PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SEPT11	2	PRCC	0	affinity chromatography technology	Boldt K (2016)	1
CUL1	7	EEF1A1	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL1	7	LUC7L3	2	affinity chromatography technology	Bennett EJ (2010)	1
EP300	36	BRCA1	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pao GM (2000), Pao GM (2000), Pao GM (2000), Pao GM (2000), Fan S (2002), Fan S (2002), Ma Y (2010), Subbaramaiah K (2011), Subbaramaiah K (2012)	9
RBMS1	1	SUGP1	2	biochemical	Havugimana PC (2012)	1
MYC	2	SERPINH1	2	affinity chromatography technology	Agrawal P (2010)	1
NABP2	0	VPS41	3	affinity chromatography technology	Hein MY (2015)	1
INTS3	2	INTS5	3	affinity chromatography technology, affinity chromatography technology	Malovannaya A (2010), Malovannaya A (2010)	2
NABP2	0	SSBP1	0	biochemical	Havugimana PC (2012)	1
NABP2	0	VPS4A	4	affinity chromatography technology	Hein MY (2015)	1
INTS5	3	INTS6	4	affinity chromatography technology, affinity chromatography technology	Malovannaya A (2010), Malovannaya A (2010)	2
MYC	2	CUL1	7	affinity chromatography technology	von der Lehr N (2003)	1
BRCA1	7	MYC	2	affinity chromatography technology, imaging technique, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Li H (2002), Xiong J (2003), Xiong J (2003), Wang Q (1998), Wang Q (1998), Wang Q (1998), Harte MT (2010), Harte MT (2010), Xiong J (2003), Xiong J (2003), Zhou C (2003)	11
SKP1	0	FBXL5	3	pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Winston JT (1999), Vashisht AA (2009), Salahudeen AA (2009), Vinas-Castells R (2013), Moroishi T (2014), Moroishi T (2014), Rolland T (2014), Yu H (2011), Wu WD (2016), Huttlin EL (2017)	10
NDUFA7	0	SUGP1	2	biochemical	Havugimana PC (2012)	1
NDUFA7	0	RBMS1	1	biochemical	Havugimana PC (2012)	1
INTS1	10	INTS6	4	affinity chromatography technology, affinity chromatography technology	Malovannaya A (2010), Malovannaya A (2010)	2
RBMS1	1	SRPRB	0	biochemical	Havugimana PC (2012)	1
MYC	2	EP300	36	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology	Faiola F (2005), Faiola F (2005), Faiola F (2005), Faiola F (2005), Faiola F (2005), Zhang K (2005), Covic M (2005), Fujii M (2006)	8
NDUFA7	0	NABP2	0	biochemical	Havugimana PC (2012)	1
RBMS1	1	SARNP	0	biochemical	Havugimana PC (2012)	1
NABP2	0	EDRF1	6	affinity chromatography technology	Hein MY (2015)	1
INTS1	10	PPP2R1A	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Malovannaya A (2010), Hein MY (2015), Yadav L (2017), Yadav L (2017)	4
MRPL53	0	NABP2	0	biochemical	Havugimana PC (2012)	1
NDUFA2	0	SUGP1	2	biochemical	Havugimana PC (2012)	1
NABP2	0	MTCH1	0	affinity chromatography technology	Hein MY (2015)	1
NABP2	0	SRPRB	0	biochemical	Havugimana PC (2012)	1
CUL1	7	SSBP1	0	affinity chromatography technology	Bennett EJ (2010)	1
SUGP1	2	NABP2	0	biochemical	Havugimana PC (2012)	1
EGFR	5	PPP2R1A	8	affinity chromatography technology	Foerster S (2013)	1
INTS1	10	NABP2	0	affinity chromatography technology	Malovannaya A (2010)	1
PPIF	0	MRPL53	0	biochemical	Havugimana PC (2012)	1
INTS1	10	INTS3	2	affinity chromatography technology, affinity chromatography technology, biochemical	Malovannaya A (2010), Malovannaya A (2010), Wan C (2015)	3
SUGP1	2	SRPRB	0	biochemical	Havugimana PC (2012)	1
INTS5	3	NABP2	0	affinity chromatography technology	Malovannaya A (2010)	1
INTS6	4	PPP2R1A	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Malovannaya A (2010), Hein MY (2015), Yadav L (2017), Yadav L (2017)	4
NDUFA2	0	NABP2	0	biochemical	Havugimana PC (2012)	1
INTS5	3	LUC7L3	2	genetic interference	Horlbeck MA (2018)	1
NABP2	0	INIP	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Huang J (2009), Huang J (2009), Huang J (2009), Huang J (2009), Wan C (2015), Hein MY (2015)	6
MRPL53	0	SUGP1	2	biochemical	Havugimana PC (2012)	1
NABP2	0	CUL1	7	affinity chromatography technology	Chen ZW (2015)	1
