PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EGLN3	0	PSMC1	2	affinity chromatography technology	Rodriguez J (2016)	1
RXRA	1	NCOA4	4	two hybrid, pull down	Heinlein CA (1999), Heinlein CA (1999)	2
KIFC3	3	HERC2	9	affinity chromatography technology	Hein MY (2015)	1
MAPK6	1	PSMC1	2	affinity chromatography technology	Rodriguez J (2016)	1
AKT1	1	AR	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin HK (2001), Lin HK (2001), Deep G (2008), Deep G (2008), Steely AM (2017)	5
KIFC3	3	NCOA4	4	affinity chromatography technology	Hein MY (2015)	1
PPARG	0	VDR	2	pull down, affinity chromatography technology	Alimirah F (2012), Alimirah F (2012)	2
NCOA4	4	TAX1BP1	3	affinity chromatography technology	Goodwin JM (2017)	1
KAT2B	2	AKT1	1	enzymatic study, affinity chromatography technology	Sundaresan NR (2011), Sundaresan NR (2011)	2
HUWE1	22	PSMC1	2	affinity chromatography technology	Thompson JW (2014)	1
AKT1	1	ESR1	0	enzymatic study	Campbell RA (2001)	1
USP43	1	NCOA4	4	affinity chromatography technology	Hein MY (2015)	1
PPARG	0	NCOA4	4	two hybrid, pull down, unspecified method	Heinlein CA (1999), Heinlein CA (1999), Lee G (2002)	3
PSMC1	2	HERC2	9	affinity chromatography technology	Hein MY (2015)	1
KIFC3	3	GMCL1	0	two hybrid	Rolland T (2014)	1
MAPK6	1	HUWE1	22	affinity chromatography technology, affinity chromatography technology	Rodriguez J (2016), Rodriguez J (2016)	2
PSMD14	3	NCOA4	4	affinity chromatography technology	Hein MY (2015)	1
ATXN2	3	NCOA4	4	two hybrid	Lim J (2006)	1
NEURL4	3	MAPK6	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Al-Hakim AK (2012), Varjosalo M (2013), Huttlin EL (2017), Rodriguez J (2016)	4
EGLN3	0	MAPK6	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang J (2011), Rodriguez J (2016), Rodriguez J (2016), Rodriguez J (2016), Rodriguez J (2016)	5
NCOA4	4	NEURL4	3	affinity chromatography technology	Huttlin EL (2017)	1
PSMC1	2	NCOA4	4	affinity chromatography technology	Hein MY (2015)	1
EGLN3	0	NCOA4	4	affinity chromatography technology	Rodriguez J (2016)	1
VDR	2	RXRA	1	pull down, two hybrid, pull down, affinity chromatography technology, imaging technique, pull down, imaging technique, imaging technique, pull down, pull down, pull down, pull down, pull down, two hybrid, pull down, two hybrid, pull down, pull down, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, imaging technique, two hybrid, two hybrid, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology	Baudino TA (1998), Baudino TA (1998), Zhang C (2001), Song CS (2006), Dunlop TW (2005), Ting HJ (2005), Kim S (2005), Kim S (2005), Solomon C (2001), Liu YY (2000), Liu YY (2000), Rachez C (2000), Jimenez-Lara AM (1999), Yanagisawa J (1999), Yanagisawa J (1999), Yanagisawa J (1999), Ismail A (2004), Carvallo L (2008), Peleg S (2010), Albers M (2005), Herdick M (2000), Pedigo NG (2005), Hsieh JC (2003), Sorg BL (2006), Seuter S (2007), Seuter S (2007), Wang J (2011), Bartik L (2010), Rochel N (2011), Molnar F (2005), Ahmad K (2015), Ahmad K (2015)	32
EGLN3	0	XPO1	8	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	PSMD14	3	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	ATXN2	3	affinity chromatography technology	Rodriguez J (2016)	1
HUWE1	22	PSMD14	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Thompson JW (2014), Jacobson AD (2014), Jacobson AD (2014)	3
KDR	4	NCOA4	4	affinity chromatography technology	Hein MY (2015)	1
TFG	3	NCOA4	4	affinity chromatography technology	Hein MY (2015)	1
FTH1	0	FTL	0	two hybrid, two hybrid, biochemical, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Stelzl U (2005), Havugimana PC (2012), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	6
MAPK6	1	PSMD14	3	affinity chromatography technology	Rodriguez J (2016)	1
ESR1	0	GTF2B	1	pull down	Lazennec G (1997)	1
