PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MID2	1	UBE2D3	1	two hybrid, two hybrid, affinity chromatography technology	Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011)	3
UBTD1	0	UBE2D3	1	two hybrid, biochemical, affinity chromatography technology	Uhler JP (2013), Uhler JP (2013), Uhler JP (2013)	3
UBE2D4	0	TRIM39	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Markson G (2009), Rolland T (2014)	3
UBE2D4	0	MID2	1	two hybrid, two hybrid, two hybrid, two hybrid, two hybrid	van Wijk SJ (2009), Napolitano LM (2011), Napolitano LM (2011), Rolland T (2014), Yu H (2011)	5
MID2	1	UBE2D2	0	two hybrid, two hybrid, affinity chromatography technology	Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011)	3
TEAD1	2	PFKM	4	affinity chromatography technology, imaging technique	Enzo E (2015), Enzo E (2015)	2
UBE2D1	0	RNF10	0	two hybrid	Markson G (2009)	1
UBE2D1	0	MID1	1	two hybrid, enzymatic study, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, pull down, two hybrid, pull down	Markson G (2009), Han X (2011), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011), Han X (2011), Du H (2014), Schweiger S (2014), Rolland T (2014), Wright KM (2017)	10
CD1A	1	UBTD1	0	two hybrid	Wang J (2011)	1
UBE2D1	0	TRIM39	0	two hybrid, two hybrid, pull down, pull down, two hybrid, two hybrid	Rual JF (2005), Markson G (2009), Huang NJ (2012), Woodsmith J (2012), Rolland T (2014), Yu H (2011)	6
UBTD1	0	BCOR	2	two hybrid	Uhler JP (2013)	1
MID1	1	UBTD1	0	two hybrid	Rolland T (2014)	1
UBTD1	0	RANBP2	9	two hybrid	Uhler JP (2013)	1
UBE2D2	0	RNF10	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Markson G (2009), Huttlin EL (2015), Huttlin EL (2017)	3
MID2	1	UBE2D1	0	two hybrid, two hybrid, affinity chromatography technology, two hybrid	Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011), Rolland T (2014)	4
PAN2	3	UBTD1	0	affinity chromatography technology	Bett JS (2013)	1
FZD5	2	UBTD1	0	two hybrid	Wang J (2011)	1
UBTD1	0	PFKM	4	two hybrid	Uhler JP (2013)	1
UBTD1	0	UBE2D2	0	two hybrid, biochemical	Uhler JP (2013), Uhler JP (2013)	2
UBTD1	0	SHROOM3	7	biochemical	Uhler JP (2013)	1
UBTD1	0	TEAD1	2	two hybrid	Uhler JP (2013)	1
UBE2D3	1	OTUB1	0	two hybrid, enzymatic study, pull down, affinity chromatography technology	Rolland T (2014), Li Y (2014), Li Y (2014), Scholz CC (2016)	4
OTUB1	0	UBTD1	0	affinity chromatography technology	Scholz CC (2016)	1
UBE2D2	0	TRIM39	0	two hybrid, pull down	Markson G (2009), Woodsmith J (2012)	2
OTUB1	0	UBE2D2	0	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Nakada S (2010), Juang YC (2012), Ernst A (2013), Juang YC (2012), Huttlin EL (2015), Scholz CC (2016), Huttlin EL (2017)	8
GJB7	1	UBTD1	0	affinity chromatography technology	Huttlin EL (2017)	1
UBTD1	0	UBE2D1	0	biochemical	Uhler JP (2013)	1
MID1	1	MID2	1	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Reymond A (2001), Reymond A (2001), Short KM (2002), Short KM (2002), Short KM (2002), Short KM (2002), Short KM (2006), Short KM (2006), Rolland T (2014), Gholkar AA (2016), Gholkar AA (2016), Gholkar AA (2016), Gholkar AA (2016)	13
OTUB1	0	UBE2D1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Sun XX (2011), Herhaus L (2013), Li Y (2014), Scholz CC (2016)	4
UBTD1	0	UBE2D4	0	two hybrid	Uhler JP (2013)	1
UBTD1	0	MRFAP1L1	0	two hybrid	Rolland T (2014)	1
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
UBE2D2	0	MID1	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, pull down	Markson G (2009), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011), Watkins GR (2012), Du H (2014), Schweiger S (2014)	7
UBE2D4	0	OTUB1	0	two hybrid	Rolland T (2014)	1
MID2	1	UBTD1	0	two hybrid	Rolland T (2014)	1
UBE2D3	1	RNF10	0	two hybrid	Markson G (2009)	1
UBE2D4	0	MID1	1	two hybrid, two hybrid, two hybrid	Markson G (2009), Napolitano LM (2011), Napolitano LM (2011)	3
TRIM39	0	UBTD1	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
UBE2D3	1	TRIM39	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Markson G (2009), Rolland T (2014)	3
UBTD1	0	KIAA2026	4	two hybrid	Uhler JP (2013)	1
UBE2D4	0	RNF10	0	two hybrid	Markson G (2009)	1
UBTD1	0	RNF10	0	two hybrid	Uhler JP (2013)	1
UBE2D3	1	MID1	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, pull down, two hybrid	Markson G (2009), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011), Watkins GR (2012), Du H (2014), Schweiger S (2014), Rolland T (2014)	8