PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EP300	36	MAF	4	two hybrid, affinity chromatography technology, affinity chromatography technology	Chen Q (2002), Chen Q (2002), Chen Q (2002)	3
ATF3	0	ATF2	1	two hybrid, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Ravasi T (2010), Reinke AW (2013), Reinke AW (2013)	3
DNMT3L	2	DDIT3	1	pull down	Pacaud R (2014)	1
ATF4	2	JUN	0	pull down, two hybrid, fluorescent resonance energy transfe, fluorescent resonance energy transfe, imaging technique	Hai T (1991), Bandyopadhyay S (2010), Reinke AW (2013), Reinke AW (2013), Chen TC (2014)	5
CEBPE	0	FOSL1	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
CEBPE	0	JUN	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
TICAM1	3	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Jiang Z (2004), Nguyen VP (2014)	2
MYC	2	FOSL1	0	affinity chromatography technology	Agrawal P (2010)	1
ATXN1	2	FOSL1	0	two hybrid	Suter B (2013)	1
DDIT3	1	JUNB	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
FOSL1	0	CALCOCO1	2	two hybrid	Rual JF (2005)	1
JUNB	0	EP300	36	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Narayanan K (2004), Narayanan K (2004), Narayanan K (2004), Wang CC (2007), Wang WM (2011)	5
CEBPA	0	MAF	4	affinity chromatography technology	Zada AA (2006)	1
MAFB	1	MAF	4	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
FOSL1	0	LDOC1	0	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
JUN	0	MYC	2	affinity chromatography technology	Levy S (2010)	1
DNMT3L	2	ATF2	1	pull down	Pacaud R (2014)	1
JUNB	0	ATF2	1	affinity chromatography technology	Huttlin EL (2017)	1
CEBPE	0	CEBPA	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe, pull down	Reinke AW (2013), Reinke AW (2013), Reddy KV (2003)	3
FOSL1	0	EP300	36	affinity chromatography technology, enzymatic study	Crish JF (2008), Wang WM (2011)	2
FOSL1	0	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Cai B (2017), Cai B (2017)	2
MYC	2	EP300	36	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology	Faiola F (2005), Faiola F (2005), Faiola F (2005), Faiola F (2005), Faiola F (2005), Zhang K (2005), Covic M (2005), Fujii M (2006)	8
JUNB	0	CREB5	4	affinity chromatography technology	Huttlin EL (2017)	1
CEBPE	0	DDIT3	1	two hybrid, pull down	Chih DY (2004), Chih DY (2004)	2
JUNB	0	JUN	0	affinity chromatography technology	Huttlin EL (2017)	1
EP300	36	HDAC1	4	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Han Y (2008), Mayanil CS (2006), Simone C (2004), Simone C (2004), Simone C (2004), Liu Y (2012), Mizuguchi Y (2012)	7
DNMT3L	2	ATF4	2	pull down	Pacaud R (2014)	1
ATF2	1	CEBPA	0	two hybrid	Hong S (2004)	1
ATF4	2	CEBPA	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
DNMT3L	2	JUN	0	pull down	Pacaud R (2014)	1
CREB5	4	JUN	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nomura N (1993), Huttlin EL (2015), Hein MY (2015), Li X (2015), Huttlin EL (2017)	5
CEBPE	0	CEBPG	1	two hybrid, pull down, fluorescent resonance energy transfe	Chih DY (2004), Chih DY (2004), Reinke AW (2013)	3
FOSL1	0	TRIM24	1	two hybrid	Ravasi T (2010)	1
FOSL1	0	JUN	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Pognonec P (1997), Pognonec P (1997), Kumar NV (2001), Kumar NV (2001), Reinke AW (2013), Reinke AW (2013)	6
DDIT3	1	ATF3	0	affinity chromatography technology, pull down, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Chen BP (1996), Chen BP (1996), Reinke AW (2013), Reinke AW (2013)	4
ATF3	0	CREBBP	29	affinity chromatography technology, pull down	Kim HB (2010), Kim HB (2010)	2
CEBPG	1	ATF2	1	fluorescent resonance energy transfe	Reinke AW (2013)	1
CEBPG	1	ATF4	2	fluorescent resonance energy transfe, two hybrid	Reinke AW (2013), Rolland T (2014)	2
ATF3	0	CEBPE	0	imaging technique, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Lopez AB (2007), Reinke AW (2013), Reinke AW (2013)	3
