PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ZNF131	0	ZBTB3	3	affinity chromatography technology	Varier RA (2016)	1
LEF1	3	SMAD3	1	pull down, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology	Labbe E (2000), Labbe E (2000), Cui Q (2005), Cui Q (2005), Cui Q (2005)	5
PPARG	0	SMAD3	1	affinity chromatography technology	Lin LC (2011)	1
LEF1	3	ZBTB3	3	two hybrid	Ravasi T (2010)	1
ZBTB18	9	ZBTB3	3	affinity chromatography technology	Huttlin EL (2017)	1
BAG3	4	SMAD3	1	affinity chromatography technology	Chen Y (2013)	1
SMAD3	1	NR3C1	2	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Li G (2003), Li G (2003), Song CZ (1999), Song CZ (1999)	4
BAG3	4	ZBTB3	3	affinity chromatography technology	Chen Y (2013)	1
ELAVL1	0	ZBTB18	9	affinity chromatography technology	Abdelmohsen K (2009)	1
PROX1	0	SMAD3	1	two hybrid	Wang J (2011)	1
GATA4	4	ZBTB3	3	two hybrid	Ravasi T (2010)	1
PPARG	0	ZBTB3	3	two hybrid	Ravasi T (2010)	1
ELAVL1	0	ZMYM2	5	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	ZNF556	0	affinity chromatography technology	Abdelmohsen K (2009)	1
IRF6	2	ZBTB3	3	two hybrid	Ravasi T (2010)	1
SSX3	0	ZBTB3	3	two hybrid	Ravasi T (2010)	1
BIN1	2	ZBTB3	3	two hybrid	Ravasi T (2010)	1
ELAVL1	0	NR3C1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
ZBTB18	9	ZNF131	0	affinity chromatography technology	Huttlin EL (2017)	1
EIF5B	2	ZBTB3	3	two hybrid	Ravasi T (2010)	1
ZBTB3	3	ZNF556	0	two hybrid	Ravasi T (2010)	1
GTF2A1L	0	ZBTB3	3	two hybrid	Ravasi T (2010)	1
BAG3	4	IKBKG	0	affinity chromatography technology	Ammirante M (2010)	1
SMAD3	1	ZBTB3	3	two hybrid	Ravasi T (2010)	1
SMAD3	1	FOXM1	3	pull down, affinity chromatography technology	Xue J (2014), Xue J (2014)	2
ELAVL1	0	ZBTB3	3	affinity chromatography technology	Abdelmohsen K (2009)	1
THRA	2	ZBTB3	3	two hybrid	Ravasi T (2010)	1
SKIL	3	ZMYM2	5	two hybrid	Colland F (2004)	1
SUPT5H	2	IKBKG	0	two hybrid	Ravasi T (2010)	1
SKIL	3	ZBTB3	3	two hybrid	Colland F (2004)	1
SMAD3	1	SKIL	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stroschein SL (2001), Stroschein SL (2001), Stroschein SL (1999), Liberati NT (2001), Tan R (2006), Mizuide M (2003), Colland F (2004), He J (2003), Jinnin M (2007), Jinnin M (2007)	10
ANKRD2	3	ZBTB3	3	two hybrid	Ravasi T (2010)	1
NR3C1	2	ZBTB3	3	two hybrid	Ravasi T (2010)	1
ELAVL1	0	BIN1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
ZMYM2	5	ZBTB3	3	two hybrid	Ravasi T (2010)	1
SUPT5H	2	ZBTB3	3	two hybrid	Ravasi T (2010)	1
IKBKG	0	ZBTB3	3	two hybrid	Ravasi T (2010)	1
NR3C1	2	PPARG	0	affinity chromatography technology	Nie M (2005)	1
JADE2	4	ZBTB3	3	two hybrid	Ravasi T (2010)	1
PKNOX1	1	ZBTB3	3	two hybrid	Ravasi T (2010)	1
FOXM1	3	ZBTB3	3	two hybrid	Ravasi T (2010)	1
PROX1	0	ZBTB3	3	two hybrid	Ravasi T (2010)	1