PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PLCG2	11	TP53	0	two hybrid	Grossmann A (2015)	1
KCTD17	0	TYW3	0	affinity chromatography technology	Huttlin EL (2017)	1
KCTD17	0	KCTD5	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KCTD17	0	THAP9	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
REPIN1	3	KCTD2	0	affinity chromatography technology	Huttlin EL (2017)	1
CYLD	2	KCTD5	0	affinity chromatography technology	Elliott PR (2016)	1
KCND2	2	KCTD17	0	affinity chromatography technology	Huttlin EL (2017)	1
TP53	0	NPM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dhar SK (2006), Kurki S (2004), Kurki S (2004), Lambert B (2006), Colombo E (2002), Colombo E (2002), Colombo E (2002), Fogeron ML (2013), Li J (2005)	9
CUL3	17	TFAM	1	affinity chromatography technology	Bennett EJ (2010)	1
TUBGCP4	3	KCTD17	0	two hybrid	Rual JF (2005)	1
PSMA1	1	KCTD17	0	two hybrid	Rual JF (2005)	1
EIF2AK2	1	KCTD17	0	affinity chromatography technology	Li S (2011)	1
RAPGEF2	5	KCTD5	0	affinity chromatography technology	Kim TY (2014)	1
ARRDC1	4	KCTD2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TP53	0	CYLD	2	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Fernandez-Majada V (2016), Fernandez-Majada V (2016), Fernandez-Majada V (2016), Fernandez-Majada V (2016)	4
STK16	1	KCTD17	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
KCTD17	0	SPECC1L	5	affinity chromatography technology	Huttlin EL (2015)	1
CUL3	17	NAALADL2	0	affinity chromatography technology	Bennett EJ (2010)	1
PDZK1	0	KCTD5	0	affinity chromatography technology	Huttlin EL (2017)	1
NAALADL2	0	KCTD17	0	affinity chromatography technology	Huttlin EL (2015)	1
KCTD17	0	MTMR6	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KCTD17	0	CTC1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KCTD17	0	LNX1	7	two hybrid	Rual JF (2005)	1
KCTD17	0	RBX1	2	affinity chromatography technology, pull down, affinity chromatography technology	Kasahara K (2014), Kasahara K (2014), Kasahara K (2014)	3
LNX1	7	CSNK1D	3	affinity chromatography technology	Lenihan JA (2017)	1
NPM1	0	EIF1AX	0	affinity chromatography technology	Hein MY (2015)	1
MTMR9	1	MTMR6	2	pull down, affinity chromatography technology, two hybrid, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Mochizuki Y (2003), Mochizuki Y (2003), Rolland T (2014), Wan C (2015), Yu H (2011), St-Denis N (2016), St-Denis N (2016), St-Denis N (2016), Huttlin EL (2017)	9
KCTD17	0	TCHP	0	pull down, enzymatic study	Kasahara K (2014), Kasahara K (2014)	2
TINF2	1	KCTD17	0	two hybrid	Lee OH (2011)	1
CYLD	2	KCTD2	0	affinity chromatography technology	Elliott PR (2016)	1
KCTD17	0	CSNK1D	3	affinity chromatography technology	Huttlin EL (2015)	1
KCTD17	0	MTMR9	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KCTD17	0	KCTD2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KCTD17	0	REPIN1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KCTD17	0	CBX4	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RAPGEF2	5	KCTD17	0	affinity chromatography technology	Kim TY (2014)	1
CYLD	2	KCTD17	0	affinity chromatography technology	Elliott PR (2016)	1
CYLD	2	PSMA1	1	affinity chromatography technology	Elliott PR (2016)	1
KCTD5	0	C21orf2	1	affinity chromatography technology	Boldt K (2016)	1
NPM1	0	KCTD17	0	affinity chromatography technology	Chen R (2013)	1
CUL3	17	MTMR9	1	affinity chromatography technology	Bennett EJ (2010)	1
KCTD17	0	KCTD17	0	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
CUL3	17	KCTD2	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Kim EJ (2017), Kim EJ (2017), Huttlin EL (2017)	4
KCTD17	0	CERK	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GLRA2	4	KCTD17	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
