PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
WT1	1	ZNF205	1	two hybrid	Vinayagam A (2011)	1
UBQLN4	2	TRAF2	1	two hybrid	Lim J (2006)	1
UBQLN4	2	ZNF205	1	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
MDFI	1	ZNF205	1	two hybrid	Rual JF (2005)	1
ZNF205	1	CALCOCO2	0	two hybrid	Rual JF (2005)	1
ZNF205	1	CCDC85B	0	two hybrid	Rual JF (2005)	1
C8orf33	3	ZNF205	1	two hybrid	Vinayagam A (2011)	1
TRAF2	1	ZNF205	1	two hybrid	Rual JF (2005)	1
MAPK6	1	ZNF205	1	two hybrid	Vinayagam A (2011)	1
C8orf33	3	MDFI	1	two hybrid	Venkatesan K (2009)	1
HDAC6	0	ZNF205	1	two hybrid	Vinayagam A (2011)	1
CDC37	0	ZNF205	1	two hybrid	Vinayagam A (2011)	1
ILK	0	ZNF205	1	two hybrid	Vinayagam A (2011)	1
MEST	2	ZNF205	1	two hybrid	Vinayagam A (2011)	1
TRAF2	1	CALCOCO2	0	two hybrid	Rual JF (2005)	1