PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBE2V2	0	UBC	7	x-ray crystallography, pull down, x-ray crystallography, x-ray crystallography, pull down	McKenna S (2003), McKenna S (2003), McKenna S (2003), Lewis MJ (2006), McKenna S (2001)	5
TP53	0	TP73	2	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Stindt MH (2015), Puca R (2011), De Laurenzi V (1998), Di Como CJ (1999)	4
MUL1	1	AKT1	1	pull down, affinity chromatography technology, enzymatic study	Bae S (2012), Bae S (2012), Bae S (2012)	3
MUL1	1	MAP3K7	2	pull down	Fujita H (2016)	1
ATRIP	1	MUL1	1	affinity chromatography technology	Huttlin EL (2017)	1
GABARAP	0	ATG13	0	affinity chromatography technology, unspecified method, two hybrid	Alemu EA (2012), Alemu EA (2012), Fujita N (2013)	3
SUMO1	0	TP73	2	two hybrid	Minty A (2000)	1
TRAF2	1	UBC	7	enzymatic study, enzymatic study	Liu J (2011), Kanayama A (2004)	2
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
TRHDE	3	MUL1	1	affinity chromatography technology	Huttlin EL (2017)	1
TRAF2	1	UBE2V2	0	pull down	Sasai M (2010)	1
UBE2E3	0	UBC	7	enzymatic study	Sheng Y (2012)	1
UBE2V2	0	VPS26A	0	biochemical	Havugimana PC (2012)	1
TMEM173	0	MUL1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Ni G (2017), Ni G (2017), Ni G (2017)	3
UBE2I	0	UBE2E1	1	biochemical	Wan C (2015)	1
UBE2D3	1	MUL1	1	two hybrid, pull down, pull down	van Wijk SJ (2009), Jung JH (2011), Ni G (2017)	3
MUL1	1	DNM1L	3	enzymatic study	Braschi E (2009)	1
TRAF2	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Ishitani T (2003), Hong S (2007), Tan B (2015)	4
SLC39A4	4	MUL1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBC	7	SUMO1	0	affinity chromatography technology	Sahin U (2014)	1
GUCY1B3	0	MUL1	1	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D2	0	MUL1	1	two hybrid, pull down, pull down, pull down	van Wijk SJ (2009), Braschi E (2009), Li W (2008), Ni G (2017)	4
MUL1	1	UBE2V2	0	pull down	Ni G (2017)	1
SLC39A12	8	MAVS	1	affinity chromatography technology	Huttlin EL (2017)	1
TRIM9	3	UBE2G2	0	affinity chromatography technology	Napolitano LM (2011)	1
ULK1	8	MUL1	1	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Li J (2015), Li J (2015), Li J (2015), Li J (2015)	4
PPP6R2	3	MUL1	1	affinity chromatography technology	Huttlin EL (2017)	1
SUMO1	0	TP53	0	two hybrid	Minty A (2000)	1
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
UBE2E3	0	MUL1	1	two hybrid, two hybrid	van Wijk SJ (2009), Ambivero CT (2014)	2
UBC	7	MAP3K7	2	pull down	Zhang X (2017)	1
TRAF2	1	MUL1	1	affinity chromatography technology	Zemirli N (2014)	1
MAVS	1	MUL1	1	affinity chromatography technology	Jenkins K (2013)	1
VPS26A	0	VPS35	2	biochemical, biochemical, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Harrison MS (2014), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Zavodszky E (2014)	8
CDC34	3	UBE2D3	1	affinity chromatography technology, affinity chromatography technology	Kuang P (2016), Kuang P (2016)	2
APPBP2	3	MUL1	1	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
MUL1	1	UBE2L3	1	two hybrid	Ambivero CT (2014)	1
UBE2I	0	TP73	2	two hybrid	Minty A (2000)	1
UBE2D2	0	UBE2L3	1	biochemical	Havugimana PC (2012)	1
TMEM173	0	TRAF2	1	affinity chromatography technology	Yao X (2016)	1
TBC1D9	3	MUL1	1	affinity chromatography technology	Huttlin EL (2017)	1
CNGA3	4	MUL1	1	affinity chromatography technology	Huttlin EL (2017)	1
UBC	7	ATG13	0	affinity chromatography technology	Matsumoto M (2005)	1
MUL1	1	UBE2N	1	pull down	Ni G (2017)	1
GABARAP	0	MUL1	1	affinity chromatography technology	Ambivero CT (2014)	1
