PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DTL	0	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jin J (2006), Higa LA (2006), Higa LA (2006), Sertic S (2013), Shibata E (2014), Hein MY (2015), Shibata E (2011), Higa LA (2006), Higa LA (2006)	9
EP300	36	FOXO3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li XN (2009), Li XN (2009), Mahmud DL (2002), Li X (2015)	4
ANAPC7	2	EP300	36	affinity chromatography technology, affinity chromatography technology	Turnell AS (2005), Turnell AS (2005)	2
CDT1	2	GRWD1	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique	Sugimoto N (2008), Sugimoto N (2008), Sugimoto N (2008), Sugimoto N (2015), Sugimoto N (2015), Sugimoto N (2015)	6
CKS2	0	CCNA1	3	pull down	Radulovic M (2010)	1
CDC20	1	TFDP1	3	affinity chromatography technology	Nath S (2014)	1
CDT1	2	FZR1	1	affinity chromatography technology, pull down	Sugimoto N (2008), Sugimoto N (2008)	2
XPO1	8	TP73	2	unspecified method	Xu D (2012)	1
COPS5	0	NPM1	0	affinity chromatography technology	Bennett EJ (2010)	1
CDT1	2	HDAC11	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Glozak MA (2009), Glozak MA (2009), Wong PG (2010), Wong PG (2010)	4
CDC5L	2	ORC1	3	pull down	Ramachandran N (2004)	1
CDT1	2	ORC2	0	pull down	Ramachandran N (2004)	1
CUL1	7	CCNA1	3	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Michel JJ (1998)	2
EP300	36	CDK1	0	affinity chromatography technology, enzymatic study	Wang SA (2014), Wang SA (2014)	2
CDT1	2	ANAPC7	2	affinity chromatography technology, pull down	Sugimoto N (2008), Sugimoto N (2008)	2
CDT1	2	GMNN	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sugimoto N (2008), Ballabeni A (2004), Nishitani H (2004), Nishitani H (2004), Teer JK (2008), Roukos V (2007), Wong PG (2010), Sugimoto N (2004), Takeda DY (2005), Ramachandran N (2004), Higa LA (2003), Higa LA (2003), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	15
CDT1	2	KPNB1	3	affinity chromatography technology	Sugimoto N (2008)	1
KAT7	3	CDC6	0	enzymatic study	Iizuka M (2006)	1
CCNB1	3	CDC6	0	enzymatic study	Jiang W (1999)	1
CDK1	0	GMNN	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDT1	2	DGCR8	4	biochemical	Havugimana PC (2012)	1
CUL1	7	GRWD1	3	affinity chromatography technology	Bennett EJ (2010)	1
CDK2	0	BZW1	0	affinity chromatography technology	Neganova I (2011)	1
USP37	1	CDT1	2	affinity chromatography technology	Hernandez-Perez S (2016)	1
CCNB1	3	CDK2	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Di Fiore B (2010), Nishiyama A (2000), Wolthuis R (2008), Desai D (1995), Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	11
DDB2	1	EP300	36	affinity chromatography technology, affinity chromatography technology	Datta A (2001), Rapic-Otrin V (2002)	2
CCNA1	3	MCM4	3	enzymatic study, pull down	Komamura-Kohno Y (2006), Ramachandran N (2004)	2
COPS5	0	CKS1B	0	affinity chromatography technology	Bennett EJ (2010)	1
CCNA2	1	GMNN	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
COPS5	0	FBXO31	4	affinity chromatography technology	Bennett EJ (2010)	1
CUL4B	8	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Jin J (2006), Wang H (2006), Higa LA (2006), Higa LA (2006), Kawajiri K (2009), Bennett EJ (2010), Havugimana PC (2012), Ji Q (2014), Wan C (2015), Hein MY (2015), Mo Y (2017), Mo Y (2017), Yang Y (2015), Yang Y (2015), Yang Y (2015), Higa LA (2006), Higa LA (2006), Ohtake F (2007), Ohtake F (2007), Ohtake F (2007)	23
CCNB1	3	EP300	36	pull down, affinity chromatography technology	Felzien LK (1998), Felzien LK (1998)	2
CDC5L	2	KPNB1	3	affinity chromatography technology	Lleres D (2010)	1
USP37	1	ANAPC7	2	affinity chromatography technology, bioid	Huang X (2011), Yeh C (2015)	2
MCM2	3	MCM7	5	pull down, pull down, two hybrid, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), You Z (1999), Fujita M (1997), You Z (2002), Havugimana PC (2012), Ramachandran N (2004), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Drissi R (2015), Boldt K (2016)	14
CDT1	2	CDC5L	2	pull down	Ramachandran N (2004)	1
CUL4B	8	CDK4	2	affinity chromatography technology	Bennett EJ (2010)	1
CCNE1	1	SKP2	2	pull down, enzymatic study	Yeh KH (2001), Enchev RI (2012)	2
KPNA2	0	CUL4B	8	pull down	Zou Y (2009)	1
CDT1	2	DDB1	6	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology	Hu J (2004), Hu J (2004), Hu J (2004), Hu J (2004), Zhang Y (2012)	5
HECW2	13	ANAPC5	2	affinity chromatography technology	Lu L (2013)	1
CDC5L	2	BZW1	0	affinity chromatography technology, biochemical, affinity chromatography technology	Ajuh P (2000), Ajuh P (2000), Lleres D (2010)	3
FZR1	1	GMNN	0	affinity chromatography technology, enzymatic study, pull down	Pfleger CM (2001), Williamson A (2011), Williamson A (2011)	3
MAPK14	0	KAT2B	2	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Pillai VB (2011), Pillai VB (2011), Pillai VB (2011), Pillai VB (2011)	4
CCNA1	3	CDK2	0	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, imaging technique	Sweeney C (1996), Yang R (1997), Yang R (1997), Mueller-Tidow C (2001), Brown NR (1999), Niida H (2005), Yam CH (2000), Wang H (2009), Narayanan R (2005), Harwell RM (2004), Shen WH (2004), He W (2003), Peiretti A (2003), Peiretti A (2003), Pan ZQ (1993), Kim KS (2002), Lyapina SA (1998), Desai D (1995), Thomas DM (2004), Johnson LN (2002), Rohaly G (2005), Chen TC (2014)	22
XPO1	8	ANAPC5	2	affinity chromatography technology	Kirli K (2015)	1
MCM4	3	MCM7	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, biochemical, biochemical, affinity chromatography technology	Yabuta N (2003), Fujita M (1997), Ishimi Y (1996), You Z (2002), Havugimana PC (2012), Ramachandran N (2004), Kristensen AR (2012), Wan C (2015), Boldt K (2016)	9
KAT2B	2	CDT1	2	enzymatic study	Glozak MA (2009)	1
MCM2	3	CUL4B	8	affinity chromatography technology	Drissi R (2015)	1
FZR1	1	DDB1	6	affinity chromatography technology, affinity chromatography technology	Lv XB (2010), Lv XB (2010)	2