DDIT3	1	CREBBP	29	affinity chromatography technology	Park SH (2010)	1
JUNB	0	FOSL1	0	two hybrid, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Rual JF (2005), Reinke AW (2013), Reinke AW (2013)	3
CEBPE	0	LDOC1	0	two hybrid, pull down	Chih DY (2004), Chih DY (2004)	2
CEBPA	0	JUN	0	affinity chromatography technology	Zada AA (2006)	1
DDIT3	1	ATF2	1	fluorescent resonance energy transfe	Reinke AW (2013)	1
DNMT3L	2	JUNB	0	pull down	Pacaud R (2014)	1
FOSL1	0	CREB5	4	two hybrid	Rolland T (2014)	1
FOSL1	0	PARVG	1	two hybrid	Wang J (2011)	1
DDIT3	1	CEBPA	0	affinity chromatography technology, two hybrid, affinity chromatography technology	Marwarha G (2016), Marwarha G (2016), Marwarha G (2016)	3
MAF	4	FOSL1	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
FOSL1	0	TAB2	5	two hybrid	Wang J (2011)	1
ATF3	0	CEBPA	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
ATF3	0	FOSL1	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
FOSL1	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology	Hoffmann E (2005), Hoffmann E (2005)	2
FOSL1	0	PSMC3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pakay JL (2012), Pakay JL (2012), Pakay JL (2012)	3
DDIT3	1	FOSL1	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
MYC	2	PSMC3	0	affinity chromatography technology, two hybrid	Koch HB (2007), Wang J (2011)	2
CEBPA	0	CEBPG	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
CREBBP	29	FOSL1	0	affinity chromatography technology	Tran NQ (2004)	1
JUN	0	HDAC1	4	affinity chromatography technology	Tenbrock K (2006)	1
CEBPG	1	JUN	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
CEBPG	1	FOSL1	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
JUN	0	ATF2	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Newell CL (1994), Newell CL (1994), Kara CJ (1990), Hai T (1991), Fuchs SY (1999), Reinke AW (2013), Reinke AW (2013), Miyamoto-Sato E (2010), Hayakawa J (2004), Hein MY (2015), Li X (2015), Huttlin EL (2017)	12
CEBPA	0	FOSL1	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
MAFB	1	ATF4	2	fluorescent resonance energy transfe	Reinke AW (2013)	1
ATF3	0	JUNB	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology	Reinke AW (2013), Reinke AW (2013), Huttlin EL (2017)	3
ATF3	0	HDAC1	4	affinity chromatography technology, pull down	Li HF (2010), Darlyuk-Saadon I (2012)	2
MAF	4	ATF4	2	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
MAFB	1	FOSL1	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
CREB5	4	ATF2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FOSL1	0	TICAM1	3	affinity chromatography technology	Cai B (2017)	1
MAF	4	CREBBP	29	affinity chromatography technology, affinity chromatography technology	Chen Q (2002), Chen Q (2002)	2
EP300	36	DDIT3	1	affinity chromatography technology, affinity chromatography technology, pull down	Jeong K (2014), Ohoka N (2007), Ohoka N (2007)	3
CEBPA	0	HDAC1	4	affinity chromatography technology, biochemical, imaging technique, affinity chromatography technology	Duan H (2005), Matsunaga N (2012), Matsunaga N (2012), Girard N (2013)	4
CREBBP	29	JUNB	0	affinity chromatography technology	Tran NQ (2004)	1
ATF4	2	EP300	36	affinity chromatography technology, pull down, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology	Lassot I (2005), Lassot I (2005), Lassot I (2005), Deng WG (2004), Deng WG (2004), Ohoka N (2007), Deng WG (2003)	7
MYC	2	LDOC1	0	pull down	Miyamoto-Sato E (2010)	1
CREBBP	29	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Crusselle-Davis VJ (2007), Dohda T (2004), Dohda T (2004)	3
ATF3	0	JUN	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Pearson AG (2003), Chen BP (1996), Hai T (1991), Filen S (2010), Reinke AW (2013), Reinke AW (2013), Hein MY (2015), Li X (2015)	8
TAB2	5	HDAC1	4	pull down	Baek SH (2002)	1
