PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RAB3GAP1	5	RAB3GAP2	7	biochemical, affinity chromatography technology, biochemical	Kristensen AR (2012), Baron Y (2014), Wan C (2015)	3
TSEN15	0	CLP1	2	affinity chromatography technology, affinity chromatography technology	Paushkin SV (2004), Huttlin EL (2017)	2
L1TD1	3	TSEN34	2	affinity chromatography technology	Hein MY (2015)	1
RAB3GAP1	5	TSEN34	2	biochemical	Kristensen AR (2012)	1
BCAR1	6	TSEN34	2	biochemical	Kristensen AR (2012)	1
GABPA	0	TSEN34	2	biochemical	Kristensen AR (2012)	1
GABPA	0	RAB3GAP2	7	biochemical	Kristensen AR (2012)	1
GABPA	0	RAB3GAP1	5	biochemical	Kristensen AR (2012)	1
HNRNPD	3	TSEN34	2	two hybrid	Lehner B (2004)	1
GNE	2	RAB3GAP2	7	biochemical	Kristensen AR (2012)	1
TSEN2	5	CLP1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Paushkin SV (2004), Paushkin SV (2004), Huttlin EL (2017)	3
TSEN34	2	ARMCX3	0	biochemical	Kristensen AR (2012)	1
EYA3	0	TSEN34	2	affinity chromatography technology	Li X (2016)	1
TSEN2	5	TSEN15	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Paushkin SV (2004), Paushkin SV (2004), Huttlin EL (2017)	3
GNE	2	TSEN34	2	biochemical	Kristensen AR (2012)	1
TSEN2	5	TSEN54	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Paushkin SV (2004), Paushkin SV (2004), Rolland T (2014), Huttlin EL (2017)	4
TSEN34	2	TSEN54	1	affinity chromatography technology, affinity chromatography technology	Paushkin SV (2004), Paushkin SV (2004)	2
CLP1	2	TSEN54	1	affinity chromatography technology	Paushkin SV (2004)	1
TSEN34	2	RAB3GAP2	7	biochemical	Kristensen AR (2012)	1
FBXW11	2	TSEN34	2	affinity chromatography technology	Low TY (2014)	1
GNE	2	GABPA	0	biochemical	Kristensen AR (2012)	1
CLP1	2	TSEN34	2	affinity chromatography technology	Paushkin SV (2004)	1
BCAR1	6	ARMCX3	0	biochemical	Kristensen AR (2012)	1
TSEN54	1	TSEN15	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Paushkin SV (2004), Paushkin SV (2004), Huttlin EL (2017)	3
FBXW11	2	HNRNPD	3	affinity chromatography technology, affinity chromatography technology	Coyaud E (2015), Low TY (2014)	2
TSEN15	0	TSEN34	2	affinity chromatography technology, affinity chromatography technology	Paushkin SV (2004), Huttlin EL (2017)	2
TSEN2	5	TSEN34	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Paushkin SV (2004), Paushkin SV (2004), Huttlin EL (2017)	3
FBXW7	2	TSEN34	2	affinity chromatography technology	Kourtis N (2015)	1
GNE	2	RAB3GAP1	5	biochemical	Kristensen AR (2012)	1