PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
7179	0	TUBB3	3	two hybrid	Wang J (2011)	1
METTL23	1	VCPKMT	2	affinity chromatography technology	Cloutier P (2013)	1
VCPKMT	2	LAGE3	0	affinity chromatography technology	Cloutier P (2013)	1
UBC	7	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhong X (2006), Dai RM (2001), Bish RA (2007), Lim JJ (2016), Zhang X (2017)	6
VCP	6	ASPSCR1	3	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Vinayagam A (2011), Alexandru G (2012), Yu CC (2013), Fogeron ML (2013), Rolland T (2014), Madsen L (2014), Madsen L (2014), Madsen L (2014), Madsen L (2014), Hein MY (2015), Raman M (2015), Huttlin EL (2017)	14
VCPKMT	2	UBB	4	affinity chromatography technology	Cloutier P (2013)	1
VCPKMT	2	HEXB	0	affinity chromatography technology	Cloutier P (2013)	1
METTL23	1	UBC	7	affinity chromatography technology	Cloutier P (2013)	1
UBXN6	1	ASPSCR1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haines DS (2012), Huttlin EL (2015), Raman M (2015), Huttlin EL (2017)	4
VCPKMT	2	VCP	6	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology	Cloutier P (2013), Cloutier P (2013), Cloutier P (2013), Huttlin EL (2017)	4
VCPKMT	2	UBXN6	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cloutier P (2013), Huttlin EL (2015), Huttlin EL (2017)	3
VCPKMT	2	UBC	7	affinity chromatography technology	Cloutier P (2013)	1
METTL21A	0	VCPKMT	2	affinity chromatography technology	Cloutier P (2013)	1
TUBB2A	2	TUBB3	3	affinity chromatography technology	Huttlin EL (2017)	1
METTL23	1	TUBB3	3	affinity chromatography technology	Cloutier P (2013)	1
UBC	7	ASPSCR1	3	affinity chromatography technology	Matsumoto M (2005)	1
METTL23	1	UBB	4	affinity chromatography technology	Cloutier P (2013)	1
VCP	6	TUBB3	3	biochemical	Wan C (2015)	1
UBXN6	1	VCP	6	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kern M (2009), Kern M (2009), Kern M (2009), Stapf C (2011), Stapf C (2011), Stapf C (2011), Alexandru G (2008), Haenzelmann P (2011), Haenzelmann P (2011), Allen MD (2006), Nagahama M (2009), Nagahama M (2009), Alexandru G (2012), Haines DS (2012), Yu CC (2013), Huttlin EL (2015), Madsen L (2014), Trusch F (2015), Raman M (2015), Raman M (2015), Guo X (2017), Guo X (2017), Huttlin EL (2017)	23
METTL21A	0	HSPA9	2	affinity chromatography technology	Cloutier P (2013)	1
VCPKMT	2	HSPA9	2	affinity chromatography technology	Cloutier P (2013)	1
VCPKMT	2	ALDOA	0	affinity chromatography technology	Cloutier P (2013)	1
VCPKMT	2	MAT2A	2	affinity chromatography technology	Cloutier P (2013)	1
VCPKMT	2	ASPSCR1	3	affinity chromatography technology, pull down	Cloutier P (2013), Cloutier P (2013)	2
VCP	6	UBB	4	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Fogeron ML (2013)	2
VCPKMT	2	TUBB3	3	affinity chromatography technology	Cloutier P (2013)	1
VCPKMT	2	TUBB2A	2	affinity chromatography technology	Cloutier P (2013)	1
METTL23	1	TUBB2A	2	affinity chromatography technology	Cloutier P (2013)	1
7179	0	VCPKMT	2	affinity chromatography technology	Li X (2016)	1