PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ZNF526	1	AFF1	1	affinity chromatography technology	Hein MY (2015)	1
SMARCB1	1	SS18	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Kato H (2002), Kato H (2002), Kato H (2002), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	6
SS18	1	MLLT10	3	two hybrid, affinity chromatography technology	de Bruijn DR (2001), de Bruijn DR (2001)	2
MLLT6	2	MLLT10	3	affinity chromatography technology	Huttlin EL (2017)	1
TMPO	0	MLLT10	3	affinity chromatography technology	Hein MY (2015)	1
ELAVL1	0	MLLT10	3	affinity chromatography technology	Abdelmohsen K (2009)	1
DISC1	6	NDEL1	2	two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Morris JA (2003), Morris JA (2003), Ozeki Y (2003), Ozeki Y (2003), Ozeki Y (2003), Park YU (2010), Camargo LM (2007), Brandon NJ (2004), Brandon NJ (2004), Huttlin EL (2017)	10
DOT1L	7	MLLT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Park G (2010), Park G (2010), Park G (2010), Yokoyama A (2010), Yokoyama A (2010), He N (2011), He N (2011)	7
ELAVL1	0	MLLT6	2	affinity chromatography technology	Abdelmohsen K (2009)	1
YEATS4	0	SMARCB1	1	affinity chromatography technology, pull down	Debernardi S (2002), Debernardi S (2002)	2
AFF1	1	DOT1L	7	affinity chromatography technology, affinity chromatography technology	Benedikt A (2011), Benedikt A (2011)	2
MLLT1	1	AFF1	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mueller D (2009), Park G (2010), Yokoyama A (2010), Yokoyama A (2010), Yokoyama A (2010), Benedikt A (2011), Zeisig DT (2005), Zeisig DT (2005), Zeisig DT (2005), Zeisig DT (2005), Lu H (2014), Ui A (2015)	12
ELAVL1	0	SS18	1	affinity chromatography technology	Abdelmohsen K (2009)	1
MLLT10	3	SMARCB1	1	affinity chromatography technology	Debernardi S (2002)	1
YEATS4	0	DOT1L	7	affinity chromatography technology	Hein MY (2015)	1
MLLT10	3	DOT1L	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Okada Y (2005), Park G (2010), Hein MY (2015)	3
MLLT3	0	AFF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Park G (2010), Monroe SC (2011), Benedikt A (2011), Biswas D (2011), Takahashi H (2011)	5
YEATS4	0	MLLT6	2	affinity chromatography technology	Hein MY (2015)	1
MLLT1	1	MLLT10	3	affinity chromatography technology, two hybrid	Park G (2010), Zeisig DT (2005)	2
PMF1	0	MLLT10	3	affinity chromatography technology	Huttlin EL (2017)	1
MLLT6	2	MLLT3	0	affinity chromatography technology	Huttlin EL (2017)	1
DOT1L	7	MLLT3	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang W (2006), Zhang W (2006), Zhang W (2006), Zhang W (2006), Zhang W (2007), Park G (2010), Park G (2010), Monroe SC (2011), Biswas D (2011), He N (2011), Hein MY (2015), Li Y (2014)	12
TCP10L	0	MLLT10	3	affinity chromatography technology	Huttlin EL (2017)	1
MLLT10	3	YEATS4	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Debernardi S (2002), Debernardi S (2002), Debernardi S (2002), Debernardi S (2002)	4
KIF6	4	MLLT10	3	affinity chromatography technology	Huttlin EL (2017)	1
PMF1	0	TCP10L	0	two hybrid	Wang J (2011)	1
DOT1L	7	MLLT6	2	two hybrid, two hybrid, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Reisenauer MR (2009), Reisenauer MR (2009), Reisenauer MR (2009), Reisenauer MR (2009), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	7
CENPJ	6	MLLT10	3	bioid	Gupta GD (2015)	1
NDEL1	2	MLLT10	3	two hybrid	Camargo LM (2007)	1
MLLT1	1	MLLT6	2	affinity chromatography technology	Park G (2010)	1
MLLT10	3	MLLT10	3	affinity chromatography technology	Linder B (2000)	1
MLLT3	0	MLLT10	3	affinity chromatography technology	Monroe SC (2011)	1
MLLT3	0	MLLT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Park G (2010), Monroe SC (2011), He N (2011), Takahashi H (2011)	4
DISC1	6	MLLT10	3	two hybrid	Camargo LM (2007)	1
ZNF526	1	MLLT10	3	affinity chromatography technology	Hein MY (2015)	1
AFF1	1	MLLT10	3	affinity chromatography technology	Benedikt A (2011)	1