PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELAVL1	0	TP53	0	affinity chromatography technology	Galban S (2003)	1
LRRN2	2	FBXO11	14	affinity chromatography technology	Huttlin EL (2017)	1
NECAP2	0	FBXO11	14	affinity chromatography technology	Huttlin EL (2015)	1
USP16	0	FBXO11	14	unspecified method	Hard RL (2010)	1
THAP7	0	FBXO11	14	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DUSP5	1	AP3S1	0	affinity chromatography technology	Li X (2016)	1
KIRREL2	1	FBXO11	14	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LNX1	7	CDK13	18	affinity chromatography technology	Lenihan JA (2017)	1
EED	1	CUL1	7	affinity chromatography technology	Cao Q (2014)	1
ZNF692	3	FBXO11	14	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	ELAVL1	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
COPS5	0	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
TCP10L	0	FBXO11	14	affinity chromatography technology	Huttlin EL (2017)	1
COPS5	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Min KW (2005), Min KW (2005), Chua YS (2011), Boh BK (2011), Emberley ED (2012), Emberley ED (2012), Choo YY (2011), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Enchev RI (2012), Birol M (2014), Pick E (2012), Sharon M (2009), Enchev RI (2012), Bornstein G (2015), Rockel B (2014), Schlierf A (2016), Reitsma JM (2017), Reitsma JM (2017)	23
TRIM25	5	CTBP1	2	affinity chromatography technology	Choudhury NR (2017)	1
SOCS6	0	LNX1	7	two hybrid	Grossmann A (2015)	1
STAU1	1	FBXO11	14	affinity chromatography technology	Huttlin EL (2017)	1
HSPB6	0	FBXO11	14	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LBHD1	0	FBXO11	14	affinity chromatography technology	Huttlin EL (2017)	1
NANOG	0	FBXO11	14	affinity chromatography technology	Oliviero G (2015)	1
LNX1	7	FBXO11	14	affinity chromatography technology	Lenihan JA (2017)	1
COPS5	0	DTL	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Sertic S (2013), Higa LA (2006), Higa LA (2006)	5
TRIM25	5	TNFRSF10A	0	affinity chromatography technology	Choudhury NR (2017)	1
COPS6	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009), Reitsma JM (2017)	7
ELAVL1	0	CTBP1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	AP3S1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
SKP1	0	RBX1	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Kumar R (2005), Wang W (2004), Ohta T (2001), Oshikawa K (2003), Liu J (2002), Li X (2003), Zhou W (2014), Zhou W (2014), Hao J (2015), Hauri S (2016)	11
FBXO11	14	RBX1	2	affinity chromatography technology	Abida WM (2007)	1
COPS6	0	DTL	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Olma MH (2009), Higa LA (2006)	4
AP3S1	0	FBXO11	14	affinity chromatography technology	Huttlin EL (2017)	1
FBXO11	14	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Abida WM (2007), Duan S (2011), Rossi M (2013), Rolland T (2014), Kuchay S (2017), Hauri S (2016)	6
STAU1	1	AP3S1	0	affinity chromatography technology	Milev MP (2012)	1
TFG	3	TRIM25	5	affinity chromatography technology	Lee NR (2013)	1
ZNF71	2	FBXO11	14	affinity chromatography technology	Huttlin EL (2017)	1
TFG	3	FBXO11	14	affinity chromatography technology	Huttlin EL (2015)	1
CTBP1	2	FBXO11	14	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STAT2	2	FBXO11	14	affinity chromatography technology	Huttlin EL (2017)	1
EED	1	FBXO11	14	affinity chromatography technology	Cao Q (2014)	1
FBXO11	14	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Abida WM (2007), Duan S (2011), Bennett EJ (2010), Jeong YT (2013), Reitsma JM (2017), Reitsma JM (2017)	6
ZNF263	2	FBXO11	14	affinity chromatography technology	Huttlin EL (2017)	1
TP53	0	CTBP1	2	affinity chromatography technology, affinity chromatography technology	Jin W (2008), Jin W (2008)	2
SOCS6	0	FBXO11	14	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PRPF3	3	FBXO11	14	affinity chromatography technology	Huttlin EL (2017)	1