TP73	2	CUL1	7	affinity chromatography technology	Peschiaroli A (2009)	1
USP37	1	CUL1	7	affinity chromatography technology	Burrows AC (2012)	1
SKP2	2	CCNB1	3	affinity chromatography technology	Bashir T (2010)	1
CUL4A	2	DTL	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Higa LA (2006), Bennett EJ (2010), Sertic S (2013), Rossi M (2013), Jin J (2006), Shibata E (2011), Higa LA (2006)	7
CDT1	2	CDK1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Sugimoto N (2004), Sugimoto N (2004), Huttlin EL (2015), Huttlin EL (2017)	4
CDT1	2	CCNA2	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Teer JK (2008), Sugimoto N (2004), Sugimoto N (2004), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	7
CDK3	0	SKP2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
XPO1	8	CDC20	1	affinity chromatography technology	Kirli K (2015)	1
MCM2	3	NPM1	0	affinity chromatography technology	Drissi R (2015)	1
MCM2	3	KPNA2	0	affinity chromatography technology	Drissi R (2015)	1
CDT1	2	CDC6	0	pull down, pull down, imaging technique	Sugimoto N (2008), Ramachandran N (2004), Sugimoto N (2015)	3
CCNB1	3	CKS2	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Wolthuis R (2008), Radulovic M (2010), Hein MY (2015), Huttlin EL (2017)	4
COPS5	0	GRWD1	3	affinity chromatography technology	Bennett EJ (2010)	1
CDK2	0	CDC20	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), So J (2015), Craney A (2016), Huttlin EL (2017)	4
CCNB1	3	PCNA	0	affinity chromatography technology, affinity chromatography technology	Zhang H (1993), Huttlin EL (2017)	2
FZR1	1	USP37	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huang X (2011), Huang X (2011), Saxena N (2014), Huttlin EL (2017)	4
COPS5	0	CDT1	2	biochemical	He YJ (2006)	1
CDC20	1	ANAPC5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sedgwick GG (2012), Kelly A (2014), Kelly A (2014), Craney A (2016), Craney A (2016), Qiao R (2016)	6
CKS2	0	CCNE1	1	affinity chromatography technology	Huttlin EL (2017)	1
COPS5	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Min KW (2005), Min KW (2005), Chua YS (2011), Boh BK (2011), Emberley ED (2012), Emberley ED (2012), Choo YY (2011), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Enchev RI (2012), Birol M (2014), Pick E (2012), Sharon M (2009), Enchev RI (2012), Bornstein G (2015), Rockel B (2014), Schlierf A (2016), Reitsma JM (2017), Reitsma JM (2017)	23
XPO1	8	NPM1	0	unspecified method	Xu D (2012)	1
CDK3	0	CCNE1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
COPS5	0	MCM7	5	affinity chromatography technology	Bennett EJ (2010)	1
USP37	1	CCNB1	3	affinity chromatography technology	Huang X (2011)	1
TOP2A	2	TOP1	1	biochemical	Wan C (2015)	1
CDT1	2	TFDP1	3	affinity chromatography technology	Hein MY (2015)	1
CDT1	2	MAPK14	0	affinity chromatography technology, enzymatic study	Chandrasekaran S (2011), Chandrasekaran S (2011)	2
USP37	1	CDC20	1	affinity chromatography technology	Huang X (2011)	1
CDK1	0	CDK3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MCM4	3	ORC2	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
XPO1	8	ANAPC7	2	affinity chromatography technology	Kirli K (2015)	1
CDC6	0	CDK2	0	affinity chromatography technology, enzymatic study	Saha P (1998), Jiang W (1999)	2
CDT1	2	PCNA	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Sugimoto N (2008), Sugimoto N (2008), Sugimoto N (2008), Senga T (2006), Hu J (2006), Arias EE (2006), Nishitani H (2006), Tsanov N (2014), Chandrasekaran S (2011), Coleman KE (2015), Higa LA (2006)	11
EP300	36	TP63	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Liao JM (2013), Liao JM (2013), MacPartlin M (2005), MacPartlin M (2005), MacPartlin M (2005), MacPartlin M (2005), MacPartlin M (2005), Restelli M (2015), Restelli M (2015)	9
TOP2A	2	COPS5	0	affinity chromatography technology, two hybrid, pull down	Chen MC (2011), Yun J (2004), Yun J (2004)	3
EP300	36	SKP2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Kitagawa M (2008), Inuzuka H (2012), Inuzuka H (2012), Oh M (2016)	4
COPS5	0	DTL	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Sertic S (2013), Higa LA (2006), Higa LA (2006)	5
CKS1B	0	GMNN	0	affinity chromatography technology	Huttlin EL (2017)	1
CUL4A	2	DDB2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Kapetanaki MG (2006), Matsuda N (2005), Higa LA (2006), Nag A (2001), Takedachi A (2010), Fischer ES (2011), Tan L (2007), He YJ (2006), He YJ (2006), Groisman R (2003), Groisman R (2003), Hrecka K (2007), Shiyanov P (1999), Shiyanov P (1999), Bennett EJ (2010), Kulaksiz G (2005), Kulaksiz G (2005), Olma MH (2009), Olma MH (2009), Olma MH (2009), Jin J (2006), Groisman R (2003), Huttlin EL (2015), Hein MY (2015), Groisman R (2006), Yang Y (2016), Huttlin EL (2017), Fantini D (2017)	31
CDK4	2	CDC6	0	enzymatic study	Anders L (2011)	1
KAT7	3	ORC2	0	enzymatic study	Iizuka M (2006)	1
CDK2	0	MCM6	5	affinity chromatography technology	Neganova I (2011)	1
CDT1	2	CUL1	7	affinity chromatography technology	Li X (2003)	1
CDT1	2	FOXO3	1	pull down, pull down	Zhang Y (2012), Zhang Y (2012)	2
NPM1	0	GRWD1	3	affinity chromatography technology	Chen R (2013)	1
CDC20	1	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Turnell AS (2005), Turnell AS (2005), Huttlin EL (2017)	3
EP300	36	KAT2B	2	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kiernan R (2003), Kim JH (2011), Lee M (2010), Santos-Rosa H (2003), Yang XJ (1996), Yang XJ (1996), Yang XJ (1996), Mizuguchi Y (2012)	8
CDT1	2	MCM4	3	affinity chromatography technology, pull down	Sugimoto N (2008), Sugimoto N (2008)	2
CDK3	0	CKS2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDC5L	2	FAF1	1	affinity chromatography technology	Lleres D (2010)	1
EP300	36	KPNA2	0	enzymatic study	Bannister AJ (2000)	1
PCNA	0	BAZ1B	5	pull down	Poot RA (2004)	1