SKP1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Min KW (2003), Lisztwan J (1998), Zheng N (2002), Ohta T (1999), Bloom J (2006), Kumar R (2005), Megumi Y (2005), Wang W (2004), Read MA (2000), Wu K (2000), Tan P (1999), Mao X (2011), Lin HK (2009), Yano H (2008), Banerjee S (2010), Gao D (2010), Chua YS (2011), Zhang M (2008), Winston JT (1999), Latres E (1999), Latres E (1999), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Emberley ED (2012), Bennett EJ (2010), Gastaldello S (2012), Michel JJ (1998), Michel JJ (1998), Michel JJ (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Yu ZK (1998), Yu ZK (1998), Postow L (2013), Cordero-Espinoza L (2013), Zhou W (2014), Zhou W (2014), Hao J (2015), Hao J (2015), Han XR (2016), Liu YQ (2015), Gorelik M (2016), Al-Yacoub N (2016), Reiterer V (2017), Hu Y (2017), Hauri S (2016), Reitsma JM (2017), Reitsma JM (2017), Chen F (2017)	59
RBMS1	1	MRPL53	0	biochemical	Havugimana PC (2012)	1
FBXL5	3	NABP2	0	affinity chromatography technology, affinity chromatography technology, pull down	Chen ZW (2015), Chen ZW (2015), Chen ZW (2015)	3
TP53	0	EP300	36	pull down, genetic interference, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, unspecified method, affinity chromatography technology, enzymatic study, unspecified method, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, unspecified method	An W (2004), Pastorcic M (2000), Livengood JA (2002), Livengood JA (2002), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Tang Y (2008), Wang H (2008), Valbuena A (2008), Shi D (2009), Vega FM (2004), Finlan L (2004), Groenroos E (2004), Zhao Y (2006), Roe JS (2006), Pedeux R (2005), Sekaric P (2007), Pan X (2009), Tang Y (2006), Sen GS (2011), Li Y (2012), Li Y (2012), Gillotin S (2010), Grossman SR (2003), Issaeva N (2004), Kitagawa M (2008), Sabbatini P (2002), Burge S (2009), Zilfou JT (2001), Issaeva N (2004), Issaeva N (2004), Feng H (2009), Feng H (2009), Lill NL (1997), Dornan D (2004), Dornan D (2004), Di Agostino S (2006), Wells M (2008), Fath DM (2006), Kobet E (2000), Costanzo A (2002), Kumazawa T (2011), Borger DR (2006), Cui D (2013), Borger DR (2006), Lee SJ (2013), Tang HY (2006), Lin C (2011), Choi WI (2014), Ding G (2013), Kim MK (2013), Ali A (2013), Wu G (2014), Mizuguchi Y (2012), Sinha S (2012), Sinha S (2012), Her YR (2013), Her YR (2013), Wu SY (2009), Wu SY (2009), Liu L (1999), Sakaguchi K (1998), Harrod R (2003), Gu W (1997), Teufel DP (2007), Mantovani F (2007), Mantovani F (2007), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), MacPartlin M (2005), Mujtaba S (2004), Wang YH (2003), Chen H (1999), Tang Z (2013), Graczyk A (2013), Graczyk A (2013), Chan HM (2001), Thomas MC (2005), Miller Jenkins LM (2015), Miller Jenkins LM (2015), Koh DI (2014), Koh DI (2014), Koh DI (2014), Li H (2015), Chen LF (2005), Shi D (2016), Wright DG (2016), Zhang X (2016), Procopio MG (2015), Tong Q (2015)	95
MYC	2	NABP2	0	affinity chromatography technology	Agrawal P (2010)	1
INTS3	2	PPP2R1A	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Malovannaya A (2010), Hein MY (2015), Yadav L (2017), Yadav L (2017)	4
NABP2	0	SKP1	0	affinity chromatography technology	Chen ZW (2015)	1
NABP2	0	GATAD2A	3	affinity chromatography technology	Hein MY (2015)	1
TP53	0	PPP2R1A	8	imaging technique, affinity chromatography technology	Chen TC (2014), Kikuchi J (2003)	2
SARNP	0	SRPRB	0	biochemical	Havugimana PC (2012)	1
TP53	0	SKP1	0	affinity chromatography technology	Fogeron ML (2013)	1
TP53	0	EEF1A1	0	affinity chromatography technology	Fogeron ML (2013)	1
EEF1A1	0	SSBP1	0	biochemical	Havugimana PC (2012)	1
SERPINH1	2	NABP2	0	biochemical	Havugimana PC (2012)	1
SEPT11	2	NABP2	0	biochemical	Havugimana PC (2012)	1
INTS3	2	NABP2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, biochemical, affinity chromatography technology	Malovannaya A (2010), Huang J (2009), Huang J (2009), Huang J (2009), Huang J (2009), Huang J (2009), Huang J (2009), Wan C (2015), Hein MY (2015)	9
NABP2	0	EP300	36	affinity chromatography technology, affinity chromatography technology	Xu S (2012), Wu Y (2015)	2
