PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
VKORC1	1	TF	2	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	TREX1	0	two hybrid	Schaafhausen A (2011)	1
VAPA	1	VAPB	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nishimura Y (1999), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	4
VKORC1	1	MSRB1	0	two hybrid	Schaafhausen A (2011)	1
TMEM63B	1	VAPA	1	affinity chromatography technology	Hein MY (2015)	1
VKORC1	1	JAGN1	0	two hybrid	Schaafhausen A (2011)	1
LMNA	2	ASGR1	0	two hybrid	Dittmer TA (2014)	1
VKORC1	1	SLC31A2	0	two hybrid	Schaafhausen A (2011)	1
LMNA	2	JAGN1	0	two hybrid	Dittmer TA (2014)	1
VKORC1	1	APLP2	2	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	CCDC167	0	two hybrid	Schaafhausen A (2011)	1
CREB3	1	FIS1	0	two hybrid	Yu H (2011)	1
COMT	2	PPA2	1	affinity chromatography technology	Hein MY (2015)	1
LIG4	0	VKORC1	1	two hybrid	Woods NT (2012)	1
LMNA	2	CLDN10	0	two hybrid	Dittmer TA (2014)	1
VKORC1	1	RMND5A	0	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	SNORA12	0	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	KCNK17	1	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	GJB1	0	two hybrid	Schaafhausen A (2011)	1
LMNA	2	CD81	0	two hybrid	Dittmer TA (2014)	1
VKORC1	1	ATP6AP2	2	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	CD63	0	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	TMEM120A	1	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	FIS1	0	two hybrid	Schaafhausen A (2011)	1
CD81	0	PDIA6	1	affinity chromatography technology	Perez-Hernandez D (2013)	1
APOA1	0	APOA2	1	pull down, pull down, biochemical	Clay MA (2000), Clay MA (2000), Cheung MC (1986)	3
GOLT1B	0	VKORC1	1	affinity chromatography technology	Hein MY (2015)	1
VKORC1	1	IFITM3	0	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	CLDN10	0	two hybrid	Schaafhausen A (2011)	1
GOLT1B	0	VAPA	1	affinity chromatography technology	Hein MY (2015)	1
VKORC1	1	PPIB	1	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	APOC3	1	two hybrid	Schaafhausen A (2011)	1
FIS1	0	BCAP31	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Iwasawa R (2011), Iwasawa R (2011), Iwasawa R (2011), Iwasawa R (2011)	4
VKORC1	1	VKORC1L1	1	affinity chromatography technology	Schaafhausen A (2011)	1
PDK1	1	VKORC1	1	affinity chromatography technology	Hein MY (2015)	1
VKORC1	1	TMEM176A	0	two hybrid	Schaafhausen A (2011)	1
APOA1	0	APOC1	1	two hybrid, affinity chromatography technology	Ritter M (2002), Zhou M (2004)	2
ATP6AP2	2	CREB3	1	two hybrid	Yu H (2011)	1
VKORC1	1	PLP2	0	two hybrid	Schaafhausen A (2011)	1
APOA1	0	APOC3	1	affinity chromatography technology	Zhou M (2004)	1
VKORC1	1	VAPB	2	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	MT1X	0	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	ASGR2	1	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	SAT1	0	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	PROCR	0	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	ASGR1	0	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	TMEM35B	0	two hybrid	Schaafhausen A (2011)	1
LMNA	2	TMEM230	0	bioid, two hybrid	Roux KJ (2012), Dittmer TA (2014)	2
VKORC1	1	HPR	1	two hybrid	Schaafhausen A (2011)	1
TMPRSS11B	0	MSMO1	2	affinity chromatography technology	Huttlin EL (2017)	1
VKORC1	1	TRAM1	0	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	C1S	0	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	APOC4	1	two hybrid	Schaafhausen A (2011)	1
LMNA	2	CREB3	1	two hybrid	Dittmer TA (2014)	1
ECHDC1	0	RMDN1	0	biochemical	Wan C (2015)	1
CREB3	1	TRAM1	0	two hybrid	Yu H (2011)	1
VKORC1	1	HSD17B7	1	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	YIF1A	8	two hybrid	Schaafhausen A (2011)	1
3240	0	APOA1	0	unspecified method	Spagnuolo MS (2005)	1
VKORC1	1	FGL1	3	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	MSMO1	2	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	PCDH1	6	two hybrid	Schaafhausen A (2011)	1
BCAP31	0	TRAM1	0	protein complementation assay, affinity chromatography technology, affinity chromatography technology	Wang B (2008), Wang B (2008), Wang B (2008)	3
TMPRSS11B	0	VKORC1	1	affinity chromatography technology	Huttlin EL (2017)	1
LMNA	2	PCMT1	1	bioid	Roux KJ (2012)	1