POLK	0	KCTD5	0	affinity chromatography technology	Hein MY (2015)	1
RGS3	0	KCTD2	0	affinity chromatography technology	Huttlin EL (2017)	1
KCTD17	0	DBR1	2	affinity chromatography technology	Huttlin EL (2015)	1
RBX1	2	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Furukawa M (2005), Hu J (2004), Furukawa M (2002), Ichikawa T (2009), Ichikawa T (2009), Lee DF (2009), Tron AE (2012), Oshikawa K (2003), Plafker KS (2009), Lu A (2013), Meyer-Schaller N (2009), Theurillat JP (2014), Huang DT (2009), Ibeawuchi SR (2015), Schumacher FR (2015), Kasahara K (2014), Kasahara K (2014)	18
CRK	0	KCTD17	0	two hybrid	Grossmann A (2015)	1
KCTD17	0	PPP1R10	3	affinity chromatography technology	Huttlin EL (2017)	1
NPM1	0	KCTD2	0	affinity chromatography technology	Chen R (2013)	1
TYW3	0	PCBP3	2	affinity chromatography technology	Huttlin EL (2017)	1
KCTD17	0	C21orf2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PDZK1	0	KCTD17	0	affinity chromatography technology	Huttlin EL (2017)	1
RGS3	0	KCTD17	0	affinity chromatography technology	Huttlin EL (2017)	1
CUL3	17	KCTD17	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Bennett EJ (2010), Ji AX (2016), Kasahara K (2014), Kasahara K (2014), Kasahara K (2014), Pinkas DM (2017)	6
KCTD17	0	LRRC18	1	two hybrid	Rual JF (2005)	1
KCTD17	0	NUDT18	0	two hybrid	Rual JF (2005)	1
TP53	0	RBX1	2	affinity chromatography technology	Fogeron ML (2013)	1
PDZK1	0	KCTD2	0	affinity chromatography technology	Huttlin EL (2017)	1
OPTN	1	CYLD	2	two hybrid, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology	Nagabhushana A (2011), Nagabhushana A (2011), Nagabhushana A (2011), Genin P (2015), Genin P (2015)	5
KCTD17	0	POLRMT	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KCTD17	0	RBM14-RBM4	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CRK	0	TP53	0	two hybrid	Grossmann A (2015)	1
RBX1	2	UBE2D1	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, unspecified method, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Li Y (2010), Shaik S (2012), Costessi A (2011), Bashir T (2010), Lan L (2012), Welcker M (2011), Wilkins A (2004), Yada M (2004), Li C (2011), Lee DF (2009), Santra MK (2009), Chen BB (2012), Liu J (2002), Duan S (2011), Barbash O (2011), Kamura T (2003), Abbas T (2008), Peschiaroli A (2009), Popov N (2010), Uchida S (2011), Dimitrova YN (2010), Maerki S (2009), Malatesta M (2012), Davis MA (2013), Chen H (2013), Mallampalli RK (2013), Rossi M (2013), Mori Y (2013), Lu A (2013), Fischer ES (2014), Andresen CA (2014), Herrero-Ruiz J (2014), Johansson P (2014), Uchiki T (2009), Min SH (2012), Gao D (2010), Canettieri G (2010), Lin MY (2011), Read MA (2000), Zhang DD (2004), Zhang DD (2005), Fukushima H (2013), Matsumoto S (2015), Ibeawuchi SR (2015), Malonia SK (2015), Liu Y (2015), Liu Y (2015), Gao J (2015), Zhang C (2015), Chu WK (2015), Barbash O (2009), Kershaw NJ (2014), Nam S (2009), Wu HC (2014), Kim JH (2015), Kung YA (2017), Nguyen TV (2016), Shimizu K (2017), Gschweitl M (2016), Terai K (2013), Chandra S (2013), Dai X (2017), Qie S (2017), Chen BB (2013), Kroenke J (2014)	65
KCTD17	0	SUV39H2	3	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
KCTD17	0	CDC42BPA	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KCTD17	0	PLD1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL3	17	POLRMT	3	affinity chromatography technology	Bennett EJ (2010)	1
KCTD17	0	PIP5K1A	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KCTD17	0	ACAD11	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NIF3L1	0	KCTD17	0	two hybrid	Rual JF (2005)	1
KCTD17	0	UBE2D1	0	pull down	Kasahara K (2014)	1
