PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRAF2	1	MAPK9	3	imaging technique	Chen TC (2014)	1
FCGR3A	0	ZBTB25	2	two hybrid	Wang J (2011)	1
SUMO2	0	TNIP1	1	two hybrid	Wang J (2011)	1
PNMA5	0	CARNMT1	2	affinity chromatography technology	Huttlin EL (2017)	1
CARNMT1	2	ZBTB25	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ZBTB25	2	SEPHS1	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
ZBTB25	2	LZTS2	4	two hybrid	Rolland T (2014)	1
COIL	1	ZBTB25	2	two hybrid	Lim J (2006)	1
ZBTB25	2	KXD1	1	two hybrid	Rual JF (2005)	1
ZBTB25	2	ZBTB25	2	two hybrid, two hybrid	Ravasi T (2010), Rolland T (2014)	2
CYP2J2	4	ZBTB25	2	two hybrid	Wang J (2011)	1
ZBTB25	2	APIP	0	two hybrid	Rolland T (2014)	1
MAPK9	3	ZBTB25	2	two hybrid	Rual JF (2005)	1
DDIT3	1	ZBTB25	2	two hybrid	Rolland T (2014)	1
TRAF2	1	LZTS2	4	two hybrid	Rual JF (2005)	1
TRAF2	1	ZBTB25	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
ZBTB25	2	TSSK3	3	two hybrid	Rolland T (2014)	1
DDIT3	1	SSX3	0	two hybrid	Ravasi T (2010)	1
ZBTB25	2	PNMA5	0	two hybrid	Rolland T (2014)	1
ZBTB25	2	ZBTB1	4	two hybrid	Ravasi T (2010)	1
ZBTB25	2	TNIP1	1	two hybrid	Rolland T (2014)	1
SUMO2	0	ZBTB25	2	pull down	Ouyang J (2009)	1
FHL2	0	ZBTB25	2	two hybrid	Yu H (2011)	1
ZBTB25	2	SSX3	0	two hybrid	Ravasi T (2010)	1
ZBTB25	2	SORBS3	5	two hybrid	Rual JF (2005)	1
MDFI	1	ZBTB25	2	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
HSPA5	0	ZBTB25	2	affinity chromatography technology	Hein MY (2015)	1
PCBD1	0	ZBTB25	2	two hybrid	Ravasi T (2010)	1
HCLS1	0	ZBTB25	2	two hybrid	Ravasi T (2010)	1
ELP6	0	ZBTB25	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ZBTB25	2	KCTD1	3	two hybrid	Rolland T (2014)	1
SUMO2	0	ZBTB1	4	affinity chromatography technology	Matic I (2010)	1