PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HOXD12	1	MAFK	0	pull down	Kataoka K (2001)	1
RELA	1	HIF1A	1	affinity chromatography technology, affinity chromatography technology	Yang W (2012), Yang W (2012)	2
RELA	1	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kiernan R (2003), Zhong H (2002), Zhong H (2002), Zhong H (2002), Zhong H (2002), Ashburner BP (2001), Ashburner BP (2001), OShea JM (2010), OShea JM (2010), Liu Y (2006), Cao W (2006), Hu J (2004), Hu J (2004), Sun JM (2007), Deckmann K (2012)	15
CREBBP	29	HDAC3	5	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Chuang HC (2006), Chuang HC (2006), Chuang HC (2006), Chuang HC (2006)	4
CREBBP	29	NFE2L2	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Katoh Y (2001), Katoh Y (2001), Katoh Y (2001), Liu GH (2008), Liu GH (2008), Sun Z (2009), Sun Z (2009), Sun Z (2009)	8
RELA	1	TP53	0	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Huang WC (2007), Huang WC (2007), Ivanov AA (2017)	3
NFATC2	1	MAFK	0	affinity chromatography technology	Gabriel CH (2016)	1
DNMT3L	2	MAFK	0	pull down	Pacaud R (2014)	1
CREBBP	29	RELA	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, genetic interference, genetic interference, genetic interference, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, genetic interference, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Jang HD (2004), Zhong H (2002), Zhong H (2002), Parry GC (1997), Parry GC (1997), Parry GC (1997), Aarnisalo P (1998), Gerritsen ME (1997), Gerritsen ME (1997), Gerritsen ME (1997), Gerritsen ME (1997), Liu GH (2008), Vanden Berghe W (1999), Naeaer AM (1999), Merika M (1998), Park J (2007), Verma UN (2004), Verma UN (2004), Verma UN (2004), Johnson J (2007), Aksoy E (2007), Azran I (2005), Silverman ES (1998), Huang WC (2007), Huang WC (2007), Aarnisalo P (1998), Kim HJ (1999), Hsu DS (2014), Chen Y (2015), Huang SM (2002)	30
PARP1	3	HDAC3	5	affinity chromatography technology, pull down	Hassa PO (2005), Hassa PO (2005)	2
HDAC1	4	HIF1A	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mahon PC (2001), Yoo YG (2006), Kim SH (2007), Kim SH (2007), Bodily JM (2011), Yeh IJ (2013), Yeh IJ (2013)	7
HIF1A	1	CREBBP	29	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down, pull down, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid	Ema M (1999), Ema M (1999), Bhattacharya S (1999), Park YK (2008), Choi SM (2006), Matt T (2004), Hubbi ME (2012), Ruas JL (2010), Ruas JL (2010), Ruas JL (2010), Ruas JL (2010), Ruas JL (2005), Arany Z (1996), Ruas JL (2005), Gradin K (2002)	15
HDAC1	4	HDAC2	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology	Hakimi MA (2002), Yao YL (2003), Yao YL (2003), Hakimi MA (2003), Fischle W (2002), Johnson CA (2002), Fischle W (2001), Fischer DD (2002), Fischer DD (2002), Ashburner BP (2001), Zhang Y (1999), Tong JK (1998), Tong JK (1998), Hassig CA (1998), Hassig CA (1998), Zhang Y (1997), van der Vlag J (1999), van der Vlag J (1999), Noh EJ (2009), Noh EJ (2009), Galasinski SC (2002), Galasinski SC (2002), Galasinski SC (2002), He S (2005), Humphrey GW (2001), Park JH (2004), Park JH (2004), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Adenuga D (2010), Xue Y (1998), Xue Y (1998), Martinez FP (2012), Martinez FP (2012), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Joshi P (2013), Schnur N (2007), Schnur N (2007), Oh YM (2009), Wan C (2015), Hein MY (2015), Chen TC (2014), Huttlin EL (2017)	48
