PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SFN	1	DTX2	3	affinity chromatography technology	Benzinger A (2005)	1
PLEKHF2	1	FRMD8	1	two hybrid	Rolland T (2014)	1
ELAVL1	0	MEAF6	0	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	APPL1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
AIDA	1	APP	1	pull down	Olah J (2011)	1
CCDC172	0	PLEKHF2	1	two hybrid	Yu H (2011)	1
USF1	0	MAX	0	affinity chromatography technology	Li X (2011)	1
S100A1	1	PLEKHF2	1	two hybrid	Rolland T (2014)	1
SEPT2	4	SEPT6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Rual JF (2005), Surka MC (2002), Kremer BE (2007), Rolland T (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	7
ELAVL1	0	CGGBP1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	USF1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
PLEKHF2	1	APP	1	pull down	Olah J (2011)	1
DRAP1	2	PLEKHF2	1	two hybrid	Yu H (2011)	1
RABAC1	0	PLEKHF2	1	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
CCDC85B	0	LDOC1	0	two hybrid	Rual JF (2005)	1
BLOC1S6	0	PLEKHF2	1	two hybrid	Rual JF (2005)	1
LDOC1	0	DPPA4	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
LDOC1	0	MEAF6	0	two hybrid	Rolland T (2014)	1
ELAVL1	0	TXNL4B	0	affinity chromatography technology	Abdelmohsen K (2009)	1
PLEKHF2	1	DUT	1	two hybrid	Venkatesan K (2009)	1
PRPSAP1	0	PLEKHF2	1	two hybrid	Rual JF (2005)	1
CXorf57	0	PLEKHF2	1	two hybrid	Yu H (2011)	1
HSPB7	1	APP	1	pull down	Olah J (2011)	1
TRAPPC3	0	PLEKHF2	1	two hybrid	Rolland T (2014)	1
RTN3	2	RTN4	4	two hybrid, affinity chromatography technology	Rual JF (2005), Huttlin EL (2017)	2
PLEKHF2	1	BEND7	0	two hybrid	Venkatesan K (2009)	1
GNMT	0	PLEKHF2	1	two hybrid	Rual JF (2005)	1
CCDC85B	0	MBIP	0	two hybrid	Rual JF (2005)	1
FRMD8	1	APP	1	pull down	Olah J (2011)	1
SPEF1	2	PLEKHF2	1	two hybrid	Rual JF (2005)	1
CHIC2	0	CEP44	2	two hybrid	Rolland T (2014)	1
RTN4	4	RABAC1	0	affinity chromatography technology	Huttlin EL (2017)	1
APPL1	1	TRAF6	0	affinity chromatography technology	Cheng KK (2013)	1
ELAVL1	0	GPBP1L1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
RTN1	3	PLEKHF2	1	two hybrid	Rual JF (2005)	1
ZNF263	2	PLEKHF2	1	two hybrid	Rual JF (2005)	1
ZNF250	2	PLEKHF2	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
THOC2	4	PLEKHF2	1	affinity chromatography technology	Hein MY (2015)	1
DRAP1	2	APP	1	pull down	Olah J (2011)	1
AIMP2	0	PLEKHF2	1	two hybrid	Rolland T (2014)	1
PLEKHF2	1	L3MBTL3	0	two hybrid	Rolland T (2014)	1
SHMT2	3	APP	1	pull down	Olah J (2011)	1
NPM2	0	PLEKHF2	1	two hybrid	Rolland T (2014)	1
CCDC85B	0	PLEKHF2	1	two hybrid	Rual JF (2005)	1
AIMP2	0	TRAF6	0	affinity chromatography technology	Kim DG (2016)	1
USF1	0	PLEKHF2	1	two hybrid	Yu H (2011)	1
GPBP1	2	PLEKHF2	1	two hybrid	Rolland T (2014)	1
ELAVL1	0	CHIC2	0	affinity chromatography technology	Abdelmohsen K (2009)	1
TNFAIP8	0	PLEKHF2	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
SEPT5	1	SEPT2	4	two hybrid, two hybrid, two hybrid, biochemical, affinity chromatography technology	Corominas R (2014), DeGrado-Warren J (2008), Rolland T (2014), Wan C (2015), Huttlin EL (2017)	5
FHL3	0	PLEKHF2	1	two hybrid	Rolland T (2014)	1
MAX	0	PLEKHF2	1	two hybrid	Rual JF (2005)	1
PLEKHF2	1	RSPO2	3	two hybrid	Rolland T (2014)	1
FBXO28	2	PLEKHF2	1	two hybrid	Rolland T (2014)	1
ARL14EP	1	PLEKHF2	1	two hybrid	Yu H (2011)	1
CCDC85B	0	ZNF250	2	two hybrid	Rual JF (2005)	1
RTN4	4	PLEKHF2	1	two hybrid	Rual JF (2005)	1
ZNF250	2	CEP44	2	two hybrid	Rual JF (2005)	1
SFN	1	PLEKHF2	1	two hybrid	Rual JF (2005)	1
TXNL4B	0	PLEKHF2	1	two hybrid	Rolland T (2014)	1
