PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRIM7	2	UBE2D2	0	two hybrid	Napolitano LM (2011)	1
SIAH1	2	UBE2D1	0	two hybrid, two hybrid, pull down, pull down, pull down	Matsuzawa SI (2001), Markson G (2009), Dimitrova YN (2010), Rott R (2008), Liu QY (2008)	5
TRIM7	2	UBE2E1	1	two hybrid	Napolitano LM (2011)	1
NDEL1	2	TRIM7	2	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D3	1	SIAH1	2	two hybrid, two hybrid, pull down, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Liu M (2012), Mei Y (2007), Kim SY (2009)	5
TRIM7	2	GYG1	1	affinity chromatography technology, two hybrid, enzymatic study, two hybrid, pull down	Skurat AV (2002), Skurat AV (2002), Skurat AV (2002), Zhai L (2004), Zhai L (2004)	5
VPS26B	0	TRIM7	2	affinity chromatography technology	Hein MY (2015)	1
TRIM7	2	TRIM7	2	two hybrid	Zhai L (2004)	1
TRIM7	2	UBE2D1	0	two hybrid	Napolitano LM (2011)	1
TRIM7	2	UBE2D3	1	two hybrid	Napolitano LM (2011)	1
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
HSP90AA1	7	TRIM7	2	affinity chromatography technology	Taipale M (2012)	1
SIAH1	2	TRIM7	2	two hybrid	Rolland T (2014)	1
UBE2D2	0	SIAH1	2	two hybrid, two hybrid, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Szargel R (2009), Winter M (2008)	4