SMARCA5	4	BAZ1B	5	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Bozhenok L (2002), Cavellan E (2006), Cavellan E (2006), Cavellan E (2006), Havugimana PC (2012), Sarshad A (2013), Sarshad A (2013)	7
CCNE1	1	CDK4	2	affinity chromatography technology, fluorescent resonance energy transfe	Datta NS (1998), Ivanov AA (2017)	2
COPS5	0	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Angers S (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009), Olma MH (2009), Rao F (2014), Pick E (2012), Groisman R (2003), Groisman R (2003), Huttlin EL (2015), Cavadini S (2016), Scherer PC (2016), Scherer PC (2016), Huttlin EL (2017)	19
TOP1	1	NPM1	0	affinity chromatography technology	Czubaty A (2005)	1
FAF1	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Zhang L (2012), Zhang L (2012)	4
CDC20	1	PCNA	0	affinity chromatography technology	Craney A (2016)	1
CCNE1	1	TP73	2	enzymatic study, pull down	Gaiddon C (2003), Gaiddon C (2003)	2
CDC5L	2	ANAPC7	2	affinity chromatography technology	Lleres D (2010)	1
EP300	36	MCM4	3	pull down	Karmakar S (2010)	1
EP300	36	MCM2	3	pull down	Karmakar S (2010)	1
CDK4	2	PCNA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Serrano M (1993), Xiong Y (1993), Takasaki Y (2001)	3
CCNB1	3	GRWD1	3	affinity chromatography technology	Lin Z (2015)	1
CDK3	0	GMNN	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDT1	2	SKP2	2	affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (2003), Li X (2003), Li X (2003), Sugimoto N (2008), Liu E (2004), Liu E (2004), Sugimoto N (2004), Takeda DY (2005), Hein MY (2015)	9
CDK1	0	CDC20	1	enzymatic study, affinity chromatography technology, enzymatic study	Yudkovsky Y (2000), Huttlin EL (2017), Jia L (2016)	3
HECW2	13	FZR1	1	affinity chromatography technology, pull down, enzymatic study	Lu L (2013), Lu L (2013), Lu L (2013)	3
COPS5	0	CDC20	1	affinity chromatography technology	Bennett EJ (2010)	1
CDK1	0	TFDP1	3	enzymatic study	Dynlacht BD (1997)	1
SLAIN2	2	CDT1	2	affinity chromatography technology	Hein MY (2015)	1
ORC1	3	MCM2	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
USP37	1	CDC23	3	bioid	Yeh C (2015)	1
CDT1	2	MAPK9	3	affinity chromatography technology	Chandrasekaran S (2011)	1
SKP2	2	CCNA2	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marti A (1999), Bashir T (2010), Rosner M (2009), Rosner M (2004), Zhang H (1995), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	8
CUL4A	2	SKP2	2	affinity chromatography technology	Bondar T (2006)	1
MCM7	5	ORC1	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CCNA2	1	CDC20	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mateo F (2009), Di Fiore B (2010), Di Fiore B (2010), Di Fiore B (2010), Wolthuis R (2008), Wolthuis R (2008), Ge S (2009), Townsend K (2009), Di Fiore B (2010), Mateo F (2009), Mateo F (2009), Huttlin EL (2015), Di Fiore B (2015), Di Fiore B (2015), Di Fiore B (2015), Di Fiore B (2015), Hein MY (2015), Voets E (2015), Kelly A (2014), Kelly A (2014), Craney A (2016), Craney A (2016), Huttlin EL (2017), Izawa D (2012), Hein JB (2016)	25
PCNA	0	FOXO3	1	affinity chromatography technology	Zhang Y (2012)	1
CDT1	2	NPM1	0	affinity chromatography technology, pull down	Sugimoto N (2008), Sugimoto N (2008)	2
CDK2	0	CUL4B	8	affinity chromatography technology	Neganova I (2011)	1
CDC6	0	FZR1	1	pull down, enzymatic study, enzymatic study	Ke PY (2004), Petersen BO (2000), Cotto-Rios XM (2011)	3
DDB1	6	PCNA	0	affinity chromatography technology	Angers S (2006)	1
PCNA	0	MCM4	3	affinity chromatography technology	Han J (2014)	1
HDAC11	0	BAZ1B	5	affinity chromatography technology	Joshi P (2013)	1
CUL1	7	CDK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Lyapina SA (1998), Huttlin EL (2015), Huttlin EL (2017)	4
CDT1	2	TOP1	1	affinity chromatography technology, pull down, affinity chromatography technology	Sugimoto N (2008), Sugimoto N (2008), Sugimoto N (2008)	3
CDT1	2	CCNB1	3	affinity chromatography technology, pull down	Sugimoto N (2004), Sugimoto N (2004)	2
CCNA2	1	CDK4	2	affinity chromatography technology, affinity chromatography technology	Datta NS (1998), Kikuchi R (2014)	2
EP300	36	TRIP4	2	two hybrid	Kim HJ (1999)	1
SKP2	2	CDK2	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marti A (1999), Yam CH (1999), Calvisi DF (2009), Gao D (2009), Bashir T (2010), Yao ZP (2006), Rosner M (2009), Lyapina SA (1998), Zhang H (1995), Zhang H (1995), Inuzuka H (2012), Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	17
GRWD1	3	CDC6	0	affinity chromatography technology, affinity chromatography technology, pull down, imaging technique	Sugimoto N (2015), Sugimoto N (2015), Sugimoto N (2015), Sugimoto N (2015)	4
CDK2	0	PCNA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Koundrioukoff S (2000), Zhang H (1993), Neganova I (2011), Wu SM (1998), Chen Z (2002), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	8
ORC1	3	ORC2	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Fujita M (2002), Vashee S (2001), Vashee S (2001), Mendez J (2002), Mendez J (2002), Ramachandran N (2004), Vermeulen M (2010), Hein MY (2015), Hein MY (2015)	11
FOXO3	1	SKP2	2	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Wang F (2011), Wang F (2011), Wu J (2012), Wu J (2012)	4
DDB1	6	TP73	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Malatesta M (2012), Malatesta M (2012), Malatesta M (2012)	3
CDC20	1	CUL1	7	affinity chromatography technology	Wu F (2017)	1
CDC20	1	GMNN	0	affinity chromatography technology, affinity chromatography technology	Pfleger CM (2001), Tsunematsu T (2013)	2
CDK1	0	SKP2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
CDC20	1	CCNA1	3	affinity chromatography technology, two hybrid, affinity chromatography technology	Ohtoshi A (2000), Ohtoshi A (2000), Gao D (2009)	3
CDK2	0	CDK1	0	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), Huttlin EL (2017)	2
CDK2	0	KPNA2	0	affinity chromatography technology	Neganova I (2011)	1
FZR1	1	CKS2	0	affinity chromatography technology	Huttlin EL (2017)	1