SHMT2	3	TNFAIP8	0	affinity chromatography technology	Castello A (2012)	1
TSC22D3	1	PLEKHF2	1	two hybrid	Rual JF (2005)	1
PRDM14	1	PLEKHF2	1	two hybrid	Yu H (2011)	1
TRAPPC3	0	APP	1	pull down	Olah J (2011)	1
DPPA4	0	FHL3	0	affinity chromatography technology	Oliviero G (2015)	1
BSCL2	2	PLEKHF2	1	two hybrid	Rolland T (2014)	1
DPPA4	0	PLEKHF2	1	two hybrid	Yu H (2011)	1
SETBP1	12	APP	1	pull down	Olah J (2011)	1
TBX3	0	PLEKHF2	1	two hybrid	Yu H (2011)	1
SEPT5	1	PLEKHF2	1	two hybrid	Yu H (2011)	1
TRAF6	0	APP	1	pull down	Olah J (2011)	1
CAVIN2	3	PLEKHF2	1	two hybrid	Rual JF (2005)	1
ELAVL1	0	FRMD8	1	affinity chromatography technology	Abdelmohsen K (2009)	1
CCDC85B	0	MEAF6	0	two hybrid	Rual JF (2005)	1
PLEKHF2	1	CGGBP1	1	two hybrid	Yu H (2011)	1
SEPT5	1	APP	1	pull down	Olah J (2011)	1
ELAVL1	0	DUT	1	biochemical	Wan C (2015)	1
DPPA4	0	L3MBTL3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2Z	0	PLEKHF2	1	two hybrid	Rual JF (2005)	1
ELAVL1	0	BLOC1S6	0	affinity chromatography technology	Abdelmohsen K (2009)	1
RTN4	4	RTN1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GPBP1L1	0	PLEKHF2	1	two hybrid	Rual JF (2005)	1
HSPB7	1	PRDM14	1	two hybrid	Rolland T (2014)	1
CHIC2	0	PLEKHF2	1	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
RTN3	2	PLEKHF2	1	two hybrid	Rual JF (2005)	1
AIDA	1	PLEKHF2	1	two hybrid	Yu H (2011)	1
TRAF6	0	PLEKHF2	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
PLEKHF2	1	MEAF6	0	two hybrid, two hybrid	Venkatesan K (2009), Rolland T (2014)	2
SEPT2	4	PLEKHF2	1	two hybrid	Rolland T (2014)	1
MAX	0	MEAF6	0	affinity chromatography technology	Cheng J (2017)	1
SEPT5	1	SEPT6	0	two hybrid, two hybrid, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Corominas R (2014), DeGrado-Warren J (2008), Rolland T (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	6
PLEKHF2	1	DTX2	3	two hybrid	Rolland T (2014)	1
PLEKHF2	1	CEP44	2	two hybrid	Rolland T (2014)	1
CEP44	2	BEND7	0	two hybrid	Rolland T (2014)	1
ELAVL1	0	TBX3	0	affinity chromatography technology	Abdelmohsen K (2009)	1
ZNF398	1	PLEKHF2	1	two hybrid	Rolland T (2014)	1
SETBP1	12	PLEKHF2	1	two hybrid	Rolland T (2014)	1
NONO	3	PLEKHF2	1	two hybrid	Rual JF (2005)	1
SEPT6	0	PLEKHF2	1	two hybrid	Rolland T (2014)	1
ELAVL1	0	NONO	3	affinity chromatography technology	Abdelmohsen K (2009)	1
SFN	1	NONO	3	affinity chromatography technology	Wilker EW (2007)	1
ELAVL1	0	PRKAR1A	4	affinity chromatography technology	Abdelmohsen K (2009)	1
MBIP	0	PLEKHF2	1	two hybrid, two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009), Rolland T (2014)	3
MOV10	6	PLEKHF2	1	affinity chromatography technology	Castello A (2012)	1
PLEKHF2	1	ACY3	1	two hybrid	Rolland T (2014)	1
HSPB7	1	PLEKHF2	1	two hybrid	Rolland T (2014)	1
BLOC1S6	0	APP	1	pull down	Olah J (2011)	1
GLUL	2	PLEKHF2	1	two hybrid	Rual JF (2005)	1
PRKAR1A	4	PLEKHF2	1	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
ELAVL1	0	TSC22D3	1	affinity chromatography technology	Abdelmohsen K (2009)	1
MOV10	6	UBE2Z	0	affinity chromatography technology	Castello A (2012)	1
SHMT2	3	PLEKHF2	1	affinity chromatography technology	Castello A (2012)	1
PLEKHF2	1	LDOC1	0	two hybrid	Venkatesan K (2009)	1
ELAVL1	0	PLEKHF2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
GFER	1	PLEKHF2	1	two hybrid	Rolland T (2014)	1
LDOC1	0	ZNF250	2	two hybrid	Rual JF (2005)	1
FHL3	0	AIMP2	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Rolland T (2014), Yu H (2011)	3
PLEKHF2	1	APPL1	1	two hybrid	Venkatesan K (2009)	1
S100A13	0	PLEKHF2	1	two hybrid	Rolland T (2014)	1
AIMP2	0	APP	1	pull down	Olah J (2011)	1
USF1	0	APP	1	pull down	Olah J (2011)	1