PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CUL5	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ehrlich ES (2009), Ehrlich ES (2009), Bennett EJ (2010)	3
TP53	0	TP73	2	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Stindt MH (2015), Puca R (2011), De Laurenzi V (1998), Di Como CJ (1999)	4
ELOC	0	ELOB	1	two hybrid, pull down, pull down, pull down, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid, affinity chromatography technology, x-ray crystallography, two hybrid, two hybrid, biochemical, affinity chromatography technology, biochemical, pull down, two hybrid, biochemical, biochemical, two hybrid	Rual JF (2005), Ohh M (1999), Aso T (1995), Li Z (2002), Kinoshita K (2007), Kinoshita K (2007), Kinoshita K (2007), Kinoshita K (2007), Lievens S (2009), Brower CS (1999), Stebbins CE (1999), Pause A (1999), Pause A (1999), Havugimana PC (2012), Wang X (2013), Kristensen AR (2012), Costessi A (2011), Rolland T (2014), Kim DY (2013), Wan C (2015), Yu H (2011)	21
ELAVL1	0	TP53	0	affinity chromatography technology	Galban S (2003)	1
TP53	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Wang C (2003), Akakura S (2001), Peng Y (2001), Nagata Y (1999), Wang J (2011), Burch L (2004), Taipale M (2012), Fogeron ML (2013), Walerych D (2004)	9
CUL5	1	ELOC	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology	Kamura T (2001), Nishiya T (2011), Wolfe LS (2010), Yu X (2003), Xiao Z (2006), Zhou X (2012), Luo K (2007), Yu Y (2004), Bennett EJ (2010), Salter JD (2012), Muniz JR (2013), Kelsall IR (2013), Han X (2014), Fribourgh JL (2014), Guo Y (2014), Guo Y (2014), Kershaw NJ (2014), Huttlin EL (2017)	18
SUV39H1	0	KDM1A	2	two hybrid	Weimann M (2013)	1
SPSB1	3	CUL5	1	affinity chromatography technology	Kamura T (2004)	1
ELOC	0	SPSB1	3	affinity chromatography technology, two hybrid, affinity chromatography technology	Nishiya T (2011), Lievens S (2009), Kamura T (2004)	3
SPSB1	3	RNF7	0	affinity chromatography technology	Kamura T (2004)	1
ELAVL1	0	PRMT6	2	affinity chromatography technology	Abdelmohsen K (2009)	1
SUV39H1	0	PRMT6	2	two hybrid	Weimann M (2013)	1
TP53	0	PRMT1	3	pull down	An W (2004)	1
SPSB1	3	RASA1	3	affinity chromatography technology	Wang D (2005)	1
PRMT6	2	TP73	2	affinity chromatography technology	Huttlin EL (2015)	1
ELAVL1	0	SPSB1	3	affinity chromatography technology	Abdelmohsen K (2009)	1
TP53	0	HNRNPL	3	affinity chromatography technology	Horikawa I (2014)	1
CUL5	1	ELOB	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down	Kamura T (2001), Nie L (2011), Wolfe LS (2010), Yu X (2003), Xiao Z (2006), Zhou X (2012), Luo K (2007), Yu Y (2004), Bennett EJ (2010), Salter JD (2012), Muniz JR (2013), Kelsall IR (2013), Han X (2014), Fribourgh JL (2014), Guo Y (2014), Guo Y (2014), Antonioli M (2014), Kershaw NJ (2014)	18
HNRNPL	3	SPSB1	3	affinity chromatography technology	Fei T (2017)	1
NOS2	6	ELOC	0	affinity chromatography technology, affinity chromatography technology	Nishiya T (2011), Nishiya T (2011)	2
HSP90AA1	7	SPSB1	3	affinity chromatography technology	Taipale M (2012)	1
TP53	0	SPSB1	3	affinity chromatography technology	Lunardi A (2010)	1
NOS2	6	ELOB	1	affinity chromatography technology	Foster MW (2013)	1
SPSB1	3	DDX4	5	unspecified method	Filippakopoulos P (2010)	1
SPSB1	3	ELOB	1	affinity chromatography technology	Kamura T (2004)	1
