PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
5430	0	ERCC4	2	affinity chromatography technology	Fousteri M (2006)	1
XAB2	0	5430	0	affinity chromatography technology, affinity chromatography technology	Nakatsu Y (2000), Fousteri M (2006)	2
ATR	6	RPA2	0	enzymatic study, affinity chromatography technology	Olson E (2006), Marechal A (2014)	2
MSH2	4	ATM	9	biochemical	Wang Y (2000)	1
PRKDC	12	ATM	9	unspecified method, affinity chromatography technology, affinity chromatography technology	Kim ST (1999), Suzuki K (1999), Suzuki K (1999)	3
ATR	6	RPA1	0	unspecified method, affinity chromatography technology, affinity chromatography technology	Kim ST (1999), Pabla N (2008), Marechal A (2014)	3
XPA	1	HMGB1	0	affinity chromatography technology	Lange SS (2009)	1
DDB2	1	EP300	36	affinity chromatography technology, affinity chromatography technology	Datta A (2001), Rapic-Otrin V (2002)	2
XPA	1	RPA1	0	two hybrid, pull down, affinity chromatography technology	Li L (1995), Li L (1995), Lange SS (2009)	3
XPA	1	GPN1	2	two hybrid	Nitta M (2000)	1
SPTA1	10	ERCC4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sridharan D (2003), Sridharan DM (2006), Sridharan DM (2006)	3
PRKDC	12	RPA2	0	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Shao RG (1999), Shao RG (1999), Shao RG (1999), Wu X (2006), Zernik-Kobak M (1997), Chan DW (2000), Marechal A (2014), Fried LM (1996)	8
RPA1	0	RPA2	0	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, biochemical, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shao RG (1999), Bochkareva E (2002), Gong Z (2011), Havugimana PC (2012), Kristensen AR (2012), Ghospurkar PL (2014), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Elia AE (2015), Elia AE (2015), Huttlin EL (2017), Feeney L (2017)	13
RPA4	0	RPA1	0	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Keshav KF (1995), Keshav KF (1995), Ghospurkar PL (2014), Huttlin EL (2015), Huttlin EL (2017)	5
ATM	9	XPC	1	imaging technique, affinity chromatography technology	Ray A (2009), Ray A (2013)	2
ERCC6	6	RPA1	0	affinity chromatography technology	Fousteri M (2006)	1
XPA	1	RPA4	0	two hybrid, pull down	Li L (1995), Li L (1995)	2
MSH2	4	RPA4	0	pull down	Zhao J (2009)	1
GTF2H1	0	XPC	1	affinity chromatography technology	Araujo SJ (2001)	1
GTF2H1	0	RPA1	0	affinity chromatography technology	Araujo SJ (2001)	1
ATR	6	EP300	36	affinity chromatography technology, affinity chromatography technology, pull down	Stauffer D (2007), Stauffer D (2007), Stauffer D (2007)	3
5430	0	ERCC1	1	affinity chromatography technology	Fousteri M (2006)	1
HERC2	9	RPA1	0	affinity chromatography technology, affinity chromatography technology	Al-Hakim AK (2012), Elia AE (2015)	2
XPO1	8	5430	0	affinity chromatography technology	Kirli K (2015)	1
XPC	1	XPA	1	affinity chromatography technology	Bunick CG (2006)	1
EP300	36	5430	0	affinity chromatography technology, affinity chromatography technology	Cho H (1998), Fousteri M (2006)	2
RPA4	0	XPC	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RPA1	0	MSH2	4	affinity chromatography technology, biochemical	Marechal A (2014), Wan C (2015)	2
MSH2	4	MSH3	4	affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, biochemical, pull down	Wang Y (2003), Guerrette S (1998), Bocker T (1999), Bocker T (1999), Acharya S (1996), Palombo F (1996), Havugimana PC (2012), Owen BA (2009)	8
ERCC6	6	ERCC4	2	affinity chromatography technology	Anindya R (2010)	1
RPA4	0	RPA2	0	two hybrid, affinity chromatography technology	Keshav KF (1995), Keshav KF (1995)	2
GTF2H1	0	RPA2	0	affinity chromatography technology	Araujo SJ (2001)	1
XPA	1	HERC2	9	affinity chromatography technology, enzymatic study	Lee TH (2012), Lee TH (2012)	2
XPC	1	DDB1	6	affinity chromatography technology	Sugasawa K (2005)	1
EP300	36	PRKDC	12	pull down	Karmakar S (2010)	1
MSH2	4	ATR	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Wang Y (2003), Wang Y (2003), Wang Y (2003), Wang Y (2003), Pabla N (2011), Pabla N (2011), Pabla N (2011)	7
MSH3	4	XPA	1	pull down	Zhao J (2009)	1
ATR	6	XPA	1	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu X (2006), Wu X (2006), Wu X (2006), Lee TH (2012)	4
ERCC6	6	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Anindya R (2010), Latini P (2011), Latini P (2011)	3
5430	0	RPA1	0	affinity chromatography technology	Fousteri M (2006)	1
SPTA1	10	RPA1	0	affinity chromatography technology, affinity chromatography technology	Sridharan DM (2006), Sridharan DM (2006)	2