IQCF1	0	MUL1	1	affinity chromatography technology	Huttlin EL (2015)	1
MAP3K7	2	MAVS	1	affinity chromatography technology	Xu LG (2005)	1
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
ARMC6	1	MUL1	1	affinity chromatography technology	Huttlin EL (2017)	1
MUL1	1	UBE2G2	0	two hybrid	Ambivero CT (2014)	1
UBC	7	UBE2N	1	affinity chromatography technology, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Matsumoto M (2005), Scheper J (2010), Wu PY (2003), McKenna S (2003), Wiener R (2012), Ye Y (2003), Bish RA (2007), Juang YC (2012), Pastushok L (2007), Singh RK (2012), McKenna S (2001), McKenna S (2001)	12
TP53	0	UBE2N	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Laine A (2006), Laine A (2006), Laine A (2006), Topisirovic I (2009), Topisirovic I (2009)	5
TMEM173	0	MAVS	1	affinity chromatography technology, affinity chromatography technology	Wang Y (2012), Chen X (2014)	2
MUL1	1	MUL1	1	enzymatic study	Li W (2008)	1
UBE2R2	2	UBE2D2	0	biochemical	Wan C (2015)	1
ERAP1	1	MUL1	1	affinity chromatography technology	Huttlin EL (2017)	1
SLC39A12	8	MUL1	1	affinity chromatography technology	Huttlin EL (2017)	1
GSDME	0	MUL1	1	affinity chromatography technology	Huttlin EL (2017)	1
MUL1	1	TRIM9	3	two hybrid	Rolland T (2014)	1
MAVS	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Xu LG (2005), Yu H (2011), Minassian A (2015), Khan M (2016), Fang R (2017), Fang R (2017)	7
UBE2I	0	UBE2D2	0	biochemical	Wan C (2015)	1
UBE2D1	0	MUL1	1	two hybrid, pull down, pull down, pull down	van Wijk SJ (2009), Jung JH (2011), Li J (2015), Ni G (2017)	4
UBC	7	UBE2L3	1	affinity chromatography technology	Bish RA (2007)	1
ULK1	8	ATG13	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Dunlop EA (2011), Nazio F (2013), Nazio F (2013), Hosokawa N (2009), Li J (2015), Dunlop EA (2014), Rui YN (2015)	7
MUL1	1	UBC	7	enzymatic study	Braschi E (2009)	1
BZW2	1	MAVS	1	affinity chromatography technology	Huttlin EL (2017)	1
UBE2L3	1	UBE2V2	0	biochemical	Havugimana PC (2012)	1
UBE2R2	2	UBC	7	two hybrid, enzymatic study	Vinayagam A (2011), Hill S (2016)	2
TP53	0	UBE2V2	0	two hybrid	Daakour S (2016)	1
ULK1	8	GABARAP	0	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology	Ewing RM (2007), Okazaki N (2000), Okazaki N (2000), Alemu EA (2012), Alemu EA (2012), Dunlop EA (2014)	6
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
DNM1L	3	UBE2L3	1	affinity chromatography technology	Malty RH (2017)	1
TRAF2	1	HTRA2	1	affinity chromatography technology	Behrends C (2010)	1
UBE2E1	1	MUL1	1	two hybrid, pull down	van Wijk SJ (2009), Ni G (2017)	2
PEX19	2	MUL1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MUL1	1	UBE2E2	1	two hybrid	Ambivero CT (2014)	1
TP53	0	MUL1	1	affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study	Jung JH (2011), Jung JH (2011), Jung JH (2011), Jung JH (2011), Jung JH (2011)	5
IQCF1	0	PEX19	2	affinity chromatography technology	Huttlin EL (2015)	1
UBE2W	0	MUL1	1	two hybrid	van Wijk SJ (2009)	1
APPBP2	3	UBE2R2	2	two hybrid	Rolland T (2014)	1
TRAF2	1	UBE2D1	0	pull down	Alvarez SE (2010)	1
RANBP6	5	MUL1	1	affinity chromatography technology	Huttlin EL (2017)	1
HAUS7	0	MUL1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MUL1	1	SUMO1	0	enzymatic study	Braschi E (2009)	1
UBE2U	0	MUL1	1	two hybrid	van Wijk SJ (2009)	1
AKT1	1	TRHDE	3	affinity chromatography technology	Zhu QS (2011)	1
MUL1	1	VPS26A	0	affinity chromatography technology	Braschi E (2010)	1
BZW2	1	MUL1	1	affinity chromatography technology	Huttlin EL (2017)	1
TRAF2	1	UBE2N	1	genetic interference, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Deng L (2000), Deng L (2000), Liu J (2011), Liu J (2011), Liu J (2011), Alvarez SE (2010), Sasai M (2010), Zhou AY (2013), Shen RR (2012)	9
