PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RIN3	2	PLB1	7	two hybrid	Grossmann A (2015)	1
RIN3	2	SPATA12	0	two hybrid	Grossmann A (2015)	1
MYC	2	RIN3	2	affinity chromatography technology	Agrawal P (2010)	1
RIN3	2	CYP2C8	3	two hybrid	Grossmann A (2015)	1
RAB5B	1	RABAC1	0	two hybrid	Wang J (2011)	1
RIN3	2	GRAP2	0	two hybrid	Grossmann A (2015)	1
RGS2	2	RIN3	2	two hybrid	Vinayagam A (2011)	1
TNFAIP1	4	SUV39H1	0	two hybrid	Weimann M (2013)	1
RIN3	2	ASB8	0	two hybrid	Grossmann A (2015)	1
RIN3	2	CYP46A1	1	two hybrid	Grossmann A (2015)	1
ID2	0	SUV39H1	0	two hybrid	Weimann M (2013)	1
MYC	2	BIN1	2	pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, two hybrid	Elliott K (1999), Elliott K (1999), Pineda-Lucena A (2005), Pineda-Lucena A (2005), Pineda-Lucena A (2005), Pineda-Lucena A (2005)	6
RIN3	2	ZBTB24	1	two hybrid	Grossmann A (2015)	1
RIN3	2	POLR3F	1	two hybrid	Grossmann A (2015)	1
RGS2	2	RABAC1	0	two hybrid	Vinayagam A (2011)	1
CRK	0	KCTD17	0	two hybrid	Grossmann A (2015)	1
RIN3	2	ZNF655	0	two hybrid	Grossmann A (2015)	1
RIN3	2	RTL8B	0	two hybrid	Grossmann A (2015)	1
CRK	0	TM4SF19	1	two hybrid	Grossmann A (2015)	1
RIN3	2	MPEG1	3	two hybrid	Grossmann A (2015)	1
BIN1	2	RIN3	2	pull down, affinity chromatography technology	Kajiho H (2003), Kajiho H (2003)	2
ZBTB24	1	SUV39H1	0	two hybrid	Weimann M (2013)	1
RABAC1	0	RIN3	2	two hybrid	Vinayagam A (2011)	1
RIN3	2	TGM1	5	two hybrid	Grossmann A (2015)	1
RIN3	2	PSMD9	0	two hybrid	Grossmann A (2015)	1
RIN3	2	RAB5B	1	two hybrid, pull down	Kajiho H (2003), Kajiho H (2003)	2
RIN3	2	TSC1	4	two hybrid	Grossmann A (2015)	1
RIN3	2	ASB3	0	two hybrid	Grossmann A (2015)	1
RIN3	2	EZH2	4	two hybrid	Grossmann A (2015)	1
RIN3	2	GATA1	1	two hybrid	Grossmann A (2015)	1
RIN3	2	DOK3	5	two hybrid	Grossmann A (2015)	1
ZNF71	2	ZBTB24	1	affinity chromatography technology	Huttlin EL (2017)	1
RIN3	2	SYMPK	3	two hybrid	Grossmann A (2015)	1
RIN3	2	ZNF639	3	two hybrid	Grossmann A (2015)	1
RIN3	2	FAM46A	2	two hybrid	Grossmann A (2015)	1
RIN3	2	SPRY4	0	two hybrid	Grossmann A (2015)	1
EZH2	4	SUV39H1	0	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
MYC	2	TSC1	4	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RIN3	2	CRK	0	two hybrid	Grossmann A (2015)	1
RIN3	2	KCTD17	0	two hybrid	Grossmann A (2015)	1
RIN3	2	CSRP3	1	two hybrid	Grossmann A (2015)	1
RIN3	2	ZNF71	2	two hybrid	Grossmann A (2015)	1
RIN3	2	SUV39H1	0	two hybrid	Grossmann A (2015)	1
RIN3	2	CRKL	1	two hybrid	Grossmann A (2015)	1
RIN3	2	ID2	0	two hybrid	Grossmann A (2015)	1
TNFAIP1	4	RIN3	2	two hybrid	Hu X (2012)	1
RAB5A	0	RIN3	2	two hybrid	Kajiho H (2003)	1
RIN3	2	TSSK3	3	two hybrid	Grossmann A (2015)	1
RIN3	2	LCK	0	two hybrid	Grossmann A (2015)	1
RIN3	2	MT2A	0	two hybrid	Grossmann A (2015)	1
CRK	0	DOK3	5	two hybrid	Grossmann A (2015)	1
RIN3	2	TM4SF19	1	two hybrid	Grossmann A (2015)	1
RAB5A	0	RABAC1	0	two hybrid	Wang J (2011)	1
RIN3	2	EPS8L2	1	two hybrid	Grossmann A (2015)	1
MYC	2	SUV39H1	0	genetic interference, affinity chromatography technology	Toyoshima M (2012), Hauri S (2016)	2