SERPINH1	2	TP53	0	affinity chromatography technology	Wang H (2008)	1
EGFR	5	NABP2	0	affinity chromatography technology	Yao Z (2017)	1
SSBP1	0	INTS3	2	affinity chromatography technology	Cotta-Ramusino C (2011)	1
NABP2	0	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down	Xu S (2012), Xu S (2012), Xu S (2012)	3
RBMS1	1	NABP2	0	biochemical	Havugimana PC (2012)	1
INTS6	4	NABP2	0	affinity chromatography technology	Malovannaya A (2010)	1
SARNP	0	NABP2	0	biochemical	Havugimana PC (2012)	1
BRCA1	7	SKP1	0	affinity chromatography technology, affinity chromatography technology	Lu Y (2012), Lu Y (2012)	2
NABP2	0	BUD13	0	affinity chromatography technology	Hein MY (2015)	1
EGFR	5	EEF1A1	0	affinity chromatography technology	Foerster S (2013)	1
PRCC	0	NABP2	0	biochemical	Havugimana PC (2012)	1
PPP2R1A	8	EEF1A1	0	affinity chromatography technology, affinity chromatography technology	Aranda-Orgilles B (2008), Aranda-Orgilles B (2008)	2
PPIF	0	SRPRB	0	biochemical	Havugimana PC (2012)	1
MYC	2	SKP1	0	affinity chromatography technology, affinity chromatography technology, two hybrid	Koch HB (2007), von der Lehr N (2003), Wang J (2011)	3
NABP2	0	YIPF5	1	affinity chromatography technology	Hein MY (2015)	1
BRCA1	7	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, biochemical, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Abramovitch S (2004), Ouchi T (1998), Dong Y (2003), Dong Y (2003), Chai YL (1999), Chai YL (1999), Zhang H (1998), Dong Y (2003), Chen Y (2006), Quaresima B (2006), Zhang H (1998), Zhang H (1998), Mark WY (2005), Jin S (2009), Jiang J (2011), Rasti M (2015), Rasti M (2015)	17
MYC	2	MRPL53	0	affinity chromatography technology	Agrawal P (2010)	1
MYC	2	TP53	0	affinity chromatography technology, fluorescent resonance energy transfe	Agrawal P (2010), Ivanov AA (2017)	2
EGFR	5	SSBP1	0	affinity chromatography technology	Tong J (2014)	1
EEF1A1	0	NABP2	0	biochemical	Havugimana PC (2012)	1
EP300	36	EEF1A1	0	pull down	Karmakar S (2010)	1
BRCA1	7	SERPINH1	2	affinity chromatography technology	Ertych N (2016)	1
EGFR	5	LUC7L3	2	affinity chromatography technology	Yao Z (2017)	1
INTS3	2	INIP	1	pull down, affinity chromatography technology, biochemical, biochemical	Huang J (2009), Huang J (2009), Havugimana PC (2012), Wan C (2015)	4
EGFR	5	SRPRB	0	affinity chromatography technology	Tong J (2014)	1
EGFR	5	PRCC	0	protein complementation assay	Deribe YL (2009)	1
INTS5	3	PPP2R1A	8	affinity chromatography technology, genetic interference, affinity chromatography technology, bioid	Malovannaya A (2010), Horlbeck MA (2018), Yadav L (2017), Yadav L (2017)	4
LUC7L3	2	PPP2R1A	8	genetic interference	Horlbeck MA (2018)	1
PPIF	0	NABP2	0	biochemical	Havugimana PC (2012)	1
SOD2	0	NABP2	0	biochemical	Havugimana PC (2012)	1
NABP2	0	LUC7L3	2	affinity chromatography technology	Hein MY (2015)	1
CUL1	7	FBXL5	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vashisht AA (2009), Salahudeen AA (2009), Liu B (2012), Vinas-Castells R (2013), Moroishi T (2014), Moroishi T (2014), Chen ZW (2015), Wu WD (2016), Huttlin EL (2017)	9
INTS1	10	INTS5	3	affinity chromatography technology, affinity chromatography technology	Malovannaya A (2010), Malovannaya A (2010)	2
MYC	2	SSBP1	0	affinity chromatography technology	Agrawal P (2010)	1
PPIF	0	SUGP1	2	biochemical	Havugimana PC (2012)	1
SERPINH1	2	SUGP1	2	biochemical	Havugimana PC (2012)	1
EP300	36	FBXL5	3	two hybrid	Wang J (2011)	1
SARNP	0	PRCC	0	affinity chromatography technology	Boldt K (2016)	1
NABP2	0	CENPJ	6	affinity chromatography technology	Hein MY (2015)	1
TP53	0	EGFR	5	genetic interference, genetic interference	Xie L (2013), Ye H (2016)	2
PPP2R1A	8	NABP2	0	affinity chromatography technology, bioid	Yadav L (2017), Yadav L (2017)	2
BRCA1	7	NABP2	0	affinity chromatography technology	Hill SJ (2014)	1
INTS3	2	INTS6	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Malovannaya A (2010), Malovannaya A (2010), Huttlin EL (2017)	3
PPIF	0	RBMS1	1	biochemical	Havugimana PC (2012)	1