ATM	9	SPSB1	3	enzymatic study, affinity chromatography technology	Richard DJ (2008), Richard DJ (2008)	2
HNRNPL	3	RASA1	3	affinity chromatography technology	Fei T (2017)	1
MET	7	SPSB1	3	affinity chromatography technology, affinity chromatography technology	Wang D (2005), Wang D (2005)	2
TP53	0	MET	7	fluorescent resonance energy transfe	Ivanov AA (2017)	1
NOS2	6	SPSB1	3	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Nishiya T (2011), Nishiya T (2011), Nishiya T (2011), Matsumoto K (2011), Matsumoto K (2011), Kuang Z (2010), Foster MW (2013)	7
SPSB1	3	PRMT6	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
ELAVL1	0	ATM	9	affinity chromatography technology	Abdelmohsen K (2009)	1
KDM1A	2	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study	Tsai WW (2008), Tsai WW (2008), Huang J (2007), Huang J (2007), Huang J (2007), Huang J (2007), Huang J (2007)	7
CUL5	1	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
NOS2	6	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Foster MW (2013), Yoshida M (2003), Yoshida M (2003)	3
NOS2	6	CUL5	1	affinity chromatography technology, affinity chromatography technology	Nishiya T (2011), Foster MW (2013)	2
TGFBR2	0	SPSB1	3	affinity chromatography technology, affinity chromatography technology	Liu S (2015), Liu S (2015)	2
RNF7	0	ELOC	0	pull down, pull down	Kim DY (2013), Kershaw NJ (2014)	2
ELAVL1	0	HNRNPL	3	affinity chromatography technology	Abdelmohsen K (2009)	1
SPSB1	3	SUV39H1	0	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
SPSB1	3	PRMT1	3	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
TP73	2	SPSB1	3	affinity chromatography technology	Lunardi A (2010)	1
MET	7	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Jang KW (2011), Prince TL (2015)	2
RNF7	0	ELOB	1	pull down, pull down	Kim DY (2013), Kershaw NJ (2014)	2
SPSB1	3	PAWR	2	unspecified method	Filippakopoulos P (2010)	1
ATM	9	TP53	0	pull down, pull down, pull down, genetic interference, unspecified method, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, imaging technique	Kang J (2005), Fabbro M (2004), Khanna KK (1998), Westphal CH (1997), Kim ST (1999), Khanna KK (1998), Lee JH (2004), Lee JH (2004), Hunt CR (2007), Lin WC (2001), Ling S (2011), Taira N (2010), Lee JH (2005), Zhou BB (2000), Chan DW (2000), Yoshiyama KO (2013), Kim ST (1999), Zhang P (2014), Wang L (2014), Golding SE (2004), Ochodnicka-Mackovicova K (2016)	21
SPSB1	3	KDM1A	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
RNF7	0	CUL5	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, enzymatic study, pull down, biochemical, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ohta T (1999), Bennett EJ (2010), Tan M (2008), Kelsall IR (2013), Kelsall IR (2013), Zhou W (2014), Rolland T (2014), Huang DT (2009), Kim DY (2013), Kim DY (2013), Yu H (2011), Bulatov E (2015), Wang X (2015), Wang X (2015), Wang X (2015), Kershaw NJ (2014), Huttlin EL (2017), Kuang P (2016), Kuang P (2016), Zhou W (2017), Zhou W (2017)	21
HNRNPL	3	CUL5	1	affinity chromatography technology	Fei T (2017)	1
HSP90AA1	7	TGFBR2	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wrighton KH (2008), Wrighton KH (2008), Wrighton KH (2008), Zhang K (2012), Zhang K (2012)	5
TP73	2	KDM1A	2	affinity chromatography technology	Tsai WW (2008)	1