PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CTDSP2	1	PRR14	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PPP2CA	7	PRR14	3	affinity chromatography technology, affinity chromatography technology	Glatter T (2009), Huttlin EL (2017)	2
PPP2R1A	8	PRR14	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Glatter T (2009), Hein MY (2015), Huttlin EL (2017), Yadav L (2017)	4
PRR14	3	PPP2R5E	4	affinity chromatography technology	Huttlin EL (2017)	1
CBX5	3	PPP2CA	7	affinity chromatography technology	Nozawa RS (2010)	1
PPP2R5D	29	PPP2R1B	4	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, two hybrid, biochemical, affinity chromatography technology	McCright B (1996), McCright B (1996), Sablina AA (2007), Havugimana PC (2012), Wallach T (2013), Wan C (2015), Hein MY (2015)	7
PPP2CA	7	PPP2R5E	4	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), McCright B (1996), McCright B (1996), Glatter T (2009), Wan C (2015), Hein MY (2015), St-Denis N (2016), Yadav L (2017)	8
PPP2R5C	3	APP	1	pull down	Olah J (2011)	1
SH3BP4	2	PRR14	3	two hybrid	Thalappilly S (2008)	1
PRR14	3	PPP2R5A	2	affinity chromatography technology	Huttlin EL (2017)	1
SH3GL2	1	APP	1	pull down	Olah J (2011)	1
PPP2CB	1	PPP2R1A	8	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Goudreault M (2009), Zhou J (2003), Zhou J (2003), Glatter T (2009), Glatter T (2009), Fogeron ML (2013), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Hein MY (2015), St-Denis N (2016), Huttlin EL (2017), Boldt K (2016), Yadav L (2017), Yadav L (2017)	15
CBX1	0	CBX3	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Rosnoblet C (2011), Hauri S (2016), Hauri S (2016)	8
PPP2R1B	4	PPP2CB	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Zhou J (2003), Zhou J (2003), Glatter T (2009), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	7
PPP2R5A	2	PPP2R1B	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical	Goudreault M (2009), Zhou J (2003), Zhou J (2003), McCright B (1996), McCright B (1996)	5
PRR14	3	MAN2B2	2	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	PPP2R1A	8	affinity chromatography technology	Foerster S (2013)	1
PPP2CB	1	PPP2R5A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017)	3
EGFR	5	PPP2R1B	4	affinity chromatography technology	Foerster S (2013)	1
PPP2CA	7	PPP2R1B	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Zhou J (2003), Zhou J (2003), Glatter T (2009), Sablina AA (2007), Sablina AA (2007), Havugimana PC (2012), Wan C (2015), Hein MY (2015), Yadav L (2017)	10
ELAVL1	0	CBX3	1	affinity chromatography technology	Abdelmohsen K (2009)	1
PPP2R5A	2	PPP2R5C	3	affinity chromatography technology	Strack S (2002)	1
PRR14	3	CBX1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016)	2
PPP2R5C	3	PPP2R1B	4	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	McCright B (1996), McCright B (1996), Sablina AA (2007), Wan C (2015)	4
PPP2CA	7	PPP2R5A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Goudreault M (2009), McCright B (1996), McCright B (1996), Widau RC (2010), Wan C (2015), Hein MY (2015), Craney A (2016), St-Denis N (2016), Yadav L (2017)	10
CBX5	3	PPP2R5A	2	affinity chromatography technology	Nozawa RS (2010)	1
PPP2R5E	4	APP	1	pull down	Olah J (2011)	1
SPINT2	0	APP	1	pull down	Olah J (2011)	1
PRR14	3	PPP2R5C	3	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	PPP2R5E	4	affinity chromatography technology	Abdelmohsen K (2009)	1
CBX5	3	PPP2CB	1	affinity chromatography technology	Nozawa RS (2010)	1
CBX1	0	CBX5	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Mateos-Langerak J (2007), Rosnoblet C (2011), Nozawa RS (2010), Hauri S (2016), Hauri S (2016)	10
EGFR	5	SH3GL2	1	affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schmidt MH (2004), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Liu W (2014), Liu W (2014)	6
SPINT2	0	PRR14	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PRR14	3	PPP2R5D	29	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	APP	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
CBX5	3	PPP2R5E	4	affinity chromatography technology	Nozawa RS (2010)	1
PPP2R1A	8	PPP2R5C	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Goudreault M (2009), Glatter T (2009), Dozier C (2004), Fogeron ML (2013), Wan C (2015), Hein MY (2015), Boldt K (2016), Shouse GP (2011), Yadav L (2017), Yadav L (2017)	10
