Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
CACNA1A 773 GABAPENTIN CHEMBL940 modulator ChemblInteractions
CACNA1A 773 GABAPENTIN ENACARBIL CHEMBL1628502 modulator ChemblInteractions
CACNA1A 773 VERAPAMIL CHEMBL6966 inhibitor DrugBank 19125880
CACNA1A 773 ATAGABALIN CHEMBL593430 modulator ChemblInteractions
CACNA1A 773 PREGABALIN CHEMBL1059 inhibitor, modulator TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 17088553, 17126531, 17489948, 17144644, 16899342
CACNA1A 773 BEPRIDIL CHEMBL1008 inhibitor TdgClinicalTrial, TEND, DrugBank 17139284, 17016423, 7565636
CACNA1A 773 CELECOXIB CHEMBL118 PharmGKB
CACNA1A 773 BEPRIDIL HYDROCHLORIDE CHEMBL1200382 blocker ChemblInteractions
CACNA1A 773 IMAGABALIN CHEMBL2103836 modulator ChemblInteractions
CACNA1A 773 NISOLDIPINE CHEMBL1726 TdgClinicalTrial, TEND
CACNA1A 773 ELPETRIGINE CHEMBL29919 blocker ChemblInteractions

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
CACNA1A rs7254351 G antiepileptics efficacy no No SNPS analyzed alone were significantly associated with drug response, but the TAGAA haplotype in CACNA1A was found to be a significant predictor of anti epileptic drug resistance (p=0.00059). Odds ratio 2.129 (95% CI: 1.373-3.299). The most common drugs were valproic acid (42.7%), oxcarbazepine (27.7%), lamotrigdine (25.4%), phenyoinum (14.8%), levetiracetam (13.3%), phenobarbital (8.3%), and topiramate (7.9%). Allele G is not associated with resistance to antiepileptics in people with Epilepsy as compared to allele T. 26216687 1447986230
CACNA1A rs10416717 G antiepileptics efficacy no No SNPS analyzed alone were significantly associated with drug response, but the TAGAA haplotype in CACNA1A was found to be a significant predictor of anti epileptic drug resistance (p=0.00059). Odds ratio 2.129 (95% CI: 1.373-3.299). The most common drugs were valproic acid (42.7%), oxcarbazepine (27.7%), lamotrigdine (25.4%), phenyoinum (14.8%), levetiracetam (13.3%), phenobarbital (8.3%), and topiramate (7.9%). Allele G is not associated with resistance to antiepileptics in people with Epilepsy as compared to allele A. 26216687 1447986224
CACNA1A rs2248069 T antiepileptics efficacy no Alleles presented as A/G. No SNPS analyzed alone were significantly associated with drug response, but the TAGAA haplotype in CACNA1A was found to be a significant predictor of anti epileptic drug resistance (p=0.00059). Odds ratio 2.129 (95% CI: 1.373-3.299). The most common drugs were valproic acid (42.7%), oxcarbazepine (27.7%), lamotrigdine (25.4%), phenyoinum (14.8%), levetiracetam (13.3%), phenobarbital (8.3%), and topiramate (7.9%). Allele T is not associated with resistance to antiepileptics in people with Epilepsy as compared to allele C. 26216687 1447986242
CACNA1A rs16030 A antiepileptics efficacy no No SNPS analyzed alone were significantly associated with drug response, but the TAGAA haplotype in CACNA1A was found to be a significant predictor of anti epileptic drug resistance (p=0.00059). Odds ratio 2.129 (95% CI: 1.373-3.299). The most common drugs were valproic acid (42.7%), oxcarbazepine (27.7%), lamotrigdine (25.4%), phenyoinum (14.8%), levetiracetam (13.3%), phenobarbital (8.3%), and topiramate (7.9%). Allele A is not associated with resistance to antiepileptics in people with Epilepsy as compared to allele G. 26216687 1447986236
CACNA1A rs2112460 A antidepressants efficacy yes Identity of minor allele not specified, so minor allele of dbSNP used here (A). Response considered to be successful with a 50% reduction at discharge of the Hamilton Rating Scale for Depression (HRSD17). Patients measured at admission and discharge, 4-6 weeks later. Specific antidepressants not listed. Allele A is associated with increased response to antidepressants in people with Depressive Disorder, Major as compared to allele G. 27091189 1447983338
CACNA1A rs2074880 A antiepileptics efficacy no No SNPS analyzed alone were significantly associated with drug response, but the TAGAA haplotype in CACNA1A was found to be a significant predictor of anti epileptic drug resistance (p=0.00059). Odds ratio 2.129 (95% CI: 1.373-3.299). The most common drugs were valproic acid (42.7%), oxcarbazepine (27.7%), lamotrigdine (25.4%), phenyoinum (14.8%), levetiracetam (13.3%), phenobarbital (8.3%), and topiramate (7.9%). Allele A is not associated with resistance to antiepileptics in people with Epilepsy as compared to allele C. 26216687 1447986214