CDT1	2	TRAPPC13	0	affinity chromatography technology	Hein MY (2015)	1
NPM1	0	SMARCA5	4	affinity chromatography technology	Hein MY (2015)	1
CDT1	2	FBXO31	4	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Johansson P (2014), Johansson P (2014), Johansson P (2014), Johansson P (2014)	4
CCNA2	1	EP300	36	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDK2	0	ORC2	0	enzymatic study, pull down	Mendez J (2002), Ramachandran N (2004)	2
KAT7	3	CDT1	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Miotto B (2008), Miotto B (2008), Miotto B (2008), Wong PG (2010), Wong PG (2010)	5
COPS5	0	CDK2	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Chun Y (2013)	2
PCNA	0	DTL	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Jascur T (2011), Jascur T (2011), Dar A (2014), Terai K (2010), Higa LA (2006), Higa LA (2006)	6
KAT7	3	MCM2	3	enzymatic study	Iizuka M (2006)	1
KAT7	3	GMNN	0	enzymatic study	Iizuka M (2006)	1
DDB2	1	DDB1	6	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bergametti F (2002), Martinez E (2001), Guerrero-Santoro J (2008), Angers S (2006), Wang H (2006), Kapetanaki MG (2006), Kapetanaki MG (2006), Higa LA (2006), Takedachi A (2010), Fischer ES (2011), Scrima A (2008), Groisman R (2003), Groisman R (2003), Schroefelbauer B (2007), Kulaksiz G (2005), Inoki T (2004), Bontron S (2002), Rapic-Otrin V (2003), Olma MH (2009), Liu W (2000), Jin J (2006), Huttlin EL (2015), Zhao R (2014), Xie X (2015), Groisman R (2006), Yang Y (2016), Huttlin EL (2017), Chitale S (2017), Fantini D (2017), Fantini D (2017), Ohtake F (2007)	31
KPNB1	3	CUL4B	8	pull down	Zou Y (2009)	1
CUL1	7	KPNA2	0	affinity chromatography technology	Bennett EJ (2010)	1
CDT1	2	CDK4	2	affinity chromatography technology	Liu E (2004)	1
CCNA2	1	CDK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henneke G (2003), Amador V (2007), Horton LE (1997), Lin ML (2011), Lin ML (2011), OConnor PM (1993), Varjosalo M (2013), Kikuchi R (2014), Mateo F (2009), So J (2015), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	13
CDC5L	2	COPS5	0	affinity chromatography technology	Lleres D (2010)	1
CDC5L	2	DDB1	6	affinity chromatography technology	Lleres D (2010)	1
HDAC11	0	GMNN	0	affinity chromatography technology	Wong PG (2010)	1
CDK1	0	CKS1B	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Wolthuis R (2008), Havugimana PC (2012), Hixon ML (1998), Varjosalo M (2013), Radulovic M (2010), Rolland T (2014), So J (2015), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	11
EP300	36	ANAPC5	2	affinity chromatography technology	Turnell AS (2005)	1
CCNA2	1	CCNA1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CKS2	0	CDT1	2	affinity chromatography technology	Huttlin EL (2017)	1
CDK3	0	CKS1B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
CUL4B	8	GRWD1	3	affinity chromatography technology, affinity chromatography technology	Higa LA (2006), Higa LA (2006)	2
CDC20	1	CDC23	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nilsson J (2008), Fogeron ML (2013), Hein JB (2014), Hein MY (2015), Kelly A (2014), Craney A (2016), Qiao R (2016), Qiao R (2016)	8
CDK2	0	SMARCA5	4	affinity chromatography technology	Neganova I (2011)	1
CDT1	2	CCNE1	1	affinity chromatography technology	Liu E (2004)	1
CDT1	2	SMARCA5	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sugimoto N (2008), Sugimoto N (2008), Sugimoto N (2008), Sugimoto N (2011), Sugimoto N (2011), Sugimoto N (2011)	6
CUL4A	2	CDT1	2	affinity chromatography technology, affinity chromatography technology, biochemical	Hu J (2004), Higa LA (2003), He YJ (2006)	3
CDC5L	2	ORC2	0	pull down, affinity chromatography technology	Ramachandran N (2004), Lleres D (2010)	2
CDK1	0	FZR1	1	enzymatic study, affinity chromatography technology	Gutierrez GJ (2010), Huttlin EL (2017)	2
CUL4A	2	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Angers S (2006), Jin J (2006), Wang H (2006), Kapetanaki MG (2006), Matsuda N (2005), Hu J (2004), Hu J (2004), Hu J (2004), Ahn J (2010), Maddika S (2009), Fischer ES (2011), Tan L (2007), He YJ (2006), He YJ (2006), He YJ (2006), McCall CM (2008), McCall CM (2008), Shiyanov P (1999), Bennett EJ (2010), Gastaldello S (2012), Kanei-Ishii C (2012), Hodgson AJ (2012), Kulaksiz G (2005), Wu Z (2012), Wu Z (2012), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Rao F (2014), Wan C (2015), Liu Y (2015), Zha Z (2015), Mouysset J (2015), Gao J (2015), Yang Y (2016), Yang Y (2016), Scherer PC (2016), Eichner R (2016), Mo Y (2017), Mo Y (2017), Peng Z (2016), Higa LA (2006), Ohtake F (2007)	46
EP300	36	PCNA	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Hasan S (2001), Hasan S (2001), Hasan S (2001), Hong R (2003), Hong R (2003), Cazzalini O (2008), Cazzalini O (2008), Naryzhny SN (2004), Cazzalini O (2014), Cazzalini O (2014)	10
CDK1	0	CKS2	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Wolthuis R (2008), Varjosalo M (2013), Radulovic M (2010), So J (2015), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	8
CDK2	0	GMNN	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
CDK3	0	CDT1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KPNB1	3	KPNA2	0	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Nagoshi E (2001), Koehler M (1999), Kutay U (1997), Hein MY (2015), Huttlin EL (2017)	5
CUL4A	2	GRWD1	3	affinity chromatography technology, affinity chromatography technology	Higa LA (2006), He YJ (2006)	2
EP300	36	DDB1	6	affinity chromatography technology, affinity chromatography technology	Datta A (2001), Rapic-Otrin V (2002)	2
DDB1	6	DTL	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jin J (2006), Jin J (2006), Jin J (2006), Higa LA (2006), Rossi M (2013), Shibata E (2011), Higa LA (2006), Higa LA (2006)	8
MCM7	5	ORC2	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
DDB1	6	SKP2	2	affinity chromatography technology	Bondar T (2006)	1