SKP1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Min KW (2003), Lisztwan J (1998), Zheng N (2002), Ohta T (1999), Bloom J (2006), Kumar R (2005), Megumi Y (2005), Wang W (2004), Read MA (2000), Wu K (2000), Tan P (1999), Mao X (2011), Lin HK (2009), Yano H (2008), Banerjee S (2010), Gao D (2010), Chua YS (2011), Zhang M (2008), Winston JT (1999), Latres E (1999), Latres E (1999), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Emberley ED (2012), Bennett EJ (2010), Gastaldello S (2012), Michel JJ (1998), Michel JJ (1998), Michel JJ (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Yu ZK (1998), Yu ZK (1998), Postow L (2013), Cordero-Espinoza L (2013), Zhou W (2014), Zhou W (2014), Hao J (2015), Hao J (2015), Han XR (2016), Liu YQ (2015), Gorelik M (2016), Al-Yacoub N (2016), Reiterer V (2017), Hu Y (2017), Hauri S (2016), Reitsma JM (2017), Reitsma JM (2017), Chen F (2017)	59
ELAVL1	0	FBXO11	14	affinity chromatography technology	Abdelmohsen K (2009)	1
TRIM25	5	TNFRSF1A	3	affinity chromatography technology	Choudhury NR (2017)	1
THAP7	0	LNX1	7	two hybrid	Rolland T (2014)	1
DUSP5	1	FBXO11	14	affinity chromatography technology	Li X (2016)	1
SCML4	3	FBXO11	14	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CCDC107	0	FBXO11	14	affinity chromatography technology	Huttlin EL (2017)	1
HDAC6	0	FBXO11	14	unspecified method	Hard RL (2010)	1
ELAVL1	0	DUSP5	1	affinity chromatography technology	Abdelmohsen K (2009)	1
COPS6	0	RBX1	2	affinity chromatography technology	Olma MH (2009)	1
CUL1	7	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, pull down, x-ray crystallography, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Dias DC (2002), Kim J (2002), Zheng N (2002), Kim AY (2008), Ohta T (1999), Ohta T (1999), Ohta T (1999), Bloom J (2006), Block K (2005), Hu J (2004), Hwang JW (2003), Furukawa M (2002), Kawakami T (2001), Ohta T (2001), Chen A (2000), Read MA (2000), Wu K (2000), Tan P (1999), Banerjee S (2010), Gao D (2010), Tron AE (2012), Tron AE (2012), Shteingart S (2012), Tan M (2010), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Huang DT (2004), Emberley ED (2012), Gastaldello S (2012), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Li X (2003), Calabrese MF (2011), Scott DC (2014), Scott DC (2014), Siergiejuk E (2009), Zhou W (2014), Zhou W (2014), Huang DT (2009), Pick E (2007), Morimoto M (2003), Morimoto M (2003), Ohki Y (2009), Duda DM (2008), Duda DM (2008), Wan C (2015), Hao J (2015), Hao J (2015), Han XR (2016), Kuang P (2016), Zhou W (2017), Hu Y (2017), Reitsma JM (2017)	59
ELAVL1	0	SKP1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
TP53	0	RBX1	2	affinity chromatography technology	Fogeron ML (2013)	1
TP53	0	SKP1	0	affinity chromatography technology	Fogeron ML (2013)	1
ZBTB48	3	FBXO11	14	affinity chromatography technology	Huttlin EL (2017)	1
CUL1	7	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
FBXO11	14	BCL6	6	affinity chromatography technology, enzymatic study	Duan S (2011), Duan S (2011)	2
PRDM5	1	FBXO11	14	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	HDAC6	0	affinity chromatography technology, affinity chromatography technology	Scott GK (2008), Scott GK (2008)	2
COPS5	0	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang XC (2008), Zhang XC (2008), Zhang XC (2008), Wang J (2006), Bech-Otschir D (2001), Bech-Otschir D (2001), Oh W (2006), Bhansali M (2014), Bhansali M (2014)	9
COPS5	0	SKP1	0	affinity chromatography technology	Bennett EJ (2010)	1
STAT2	2	ZNF692	3	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	FBXO11	14	affinity chromatography technology	Choudhury NR (2017)	1
TP53	0	FBXO11	14	affinity chromatography technology, pull down, affinity chromatography technology	Abida WM (2007), Abida WM (2007), Abida WM (2007)	3
