennett EJ (2010)	1
MALT1	1	BCL10	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Uren AG (2000), Uren AG (2000), Uren AG (2000), Noels H (2009), Carvalho G (2010), Welteke V (2009), Oruganti SR (2011), Lucas PC (2001), Langel FD (2008), Langel FD (2008), Blonska M (2007), Oeckinghaus A (2007), Park Y (2013), Park Y (2013), Borthakur A (2013), Zhou H (2004), Zhou H (2004), Chen J (2015), Karim ZA (2015), Nie Z (2015), Eitelhuber AC (2011), Paul S (2012), Yang YK (2016), Liu Y (2012), Bidere N (2009), Bidere N (2009), Afonina IS (2016), Howes A (2016)	28
CAMK2A	6	GRIN2B	30	pull down	Bayer KU (2001)	1
CUL3	17	FLNA	10	affinity chromatography technology	Bennett EJ (2010)	1
CAMK2G	4	SBDS	5	biochemical	Wan C (2015)	1
MYC	2	CALM1	0	affinity chromatography technology, pull down	Agrawal P (2010), Raffeiner P (2017)	2
MYC	2	CAMK2G	4	genetic interference	Toyoshima M (2012)	1
CALM1	0	CAMK2G	4	pull down	Kwiatkowski AP (2000)	1
SYNPO	5	DBN1	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
CAMK2G	4	GRIN2B	30	enzymatic study	Wechsler A (1998)	1
IQGAP1	1	FLNA	10	affinity chromatography technology	Hein MY (2015)	1
TUBG1	2	HSP90AA1	7	biochemical, affinity chromatography technology, affinity chromatography technology	Wigley WC (1999), Fogeron ML (2013), Hein MY (2015)	3
MYC	2	FLNA	10	affinity chromatography technology	Agrawal P (2010)	1
MYC	2	NDUFA8	1	affinity chromatography technology	Koch HB (2007)	1
DACT2	1	CAMK2G	4	affinity chromatography technology	Huttlin EL (2015)	1
DBN1	1	CAPZA2	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2