PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBL4A	0	VAPB	2	affinity chromatography technology, affinity chromatography technology	Xu Y (2012), Baron Y (2014)	2
VAPB	2	BAG6	2	affinity chromatography technology, affinity chromatography technology	Baron Y (2014), Baron Y (2014)	2
USP13	2	UBL4A	0	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Sowa ME (2009), Liu Y (2014), Liu Y (2014), Liu Y (2014)	4
FAF2	4	RNF126	2	affinity chromatography technology	Alexandru G (2008)	1
UBL4A	0	FAF2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Xu Y (2012), Xu Y (2013)	3
DERL2	0	FAF2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Greenblatt EJ (2011), Christianson JC (2012), Christianson JC (2012), Christianson JC (2012), Huttlin EL (2015), Raman M (2015), Huttlin EL (2017)	7
GET4	3	FAF2	4	affinity chromatography technology, affinity chromatography technology	Xu Y (2013), Xu Y (2013)	2
UBQLN1	1	UBXN1	0	biochemical, two hybrid	Havugimana PC (2012), Rolland T (2014)	2
BAG6	2	HIST2H3C	0	affinity chromatography technology, affinity chromatography technology	Wakeman TP (2012), Wakeman TP (2012)	2
UBXN1	0	MAVS	1	affinity chromatography technology, affinity chromatography technology	Wang P (2013), Wang P (2013)	2
FAF2	4	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Lee JN (2008), Alexandru G (2008), Alexandru G (2008), Mueller B (2008), Alexandru G (2012), Xu Y (2013), Christianson JC (2012), Besten Wd (2012), Madsen L (2014), Raman M (2015)	10
FAF2	4	VAPB	2	affinity chromatography technology	Christianson JC (2012)	1
BAG6	2	DOT1L	7	affinity chromatography technology, affinity chromatography technology	Wakeman TP (2012), Wakeman TP (2012)	2
UBL4A	0	UBQLN1	1	affinity chromatography technology	Xu Y (2012)	1
UBL4A	0	RNF126	2	affinity chromatography technology, pull down, pull down	Xu Y (2012), Krysztofinska EM (2016), Krysztofinska EM (2016)	3
RNF126	2	GET4	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VCP	6	DNAJB11	3	affinity chromatography technology	Fogeron ML (2013)	1
AMFR	2	FAF2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee JN (2008), Lee JN (2008), Alexandru G (2008), Wang Q (2011), Xu Y (2013), Wang Q (2011), Christianson JC (2012), Christianson JC (2012), Zhang T (2015)	9
AMFR	2	AIFM1	1	affinity chromatography technology	Jo Y (2011)	1
VCP	6	HLA-A	0	affinity chromatography technology	Soetandyo N (2010)	1
REG1B	0	BAG6	2	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
DOT1L	7	HIST2H3C	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Wu L (2011), Wakeman TP (2012), Wakeman TP (2012)	3
PCK1	1	BAG6	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jiang W (2011), Jiang W (2011), Jiang W (2011)	3
SMN1	0	PPP4C	0	affinity chromatography technology	Carnegie GK (2003)	1
SPP1	0	BAG6	2	two hybrid, two hybrid	Long P (2012), Wang J (2011)	2
GET4	3	CDKN1A	1	two hybrid	Stelzl U (2005)	1
BAG6	2	BAG6	2	pull down, pull down	Xu Y (2013), Binici J (2013)	2
APLP2	2	BAG6	2	affinity chromatography technology, affinity chromatography technology	Wu W (2012), Wu W (2012)	2
XRN1	4	BAG6	2	two hybrid, affinity chromatography technology	Lehner B (2004), Hein MY (2015)	2
UBL4A	0	GET4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Xu Y (2012), Huttlin EL (2015), Huttlin EL (2017)	4
PPP4C	0	BAG6	2	affinity chromatography technology, biochemical	Ewing RM (2007), Kristensen AR (2012)	2
USP13	2	GET4	3	affinity chromatography technology	Liu Y (2014)	1
UBL4A	0	ASNA1	2	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Xu Y (2012)	2
