PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NINL	1	LZTS2	4	two hybrid, bioid	Rual JF (2005), Gupta GD (2015)	2
NINL	1	ZNF426	2	two hybrid	Rual JF (2005)	1
MPPE1	1	ZNF426	2	two hybrid	Rolland T (2014)	1
ZNF426	2	KRTAP4-12	2	two hybrid	Rual JF (2005)	1
USP25	0	ZNF426	2	two hybrid	Rolland T (2014)	1
GLRX3	1	KRTAP4-12	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
BAG3	4	ZNF426	2	affinity chromatography technology	Chen Y (2013)	1
EFEMP2	0	ZNF426	2	two hybrid	Rual JF (2005)	1
CALCOCO2	0	ZNF426	2	two hybrid	Rual JF (2005)	1
CCDC85B	0	ZNF426	2	two hybrid	Rual JF (2005)	1
ZNF426	2	TSGA10	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
ZNF426	2	LZTS2	4	two hybrid	Rolland T (2014)	1
MTUS2	4	ZNF426	2	two hybrid	Rolland T (2014)	1
CCDC85B	0	LZTS2	4	two hybrid	Rual JF (2005)	1
MDFI	1	ZNF426	2	two hybrid	Rual JF (2005)	1
LPXN	4	ZNF426	2	two hybrid	Rual JF (2005)	1
CCDC85B	0	CEP70	1	two hybrid	Rual JF (2005)	1
GLRX3	1	EFEMP2	0	two hybrid	Rual JF (2005)	1
ZNF426	2	CIB3	0	two hybrid	Rolland T (2014)	1
ELAVL1	0	ZNF426	2	affinity chromatography technology	Abdelmohsen K (2009)	1
ZNF426	2	CEP70	1	two hybrid	Rual JF (2005)	1
GLRX3	1	ZNF426	2	two hybrid	Rolland T (2014)	1