PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRIM5	4	UBC	7	enzymatic study	Pertel T (2011)	1
TRIM25	5	MAVS	1	affinity chromatography technology	Liu B (2017)	1
UBC	7	TRIM26	1	affinity chromatography technology	Matsumoto M (2005)	1
TRAF6	0	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Muroi M (2011), Park S (2013), Sun L (2004), Kanayama A (2004), Sakamoto H (2015), Yu J (2016), Middleton AJ (2017)	7
USP28	3	OTUB2	0	enzymatic study	Loch CM (2012)	1
OTUB2	0	UBC	7	enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down	Edelmann MJ (2009), Mevissen TE (2013), Altun M (2015), Altun M (2015), Kwasna D (2018)	5
OTUB2	0	TRAF3	1	affinity chromatography technology	Li S (2010)	1
GPBP1	2	OTUB2	0	affinity chromatography technology	Huttlin EL (2017)	1
UBE2N	1	TRIM27	2	two hybrid, affinity chromatography technology	Napolitano LM (2011), Napolitano LM (2011)	2
RFFL	0	ATXN3	2	enzymatic study	Loch CM (2012)	1
UBE2N	1	SIAH1	2	two hybrid	Markson G (2009)	1
TRIM25	5	FAM168A	0	affinity chromatography technology	Choudhury NR (2017)	1
OTUB2	0	TRIM25	5	two hybrid	Hayes SD (2012)	1
OTUB2	0	TRIM27	2	two hybrid	Hayes SD (2012)	1
RBCK1	0	UBC	7	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, pull down, pull down, pull down, enzymatic study, pull down	Tatematsu K (2008), Yoshimoto N (2009), Sato Y (2011), Kirisako T (2006), Haas TL (2009), Yoshimoto N (2009), Sato Y (2011), Emmerich CH (2013), Emmerich CH (2013), Zhang X (2017)	10
USP21	2	USP28	3	enzymatic study, enzymatic study	Loch CM (2012), Loch CM (2012)	2
GTF2I	1	TRAF6	0	two hybrid	Corominas R (2014)	1
PJA1	1	USP28	3	enzymatic study	Loch CM (2012)	1
TRIM25	5	APP	1	affinity chromatography technology	Choudhury NR (2017)	1
TRIM63	0	TRIM54	1	two hybrid, pull down	Centner T (2001), Centner T (2001)	2
PJA1	1	OTUB2	0	enzymatic study	Loch CM (2012)	1
OTUB2	0	APP	1	pull down	Olah J (2011)	1
TRAF3	1	MAVS	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakhaei P (2009), Arnaud N (2011), Paz S (2011), Wang Y (2012), Saha SK (2006), Saha SK (2006), Ng MH (2011), Johnsen IB (2009), van Zuylen WJ (2012), Belgnaoui SM (2012), Chen X (2014), Wang P (2013), Wang P (2013), Minassian A (2015), Gu L (2017), Khan M (2016), Fang R (2017), Fang R (2017)	18
MAGEA11	1	OTUB2	0	two hybrid	Rual JF (2005)	1
UBC	7	PJA1	1	affinity chromatography technology	Matsumoto M (2005)	1
UBE2N	1	RBCK1	0	two hybrid	Markson G (2009)	1
OTUB2	0	MAVS	1	affinity chromatography technology	Li S (2010)	1
USP21	2	RBCK1	0	two hybrid	Hayes SD (2012)	1
TRIM26	1	RNF126	2	two hybrid	Woodsmith J (2012)	1
MID2	1	TRIM54	1	two hybrid	Rolland T (2014)	1
TRIM27	2	SIAH1	2	two hybrid	Rolland T (2014)	1
USP21	2	ATXN3	2	enzymatic study	Loch CM (2012)	1
USP21	2	OTUB2	0	enzymatic study	Loch CM (2012)	1
RBCK1	0	APP	1	pull down	Olah J (2011)	1
SIAH1	2	OTUB2	0	two hybrid	Rolland T (2014)	1
USP28	3	UBC	7	enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down, enzymatic study, pull down	Loch CM (2012), Zhen Y (2014), Wen Y (2015), Wen Y (2015), Wen Y (2015), Wrigley JD (2017), Kwasna D (2018)	7
TRIM54	1	ATXN3	2	enzymatic study	Loch CM (2012)	1
TRIM63	0	ATXN3	2	enzymatic study	Loch CM (2012)	1
RNF126	2	PJA1	1	affinity chromatography technology	Huttlin EL (2015)	1
UBC	7	RNF126	2	affinity chromatography technology, enzymatic study, pull down	Matsumoto M (2005), Hou X (2012), Lee NS (2017)	3
TRIM55	2	TRIM27	2	two hybrid	Woodsmith J (2012)	1
RFFL	0	OTUB2	0	enzymatic study	Loch CM (2012)	1