ZNF687	8	ZMYND8	5	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
KCTD17	0	MPLKIP	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL3	17	EIF2AK2	1	affinity chromatography technology	Bennett EJ (2010)	1
TP53	0	POLRMT	3	affinity chromatography technology	Li X (2015)	1
KCND2	2	KCTD5	0	affinity chromatography technology	Huttlin EL (2017)	1
OPTN	1	KCTD17	0	affinity chromatography technology	Li S (2011)	1
PDZK1	0	CDK5RAP1	1	affinity chromatography technology	Huttlin EL (2017)	1
MTMR9	1	LNX1	7	two hybrid	Rolland T (2014)	1
PLCG2	11	PLD1	5	affinity chromatography technology	Wang J (2006)	1
CSNK1D	3	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, imaging technique	Kulikov R (2006), Alsheich-Bartok O (2008), Alsheich-Bartok O (2008), Wolff S (2006), Chen TC (2014)	5
KCTD17	0	PCBP3	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KCTD17	0	CTU2	0	affinity chromatography technology	Huttlin EL (2015)	1
STK16	1	NIF3L1	0	two hybrid	Rolland T (2014)	1
CRK	0	PTPN4	0	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
LNX1	7	SUV39H2	3	two hybrid	Weimann M (2013)	1
KCTD17	0	RECQL4	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARRDC1	4	KCTD5	0	affinity chromatography technology	Huttlin EL (2015)	1
TP53	0	EIF2AK2	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Cuddihy AR (1999), Cuddihy AR (1999), Cuddihy AR (1999), Cuddihy AR (1999), Cuddihy AR (1999), Morel M (2009), Morel M (2009)	7
CD93	1	KCTD17	0	affinity chromatography technology	Huttlin EL (2017)	1
KCTD17	0	ZMYND8	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL3	17	UBE2D1	0	pull down	Sumara I (2007)	1
CUL3	17	NPM1	0	affinity chromatography technology	Bennett EJ (2010)	1
KCTD17	0	POLK	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RIN3	2	CRK	0	two hybrid	Grossmann A (2015)	1
KCTD17	0	ZNF696	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARRDC1	4	KCTD17	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DMC1	2	NIF3L1	0	two hybrid	Rolland T (2014)	1
RIN3	2	KCTD17	0	two hybrid	Grossmann A (2015)	1
DBR1	2	MPLKIP	1	affinity chromatography technology	Huttlin EL (2017)	1
PLCG2	11	KCTD17	0	two hybrid	Grossmann A (2015)	1
KCTD17	0	FRMD6	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CYLD	2	NPM1	0	affinity chromatography technology	Elliott PR (2016)	1
KCTD17	0	RWDD4	1	two hybrid	Rual JF (2005)	1
CBX4	1	NPM1	0	affinity chromatography technology	Vandamme J (2011)	1
GLRA2	4	KCTD2	0	affinity chromatography technology	Huttlin EL (2017)	1
KCTD17	0	ZNF687	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KCTD17	0	EIF1AX	0	affinity chromatography technology	Huttlin EL (2015)	1
KCTD17	0	PPP1R9A	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NPM1	0	EIF2AK2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study	Garcia MA (2006), Garcia MA (2006), Pang Q (2003), Pang Q (2003), Pang Q (2003), Pang Q (2003), Pang Q (2003)	7
CYLD	2	TFAM	1	affinity chromatography technology	Elliott PR (2016)	1
KCND2	2	KCTD2	0	affinity chromatography technology	Huttlin EL (2017)	1
KCTD17	0	DUSP11	2	affinity chromatography technology	Huttlin EL (2015)	1
KCTD17	0	PTPN4	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NPM1	0	KCTD5	0	affinity chromatography technology	Chen R (2013)	1
KCTD17	0	TFAM	1	affinity chromatography technology	Huttlin EL (2015)	1
AQP1	1	KCTD17	0	two hybrid	Rual JF (2005)	1
DMC1	2	KCTD17	0	two hybrid	Rolland T (2014)	1
KCTD17	0	CDK5RAP1	1	affinity chromatography technology	Huttlin EL (2015)	1
TP53	0	KCTD17	0	affinity chromatography technology	Horikawa I (2014)	1
KCTD5	0	CUL3	17	affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down	Bayon Y (2008), Bayon Y (2008), Bennett EJ (2010), Balasco N (2014), Ji AX (2016), Pinkas DM (2017)	6