ZFAND2B	1	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Glinka T (2014), Glinka T (2014), Glinka T (2014), Braunstein I (2015)	4
DERL2	0	BAG6	2	affinity chromatography technology, affinity chromatography technology	Claessen JH (2011), Claessen JH (2014)	2
BAG6	2	VCP	6	affinity chromatography technology, affinity chromatography technology, biochemical	Wang Q (2011), Yu CC (2013), Xu Y (2013)	3
AMFR	2	VCP	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, two hybrid, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhong X (2004), Zhong X (2004), Lee JN (2008), Cao J (2007), Ballar P (2007), Ballar P (2007), Ye Y (2005), Ye Y (2005), Zhong X (2004), Yang H (2010), Yang H (2010), Ballar P (2010), Jo Y (2011), St-Pierre P (2012), Grelle G (2006), Scheich C (2007), Ballar P (2006), Haenzelmann P (2011), Haenzelmann P (2011), Haenzelmann P (2011), Wang Q (2011), Yu CC (2013), Erzurumlu Y (2013), Liu S (2013), Wang Q (2011), Grelle G (2006), Grelle G (2006), Grelle G (2006), Grelle G (2006), Christianson JC (2012), Zhang T (2015), Khodayari N (2017)	32
GET4	3	TTR	0	two hybrid	Stelzl U (2005)	1
ASNA1	2	STX5	0	pull down	Mariappan M (2010)	1
AMFR	2	UBL4A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Wang Q (2011), Wang Q (2011), Liu Y (2014), Liu Y (2014)	4
RNF126	2	CDKN1A	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Zhi X (2012), Zhi X (2012), Zhi X (2012)	3
SGTA	1	GET4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Huttlin EL (2015)	3
6955	0	GET4	3	affinity chromatography technology	Wang Q (2011)	1
AMFR	2	MAVS	1	affinity chromatography technology	Jacobs JL (2014)	1
MAVS	1	BAG6	2	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
USP13	2	FAF2	4	affinity chromatography technology	Sowa ME (2009)	1
UBQLN1	1	ZFAND2B	1	two hybrid	Rolland T (2014)	1
UBXN1	0	6955	0	affinity chromatography technology	Park ES (2017)	1
VAPB	2	VCP	6	affinity chromatography technology	Baron Y (2014)	1
EEF1D	3	BAG6	2	biochemical, biochemical	Kristensen AR (2012), Kristensen AR (2012)	2
VCP	6	ICK	1	affinity chromatography technology	Yu CC (2013)	1
UBQLN1	1	VCP	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lim PJ (2009), Yu CC (2013), Lim PJ (2009), Lim PJ (2009)	4
DNAJB11	3	UBQLN4	2	two hybrid	Vinayagam A (2011)	1
UBQLN4	2	SPP1	0	two hybrid, two hybrid	Matsuda M (2001), Lim J (2006)	2
6955	0	BAG6	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang Q (2011), Xu Y (2012), Claessen JH (2014)	3
BAG6	2	LCK	0	affinity chromatography technology, affinity chromatography technology	Rangachari M (2012), Rangachari M (2012)	2
CDKN1A	1	BAG6	2	two hybrid, two hybrid	Vinayagam A (2011), Wang J (2011)	2
UBL4A	0	HSPA2	3	affinity chromatography technology	Xu Y (2012)	1
UBXN1	0	GET4	3	affinity chromatography technology	Raman M (2015)	1
DNAJB11	3	UBXN1	0	biochemical	Havugimana PC (2012)	1
RNF126	2	ASNA1	2	affinity chromatography technology	Huttlin EL (2015)	1
UBXN1	0	AMFR	2	affinity chromatography technology	Alexandru G (2008)	1
MAPK6	1	GET4	3	affinity chromatography technology	Rodriguez J (2016)	1
UBL4A	0	SGTA	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography	Sowa ME (2009), Xu Y (2012), Xu Y (2012), Xu Y (2012), Xu Y (2012), Xu Y (2012), Xu Y (2012), Leznicki P (2013), Taipale M (2014), Taipale M (2014), Darby JF (2014), Darby JF (2014), Darby JF (2014)	13
TTR	0	VCP	6	affinity chromatography technology	Kadowaki H (2015)	1
MAPK6	1	ASNA1	2	affinity chromatography technology	Rodriguez J (2016)	1
ZFAND2B	1	FAF2	4	affinity chromatography technology, affinity chromatography technology, biochemical	Glinka T (2014), Glinka T (2014), Glinka T (2014)	3