HDAC3	5	HIF1A	1	pull down, affinity chromatography technology, pull down	Mahon PC (2001), Kim SH (2007), Kim SH (2007)	3
BACH1	3	HDAC1	4	affinity chromatography technology	Dohi Y (2008)	1
NFE2L2	1	HDAC2	1	affinity chromatography technology	Lee DY (2012)	1
CREBBP	29	HDAC2	1	affinity chromatography technology, affinity chromatography technology	Ito K (2000), Adenuga D (2010)	2
CREBBP	29	MAFK	0	affinity chromatography technology	Liu GH (2008)	1
MAFK	0	RELA	1	affinity chromatography technology	Liu GH (2008)	1
TP53	0	SMAD3	1	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Cordenonsi M (2003), Cordenonsi M (2003), Lu D (2013), Ali A (2013)	4
NFE2L2	1	HDAC3	5	affinity chromatography technology	Lee DY (2012)	1
RELA	1	PARP1	3	affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Hassa PO (2001), Hassa PO (2001), Hassa PO (2005), Hassa PO (2005), Hassa PO (2008), Hassa PO (2008)	6
CREBBP	29	NFATC2	1	pull down, pull down	Garcia-Rodriguez C (1998), Falvo JV (2008)	2
CREBBP	29	HOXD12	1	pull down	Shen WF (2001)	1
SMAD3	1	HDAC1	4	two hybrid, pull down	Liberati NT (2001), Akiyoshi S (1999)	2
RELA	1	SMAD3	1	two hybrid	Wang J (2011)	1
SMAD3	1	BACH1	3	affinity chromatography technology	Okita Y (2013)	1
DNMT3L	2	TP53	0	pull down	Pacaud R (2014)	1
TP53	0	MAFK	0	affinity chromatography technology	Dohi Y (2008)	1
PARP1	3	HDAC1	4	affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Hassa PO (2005), Hassa PO (2005), Hang CT (2010), Rajamohan SB (2009)	4
PARP1	3	TP53	0	affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, pull down, pull down	Gueven N (2004), Malanga M (1998), Vaziri H (1997), Vaziri H (1997), Wesierska-Gadek J (2003), Simbulan-Rosenthal CM (2003)	6
MAFK	0	HDAC1	4	affinity chromatography technology	Liu GH (2008)	1
MAFK	0	HDAC3	5	affinity chromatography technology	Liu GH (2008)	1
CREBBP	29	TP53	0	enzymatic study, pull down, genetic interference, pull down, enzymatic study, fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, imaging technique, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, affinity chromatography technology, unspecified method, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, x-ray crystallography, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Ito A (2002), Livengood JA (2002), Livengood JA (2002), Giebler HA (2000), Tang Y (2008), Jenkins LM (2009), Shi D (2009), Zhao Y (2006), Saifudeen Z (2005), Scolnick DM (1997), Scolnick DM (1997), Gu W (1997), Gu W (1997), Matsuda S (2004), Pasqualucci L (2011), Lee SK (1999), Dai C (2011), Lee CW (2010), Ferreon JC (2009), Ruas JL (2010), Ruas JL (2010), Huang WC (2007), Huang WC (2007), Mujtaba S (2004), Mujtaba S (2004), Mujtaba S (2004), Mujtaba S (2004), Col E (2002), Jansma AL (2014), Jansma AL (2014), Krois AS (2016), Hasegawa K (2008), Huang X (2013), Huang X (2013), Piskacek M (2016)	35
HIF1A	1	SMAD3	1	imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sanchez-Elsner T (2001), Sanchez-Elsner T (2001), Sanchez-Elsner T (2001), Sanchez-Elsner T (2001), Sanchez-Elsner T (2002)	5
KAT6A	19	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Rokudai S (2009), Rokudai S (2009), Rokudai S (2009), Rokudai S (2013), Rokudai S (2013)	5
KAT6A	19	CREBBP	29	affinity chromatography technology, affinity chromatography technology, pull down	Kindle KB (2005), Yin H (2007), Yin H (2007)	3