CPSF6	1	OTUB2	0	two hybrid	Rolland T (2014)	1
TRIM27	2	MID2	1	two hybrid	Rolland T (2014)	1
UBC	7	GTF2I	1	pull down	Zhang X (2017)	1
USP21	2	TRAF6	0	enzymatic study	Bremm A (2010)	1
TP53BP2	5	OTUB2	0	two hybrid	Rolland T (2014)	1
PJA1	1	GTF2I	1	enzymatic study	Loch CM (2011)	1
KRT31	0	OTUB2	0	two hybrid	Rolland T (2014)	1
UBE2N	1	MID2	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology	van Wijk SJ (2009), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011)	4
OTUB2	0	TRIM39	0	two hybrid	Hayes SD (2012)	1
USP21	2	TRIM5	4	two hybrid	Hayes SD (2012)	1
TRIM63	0	UBE2N	1	pull down	Kim HT (2007)	1
TRAF6	0	APP	1	pull down	Olah J (2011)	1
UBC	7	UBE2N	1	affinity chromatography technology, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Matsumoto M (2005), Scheper J (2010), Wu PY (2003), McKenna S (2003), Wiener R (2012), Ye Y (2003), Bish RA (2007), Juang YC (2012), Pastushok L (2007), Singh RK (2012), McKenna S (2001), McKenna S (2001)	12
TRIM55	2	OTUB2	0	enzymatic study	Loch CM (2012)	1
TRIM25	5	NMRAL1	1	affinity chromatography technology	Choudhury NR (2017)	1
OTUB2	0	TRIM5	4	two hybrid	Hayes SD (2012)	1
UBE2N	1	TRIM5	4	two hybrid, pull down, x-ray crystallography	Markson G (2009), Yudina Z (2015), Yudina Z (2015)	3
TRIM39	0	UBC	7	enzymatic study	Woodsmith J (2012)	1
OTUB2	0	TRIM2	1	two hybrid	Hayes SD (2012)	1
RNF126	2	UBE2N	1	pull down	Smith CJ (2013)	1
TRIM63	0	OTUB2	0	enzymatic study	Loch CM (2012)	1
RBCK1	0	TRAF6	0	affinity chromatography technology	Tian Y (2007)	1
TRIM39	0	UBE2N	1	pull down	Woodsmith J (2012)	1
TRIM54	1	OTUB2	0	enzymatic study, two hybrid	Loch CM (2012), Rolland T (2014)	2
MID1	1	MID2	1	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Reymond A (2001), Reymond A (2001), Short KM (2002), Short KM (2002), Short KM (2002), Short KM (2002), Short KM (2006), Short KM (2006), Rolland T (2014), Gholkar AA (2016), Gholkar AA (2016), Gholkar AA (2016), Gholkar AA (2016)	13
OTUB2	0	TRIM8	6	two hybrid	Hayes SD (2012)	1
USP21	2	TRIM8	6	two hybrid	Hayes SD (2012)	1
MAGEA11	1	TRIM27	2	two hybrid	Rual JF (2005)	1
TRIM63	0	TRIM55	2	two hybrid, two hybrid	Centner T (2001), Witt CC (2008)	2
TRIM25	5	RBCK1	0	affinity chromatography technology, imaging technique, pull down, enzymatic study	Inn KS (2011), Inn KS (2011), Inn KS (2011), Inn KS (2011)	4
TRAF6	0	UBE2N	1	genetic interference, pull down, two hybrid, biochemical, two hybrid, x-ray crystallography, two hybrid, enzymatic study, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, two hybrid	Deng L (2000), Deng L (2000), Markson G (2009), Yin Q (2009), Dynek JN (2010), Yin Q (2009), Yin Q (2009), Petroski MD (2007), Mercier P (2007), Lamothe B (2008), Kanayama A (2004), Murata H (2013), Ning S (2008), Markson G (2009), Lin Y (2014), Chen J (2015), Zhang J (2016), Boldt K (2016), Rezaeian AH (2017), Xing J (2016), Schimmack G (2017), Schimmack G (2017)	22
CPLX3	3	OTUB2	0	affinity chromatography technology	Huttlin EL (2017)	1
OTUB2	0	TRIM26	1	two hybrid	Hayes SD (2012)	1
PJA1	1	ATXN3	2	enzymatic study	Loch CM (2012)	1
OTUB2	0	RNF126	2	two hybrid	Hayes SD (2012)	1
MID2	1	OTUB2	0	two hybrid	Rolland T (2014)	1
OTUB2	0	RBCK1	0	two hybrid	Hayes SD (2012)	1
TRIM63	0	USP28	3	enzymatic study	Loch CM (2012)	1
MID1	1	OTUB2	0	two hybrid	Rolland T (2014)	1
OTUB2	0	LZTS2	4	two hybrid	Rolland T (2014)	1
TRIM54	1	USP21	2	enzymatic study	Loch CM (2012)	1
