PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SELENOS	0	VCP	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye Y (2004), Ye Y (2004), Wang Q (2008), Ballar P (2007), Ballar P (2007), Schulze A (2005), Zhong Y (2011), Zhong Y (2011), Christianson JC (2012), Liu Y (2014), Noda C (2014), Lee JH (2014), Mountassif D (2015)	13
NXF1	0	SLC25A4	0	affinity chromatography technology	Castello A (2012)	1
MOV10	6	NPLOC4	4	affinity chromatography technology	Castello A (2012)	1
VCP	6	UFD1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Wang Q (2008), Ballar P (2007), Alexandru G (2008), Zhong X (2006), Fernandez-Saiz V (2010), Nagahama M (2009), Noguchi M (2005), Bruderer RM (2004), Bruderer RM (2004), Bruderer RM (2004), Erzurumlu Y (2013), Li JM (2013), Fogeron ML (2013), Haenzelmann P (2016), Haenzelmann P (2016), Haenzelmann P (2016), Raman M (2015), Raman M (2015), Mountassif D (2015), Wang T (2016), Guo X (2017)	21
UBXN8	0	MTCH2	2	affinity chromatography technology	Raman M (2015)	1
UBXN8	0	SURF4	1	affinity chromatography technology	Raman M (2015)	1
UBXN8	0	ATP2B2	10	affinity chromatography technology	Raman M (2015)	1
NXF1	0	VCPIP1	4	affinity chromatography technology	Castello A (2012)	1
NXF1	0	SURF4	1	affinity chromatography technology	Castello A (2012)	1
ADRB2	0	UFD1	1	affinity chromatography technology	Roy SJ (2013)	1
EGLN3	0	TBC1D15	1	affinity chromatography technology	Rodriguez J (2016)	1
UBXN8	0	VCP	6	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Alexandru G (2008), Madsen L (2011), Madsen L (2011), Madsen L (2014), Raman M (2015)	5
TBC1D15	1	UBXN8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Raman M (2015), Raman M (2015), Raman M (2015), Huttlin EL (2017)	4
EGLN3	0	SUCLA2	1	affinity chromatography technology	Rodriguez J (2016)	1
SELENOS	0	SYVN1	2	affinity chromatography technology, affinity chromatography technology	Ballar P (2007), Schulze A (2005)	2
EGLN3	0	TMEM165	2	affinity chromatography technology	Rodriguez J (2016)	1
SLC15A1	0	UBXN8	0	affinity chromatography technology	Huttlin EL (2017)	1
SELENOS	0	UFD1	1	affinity chromatography technology	Ye Y (2004)	1
UFD1	1	NPLOC4	4	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, x-ray crystallography, biochemical, affinity chromatography technology, affinity chromatography technology	Botta A (2001), Lass A (2008), Vong QP (2005), Bruderer RM (2004), Havugimana PC (2012), Li JM (2013), Pye VE (2007), Wan C (2015), Raman M (2015), Raman M (2015)	10
UBXN8	0	SLC7A1	2	affinity chromatography technology	Raman M (2015)	1
TBC1D15	1	TBC1D17	2	affinity chromatography technology	Huttlin EL (2017)	1
MOV10	6	SLC25A4	0	affinity chromatography technology	Castello A (2012)	1
SLC7A1	2	MTCH2	2	affinity chromatography technology	Huttlin EL (2017)	1
TBC1D17	2	UBXN8	0	affinity chromatography technology	Raman M (2015)	1
SELENOS	0	UBXN8	0	affinity chromatography technology	Christianson JC (2012)	1
UBXN8	0	NPLOC4	4	affinity chromatography technology	Alexandru G (2008)	1