VKORC1	1	CNN3	0	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	CD9	1	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	RMDN1	0	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	METTL7B	0	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	PDIA6	1	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	HOMER2	0	two hybrid	Schaafhausen A (2011)	1
GOLT1B	0	BCAP31	0	affinity chromatography technology	Hein MY (2015)	1
CREB3	1	VKORC1	1	two hybrid	Yu H (2011)	1
VKORC1	1	EBP	1	two hybrid, affinity chromatography technology	Schaafhausen A (2011), Schaafhausen A (2011)	2
CDC23	3	VKORC1	1	affinity chromatography technology	Hein MY (2015)	1
VKORC1	1	CD81	0	two hybrid	Schaafhausen A (2011)	1
HDAC6	0	PCMT1	1	affinity chromatography technology	Watson GW (2016)	1
VKORC1	1	SAA1	0	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	ATP5G3	0	two hybrid	Schaafhausen A (2011)	1
VAPA	1	YIF1A	8	affinity chromatography technology	Hein MY (2015)	1
LMNA	2	PLP2	0	two hybrid	Dittmer TA (2014)	1
VKORC1	1	SLC15A3	0	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	PPA2	1	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	FTL	0	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	CXADR	2	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	SERP1	0	two hybrid, affinity chromatography technology	Schaafhausen A (2011), Schaafhausen A (2011)	2
VKORC1	1	PCMT1	1	two hybrid	Schaafhausen A (2011)	1
ILK	0	VKORC1	1	affinity chromatography technology	Varjosalo M (2013)	1
GOLT1B	0	VAPB	2	affinity chromatography technology	Hein MY (2015)	1
TMBIM4	0	PPIB	1	affinity chromatography technology	Ewing RM (2007)	1
VKORC1	1	FGG	1	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	APOC1	1	two hybrid	Schaafhausen A (2011)	1
LMNA	2	APOA2	1	two hybrid	Dittmer TA (2014)	1
CD63	0	CD9	1	affinity chromatography technology	Radford KJ (1996)	1
VAPA	1	SLC25A1	2	affinity chromatography technology	Hein MY (2015)	1
LMNA	2	SERP1	0	two hybrid	Dittmer TA (2014)	1
VKORC1	1	SERPINA1	1	two hybrid	Schaafhausen A (2011)	1
REEP5	1	EBP	1	affinity chromatography technology	Huttlin EL (2017)	1
VKORC1	1	SPTSSA	0	two hybrid	Schaafhausen A (2011)	1
ILK	0	SLC25A1	2	affinity chromatography technology	So J (2015)	1
VKORC1	1	BCAP31	0	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	3240	0	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	ARL6IP5	0	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	HDAC6	0	two hybrid, affinity chromatography technology	Schaafhausen A (2011), Hein MY (2015)	2
VKORC1	1	TMEM242	2	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	STAT6	1	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	CCDC12	0	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	TMEM134	0	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	SLC25A1	2	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	TMEM256	0	two hybrid	Schaafhausen A (2011)	1
TMEM63B	1	VKORC1	1	affinity chromatography technology	Hein MY (2015)	1
VKORC1	1	SURF4	1	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	AHSG	0	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	TMBIM4	0	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	APOA1	0	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	TMEM45B	0	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	TMEM230	0	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	PIGH	0	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	REEP5	1	two hybrid	Schaafhausen A (2011)	1
LMNA	2	VKORC1	1	two hybrid	Dittmer TA (2014)	1
LMNA	2	GOLT1B	0	two hybrid	Dittmer TA (2014)	1
VKORC1	1	ZCCHC24	1	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	DPM2	0	two hybrid	Schaafhausen A (2011)	1
CREB3	1	APOA2	1	two hybrid	Yu H (2011)	1
CD63	0	CD81	0	biochemical	Booth AM (2006)	1
VAPA	1	VKORC1	1	affinity chromatography technology	Hein MY (2015)	1
REEP5	1	GOLT1B	0	affinity chromatography technology	Hein MY (2015)	1
VKORC1	1	VKORC1	1	two hybrid, affinity chromatography technology	Schaafhausen A (2011), Schaafhausen A (2011)	2
VKORC1	1	COMT	2	two hybrid	Schaafhausen A (2011)	1
ILK	0	LMNA	2	affinity chromatography technology	So J (2015)	1
CD81	0	CD9	1	affinity chromatography technology, biochemical	Radford KJ (1996), Horvath G (1998)	2
VAPA	1	SURF4	1	affinity chromatography technology	Hein MY (2015)	1
VKORC1	1	ECHDC1	0	two hybrid	Schaafhausen A (2011)	1
VKORC1	1	APOA2	1	two hybrid	Schaafhausen A (2011)	1
CREB3	1	TMEM230	0	two hybrid	Yu H (2011)	1
VKORC1	1	HAMP	1	two hybrid	Schaafhausen A (2011)	1