PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELOC	0	ELOB	1	two hybrid, pull down, pull down, pull down, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid, affinity chromatography technology, x-ray crystallography, two hybrid, two hybrid, biochemical, affinity chromatography technology, biochemical, pull down, two hybrid, biochemical, biochemical, two hybrid	Rual JF (2005), Ohh M (1999), Aso T (1995), Li Z (2002), Kinoshita K (2007), Kinoshita K (2007), Kinoshita K (2007), Kinoshita K (2007), Lievens S (2009), Brower CS (1999), Stebbins CE (1999), Pause A (1999), Pause A (1999), Havugimana PC (2012), Wang X (2013), Kristensen AR (2012), Costessi A (2011), Rolland T (2014), Kim DY (2013), Wan C (2015), Yu H (2011)	21
AP2M1	5	ACTB	8	affinity chromatography technology	Brehme M (2009)	1
MMGT1	0	CORO7	0	affinity chromatography technology	Hein MY (2015)	1
NTRK1	1	CORO7	0	affinity chromatography technology	Emdal KB (2015)	1
CORO7	0	TOB1	1	affinity chromatography technology, two hybrid, enzymatic study	Watanabe M (2011), Watanabe M (2011), Watanabe M (2011)	3
ASB6	1	CORO7	0	affinity chromatography technology	Huttlin EL (2017)	1
RBX1	2	CORO7	0	affinity chromatography technology	Watanabe M (2011)	1
ELOC	0	ASB6	1	two hybrid, affinity chromatography technology	Lievens S (2009), Huttlin EL (2017)	2
CNTF	3	CORO7	0	affinity chromatography technology	Huttlin EL (2017)	1
AP2M1	5	CORO7	0	unspecified method	Rybakin V (2006)	1
RBX1	2	ELOC	0	affinity chromatography technology	Brower CS (2002)	1
FOXA1	2	CORO7	0	affinity chromatography technology	Jozwik KM (2016)	1
CORO7	0	DAG1	3	biochemical	Havugimana PC (2012)	1
SRC	2	CORO7	0	enzymatic study, affinity chromatography technology	Rybakin V (2008), Rybakin V (2008)	2
EPS15	1	AP2M1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009), Li J (2013), Huttlin EL (2015), Huttlin EL (2017)	5
NTRK1	1	EPS15	1	affinity chromatography technology	Emdal KB (2015)	1
SETD4	1	CORO7	0	affinity chromatography technology	Hein MY (2015)	1
CORO7	0	EPS15	1	affinity chromatography technology, pull down	Yuan WC (2014), Yuan WC (2014)	2
ASB6	1	ELOB	1	affinity chromatography technology, affinity chromatography technology	Andresen CA (2014), Huttlin EL (2017)	2
CDC34	3	CORO7	0	affinity chromatography technology	Watanabe M (2011)	1
MRPL50	2	CORO7	0	affinity chromatography technology	Hein MY (2015)	1
ELOC	0	CORO7	0	affinity chromatography technology	Watanabe M (2011)	1
ELOB	1	CORO7	0	affinity chromatography technology	Watanabe M (2011)	1
THBS3	3	CORO7	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL1	7	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, pull down, x-ray crystallography, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Dias DC (2002), Kim J (2002), Zheng N (2002), Kim AY (2008), Ohta T (1999), Ohta T (1999), Ohta T (1999), Bloom J (2006), Block K (2005), Hu J (2004), Hwang JW (2003), Furukawa M (2002), Kawakami T (2001), Ohta T (2001), Chen A (2000), Read MA (2000), Wu K (2000), Tan P (1999), Banerjee S (2010), Gao D (2010), Tron AE (2012), Tron AE (2012), Shteingart S (2012), Tan M (2010), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Huang DT (2004), Emberley ED (2012), Gastaldello S (2012), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Li X (2003), Calabrese MF (2011), Scott DC (2014), Scott DC (2014), Siergiejuk E (2009), Zhou W (2014), Zhou W (2014), Huang DT (2009), Pick E (2007), Morimoto M (2003), Morimoto M (2003), Ohki Y (2009), Duda DM (2008), Duda DM (2008), Wan C (2015), Hao J (2015), Hao J (2015), Han XR (2016), Kuang P (2016), Zhou W (2017), Hu Y (2017), Reitsma JM (2017)	59