OTUB2	0	TRAF6	0	affinity chromatography technology, two hybrid	Li S (2010), Hayes SD (2012)	2
OTUB2	0	NMRAL1	1	affinity chromatography technology	Peng Y (2014)	1
OTUB2	0	KRT40	0	two hybrid	Rolland T (2014)	1
NMRAL1	1	TRAF3	1	affinity chromatography technology, affinity chromatography technology	Peng Y (2014), Peng Y (2014)	2
UBE2N	1	MID1	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Markson G (2009), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011)	4
ATXN3	2	UBC	7	pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, pull down, x-ray crystallography, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, x-ray crystallography, pull down, imaging technique, enzymatic study, pull down	Winborn BJ (2008), Mao Y (2005), Berke SJ (2005), Matsumoto M (2005), Bremm A (2010), Nicastro G (2010), Nicastro G (2010), Donaldson KM (2003), Chai Y (2004), Chai Y (2004), Nathan JA (2013), Seki T (2013), Yang H (2014), Yang H (2014), Blount JR (2014), Evers MM (2013), Weeks SD (2011), Donaldson KM (2003), Winborn BJ (2008), Faggiano S (2015), Wauer T (2015), Satoh T (2014), Satoh T (2014), Zhang X (2017), Toonen LJA (2017), Toonen LJA (2017), Kwasna D (2018)	27
TRIM55	2	USP28	3	enzymatic study	Loch CM (2012)	1
ATXN3	2	OTUB2	0	affinity chromatography technology	Sowa ME (2009)	1
MAVS	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Wang Y (2012), Xu LG (2005), Wang P (2013), Wang P (2013), Shi Z (2015), Shi Z (2015), Minassian A (2015), Khan M (2016), Fang R (2017), Fang R (2017)	11
ATXN3	2	APP	1	pull down	Olah J (2011)	1
TRIM8	6	TRIM2	1	two hybrid	Woodsmith J (2012)	1
TRIM25	5	TRIM8	6	two hybrid	Woodsmith J (2012)	1
UBE2N	1	TRIM25	5	two hybrid, pull down, x-ray crystallography, affinity chromatography technology	Markson G (2009), Sanchez JG (2016), Sanchez JG (2016), Choudhury NR (2017)	4
TRIM55	2	ATXN3	2	enzymatic study	Loch CM (2012)	1
TRIM39	0	APP	1	pull down	Olah J (2011)	1
REL	5	OTUB2	0	two hybrid	Rolland T (2014)	1
MID1	1	UBC	7	affinity chromatography technology, affinity chromatography technology	Trockenbacher A (2001), Trockenbacher A (2001)	2
TRIM63	0	USP21	2	enzymatic study	Loch CM (2012)	1
TRIM63	0	APP	1	pull down	Olah J (2011)	1
ATXN3	2	TRAF6	0	enzymatic study	Bremm A (2010)	1
TRAF6	0	TRIM25	5	two hybrid	Woodsmith J (2012)	1
220594	0	OTUB2	0	affinity chromatography technology	Sowa ME (2009)	1
TRIP6	2	OTUB2	0	two hybrid	Rolland T (2014)	1
RFFL	0	USP28	3	enzymatic study	Loch CM (2012)	1
OTUB2	0	GTF2I	1	affinity chromatography technology	Sowa ME (2009)	1
SIAH1	2	TRIM8	6	two hybrid	Woodsmith J (2012)	1
SIAH1	2	TP53BP2	5	two hybrid, two hybrid	Wang J (2011), Rolland T (2014)	2
TRIM8	6	TRIM39	0	two hybrid	Woodsmith J (2012)	1
TRIM25	5	UBC	7	enzymatic study	Sanchez JG (2016)	1
TRIM25	5	RFFL	0	affinity chromatography technology	Choudhury NR (2017)	1
UBE2N	1	CPSF6	1	affinity chromatography technology	Boldt K (2016)	1
ARRDC3	0	OTUB2	0	two hybrid	Rolland T (2014)	1
UBC	7	TRIM27	2	affinity chromatography technology	Matsumoto M (2005)	1
USP21	2	KRT40	0	two hybrid	Rolland T (2014)	1
OTUB2	0	UBE2N	1	pull down	Nakada S (2010)	1
USP21	2	UBC	7	enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, unspecified method, enzymatic study, enzymatic study, pull down, enzymatic study	Bremm A (2010), Faesen AC (2011), Ye Y (2011), Urbe S (2012), Loch CM (2012), Ernst A (2013), Ye Y (2011), Wauer T (2015), Leung I (2016), Michel MA (2017)	10
FAM168A	0	OTUB2	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2