PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RAB11A	4	EVI5	2	affinity chromatography technology	Hein MY (2015)	1
AURKB	2	INCENP	4	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Gassmann R (2004), Xu Z (2009), Xu Z (2009), Katayama H (2008), Kaitna S (2000), Maerki S (2009), Vader G (2006), Honda R (2003), Ban R (2011), Sun L (2008), Nozawa RS (2010), Jeyaprakash AA (2007), Klein UR (2006), Klein UR (2006), Fu J (2009), Fu J (2009), Li X (2004), Gomez V (2010)	18
EVI5	2	BIRC5	1	affinity chromatography technology, pull down	Faitar SL (2006), Faitar SL (2006)	2
MYO5B	13	RAB11A	4	two hybrid, affinity chromatography technology	Roland JT (2007), Vogel GF (2015)	2
EVI5	2	SYTL4	0	affinity chromatography technology	Vogel GF (2015)	1
EVI5	2	FBXO5	2	affinity chromatography technology, pull down, affinity chromatography technology	Eldridge AG (2006), Eldridge AG (2006), Eldridge AG (2006)	3
EVI5	2	MYO5B	13	affinity chromatography technology	Vogel GF (2015)	1
EVI5	2	INCENP	4	affinity chromatography technology, pull down	Faitar SL (2006), Faitar SL (2006)	2
MYO5B	13	STX3	3	affinity chromatography technology, affinity chromatography technology	Vogel GF (2015), Vogel GF (2015)	2
RAB11A	4	STX3	3	affinity chromatography technology, affinity chromatography technology	Vogel GF (2015), Vogel GF (2015)	2
ELAVL1	0	RAB11A	4	affinity chromatography technology	Abdelmohsen K (2009)	1
PLK1	0	FBXO5	2	affinity chromatography technology	Hansen DV (2004)	1
CHMP4B	2	EVI5	2	affinity chromatography technology	Hein MY (2015)	1
ELAVL1	0	RNF41	2	affinity chromatography technology	Abdelmohsen K (2009)	1
RNF41	2	EVI5	2	affinity chromatography technology	Hein MY (2015)	1
EVI5	2	AURKB	2	affinity chromatography technology, pull down	Faitar SL (2006), Faitar SL (2006)	2
ELAVL1	0	EVI5	2	affinity chromatography technology	Abdelmohsen K (2009)	1
BIRC5	1	AURKB	2	two hybrid, pull down, genetic interference, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wheatley SP (2001), Chen J (2003), Chen J (2003), Wheatley SP (2001), Xu Z (2009), Maerki S (2009), Knauer SK (2006), Knauer SK (2006), Ban R (2011), Sun L (2008), Noton EA (2006), Noton EA (2006), Fu J (2009), Gomez V (2010)	14
EVI5	2	STX3	3	affinity chromatography technology, pull down	Vogel GF (2015), Vogel GF (2015)	2
RAB11A	4	SYTL4	0	affinity chromatography technology	Vogel GF (2015)	1
NDEL1	2	EVI5	2	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	BIRC5	1	affinity chromatography technology	Abdelmohsen K (2009)	1
SYTL4	0	STX3	3	affinity chromatography technology, affinity chromatography technology	van Breevoort D (2014), Vogel GF (2015)	2
MYO5B	13	SYTL4	0	affinity chromatography technology	Vogel GF (2015)	1
FZD10	5	EVI5	2	affinity chromatography technology	Huttlin EL (2017)	1
PLK1	0	EVI5	2	affinity chromatography technology	Hein MY (2015)	1
BIRC5	1	INCENP	4	pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Wheatley SP (2001), Wheatley SP (2001), Xu Z (2009), Vader G (2006), Knauer SK (2006), Knauer SK (2006), Jeyaprakash AA (2007), Klein UR (2006), Klein UR (2006), Klein UR (2006), Huttlin EL (2017)	11
CHMP4B	2	FBXO5	2	affinity chromatography technology	Hein MY (2015)	1