PSMD14	3	PSMC1	2	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Wang X (2007), Wan C (2015), Hein MY (2015), Hein MY (2015)	7
XPO1	8	ESR1	0	affinity chromatography technology	Castoria G (2012)	1
HUWE1	22	NCOA4	4	affinity chromatography technology	Hein MY (2015)	1
AR	3	NCOA4	4	two hybrid, two hybrid, two hybrid, two hybrid, pull down, two hybrid, two hybrid, pull down, pull down, far western blotting, two hybrid, unspecified method, two hybrid, pull down, two hybrid, two hybrid, two hybrid, pull down	Alen P (1999), Yeh S (1996), Miyamoto H (1998), Lin HK (2001), Alen P (1999), Yeh S (1999), Zhou ZX (2002), Zhou ZX (2002), Yeh S (1996), Yeh S (1996), He B (2002), He B (2002), Gao T (1999), Gao T (1999), He B (2003), Albers M (2005), Heinlein CA (1999), Heinlein CA (1999)	18
HERC2	9	FTL	0	affinity chromatography technology	Galligan JT (2015)	1
MAPK6	1	NCOA4	4	affinity chromatography technology	Rodriguez J (2016)	1
MAPK6	1	HERC2	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2017), Rodriguez J (2016)	3
NCOA4	4	GMCL1	0	affinity chromatography technology	Huttlin EL (2017)	1
XRCC3	1	NCOA4	4	affinity chromatography technology	Hein MY (2015)	1
XPO1	8	PPARG	0	affinity chromatography technology	von Knethen A (2010)	1
HERC2	9	NEURL4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Al-Hakim AK (2012), Al-Hakim AK (2012), Al-Hakim AK (2012), Al-Hakim AK (2012), Galligan JT (2015)	5
NCOA4	4	FTH1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Mancias JD (2015), Mancias JD (2015), Huttlin EL (2017), Goodwin JM (2017)	4
HUWE1	22	XPO1	8	affinity chromatography technology	Thompson JW (2014)	1
AKT1	1	NCOA4	4	two hybrid	Wang J (2008)	1
XPO1	8	XRCC3	1	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	NCOA4	4	affinity chromatography technology	Kirli K (2015)	1
PSMD14	3	HERC2	9	affinity chromatography technology, affinity chromatography technology	Jacobson AD (2014), Jacobson AD (2014)	2
NCOA4	4	ESR1	0	pull down	Alen P (1999)	1
HERC2	9	NCOA4	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Galligan JT (2015), Mancias JD (2015), Mancias JD (2015), Mancias JD (2015), Huttlin EL (2017)	5
NCOA4	4	NR3C1	2	two hybrid	Gao T (1999)	1
KIF21A	7	NCOA4	4	affinity chromatography technology	Hein MY (2015)	1
HERC2	9	FTH1	0	affinity chromatography technology, affinity chromatography technology	Galligan JT (2015), Galligan JT (2015)	2
AR	3	KAT2B	2	pull down, enzymatic study	Fu M (2000), Fu M (2000)	2
NR3C1	2	FTH1	0	two hybrid	Albers M (2005)	1
NCOA4	4	VDR	2	two hybrid, pull down	Ting HJ (2005), Ting HJ (2005)	2
GRIA2	4	NCOA4	4	affinity chromatography technology	Hein MY (2015)	1
NR3C1	2	PPARG	0	affinity chromatography technology	Nie M (2005)	1
RXRA	1	PPARG	0	biochemical, pull down, x-ray crystallography, pull down, pull down, pull down, imaging technique, pull down, pull down, pull down, pull down, x-ray crystallography, affinity chromatography technology, x-ray crystallography, pull down, x-ray crystallography, pull down, pull down, pull down, pull down, two hybrid, x-ray crystallography, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tontonoz P (1994), Berger J (2000), Gampe RT (2000), Tontonoz P (1998), Billiet L (2008), Tachibana K (2013), Song K (2013), Mukherjee R (1997), Lee G (2002), Li S (2013), Bernardes A (2012), Bernardes A (2012), Nickkho-Amiry M (2012), Jurkowski W (2011), Gupta RA (2003), Rochel N (2011), Rochel N (2011), Malerod L (2003), Chen F (2003), Chen F (2003), Tagami T (2009), Chandra V (2008), Lu J (2008), Molnar F (2005), Jeninga EH (2007), Ray DM (2008), Ray DM (2008), DiRenzo J (1997), Li X (2015), Park S (2015)	30
PSMC1	2	NEURL4	3	affinity chromatography technology	Hein MY (2015)	1
NCOA4	4	FTL	0	affinity chromatography technology	Huttlin EL (2017)	1
NCOA4	4	GTF2B	1	pull down	Alen P (1999)	1
NCOA4	4	KAT2B	2	pull down	Alen P (1999)	1