MCM4	3	MCM2	3	pull down, two hybrid, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), You Z (1999), Ishimi Y (1996), Tan BC (2006), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Drissi R (2015), Boldt K (2016)	11
MCM2	3	MCM6	5	two hybrid, pull down, pull down, two hybrid, two hybrid, two hybrid, biochemical, affinity chromatography technology, biochemical, biochemical, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Yabuta N (2003), Yabuta N (2003), Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), You Z (1999), You Z (2002), Havugimana PC (2012), Kristensen AR (2012), Rolland T (2014), Wan C (2015), Hein MY (2015), Drissi R (2015), Boldt K (2016)	15
TOP1	1	CDC6	0	genetic interference	Srivas R (2016)	1
CDK2	0	MCM2	3	enzymatic study, affinity chromatography technology	Montagnoli A (2006), Neganova I (2011)	2
CKS1B	0	CKS2	0	affinity chromatography technology	Huttlin EL (2017)	1
MAPK14	0	CDK4	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
HECW2	13	CCNA1	3	affinity chromatography technology	Lu L (2013)	1
CUL1	7	NPM1	0	affinity chromatography technology	Bennett EJ (2010)	1
HECW2	13	CDT1	2	affinity chromatography technology	Lu L (2013)	1
CDT1	2	TRIP4	2	affinity chromatography technology	Hein MY (2015)	1
COPS5	0	TOP1	1	affinity chromatography technology	Bennett EJ (2010)	1
CDC5L	2	CCNB1	3	affinity chromatography technology	Lleres D (2010)	1
CDT1	2	ANKHD1	0	affinity chromatography technology	Hein MY (2015)	1
CDK2	0	NPM1	0	enzymatic study	Tokuyama Y (2001)	1
FZR1	1	CCNE1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
GMNN	0	SKP2	2	affinity chromatography technology	Huttlin EL (2017)	1
CUL4B	8	DDB2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Higa LA (2006), Bennett EJ (2010), Jin J (2006), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	9
CDC6	0	CDC20	1	pull down	Ke PY (2004)	1
CDT1	2	ANAPC5	2	affinity chromatography technology	Sugimoto N (2008)	1
FZR1	1	CDC20	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Stewart S (2005), Stewart S (2005), Wang Y (2007), Wang Y (2007), Tian W (2012), Hyun SY (2013), Hyun SY (2013)	7
CUL4B	8	CDT1	2	affinity chromatography technology	Higa LA (2003)	1
ORC2	0	MCM2	3	two hybrid, two hybrid, affinity chromatography technology, pull down	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Ramachandran N (2004)	4
TP73	2	CDC20	1	affinity chromatography technology, affinity chromatography technology	Katayama H (2012), Katayama H (2012)	2
CDK2	0	TFDP1	3	enzymatic study, affinity chromatography technology, affinity chromatography technology	Dynlacht BD (1997), Dynlacht BD (1997), So J (2015)	3
CUL1	7	FZR1	1	affinity chromatography technology, affinity chromatography technology	Fukushima H (2013), Fukushima H (2013)	2
CDC20	1	CKS2	0	affinity chromatography technology	Huttlin EL (2017)	1
CKS1B	0	CCNE1	1	affinity chromatography technology	Huttlin EL (2017)	1
FZR1	1	CCNA1	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Sorensen CS (2001), Sorensen CS (2001), Gao D (2009), Fukushima H (2013)	4
SKP2	2	CKS1B	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, fluorescent resonance energy transfe, pull down, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Wang W (2003), Wang W (2003), Sitry D (2002), Sitry D (2002), Ganoth D (2001), Calvisi DF (2008), Xu S (2007), Ungermannova D (2005), Spruck C (2001), Yao ZP (2006), Seeliger MA (2005), Huang KS (2005), Rodier G (2008), Ungermannova D (2013), Radulovic M (2010), Huttlin EL (2017)	16
CDT1	2	CDC20	1	pull down	Sugimoto N (2008)	1
XPO1	8	KAT7	3	affinity chromatography technology	Kirli K (2015)	1
CDK1	0	CDC6	0	enzymatic study	Jiang W (1999)	1
CUL1	7	TOP1	1	affinity chromatography technology	Bennett EJ (2010)	1
KAT7	3	ORC1	3	affinity chromatography technology, pull down, two hybrid	Iizuka M (1999), Iizuka M (1999), Iizuka M (1999)	3
CUL1	7	CKS1B	0	affinity chromatography technology, pull down, affinity chromatography technology	Bennett EJ (2010), Radulovic M (2010), Huttlin EL (2017)	3
CDT1	2	BAZ1B	5	affinity chromatography technology, pull down	Sugimoto N (2008), Sugimoto N (2008)	2
CUL1	7	DDB1	6	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Gastaldello S (2012)	2
GMNN	0	TFDP1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016)	2
ANAPC5	2	TFDP1	3	affinity chromatography technology	Nath S (2014)	1
CKS2	0	GMNN	0	affinity chromatography technology	Huttlin EL (2017)	1
CCNE1	1	CDK1	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Koff A (1992), Koff A (1992), Horton LE (1997)	4
SKP2	2	ORC1	3	pull down, affinity chromatography technology	Mendez J (2002), Mendez J (2002)	2
CUL1	7	CDK3	0	affinity chromatography technology	Bennett EJ (2010)	1
CDT1	2	CDK2	0	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Liu E (2004), Sugimoto N (2004), Sugimoto N (2004), Takeda DY (2005), Varjosalo M (2013), Hein MY (2015)	6
CUL4B	8	PCNA	0	affinity chromatography technology	Banks D (2006)	1
XPO1	8	FOXO3	1	affinity chromatography technology	Kirli K (2015)	1
DDB1	6	COPS5	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Angers S (2006), Jin J (2006), Emberley ED (2012), Bennett EJ (2010), Olma MH (2009), He F (2013)	6
CDT1	2	MCM2	3	pull down	Chandrasekaran S (2011)	1
USP37	1	MCM6	5	bioid	Yeh C (2015)	1
XPO1	8	CCNB1	3	affinity chromatography technology	Kirli K (2015)	1
FZR1	1	ANAPC5	2	unspecified method, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Sedgwick GG (2012), Huttlin EL (2017)	3
CUL4A	2	NPM1	0	affinity chromatography technology	Bennett EJ (2010)	1
TP73	2	KAT2B	2	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhao LY (2003), Zhao LY (2003), Zhao LY (2003), Zhao LY (2003), Hoffmann A (2008)	5
DTL	0	CDT1	2	enzymatic study, pull down, pull down	Hayashi A (2014), Chandrasekaran S (2011), Coleman KE (2015)	3
CCNA1	3	SKP2	2	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ji P (2006), Ji P (2006), Ji P (2006), Yam CH (2000), Gao D (2009), Ji P (2007)	6
