PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CALCR	0	GPRASP2	0	pull down	Simonin F (2004)	1
APOB	8	CALCR	0	affinity chromatography technology, biochemical	Zhang J (2003), Zhang J (2003)	2
CALCR	0	THBS1	6	pull down	Goicoechea S (2002)	1
CALCR	0	GPRASP1	5	pull down	Simonin F (2004)	1
CALCR	0	LRP1	25	pull down, affinity chromatography technology	Orr AW (2003), Orr AW (2003)	2
GPRASP2	0	GPRASP1	5	affinity chromatography technology	Li S (2014)	1
THBS1	6	LRP1	25	pull down, pull down, pull down	Wang S (2004), Mikhailenko I (1997), Godyna S (1995)	3