CREBBP	29	SMAD3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kang JS (2005), Alliston T (2005), Xi Q (2008), Cui Q (2005), Cui Q (2005), Chen W (2007), Nishihara A (1999), Tomita M (2004), Oussaief L (2009), Oussaief L (2009), Cui Q (2005)	11
HIF1A	1	MAFK	0	pull down	Ueda K (2008)	1
NFE2L3	6	MAFK	0	two hybrid, affinity chromatography technology	Kobayashi A (1999), Huttlin EL (2017)	2
HDAC2	1	HIF1A	1	pull down, imaging technique	Mahon PC (2001), Chen TC (2014)	2
NFATC2	1	HDAC1	4	affinity chromatography technology	Gabriel CH (2016)	1
RELA	1	HDAC2	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Kiernan R (2003), Yu Z (2002), Yu Z (2002), Ito K (2001), Ito K (2000), Sun JM (2007), Adenuga D (2010), Wang H (2010), Chen TC (2014)	9
NFATC2	1	PARP1	3	affinity chromatography technology	Gabriel CH (2016)	1
DNMT3L	2	RELA	1	pull down, imaging technique, affinity chromatography technology, pull down	Pacaud R (2014), Pacaud R (2014), Pacaud R (2014), Pacaud R (2014)	4
HIF1A	1	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Chen D (2003), Ravi R (2000), Hansson LO (2002), An WG (1998), An WG (1998), Chowdhury AR (2017), Chowdhury AR (2017), Suzuki H (2001), Sanchez-Puig N (2005)	9
MAFK	0	HDAC2	1	affinity chromatography technology	Liu GH (2008)	1
HDAC1	4	CREBBP	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mayanil CS (2006), Chuang HC (2006), Chuang HC (2006)	3
CREBBP	29	PARP1	3	enzymatic study, imaging technique	Hassa PO (2005), Chen H (2014)	2
TP53	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique	Ito A (2002), Wang C (2005), Dohi Y (2008), Jin W (2008), Lei Q (2006), Wu Y (2001), Wu Y (2001), Luo J (2000), Juan LJ (2000), Juan LJ (2000), Juan LJ (2000), Murphy M (1999), Insinga A (2004), Sun JM (2007), Yu XY (2010), Sinha S (2010), Sinha S (2010), Li Y (2012), Di Agostino S (2006), Pavithra L (2009), Pavithra L (2009), Luo J (2000), Chen TC (2014), Park EK (2015), Park EK (2015), Park EK (2015)	26
BACH1	3	MAFK	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Dohi Y (2008), Dohi Y (2008), Dohi Y (2008), Hein MY (2015), Huttlin EL (2017)	5
SMAD3	1	MAFK	0	affinity chromatography technology	Okita Y (2013)	1
TP53	0	HDAC2	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li P (2010), Insinga A (2004), Sun JM (2007), Tian B (2011), Adenuga D (2010), Brandl A (2012)	6
NFE2L3	6	NFE2L2	1	fluorescent resonance energy transfe	Reinke AW (2013)	1
MAFK	0	NFE2L2	1	pull down, two hybrid, affinity chromatography technology	Nguyen T (2000), Wang J (2011), Okita Y (2013)	3
PARP1	3	HIF1A	1	affinity chromatography technology	Elser M (2008)	1
MAFK	0	KAT6A	19	affinity chromatography technology, pull down	Ohta K (2007), Ohta K (2007)	2
BACH1	3	NFE2L2	1	imaging technique, imaging technique	Dhakshinamoorthy S (2005), Dhakshinamoorthy S (2005)	2
PARP1	3	HDAC2	1	affinity chromatography technology, pull down, affinity chromatography technology	Hassa PO (2005), Hassa PO (2005), Hang CT (2010)	3
RELA	1	HDAC3	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen Lf (2001), Chen Lf (2001), Hu J (2004), Hu J (2004)	4
DNMT3L	2	HDAC1	4	pull down, pull down, pull down, pull down, affinity chromatography technology	Aapola U (2002), Aapola U (2002), Deplus R (2002), Deplus R (2002), Deplus R (2002)	5
NFE2L2	1	HDAC1	4	affinity chromatography technology	Lee DY (2012)	1
BACH1	3	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down	Dohi Y (2008), Dohi Y (2008), Dohi Y (2008)	3
DNMT3L	2	SMAD3	1	pull down	Pacaud R (2014)	1
PARP1	3	MAFK	0	affinity chromatography technology	Wu T (2013)	1