MCM6	5	MCM7	5	pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), Fujita M (1997), You Z (2002), Havugimana PC (2012), Ryu MJ (2006), Wan C (2015), Hein MY (2015), Boldt K (2016)	10
CDK2	0	KPNB1	3	affinity chromatography technology	Neganova I (2011)	1
CDC5L	2	TOP2A	2	affinity chromatography technology, biochemical, affinity chromatography technology	Ajuh P (2000), Ajuh P (2000), Lleres D (2010)	3
EP300	36	CDT1	2	enzymatic study	Glozak MA (2009)	1
FAF1	1	CDT1	2	affinity chromatography technology	Franz A (2016)	1
COPS5	0	KPNB1	3	affinity chromatography technology	Bennett EJ (2010)	1
CDC5L	2	MCM4	3	pull down	Ramachandran N (2004)	1
XPO1	8	CDT1	2	affinity chromatography technology	Kirli K (2015)	1
ANAPC5	2	ANAPC7	2	biochemical, affinity chromatography technology	Havugimana PC (2012), Sedgwick GG (2012)	2
CCNA2	1	CKS2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wolthuis R (2008), Mateo F (2009), Huttlin EL (2015), Huttlin EL (2017)	4
COPS5	0	SKP2	2	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
CDK2	0	TOP1	1	affinity chromatography technology	Neganova I (2011)	1
MAPK14	0	COPS5	0	two hybrid	Wang J (2008)	1
DDB2	1	KAT7	3	affinity chromatography technology	Matsunuma R (2015)	1
CCNA1	3	CDK1	0	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Sweeney C (1996), Lukas J (1992), Desai D (1995), Rohaly G (2005)	4
FBXO31	4	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kumar R (2005), Bennett EJ (2010), Vadhvani M (2013), Jeong YT (2013), Hein MY (2015), Malonia SK (2015), Jeffery JM (2017), Reitsma JM (2017)	8
HECW2	13	CDC20	1	affinity chromatography technology	Lu L (2013)	1
CDK2	0	TP73	2	enzymatic study	Gaiddon C (2003)	1
CCNB1	3	CDK3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin Z (2015), Lin Z (2015), Huttlin EL (2017)	3
MCM4	3	ORC1	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
FZR1	1	ANAPC7	2	unspecified method, affinity chromatography technology	Vodermaier HC (2003), Sedgwick GG (2012)	2
CDT1	2	KPNA2	0	affinity chromatography technology	Sugimoto N (2008)	1
MCM6	5	ORC2	0	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CDC5L	2	SMARCA5	4	affinity chromatography technology	Lleres D (2010)	1
SKP2	2	TP73	2	affinity chromatography technology	Huttlin EL (2017)	1
CDK2	0	CDC5L	2	enzymatic study	Boudrez A (2000)	1
XPO1	8	GRWD1	3	affinity chromatography technology	Kirli K (2015)	1
CDT1	2	CDC23	3	affinity chromatography technology, pull down	Sugimoto N (2008), Sugimoto N (2008)	2
TP73	2	EP300	36	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Strano S (2005), Uramoto H (2004), Zeng X (2000), Zeng X (2000), Zeng X (2000), Zeng X (2000), Zeng X (2000), Mantovani F (2004), Burge S (2009), Burge S (2009), Costanzo A (2002), Hoffmann A (2008), Kramer D (2015)	13
CDK2	0	CKS1B	0	x-ray crystallography, affinity chromatography technology, x-ray crystallography, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Bourne Y (1996), Xu S (2007), Yao ZP (2006), Seeliger MA (2005), Varjosalo M (2013), Radulovic M (2010), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	12
CDK2	0	MCM4	3	enzymatic study, enzymatic study	Ishimi Y (2000), Komamura-Kohno Y (2006)	2
XPO1	8	TRIP4	2	affinity chromatography technology	Kirli K (2015)	1
NPM1	0	SLAIN2	2	affinity chromatography technology	Chen R (2013)	1
CUL4A	2	ANAPC5	2	affinity chromatography technology	Bennett EJ (2010)	1
CDK3	0	CCNA2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
ORC2	0	CCNA2	1	affinity chromatography technology	Mendez J (2002)	1
COPS5	0	CDK3	0	affinity chromatography technology	Bennett EJ (2010)	1
USP37	1	CCNA2	1	affinity chromatography technology, enzymatic study	Huang X (2011), Huang X (2011)	2
CUL1	7	CCNA2	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Hein MY (2015)	2
CUL4A	2	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guerrero-Santoro J (2008), Angers S (2006), Bennett EJ (2010), Bennett EJ (2010), Sertic S (2013)	5
USP37	1	MCM4	3	bioid	Yeh C (2015)	1
MCM2	3	KPNB1	3	affinity chromatography technology	Drissi R (2015)	1
XPO1	8	CDC23	3	affinity chromatography technology	Kirli K (2015)	1
MCM2	3	XPO1	8	affinity chromatography technology	Drissi R (2015)	1
CDC5L	2	CDC20	1	affinity chromatography technology	Lleres D (2010)	1
COPS5	0	KPNA2	0	affinity chromatography technology	Bennett EJ (2010)	1
CKS1B	0	CCNA2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jackman M (2002), Wolthuis R (2008), Mateo F (2009), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	6
CDK2	0	MCM7	5	affinity chromatography technology	Neganova I (2011)	1
CDC5L	2	TOP1	1	affinity chromatography technology	Lleres D (2010)	1
CDT1	2	ORC1	3	pull down	Ramachandran N (2004)	1
MCM6	5	ORC1	3	two hybrid, two hybrid	Kneissl M (2003), Kneissl M (2003)	2
CDC5L	2	CDC23	3	affinity chromatography technology	Lleres D (2010)	1
CDT1	2	CCNA1	3	affinity chromatography technology, affinity chromatography technology	Nishitani H (2004), Liu E (2004)	2
CUL1	7	CDK4	2	affinity chromatography technology	Bennett EJ (2010)	1
CDK2	0	USP37	1	enzymatic study, bioid	Huang X (2011), Yeh C (2015)	2
CUL4A	2	PCNA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Lo YH (2012), Banks D (2006)	3
CUL4B	8	CCNE1	1	affinity chromatography technology, affinity chromatography technology	Higa LA (2006), Higa LA (2006)	2
CCNB1	3	FZR1	1	pull down, enzymatic study, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, imaging technique, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology	Ke PY (2004), Huang NJ (2012), Pfleger CM (2001), Miller JJ (2006), Song MS (2011), Frye JJ (2013), Lau AW (2013), Brown NG (2014), Summers MK (2009), ODonovan KJ (2010), Wu T (2010), Shoji S (2014), Vodermaier HC (2003), Kim HS (2011), Lu L (2013), Yamaguchi M (2015), Brown NG (2015), Chen TC (2014), Williamson A (2011), Qiao R (2016), Brown NG (2016), Huttlin EL (2017)	22