PRR14	3	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
PRR14	3	PPP2R1B	4	affinity chromatography technology	Huttlin EL (2017)	1
PPP2CA	7	PPP2R5C	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ito A (2000), Goudreault M (2009), McCright B (1996), McCright B (1996), Glatter T (2009), Dozier C (2004), Letourneux C (2006), Wan C (2015), St-Denis N (2016), Shouse GP (2011), Shouse GP (2011), Yadav L (2017)	12
CBX3	1	PRR14	3	affinity chromatography technology	Hauri S (2016)	1
PPP2CB	1	PPP2R5C	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Glatter T (2009), Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017)	4
ELAVL1	0	PRR14	3	affinity chromatography technology	Abdelmohsen K (2009)	1
PPP2CB	1	PPP2R5E	4	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Glatter T (2009), Huttlin EL (2015), Wan C (2015), Hein MY (2015), St-Denis N (2016), Huttlin EL (2017)	6
CBX3	1	CBX5	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Quivy JP (2004), Quivy JP (2004), Quivy JP (2004), Kiyomitsu T (2010), Rosnoblet C (2011), Nozawa RS (2010), Vermeulen M (2010), Vermeulen M (2010), Hauri S (2016), Hauri S (2016)	15
CELA1	3	PRR14	3	affinity chromatography technology	Huttlin EL (2017)	1
PPP2R5A	2	PPP2R5D	29	biochemical	Wan C (2015)	1
EGFR	5	PRR14	3	affinity chromatography technology	Yao Z (2017)	1
PPP2CB	1	PRR14	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Glatter T (2009), Huttlin EL (2015), Huttlin EL (2017)	3
SH3GL2	1	PRR14	3	two hybrid	Vinayagam A (2011)	1
PPP2CB	1	PPP2R5D	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Glatter T (2009), Huttlin EL (2015), Wan C (2015), Hein MY (2015), St-Denis N (2016), Huttlin EL (2017)	7
C6orf141	1	PRR14	3	affinity chromatography technology	Huttlin EL (2017)	1
PPP2R5E	4	PPP2R1B	4	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, two hybrid, biochemical	McCright B (1996), McCright B (1996), Sablina AA (2007), Sablina AA (2007), Wallach T (2013), Wan C (2015)	6
PPP2R1A	8	PPP2R5E	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Goudreault M (2009), Glatter T (2009), Fogeron ML (2013), Wallach T (2013), Wan C (2015), Hein MY (2015), Boldt K (2016), Yadav L (2017), Yadav L (2017)	9
PPP2R1A	8	PPP2R5D	29	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Goudreault M (2009), Glatter T (2009), Havugimana PC (2012), Fogeron ML (2013), Wallach T (2013), Wan C (2015), Hein MY (2015), Hein MY (2015), Boldt K (2016), Yadav L (2017), Yadav L (2017)	11
PPP2CB	1	PPP2CA	7	biochemical, affinity chromatography technology	Wan C (2015), St-Denis N (2016)	2
LYPD4	1	PRR14	3	affinity chromatography technology	Huttlin EL (2017)	1
PPP2CA	7	PPP2R5D	29	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Goudreault M (2009), McCright B (1996), McCright B (1996), Glatter T (2009), Wan C (2015), Hein MY (2015), Hein MY (2015), St-Denis N (2016), Yadav L (2017), Yadav L (2017)	10
ELAVL1	0	PPP2R1A	8	affinity chromatography technology	Abdelmohsen K (2009)	1
PPP2R1A	8	PPP2R1B	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Goudreault M (2009), Sablina AA (2007), Fogeron ML (2013), Wan C (2015), Hein MY (2015)	5
PPP2R1A	8	PPP2R5A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, bioid	Goudreault M (2009), Goudreault M (2009), Zhou J (2003), Zhou J (2003), Widau RC (2010), Wan C (2015), Hein MY (2015), Yadav L (2017), Yadav L (2017)	9
EGFR	5	PPP2R5C	3	affinity chromatography technology	Tong J (2014)	1
EGFR	5	PPP2R5E	4	affinity chromatography technology	Foerster S (2013)	1
PPP2R5E	4	PPP2R5C	3	biochemical	Wan C (2015)	1
PPP2CA	7	PPP2R1A	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, bioid	Goudreault M (2009), Goudreault M (2009), Zhou J (2003), Zhou J (2003), Glatter T (2009), Glatter T (2009), Sablina AA (2007), Sablina AA (2007), Kong M (2009), Kong M (2009), Shamay M (2012), Havugimana PC (2012), Junttila MR (2007), Junttila MR (2007), Nazarenko I (2007), Kristensen AR (2012), Fogeron ML (2013), Sablina AA (2010), Lee CW (2014), Wan C (2015), Hein MY (2015), Hein MY (2015), Cianfanelli V (2015), St-Denis N (2016), Bryant JC (1999), Shouse GP (2011), Yadav L (2017), Yadav L (2017), Yadav L (2017), Yadav L (2017)	30
CBX5	3	PRR14	3	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Nozawa RS (2010), Huttlin EL (2017), Hauri S (2016)	4