PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EGFR	5	RASA1	3	pull down, unspecified method, pull down	Daly RJ (1996), Jones RB (2006), Marengere LE (1992)	3
XPO1	8	CSNK1E	0	affinity chromatography technology	Kirli K (2015)	1
BBS7	2	BBS10	2	affinity chromatography technology	Huttlin EL (2017)	1
RGS2	2	BBS10	2	two hybrid	Vinayagam A (2011)	1
PTK2	2	BBS10	2	two hybrid	Vinayagam A (2011)	1
YAE1D1	1	BBS10	2	two hybrid	Vinayagam A (2011)	1
HDAC6	0	XPO1	8	affinity chromatography technology, affinity chromatography technology	Riolo MT (2012), Kirli K (2015)	2
XPO1	8	NR4A1	4	affinity chromatography technology	Kirli K (2015)	1
MAP3K7	2	BBS10	2	two hybrid	Vinayagam A (2011)	1
MAPK6	1	BBS10	2	two hybrid	Vinayagam A (2011)	1
HDAC6	0	BBS10	2	two hybrid	Vinayagam A (2011)	1
EGFR	5	HDAC6	0	affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Gao YS (2010), Deribe YL (2009), Deribe YL (2009), Deribe YL (2009), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	7
NR4A1	4	BBS10	2	two hybrid	Vinayagam A (2011)	1
XPO1	8	MAP3K7	2	affinity chromatography technology	Kirli K (2015)	1
EGFR	5	BBS10	2	affinity chromatography technology	Yao Z (2017)	1
MAPK6	1	DNAJC7	2	affinity chromatography technology	Rodriguez J (2016)	1
RASA1	3	BBS10	2	two hybrid	Vinayagam A (2011)	1
XPO1	8	BBS10	2	affinity chromatography technology	Kirli K (2015)	1
MAPK6	1	SSSCA1	0	affinity chromatography technology	Rodriguez J (2016)	1
XPO1	8	YAE1D1	1	affinity chromatography technology	Kirli K (2015)	1
MAPK6	1	MAP3K7	2	two hybrid	Vinayagam A (2011)	1
EGFR	5	RGS2	2	enzymatic study	Derrien A (2001)	1
PTK2	2	EGFR	5	affinity chromatography technology, two hybrid, protein complementation assay	Sieg DJ (2000), Kotlyar M (2015), Petschnigg J (2014)	3
EGFR	5	XPO1	8	affinity chromatography technology	Foerster S (2013)	1
NR4A1	4	HDAC6	0	affinity chromatography technology	Rambaud J (2009)	1
CSNK1E	0	BBS10	2	two hybrid	Vinayagam A (2011)	1
TNFSF11	0	BBS10	2	two hybrid	Vinayagam A (2011)	1
MAPK8IP2	5	BBS10	2	two hybrid	Vinayagam A (2011)	1
FRZB	2	BBS10	2	two hybrid	Vinayagam A (2011)	1
DNAJC7	2	BBS10	2	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	MAPK8IP2	5	unspecified method, two hybrid, protein complementation assay	Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014)	3
SSSCA1	0	BBS10	2	affinity chromatography technology	Huttlin EL (2017)	1