MCM4	3	MCM6	5	pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), Ishimi Y (1996), You Z (2002), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Boldt K (2016)	10
CCNE1	1	CDC6	0	enzymatic study	Jiang W (1999)	1
TFDP1	3	CDK3	0	affinity chromatography technology	Hofmann F (1996)	1
CDC20	1	ANAPC7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nilsson J (2008), Townsend K (2009), Townsend K (2009), Townsend K (2009), Sedgwick GG (2012), Fogeron ML (2013), Hein JB (2014), Vodermaier HC (2003), Kelly A (2014), Craney A (2016), Craney A (2016), Qiao R (2016), Hein JB (2016)	13
SKP2	2	FZR1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Calvisi DF (2009), Cen B (2010), Bashir T (2004), Bashir T (2004), Hu D (2011), Fukushima H (2013), Gao D (2009), Gao D (2009), Inuzuka H (2012), Inuzuka H (2012), Inuzuka H (2012), Huttlin EL (2017)	12
PCNA	0	TOP1	1	affinity chromatography technology	Takasaki Y (2001)	1
TP63	0	CDT1	2	affinity chromatography technology	Lunardi A (2010)	1
CCNA2	1	FZR1	1	pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Mateo F (2009), Jin L (2008), Mateo F (2009), Mateo F (2009), Huttlin EL (2015), Williamson A (2011), Huttlin EL (2017), Choudhury R (2016)	8
TOP1	1	DDB2	1	unspecified method	Trzcinska AM (2002)	1
HECW2	13	TP73	2	affinity chromatography technology, affinity chromatography technology, pull down	Miyazaki K (2003), Miyazaki K (2003), Miyazaki K (2003)	3
CDC20	1	CKS1B	0	affinity chromatography technology, affinity chromatography technology	Bashir T (2004), Huttlin EL (2017)	2
CDC6	0	MCM7	5	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Fujita M (1999), Fujita M (1999), Sugimoto N (2015), Hubbi ME (2013)	7
CUL4A	2	CUL1	7	biochemical	He YJ (2006)	1
CDC20	1	CCNB1	3	enzymatic study, enzymatic study, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, pull down, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Garnett MJ (2009), ODonovan KJ (2010), Ke PY (2004), Braunstein I (2007), van Zon W (2010), van Zon W (2010), Pfleger CM (2001), Wolthuis R (2008), Kwan PS (2013), Tian W (2012), Han JS (2013), Lim HJ (2013), Han JS (2014), Brown NG (2014), Townsend K (2009), Sedgwick GG (2013), Lara-Gonzalez P (2011), Wu T (2010), Shoji S (2014), Vodermaier HC (2003), Kim HS (2011), Wu T (2010), Uzunova K (2012), Shoji S (2014), Sedgwick GG (2013), Lara-Gonzalez P (2011), Diaz-Martinez LA (2015), Brown NG (2015), Lischetti T (2014), Tipton AR (2013), Lee SB (2015), Lee SB (2015), Jia L (2016)	33
MCM2	3	CUL4A	2	affinity chromatography technology	Drissi R (2015)	1
CDK4	2	MCM2	3	pull down	Ramachandran N (2004)	1
MCM7	5	GRWD1	3	imaging technique	Sugimoto N (2015)	1
TP73	2	CDT1	2	affinity chromatography technology	Lunardi A (2010)	1
CCNB1	3	CDK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Yang Q (2000), Pines J (1989), Kong M (2000), Amador V (2007), Paulsen MT (2006), Niida H (2005), Pereg Y (2010), Tamura D (2010), Kiviharju-af Haellstroem TM (2007), Pan ZQ (1993), Pan ZQ (1993), Pan ZQ (1993), van Zon W (2010), Desai D (1995), Vazquez-Novelle MD (2010), Smith EM (2008), Poon RY (1996), OConnor PM (1993), Fosbrink M (2009), Linares JF (2011), Varjosalo M (2013), Felzien LK (1998), Toby GG (2003), So J (2015), Huttlin EL (2015), Wan C (2015), Jenkins RH (2014), Hein MY (2015), Hein MY (2015), Voets E (2015), Lin Z (2015), Lin Z (2015), Huttlin EL (2017)	34
COPS5	0	DDB2	1	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), He YJ (2006), Groisman R (2003), Groisman R (2003), Bennett EJ (2010), Kulaksiz G (2005), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	9
MAPK14	0	EP300	36	pull down, enzymatic study, affinity chromatography technology	Pillai VB (2011), Pillai VB (2011), Saha RN (2007)	3
CKS1B	0	CCNA1	3	pull down	Radulovic M (2010)	1
CCNA1	3	MCM6	5	pull down	Ramachandran N (2004)	1
FZR1	1	CDC23	3	unspecified method, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Hein MY (2015), Huttlin EL (2017)	3
CDT1	2	BZW1	0	affinity chromatography technology	Hein MY (2015)	1
EP300	36	ORC2	0	pull down	Karmakar S (2010)	1
CCNA2	1	CDK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henneke G (2003), Naderi S (2005), Varshochi R (2005), Di Fiore B (2010), Mateo F (2009), Abbas T (2007), Schulman BA (1998), Datta NS (1998), Wu G (1997), Sebastian B (1993), Liu S (2009), Ciarallo S (2002), Wolthuis R (2008), Vicent GP (2011), Zhang H (1995), Sayle KL (2003), Jeffrey PD (1995), Davies TG (2001), Cook A (2002), Pevarello P (2006), Levkau B (1998), Poon RY (1996), OConnor PM (1993), Davies TG (2002), Kontopidis G (2003), Andrews MJ (2004), Pevarello P (2004), Pevarello P (2005), Varjosalo M (2013), Varjosalo M (2013), Kikuchi R (2014), Kikuchi R (2014), Mateo F (2009), So J (2015), Okamoto K (2002), Song MS (2011), Huttlin EL (2015), Di Fiore B (2015), Pan ZQ (1993), Pan ZQ (1993), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	43
TOP2A	2	CDC6	0	genetic interference	Srivas R (2016)	1
CUL1	7	TIMM13	0	affinity chromatography technology	Bennett EJ (2010)	1
CDT1	2	MCM6	5	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology	Sugimoto N (2008), Teer JK (2008), Liu C (2011), Hein MY (2015)	4
CDC6	0	ORC1	3	two hybrid, two hybrid, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, pull down	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Saha P (1998), Saha P (1998), Saha P (1998), Ramachandran N (2004)	7
CCNB1	3	TP73	2	pull down	Gaiddon C (2003)	1
EP300	36	NPM1	0	enzymatic study	Swaminathan V (2005)	1
DDB1	6	GRWD1	3	affinity chromatography technology	He YJ (2006)	1
CDC5L	2	KPNA2	0	affinity chromatography technology	Lleres D (2010)	1
CDT1	2	TIMM13	0	affinity chromatography technology	Hein MY (2015)	1
COPS5	0	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), He F (2013), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	9
TOP1	1	GRWD1	3	unspecified method	Trzcinska AM (2002)	1