NTRK1	1	CUL1	7	affinity chromatography technology	Emdal KB (2015)	1
AP1M1	3	CORO7	0	unspecified method	Rybakin V (2006)	1
EPS15	1	ACTB	8	affinity chromatography technology	Brehme M (2009)	1
NTRK1	1	SRC	2	affinity chromatography technology	Emdal KB (2015)	1
AP1G1	8	AP2M1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Page LJ (1995), Hirst J (2000), Huttlin EL (2015), Huttlin EL (2017)	4
NTRK1	1	AP1M1	3	affinity chromatography technology	Emdal KB (2015)	1
SRC	2	DAG1	3	enzymatic study, pull down, affinity chromatography technology	Sotgia F (2001), Sotgia F (2001), Sotgia F (2001)	3
S100A4	0	CORO7	0	affinity chromatography technology	Hein MY (2015)	1
CUL1	7	ACTB	8	affinity chromatography technology	Bennett EJ (2010)	1
KLHL20	2	CORO7	0	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Yuan WC (2014), Yuan WC (2014), Yuan WC (2014), Huttlin EL (2015), Huttlin EL (2017)	5
CDC34	3	CUL1	7	pull down, pull down, fluorescent resonance energy transfe, pull down, affinity chromatography technology	Block K (2005), Wirbelauer C (2000), Saha A (2008), Sandoval D (2014), Wu K (2016)	5
CORO7	0	ACTB	8	pull down	Yuan WC (2014)	1
ZRANB1	3	CORO7	0	enzymatic study	Yuan WC (2014)	1
AZIN2	2	CORO7	0	affinity chromatography technology	Huttlin EL (2017)	1
RBX1	2	CDC34	3	pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Wu K (2002), Block K (2005), Block K (2005), Chen A (2000), Cen B (2010), Cen B (2009), DAngiolella V (2010), Spruck C (2001), Shaik S (2012), Kruiswijk F (2012), Tan M (2010), Bashir T (2010), Higa LA (2003), Kanayama A (2004), Lan L (2012), Welcker M (2011), Banks D (2006), Kumar KG (2003), Higa LA (2006), Saha A (2008), Jin J (2005), Cen B (2009), Tedesco D (2002), Choi YS (2010), Duan S (2011), Li X (2003), Wang W (2003), Gallegos JR (2008), Peschiaroli A (2009), Banerjee S (2010), Duan S (2011), Wang F (2011), Chen H (2013), Rodier G (2008), Rossi M (2013), Ungermannova D (2013), Ooi LC (2013), Ziemba A (2013), Huang H (2014), Herrero-Ruiz J (2014), Kim J (2014), Min SH (2012), Watanabe M (2011), Gao D (2010), Zhou W (2014), Canettieri G (2010), Morimoto M (2003), Chen A (2002), Pashkova N (2010), Read MA (2000), Bassermann F (2005), Duda DM (2008), Enchev RI (2012), Fukushima H (2013), Tintignac LA (2005), Ungermannova D (2005), Low TY (2014), Walter D (2016), Gao J (2015), Orthwein A (2015), Wu K (2016), Wu K (2016), Nateri AS (2004), Pierce NW (2009), Kim JH (2015), Shimizu K (2017), Gschweitl M (2016), Ibarra R (2016), Kuang P (2016), Kuang P (2016), Kuang P (2016), Ferretti LP (2016), Kuchay S (2017), Gazdoiu S (2007), Dai X (2017)	75
CORO7	0	JUN	0	affinity chromatography technology	Yuan WC (2014)	1
AP1G1	8	JUN	0	affinity chromatography technology	Camus G (2007)	1
AP1G1	8	AP1M1	3	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Foelsch H (1999), Page LJ (1995), Havugimana PC (2012), Hirst J (2000), Wan C (2015)	5
JUN	0	BLM	2	pull down, pull down	Chandra S (2013), Chandra S (2013)	2
NTRK1	1	AP1G1	8	affinity chromatography technology	Emdal KB (2015)	1
AP1G1	8	CORO7	0	affinity chromatography technology, affinity chromatography technology	Rybakin V (2006), Rybakin V (2006)	2
BLM	2	CORO7	0	affinity chromatography technology	Hein MY (2015)	1
ELOB	1	RBX1	2	affinity chromatography technology, affinity chromatography technology	Kamura T (2002), Brower CS (2002)	2
EPS15	1	AP1G1	8	affinity chromatography technology, pull down, pull down	Chi S (2008), Chi S (2008), Chi S (2008)	3
CUL1	7	CORO7	0	affinity chromatography technology	Watanabe M (2011)	1