VCP	6	SYVN1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, unspecified method, affinity chromatography technology, biochemical	Ballar P (2007), Schulze A (2005), Schulze A (2005), Schulze A (2005), Ye Y (2005), Ye Y (2005), Zhong X (2006), Fernandez-Saiz V (2010), Liu S (2013), Liu S (2013), Liu S (2013), Liu S (2013), Zhang T (2015), Hosokawa N (2016)	14
SELENOS	0	NPLOC4	4	affinity chromatography technology	Ballar P (2007)	1
EGLN3	0	NPLOC4	4	affinity chromatography technology	Rodriguez J (2016)	1
UBXN8	0	ELAVL2	4	affinity chromatography technology	Raman M (2015)	1
MOV10	6	UBXN8	0	affinity chromatography technology	Castello A (2012)	1
NPLOC4	4	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Lass A (2008), Ballar P (2007), Alexandru G (2008), Alexandru G (2008), Fernandez-Saiz V (2010), Noguchi M (2005), Bruderer RM (2004), Bruderer RM (2004), Lee JJ (2013), Erzurumlu Y (2013), Raman M (2015), Raman M (2015), Mountassif D (2015), Wang T (2016), Guo X (2017)	15
VCPIP1	4	UFD1	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Raman M (2015)	2
MOV10	6	VCPIP1	4	affinity chromatography technology	Castello A (2012)	1
VCPIP1	4	NPLOC4	4	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Raman M (2015)	2
UBXN8	0	RHBDD2	3	affinity chromatography technology	Raman M (2015)	1
ELAVL2	4	MOV10	6	affinity chromatography technology	Huttlin EL (2017)	1
UBXN8	0	VDAC3	1	affinity chromatography technology	Raman M (2015)	1
EGLN3	0	VDAC3	1	affinity chromatography technology	Rodriguez J (2016)	1
NXF1	0	NPLOC4	4	affinity chromatography technology	Castello A (2012)	1
UBXN8	0	UFD1	1	affinity chromatography technology	Alexandru G (2008)	1
UBXN8	0	ATP4A	6	affinity chromatography technology	Raman M (2015)	1
ADRB2	0	UBXN8	0	affinity chromatography technology	Roy SJ (2013)	1
UBXN8	0	SUCLA2	1	affinity chromatography technology	Raman M (2015)	1
NXF1	0	UBXN8	0	affinity chromatography technology	Castello A (2012)	1
MOV10	6	RHBDD2	3	biochemical	Havugimana PC (2012)	1
UBXN8	0	MSH2	4	affinity chromatography technology	Raman M (2015)	1
ADRB2	0	NPLOC4	4	affinity chromatography technology	Roy SJ (2013)	1
MTCH2	2	VDAC3	1	biochemical	Wan C (2015)	1
EGLN3	0	MSH2	4	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	MTCH2	2	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	UBXN8	0	affinity chromatography technology	Rodriguez J (2016)	1
ADRB2	0	EGLN3	0	affinity chromatography technology, pull down, pull down	Xie L (2009), Xie L (2009), Xie L (2009)	3
EGLN3	0	VCP	6	affinity chromatography technology	Rodriguez J (2016)	1
SYVN1	2	UBXN8	0	affinity chromatography technology	Madsen L (2011)	1
C5AR2	1	UBXN8	0	affinity chromatography technology	Huttlin EL (2017)	1
ADRB2	0	VCP	6	affinity chromatography technology	Roy SJ (2013)	1
UBXN8	0	SLC25A4	0	affinity chromatography technology	Raman M (2015)	1
MOV10	6	SURF4	1	affinity chromatography technology	Castello A (2012)	1
VCPIP1	4	VCP	6	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Totsukawa G (2011), Totsukawa G (2013), Totsukawa G (2013), Zhang X (2014), Raman M (2015)	6
UBXN8	0	SLC38A1	2	affinity chromatography technology	Raman M (2015)	1
UBXN8	0	TMEM165	2	affinity chromatography technology	Raman M (2015)	1
UBXN8	0	VCPIP1	4	affinity chromatography technology	Alexandru G (2008)	1
MOV10	6	UFD1	1	affinity chromatography technology	Castello A (2012)	1