FOSL2	2	FBXO11	14	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ERN1	1	COPS5	0	affinity chromatography technology, two hybrid, affinity chromatography technology	Hsieh YH (2007), Oono K (2004), Oono K (2004)	3
TP53	0	ERN1	1	affinity chromatography technology	Namba T (2015)	1
FBXO11	14	FBXO11	14	pull down, x-ray crystallography	Munoz-Escobar J (2017), Munoz-Escobar J (2017)	2
CUL1	7	WWP2	7	affinity chromatography technology	Bennett EJ (2010)	1
DUSP8	0	FBXO11	14	affinity chromatography technology	Li X (2016)	1
STAC	0	FBXO11	14	affinity chromatography technology	Huttlin EL (2015)	1
CDK13	18	PRPF3	3	biochemical	Havugimana PC (2012)	1
DEFA6	0	FBXO11	14	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	PRPF3	3	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	STAT2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
CDK13	18	FBXO11	14	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ELAVL1	0	UBXN4	0	affinity chromatography technology	Abdelmohsen K (2009)	1
AURKAIP1	0	FBXO11	14	affinity chromatography technology	Huttlin EL (2017)	1
CUL1	7	STAU1	1	affinity chromatography technology	Bennett EJ (2010)	1
DTL	0	RBX1	2	affinity chromatography technology	Shibata E (2011)	1
ELAVL1	0	STAU1	1	affinity chromatography technology, affinity chromatography technology	Abdelmohsen K (2009), Milev MP (2012)	2
ZNRF4	1	FBXO11	14	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	CDK13	18	affinity chromatography technology	Choudhury NR (2017)	1
ELAVL1	0	TNFRSF1A	3	affinity chromatography technology	Abdelmohsen K (2009)	1
COPS5	0	COPS6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Fang L (2008), Sharon M (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Choi HH (2011), Kristensen AR (2012), Birol M (2014), Birol M (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	18
BCL6	6	CTBP1	2	pull down, affinity chromatography technology, imaging technique	Mendez LM (2008), Mendez LM (2008), Mendez LM (2008)	3
DTL	0	TP53	0	affinity chromatography technology, enzymatic study	Banks D (2006), Banks D (2006)	2
WWP2	7	FBXO11	14	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
COPS5	0	FBXO11	14	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
UNK	3	TFG	3	affinity chromatography technology	Murn J (2015)	1
FOXJ1	0	FBXO11	14	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
CTBP1	2	LNX1	7	two hybrid	Corominas R (2014)	1
TNFRSF10A	0	FBXO11	14	affinity chromatography technology	Huttlin EL (2017)	1
UNK	3	FBXO11	14	affinity chromatography technology	Murn J (2015)	1
UBXN4	0	FBXO11	14	affinity chromatography technology	Huttlin EL (2015)	1
DTL	0	FBXO11	14	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Rossi M (2013), Rossi M (2013), Rossi M (2013), Dar A (2014)	4
EED	1	SKP1	0	affinity chromatography technology	Cao Q (2014)	1
BCAN	1	FBXO11	14	affinity chromatography technology	Huttlin EL (2015)	1
TP53	0	BCL6	6	pull down	Kotlyar M (2015)	1
MYLK2	1	FBXO11	14	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ZNRF4	1	ERN1	1	affinity chromatography technology	Huttlin EL (2017)	1
ERN1	1	FBXO11	14	affinity chromatography technology	Zhu X (2014)	1
TNFRSF1A	3	FBXO11	14	affinity chromatography technology	Huttlin EL (2017)	1
COPS6	0	FBXO11	14	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
CUL1	7	TFG	3	affinity chromatography technology	Bennett EJ (2010)	1
ZNF785	0	FBXO11	14	affinity chromatography technology	Huttlin EL (2017)	1
COPS6	0	SKP1	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009)	2
IKZF5	0	FBXO11	14	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	RBX1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
COPS5	0	RBX1	2	affinity chromatography technology	Olma MH (2009)	1
COPS6	0	TFG	3	affinity chromatography technology	Bennett EJ (2010)	1
EED	1	ELAVL1	0	affinity chromatography technology	Cao Q (2014)	1
COPS5	0	TFG	3	affinity chromatography technology	Bennett EJ (2010)	1