PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HSP90AA1	7	UBA1	1	affinity chromatography technology	Falsone SF (2005)	1
VIM	0	INA	2	affinity chromatography technology	Huttlin EL (2017)	1
CUL3	17	VIM	0	affinity chromatography technology	Bennett EJ (2010)	1
GAN	4	CUL3	17	affinity chromatography technology, affinity chromatography technology	Zhang DD (2005), Bennett EJ (2010)	2
GAN	4	UBA1	1	two hybrid, affinity chromatography technology	Allen E (2005), Allen E (2005)	2
HSP90AA1	7	GAN	4	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Johnson-Kerner BL (2015)	2
VIM	0	PRPH	3	two hybrid	Vinayagam A (2011)	1
RELA	1	GAN	4	affinity chromatography technology, affinity chromatography technology	Veena MS (2014), Veena MS (2014)	2
CUL3	17	UBA1	1	affinity chromatography technology	Bennett EJ (2010)	1
SFN	1	GAN	4	affinity chromatography technology, affinity chromatography technology	Benzinger A (2005), Huttlin EL (2015)	2
GAN	4	VIM	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Johnson-Kerner BL (2015), Johnson-Kerner BL (2015), Johnson-Kerner BL (2015), Huttlin EL (2017)	4
VIM	0	NEFM	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
CUL3	17	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Taipale M (2012)	2
NEFM	0	INA	2	affinity chromatography technology	Huttlin EL (2017)	1
GAN	4	NEFM	0	affinity chromatography technology, affinity chromatography technology	Johnson-Kerner BL (2015), Huttlin EL (2017)	2
GAN	4	ZC3H13	8	affinity chromatography technology, affinity chromatography technology	Johnson-Kerner BL (2015), Huttlin EL (2017)	2
CUL3	17	PRPH	3	affinity chromatography technology	Bennett EJ (2010)	1
GAN	4	INA	2	affinity chromatography technology, affinity chromatography technology	Johnson-Kerner BL (2015), Huttlin EL (2017)	2
GAN	4	TBCB	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang W (2005), Wang W (2005), Wang W (2005), Tan H (2017), Tan H (2017)	5
CSPP1	7	GAN	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GAN	4	PRPH	3	affinity chromatography technology, affinity chromatography technology	Johnson-Kerner BL (2015), Johnson-Kerner BL (2015)	2