SGTA	1	SPP1	0	two hybrid, two hybrid, two hybrid, two hybrid	Rual JF (2005), Long P (2012), Wang J (2011), Rolland T (2014)	4
BAG6	2	UBXN1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Raman M (2015), Raman M (2015), Raman M (2015)	3
CDK18	3	UBL4A	0	affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Hein MY (2015)	2
GTF2F2	0	BAG6	2	affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Hein MY (2015)	2
MAPK6	1	RNF126	2	affinity chromatography technology	Rodriguez J (2016)	1
BAG6	2	KLHL12	4	two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Rolland T (2014), McGourty CA (2016)	3
6955	0	HLA-A	0	x-ray crystallography	Ding YH (1998)	1
BAG6	2	GET4	3	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, x-ray crystallography, two hybrid, affinity chromatography technology, pull down	Xu Y (2013), Xu Y (2013), Mock JY (2015), Huttlin EL (2015), Hein MY (2015), Rodrigo-Brenni MC (2014), Huttlin EL (2017), Mock JY (2017), Mock JY (2017), Mock JY (2017), Mock JY (2017)	11
BAG6	2	ASNA1	2	biochemical, affinity chromatography technology, biochemical	Kristensen AR (2012), Baron Y (2014), Rodrigo-Brenni MC (2014)	3
UBL4A	0	SMN1	0	affinity chromatography technology	Xu Y (2012)	1
VAPB	2	ASNA1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Baron Y (2014), Baron Y (2014), Baron Y (2014)	3
BAG6	2	FAF2	4	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xu Y (2012), Xu Y (2013), Xu Y (2013), Raman M (2015)	4
UBQLN1	1	BAG6	2	affinity chromatography technology, affinity chromatography technology	Kurlawala Z (2017), Kurlawala Z (2017)	2
UBQLN4	2	BAG6	2	two hybrid, affinity chromatography technology	Lim J (2006), Suzuki R (2016)	2
USP13	2	AMFR	2	affinity chromatography technology, pull down, affinity chromatography technology	Liu Y (2014), Liu Y (2014), Liu Y (2014)	3
ICK	1	BAG6	2	pull down, enzymatic study	Fu Z (2006), Fu Z (2006)	2
MAPK6	1	HLA-A	0	affinity chromatography technology	Rodriguez J (2016)	1
STX5	0	VAPB	2	pull down	Li G (2003)	1
GET4	3	ASNA1	2	affinity chromatography technology, two hybrid	Huttlin EL (2015), Yu H (2011)	2
CDK18	3	BAG6	2	affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Hein MY (2015)	2
UBL4A	0	VCP	6	affinity chromatography technology, affinity chromatography technology	Wang Q (2011), Xu Y (2012)	2
UBQLN4	2	UBXN1	0	biochemical	Havugimana PC (2012)	1
CDKN1A	1	HSPA2	3	affinity chromatography technology	Fogeron ML (2013)	1
STX5	0	BAG6	2	two hybrid, pull down	Stelzl U (2005), Mariappan M (2010)	2
VAPB	2	GET4	3	affinity chromatography technology	Baron Y (2014)	1
TTR	0	ASNA1	2	two hybrid	Vinayagam A (2011)	1
SGTA	1	BAG6	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, affinity chromatography technology, pull down, pull down	Winnefeld M (2006), Xu Y (2012), Xu Y (2012), Xu Y (2012), Leznicki P (2013), Taipale M (2014), Taipale M (2014), Rolland T (2014), Darby JF (2014), Darby JF (2014), Darby JF (2014), Liu Y (2014), Krysztofinska EM (2016), Krysztofinska EM (2016)	14
MAPK6	1	UBL4A	0	affinity chromatography technology	Rodriguez J (2016)	1
AMFR	2	DERL2	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Morito D (2008), Zhong Y (2011), Huang CH (2013), Christianson JC (2012), Zhang T (2015)	5
TTR	0	BAG6	2	two hybrid, affinity chromatography technology	Vinayagam A (2011), Kadowaki H (2015)	2
DERL2	0	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lilley BN (2005), Greenblatt EJ (2011), Huang CH (2013), Christianson JC (2012)	4
6955	0	UBL4A	0	affinity chromatography technology	Wang Q (2011)	1
