PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
COPS5	0	HNRNPL	3	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Fei T (2017)	2
TRIM13	1	CALM1	0	affinity chromatography technology, affinity chromatography technology	Lerner M (2007), Lerner M (2007)	2
CAND1	2	HNRNPL	3	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Fei T (2017)	2
HNRNPL	3	CACNB3	2	affinity chromatography technology	Fei T (2017)	1
CACNB3	2	CACNA1C	8	x-ray crystallography	Chen YH (2004)	1
CABP1	0	CACNA1C	8	pull down, pull down, affinity chromatography technology	Zhou H (2004), Zhou H (2004), Zhou H (2004)	3
COPS5	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Min KW (2005), Min KW (2005), Chua YS (2011), Boh BK (2011), Emberley ED (2012), Emberley ED (2012), Choo YY (2011), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Enchev RI (2012), Birol M (2014), Pick E (2012), Sharon M (2009), Enchev RI (2012), Bornstein G (2015), Rockel B (2014), Schlierf A (2016), Reitsma JM (2017), Reitsma JM (2017)	23
TRIM13	1	VCP	6	affinity chromatography technology, affinity chromatography technology	Lerner M (2007), Lerner M (2007)	2
COPS5	0	CAND1	2	biochemical, affinity chromatography technology	Bornstein G (2006), Bennett EJ (2010)	2
CACNA1C	8	RYR2	26	pull down	Mouton J (2001)	1
SIRT1	3	HDAC4	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhao X (2005), Dehennaut V (2013), Dehennaut V (2013)	3
CUL1	7	HNRNPL	3	affinity chromatography technology	Bennett EJ (2010)	1
SIRT1	3	CACNA1C	8	affinity chromatography technology	Law IK (2009)	1
CACNA1C	8	DERL1	2	affinity chromatography technology	Altier C (2011)	1
CACNA1C	8	HDAC4	10	pull down	Kehat I (2011)	1
CACNA1C	8	KCNE2	1	affinity chromatography technology, pull down, fluorescent resonance energy transfe, affinity chromatography technology	Liu W (2014), Liu W (2014), Liu W (2014), Liu W (2014)	4
CAND1	2	CACNA1C	8	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology	Cayli S (2009), Cayli S (2009), Cayli S (2009), Cayli S (2009), Bennett EJ (2010)	5
CUL1	7	CACNA1C	8	affinity chromatography technology	Bennett EJ (2010)	1
SRI	1	RYR2	26	affinity chromatography technology, affinity chromatography technology	Meyers MB (1995), Meyers MB (1995)	2
VCP	6	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Besten Wd (2012), Zhang Z (2015)	3
DERL1	2	CAND1	2	affinity chromatography technology	You H (2017)	1
CACNA1C	8	VCP	6	affinity chromatography technology	Altier C (2011)	1
CACNA1C	8	COPS5	0	two hybrid	Kameda K (2006)	1
CACNA1C	8	TRIM13	1	affinity chromatography technology	Altier C (2011)	1
HNRNPL	3	CACNA1C	8	affinity chromatography technology	Fei T (2017)	1
CUL1	7	PCBD1	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL1	7	CALM1	0	affinity chromatography technology	Bennett EJ (2010)	1
CALM1	0	RYR2	26	pull down, affinity chromatography technology	Nyegaard M (2012), Vassilakopoulou V (2015)	2
CACNA1C	8	SRI	1	pull down	Meyers MB (1998)	1
VCP	6	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography	Wang Q (2008), Ballar P (2007), Schulze A (2005), Schulze A (2005), Ye Y (2005), Lilley BN (2005), Greenblatt EJ (2011), Younger JM (2006), Christianson JC (2012), You H (2017), Lim JJ (2016), Lim JJ (2016)	12
HNRNPL	3	HDAC4	10	affinity chromatography technology	Fei T (2017)	1
COPS5	0	PCBD1	0	affinity chromatography technology	Bennett EJ (2010)	1
PCBD1	0	CACNA1C	8	two hybrid	Waters PJ (2001)	1
CALM1	0	CACNA1C	8	x-ray crystallography	Fallon JL (2005)	1
CUL1	7	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Min KW (2003), Menon S (2008), Chew EH (2007), Min KW (2005), Min KW (2005), Min KW (2005), Hwang JW (2003), Hwang JW (2003), Mao X (2011), Chua YS (2011), Chua YS (2011), Tron AE (2012), Zheng J (2002), Zheng J (2002), Bornstein G (2006), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), He YJ (2006), Emberley ED (2012), Choo YY (2011), Jonason JH (2007), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Liu J (2002), Liu J (2002), Liu J (2002), Liu J (2002), Korzeniewski N (2012), Pierce NW (2013), Kim AY (2008), Zhang S (2016), Tikhmyanova N (2017), Tikhmyanova N (2017), Reitsma JM (2017), Reitsma JM (2017)	41