PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CHMP6	0	METTL9	0	two hybrid	Tsang HT (2006)	1
RAB17	2	CHMP6	0	affinity chromatography technology	Ewing RM (2007)	1
BAIAP2	6	CHMP6	0	affinity chromatography technology	Hein MY (2015)	1
SUN2	1	CHMP6	0	affinity chromatography technology	Huttlin EL (2017)	1
SNF8	2	CHMP6	0	two hybrid, two hybrid	Bowers K (2006), von Schwedler UK (2003)	2
CHMP6	0	NXN	2	affinity chromatography technology	Ewing RM (2007)	1
VPS36	3	CHMP6	0	two hybrid	von Schwedler UK (2003)	1
VPS25	1	VPS36	3	two hybrid, two hybrid, pull down, x-ray crystallography, two hybrid, two hybrid, two hybrid, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Bowers K (2006), Bowers K (2006), Bowers K (2006), Im YJ (2008), Langelier C (2006), Langelier C (2006), von Schwedler UK (2003), Wang T (2006), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	12
CHMP6	0	CHMP4B	2	two hybrid, two hybrid, affinity chromatography technology, pull down	von Schwedler UK (2003), Tsang HT (2006), Yorikawa C (2005), Yorikawa C (2005)	4
VPS36	3	TSG101	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology, imaging technique	Langelier C (2006), Langelier C (2006), von Schwedler UK (2003), Kumar B (2016), Kumar B (2016)	5
SNF8	2	TSG101	1	two hybrid, two hybrid, two hybrid	Langelier C (2006), Langelier C (2006), von Schwedler UK (2003)	3
SNF8	2	VPS36	3	two hybrid, two hybrid, x-ray crystallography, two hybrid, two hybrid, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Bowers K (2006), Bowers K (2006), Im YJ (2008), Langelier C (2006), Langelier C (2006), von Schwedler UK (2003), Wang T (2006), Wan C (2015), Huttlin EL (2017)	9
RIPPLY1	1	CHMP6	0	affinity chromatography technology	Huttlin EL (2017)	1
VPS25	1	CHMP6	0	two hybrid, two hybrid, two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, pull down	Bowers K (2006), Bowers K (2006), Langelier C (2006), Langelier C (2006), Langelier C (2006), Langelier C (2006), von Schwedler UK (2003), Tsang HT (2006), Yorikawa C (2005), Yorikawa C (2005)	10
CHMP4B	2	TSG101	1	affinity chromatography technology	Hein MY (2015)	1
CHMP6	0	ELOF1	2	two hybrid	Tsang HT (2006)	1
SNF8	2	VPS25	1	two hybrid, two hybrid, two hybrid, pull down, two hybrid, two hybrid, two hybrid, affinity chromatography technology, two hybrid, biochemical, two hybrid	Rual JF (2005), Bowers K (2006), Bowers K (2006), Bowers K (2006), Langelier C (2006), Langelier C (2006), von Schwedler UK (2003), Wang T (2006), Rolland T (2014), Wan C (2015), Yu H (2011)	11
CCDC8	1	CHMP6	0	affinity chromatography technology	Hanson D (2014)	1
TSG101	1	CHMP6	0	affinity chromatography technology, imaging technique	Kumar B (2016), Kumar B (2016)	2