HDAC1	4	MYC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Matsuoka Y (2008), Matsuoka Y (2008), Liu T (2007), Liu T (2007), Liu T (2007), Koch HB (2007), Hwang IY (2012), Hein MY (2015)	8
DDIT3	1	JUN	0	pull down, affinity chromatography technology, fluorescent resonance energy transfe	Ubeda M (1999), Ubeda M (1999), Reinke AW (2013)	3
FOSL1	0	KPNA1	5	two hybrid	Wang J (2011)	1
HDAC1	4	CREBBP	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mayanil CS (2006), Chuang HC (2006), Chuang HC (2006)	3
ATF2	1	FOSL1	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
ATF4	2	FOSL1	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
CALCOCO1	2	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Kim JH (2006), Kim JH (2006), Yang CK (2006), Yang CK (2006)	4
FOSL1	0	WFDC1	0	two hybrid	Wang J (2011)	1
DNMT3L	2	ATF3	0	pull down	Pacaud R (2014)	1
DDIT3	1	HDAC1	4	affinity chromatography technology, affinity chromatography technology	Alter J (2012), Ohoka N (2007)	2
ATF4	2	DDIT3	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe, two hybrid	Reinke AW (2013), Reinke AW (2013), DeGrado-Warren J (2008)	3
ATF4	2	JUNB	0	two hybrid	Wang J (2011)	1
ATF4	2	LDOC1	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
USF1	0	FOSL1	0	two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid	Pognonec P (1997), Pognonec P (1997), Pognonec P (1997), Pognonec P (1997), Rolland T (2014)	5
ATXN1	2	PSMC3	0	two hybrid	Lim J (2006)	1
ATF4	2	CREBBP	29	pull down, affinity chromatography technology, imaging technique	Liang G (1997), Venza I (2001), Chen TC (2014)	3
MYC	2	CEBPA	0	affinity chromatography technology	Tinel M (2003)	1
ATF3	0	CEBPG	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
CREBBP	29	ATF2	1	pull down, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Sano Y (1998), Sano Y (1998), Sano Y (1998), Sano Y (1998), Deb S (2006), Merika M (1998), Johnson J (2007), Venza I (2001)	8
DNMT3L	2	HDAC1	4	pull down, pull down, pull down, pull down, affinity chromatography technology	Aapola U (2002), Aapola U (2002), Deplus R (2002), Deplus R (2002), Deplus R (2002)	5
FOSL1	0	NME7	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
CEBPG	1	DDIT3	1	two hybrid, affinity chromatography technology, two hybrid	Rual JF (2005), Hattori T (2003), Rolland T (2014)	3
ATF4	2	ATF2	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
ATF4	2	CEBPE	0	imaging technique, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Lopez AB (2007), Reinke AW (2013), Reinke AW (2013)	3
EP300	36	JUN	0	pull down, biochemical, x-ray crystallography, affinity chromatography technology, pull down, enzymatic study, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Campbell KM (2002), Campbell KM (2002), Campbell KM (2002), Subbaramaiah K (2002), Duyndam MC (1999), Wang WM (2011), Deng WG (2004), Deng WG (2004), Cheng SE (2011), Cheng SE (2011), Kim BK (2014), Vries RG (2001), Deng WG (2003), Liu L (2017), Liu L (2017)	15
DNMT3L	2	FOSL1	0	pull down	Pacaud R (2014)	1
ATF4	2	TRIM24	1	two hybrid	Ravasi T (2010)	1
ATF4	2	ATF3	0	affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Wang Q (2009), Reinke AW (2013), Reinke AW (2013)	3
HDAC1	4	KPNA1	5	affinity chromatography technology	Joshi P (2013)	1
CREBBP	29	JUN	0	pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, far western blotting	Sano Y (1998), Sano Y (1998), Merika M (1998), Duyndam MC (1999), Johnson J (2007), Yamaguchi K (2005), Tsai LN (2008), Arias J (1994)	8
EP300	36	ATF2	1	biochemical	Duyndam MC (1999)	1
CREBBP	29	MYC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, enzymatic study	de Nigris F (2007), de Nigris F (2007), Vervoorts J (2003), Vervoorts J (2003), Vervoorts J (2003), Vervoorts J (2003), Vervoorts J (2003)	7
USF1	0	EP300	36	affinity chromatography technology	Crusselle-Davis VJ (2007)	1