AMFR	2	GET4	3	affinity chromatography technology, affinity chromatography technology	Wang Q (2011), Liu Y (2014)	2
VCP	6	RNF126	2	affinity chromatography technology	Yu CC (2013)	1
UBL4A	0	BAG6	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Wang Q (2011), Wang Q (2011), Mariappan M (2010), Xu Y (2012), Xu Y (2012), Xu Y (2012), Xu Y (2012), Mock JY (2015), Mock JY (2015), Kuwabara N (2015), Kuwabara N (2015), Kuwabara N (2015), Wu W (2014), Wu W (2014), Wan C (2015), Hein MY (2015), Rodrigo-Brenni MC (2014), Huttlin EL (2017)	19
UBXN1	0	FAF2	4	affinity chromatography technology	Raman M (2015)	1
VCP	6	UBXN1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), McNeill H (2004), LaLonde DP (2011), LaLonde DP (2011), LaLonde DP (2011), LaLonde DP (2011), Rolland T (2014), McNeill H (2004), Raman M (2015), Park ES (2017)	11
VCP	6	GET4	3	affinity chromatography technology	Yu CC (2013)	1
TTR	0	DERL2	0	affinity chromatography technology	Kadowaki H (2015)	1
NCR3	0	BAG6	2	unspecified method, pull down	Binici J (2013), Binici J (2013)	2
6955	0	VCP	6	affinity chromatography technology	Wang Q (2011)	1
AMFR	2	BAG6	2	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang Q (2011), Wang Q (2011), Wang Q (2011), Xu Y (2012), Xu Y (2012), Xu Y (2012), Wang Q (2011), Liu Y (2014), Zhang T (2015)	9
UBXN1	0	KLHL12	4	affinity chromatography technology	Alexandru G (2008)	1
MAPK6	1	FAF2	4	affinity chromatography technology	Rodriguez J (2016)	1
CTCFL	0	BAG6	2	affinity chromatography technology, affinity chromatography technology, two hybrid	Nguyen P (2008), Nguyen P (2008), Nguyen P (2008)	3
BAG6	2	HSPA2	3	imaging technique, affinity chromatography technology, affinity chromatography technology	Bromfield E (2015), Bromfield E (2015), Bromfield E (2015)	3
SGTA	1	ASNA1	2	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
VCP	6	CDKN1A	1	affinity chromatography technology	Yu CC (2013)	1
TAC1	0	BAG6	2	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
USP13	2	VCP	6	pull down, affinity chromatography technology	Liu Y (2014), Liu Y (2014)	2
HLA-A	0	BAG6	2	affinity chromatography technology, affinity chromatography technology	Wang Q (2011), Wang Q (2011)	2
DNAJB11	3	BAG6	2	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
PCK1	1	FAF2	4	affinity chromatography technology	Jiang W (2011)	1
ZFAND2B	1	BAG6	2	affinity chromatography technology, affinity chromatography technology	Glinka T (2014), Braunstein I (2015)	2
UBQLN4	2	UBQLN1	1	two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology	Lim J (2006), Havugimana PC (2012), Lee DY (2013), Lee DY (2013)	4
BAG6	2	RNF123	11	affinity chromatography technology, biochemical	Rodrigo-Brenni MC (2014), Rodrigo-Brenni MC (2014)	2
SMN1	0	BAG6	2	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
MAPK6	1	SGTA	1	affinity chromatography technology	Rodriguez J (2016)	1
UBXN1	0	UBL4A	0	affinity chromatography technology	Raman M (2015)	1
USP13	2	BAG6	2	affinity chromatography technology, pull down, pull down	Liu Y (2014), Liu Y (2014), Liu Y (2014)	3
MAPK6	1	BAG6	2	two hybrid, affinity chromatography technology	Vinayagam A (2011), Rodriguez J (2016)	2
BAG6	2	RNF126	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down	Rolland T (2014), Huttlin EL (2015), Hein MY (2015), OConnor HF (2015), Rodrigo-Brenni MC (2014), Rodrigo-Brenni MC (2014), Rodrigo-Brenni MC (2014), Huttlin EL (2017), Krysztofinska EM (2016), Krysztofinska EM (2016), Krysztofinska EM (2016)	11
BAG6	2	AIFM1	1	affinity chromatography technology, pull down, affinity chromatography technology	Desmots F (2008), Desmots F (2008), Preta G (2012)	3