ORC1	3	CCNA2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mendez J (2002), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	4
CUL1	7	PCNA	0	affinity chromatography technology	Bennett EJ (2010)	1
CKS2	0	CDK2	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Radulovic M (2010), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	6
CDC6	0	MCM2	3	pull down, affinity chromatography technology	Ramachandran N (2004), Hubbi ME (2013)	2
ANAPC5	2	CDC23	3	biochemical, affinity chromatography technology	Havugimana PC (2012), Hein MY (2015)	2
PCNA	0	CCNE1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SKP2	2	CDC20	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cen B (2010), Bashir T (2004), Kelly A (2014), Craney A (2016), Huttlin EL (2017)	5
KAT2B	2	CCNA2	1	affinity chromatography technology, pull down, enzymatic study	Mateo F (2009), Mateo F (2009), Mateo F (2009)	3
CDC23	3	ANAPC7	2	biochemical, affinity chromatography technology, affinity chromatography technology	Wan C (2015), Hein MY (2015), Boldt K (2016)	3
FZR1	1	CDK4	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CDT1	2	DDB2	1	affinity chromatography technology	Hu J (2004)	1
USP37	1	ANAPC5	2	affinity chromatography technology, bioid	Huang X (2011), Yeh C (2015)	2
COPS5	0	CDK4	2	affinity chromatography technology	Bennett EJ (2010)	1
CDC6	0	CCNA2	1	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Petersen BO (1999), Petersen BO (1999), Saha P (1998), Jiang W (1999)	4
EP300	36	CDK2	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Felzien LK (1999), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	4
CDK2	0	FZR1	1	enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology	Sorensen CS (2001), Fukushima H (2013), Lau AW (2013), Chang L (2015), Huttlin EL (2017)	5
PCNA	0	MCM7	5	affinity chromatography technology	Han J (2014)	1
SKP2	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (2003), Min KW (2003), Lisztwan J (1998), Lisztwan J (1998), Marti A (1999), Zheng N (2002), Menon S (2008), Chew EH (2007), Chew EH (2007), Ji P (2006), Sabile A (2006), Tan P (1999), Lin HK (2009), Nie L (2011), Chua YS (2011), Huang Z (2004), Wu J (2012), Koyama-Nasu R (2007), Bashir T (2010), Saiga T (2009), Choo YY (2011), Jonason JH (2007), Jonason JH (2007), Bennett EJ (2010), Michel JJ (1998), Carrano AC (1999), Lyapina SA (1998), Lyapina SA (1998), Wu J (2012), Yu ZK (1998), Yu ZK (1998), Rodier G (2008), Swarnalatha M (2013), Cordero-Espinoza L (2013), Yumimoto K (2013), Chung FZ (2014), Zhou W (2014), Zhou W (2014), Yumimoto K (2012), Zhang S (2016), Zhang S (2016), Huttlin EL (2017), Kuchay S (2017), Reitsma JM (2017), Reitsma JM (2017), Ma X (2017)	46
COPS5	0	CCNA2	1	affinity chromatography technology	Bennett EJ (2010)	1
FZR1	1	CKS1B	0	affinity chromatography technology	Bashir T (2004)	1
COPS5	0	ANAPC7	2	affinity chromatography technology	Bennett EJ (2010)	1
CKS1B	0	CDT1	2	affinity chromatography technology	Huttlin EL (2017)	1
TIMM13	0	TIMM8A	0	affinity chromatography technology, affinity chromatography technology, biochemical	Ewing RM (2007), Roesch K (2002), Wan C (2015)	3
ORC1	3	CDK2	0	affinity chromatography technology, enzymatic study	Mendez J (2002), Mendez J (2002)	2
XPO1	8	SLAIN2	2	affinity chromatography technology	Kirli K (2015)	1
COPS5	0	CCNA1	3	affinity chromatography technology	Bennett EJ (2010)	1
CCNA2	1	PCNA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henneke G (2003), Huttlin EL (2015), Huttlin EL (2017)	3
CDK2	0	CDK3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
CCNB1	3	CKS1B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wolthuis R (2008), Hein MY (2015), Huttlin EL (2017)	3
CCNA2	1	TP73	2	enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Gaiddon C (2003), Gaiddon C (2003), Gaiddon C (2003), Gaiddon C (2003)	4
GMNN	0	MCM6	5	pull down	Ramachandran N (2004)	1
HECW2	13	CDC23	3	affinity chromatography technology	Lu L (2013)	1
CDT1	2	TIMM8A	0	affinity chromatography technology	Hein MY (2015)	1
CDK4	2	TOP1	1	genetic interference	Shen JP (2017)	1
MCM7	5	CDT1	2	imaging technique	Sugimoto N (2015)	1
CUL1	7	CDC5L	2	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Lleres D (2010)	2
CDT1	2	TOP2A	2	pull down, affinity chromatography technology, affinity chromatography technology	Sugimoto N (2008), Sugimoto N (2008), Sugimoto N (2008)	3
CDC6	0	ORC2	0	two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down	Kneissl M (2003), Kneissl M (2003), Kneissl M (2003), Mendez J (2000), Ramachandran N (2004)	5
TP63	0	TP73	2	affinity chromatography technology	Huttlin EL (2017)	1
KAT2B	2	TP63	0	enzymatic study, enzymatic study	MacPartlin M (2005), Chae YS (2012)	2
KAT2B	2	CDK2	0	pull down, affinity chromatography technology, enzymatic study	Mateo F (2009), Mateo F (2009), Mateo F (2009)	3
CCNE1	1	CDK2	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McKenzie PP (2003), Shanahan F (1999), Koff A (1992), Koff A (1992), Mayer C (2004), Connor MK (2003), Boudrez A (2000), Varshochi R (2005), Jeong JH (2010), Bustany S (2011), Yeh ES (2006), Hui S (2011), Kim J (2007), Kiviharju-af Haellstroem TM (2007), Abbas T (2007), Nishimura T (2005), Matsumoto Y (2004), Harwell RM (2004), Harwell RM (2004), Peiretti A (2003), Peiretti A (2003), Kim YB (2000), Manenti S (1999), Datta NS (1998), Sheaff RJ (1997), Higashi H (1996), Higashi H (1996), Musgrove EA (1996), Vlach J (1996), Grim JE (2008), Liu S (2009), Ciarallo S (2002), Desai D (1995), Baydoun HH (2010), Baydoun HH (2010), Chu I (2007), Chu I (2007), Levkau B (1998), Poon RY (1996), Zhao J (1998), Zhao J (1998), Larrea MD (2009), Varjosalo M (2013), Varjosalo M (2013), Chan HM (2001), So J (2015), Ungermannova D (2005), Song MS (2011), Huttlin EL (2015), Hein MY (2015), Lin CH (2015), Lin CH (2015), Davis RJ (2017), Huttlin EL (2017)	54
PCNA	0	CDC6	0	two hybrid	Saha P (1998)	1