UBE2D4	0	MUL1	1	two hybrid, pull down	van Wijk SJ (2009), Ni G (2017)	2
MUL1	1	UBE2I	0	affinity chromatography technology	Braschi E (2009)	1
CDC34	3	UBC	7	pull down, x-ray crystallography, enzymatic study, enzymatic study, x-ray crystallography, pull down, fluorescent resonance energy transfe, affinity chromatography technology, enzymatic study, enzymatic study	Choi YS (2010), Choi YS (2010), Sheng Y (2012), Enchev RI (2012), Huang H (2014), Huang H (2014), Huang H (2014), Bish RA (2007), Chong RA (2014), Phillips AH (2013)	10
UBC	7	APPBP2	3	affinity chromatography technology	Matsumoto M (2005)	1
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
TP73	2	MUL1	1	affinity chromatography technology, enzymatic study	Min B (2015), Min B (2015)	2
UBE2G2	0	UBC	7	x-ray crystallography, pull down, pull down	Bocik WE (2011), Bocik WE (2011), Reyes LF (2006)	3
MUL1	1	UBE2R2	2	pull down	Ni G (2017)	1
ATG13	0	MUL1	1	affinity chromatography technology	Li J (2015)	1
TP53	0	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
UBE2I	0	TP53	0	two hybrid, two hybrid, two hybrid, enzymatic study, two hybrid, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Minty A (2000), Gallagher WM (1999), Shen Z (1996), Bernier-Villamor V (2002), Wang J (2008), Spektor TM (2011), Jakobs A (2007), Mohideen F (2009), Lin JY (2004), Bennett RL (2012), Heo KS (2013), Morimoto M (2003), Rodriguez MS (1999), Muller S (2000), Fernandez-Lloris R (2006), Mohan RD (2007), Brandt M (2013), Weger S (2005)	18
SCN3B	0	MUL1	1	affinity chromatography technology	Huttlin EL (2017)	1
MUL1	1	CDC34	3	pull down	Ni G (2017)	1
DNM1L	3	VPS26A	0	biochemical	Kristensen AR (2012)	1
MUL1	1	VPS35	2	affinity chromatography technology	Braschi E (2010)	1
MUL1	1	TAP1	0	two hybrid	Wang J (2011)	1
UBE2I	0	SUMO1	0	affinity chromatography technology, pull down, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, two hybrid, two hybrid, pull down, pull down, two hybrid, pull down, fluorescent resonance energy transfe, pull down, two hybrid, pull down, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Tatham MH (2003), Minty A (2000), Shen Z (1996), Song Y (2011), Knipscheer P (2007), Boutell C (2011), Gong L (1997), Gong L (1997), Hemelaar J (2004), Hecker CM (2006), Hecker CM (2006), Martin SF (2008), Everett RD (2014), Rolland T (2014), Zilio N (2013), Carbia-Nagashima A (2007), Knipscheer P (2007), Matic I (2008), Wan C (2015), Hein MY (2015)	21
UBE2L6	0	MUL1	1	two hybrid	van Wijk SJ (2009)	1
UBE2V2	0	UBE2N	1	pull down, two hybrid, x-ray crystallography, two hybrid, two hybrid, two hybrid, pull down, pull down, x-ray crystallography, affinity chromatography technology, pull down, two hybrid, pull down, pull down, affinity chromatography technology, two hybrid, pull down, biochemical, x-ray crystallography, pull down, affinity chromatography technology, pull down, x-ray crystallography, biochemical, x-ray crystallography, affinity chromatography technology	Andersen PL (2005), Andersen PL (2005), Markin CJ (2010), Wooff J (2004), Wooff J (2004), Plans V (2006), Wu PY (2003), McKenna S (2003), McKenna S (2003), Zou W (2005), Takeuchi T (2005), Pastushok L (2005), Pastushok L (2005), Pastushok L (2005), Huen MS (2008), Huen MS (2008), Ye Y (2003), Havugimana PC (2012), Moraes TF (2001), Pastushok L (2007), Zou W (2005), McKenna S (2001), Hodge CD (2015), Wan C (2015), Branigan E (2015), Boldt K (2016)	26
HTRA2	1	MUL1	1	enzymatic study	Cilenti L (2014)	1