DDB2	1	DDB1	6	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bergametti F (2002), Martinez E (2001), Guerrero-Santoro J (2008), Angers S (2006), Wang H (2006), Kapetanaki MG (2006), Kapetanaki MG (2006), Higa LA (2006), Takedachi A (2010), Fischer ES (2011), Scrima A (2008), Groisman R (2003), Groisman R (2003), Schroefelbauer B (2007), Kulaksiz G (2005), Inoki T (2004), Bontron S (2002), Rapic-Otrin V (2003), Olma MH (2009), Liu W (2000), Jin J (2006), Huttlin EL (2015), Zhao R (2014), Xie X (2015), Groisman R (2006), Yang Y (2016), Huttlin EL (2017), Chitale S (2017), Fantini D (2017), Fantini D (2017), Ohtake F (2007)	31
ERCC1	1	RPA2	0	fluorescent resonance energy transfe	Friboulet L (2013)	1
HMGB1	0	XPC	1	pull down, affinity chromatography technology, affinity chromatography technology	Lange SS (2009), Lange SS (2009), Lange SS (2009)	3
5430	0	DDB1	6	affinity chromatography technology	Fousteri M (2006)	1
5430	0	XPA	1	affinity chromatography technology	Fousteri M (2006)	1
MSH3	4	RPA1	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Marechal A (2014)	2
XPA	1	XAB2	0	two hybrid, pull down	Nakatsu Y (2000), Nakatsu Y (2000)	2
EP300	36	XPA	1	affinity chromatography technology	Hasan S (2001)	1
RPA2	0	MSH3	4	affinity chromatography technology	Marechal A (2014)	1
XPA	1	ERCC4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EP300	36	DDB1	6	affinity chromatography technology, affinity chromatography technology	Datta A (2001), Rapic-Otrin V (2002)	2
GTF2H1	0	5430	0	enzymatic study, biochemical, enzymatic study	Moisan A (2004), Yankulov K (1999), Parada CA (1996)	3
RPA2	0	MSH2	4	affinity chromatography technology	Marechal A (2014)	1
RHOU	0	XPA	1	pull down	Dart AE (2015)	1
XPC	1	DDB2	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Sugasawa K (2005), Fei J (2011), Robu M (2013), Yang Y (2016)	4
XPA	1	ERCC1	1	two hybrid, pull down, two hybrid, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Li L (1994), Li L (1994), Li L (1994), Nagai A (1995), Nagai A (1995), Wakasugi M (2009), Huttlin EL (2015), Huttlin EL (2017), Friboulet L (2013)	9
RPA2	0	DDB1	6	affinity chromatography technology	Marechal A (2014)	1
GTF2E2	2	5430	0	affinity chromatography technology, biochemical	Watanabe T (2003), Wan C (2015)	2
XPA	1	RPA2	0	pull down, affinity chromatography technology	Mer G (2000), Fan W (2010)	2
DDB1	6	NUP43	0	affinity chromatography technology	He YJ (2006)	1
XPA	1	ZNF518A	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM27	2	XPA	1	two hybrid	Rolland T (2014)	1
ATM	9	5430	0	imaging technique, enzymatic study	Fang L (2014), Baskaran R (1997)	2
ATM	9	XPA	1	enzymatic study	Wu X (2006)	1
XPA	1	DDB1	6	pull down	Wakasugi M (2009)	1
TRIM27	2	NDEL1	2	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
ERCC6	6	5430	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Anindya R (2010), Fousteri M (2006), Fousteri M (2006)	3
ERCC6	6	XPA	1	pull down, affinity chromatography technology	Selby CP (1997), Anindya R (2010)	2
XPA	1	NUP43	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RPA2	0	XPC	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GPN1	2	DDB1	6	affinity chromatography technology	Jeronimo C (2007)	1
XAB2	0	ERCC6	6	affinity chromatography technology	Nakatsu Y (2000)	1
ERCC1	1	ERCC4	2	pull down, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	de Laat WL (1998), Park CH (1994), Ciccia A (2007), Havugimana PC (2012), Lan L (2004), Lan L (2004), Lan L (2004), Huttlin EL (2015), Wan C (2015), Perez-Oliva AB (2015), Perez-Oliva AB (2015), Liccardi G (2014), Huttlin EL (2017), Friboulet L (2013)	14
SPTA1	10	ERCC6	6	affinity chromatography technology, affinity chromatography technology	Sridharan DM (2006), Sridharan DM (2006)	2
XPA	1	GTF2E2	2	pull down	Park CH (1995)	1
PRKDC	12	XPA	1	enzymatic study	Wu X (2006)	1
ATM	9	RPA2	0	enzymatic study	Chan DW (2000)	1
ERCC1	1	RPA1	0	fluorescent resonance energy transfe	Friboulet L (2013)	1
ATR	6	ATM	9	unspecified method, enzymatic study	Kim ST (1999), Stiff T (2006)	2
MSH3	4	RPA4	0	pull down	Zhao J (2009)	1
RPA1	0	DDB1	6	affinity chromatography technology	Marechal A (2014)	1
PRKDC	12	RPA1	0	pull down, affinity chromatography technology, affinity chromatography technology	Shao RG (1999), Gong Z (2011), Marechal A (2014)	3
GPN1	2	5430	0	affinity chromatography technology	Jeronimo C (2007)	1
XPA	1	DDB2	1	pull down, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Wakasugi M (2009), Wakasugi M (2009), Wakasugi M (2009), Wakasugi M (2009), Wakasugi M (2009)	5
RPA1	0	XPC	1	pull down	Thoma BS (2005)	1
XPA	1	NDEL1	2	two hybrid	Rolland T (2014)	1
ATM	9	RPA1	0	enzymatic study	Chan DW (2000)	1
GTF2H1	0	XPA	1	affinity chromatography technology	Araujo SJ (2001)	1
ERCC1	1	MSH2	4	affinity chromatography technology, affinity chromatography technology, biochemical	Lan L (2004), Lan L (2004), Lan L (2004)	3
SPTA1	10	ERCC1	1	affinity chromatography technology	Sridharan DM (2006)	1
GTF2H1	0	ERCC4	2	affinity chromatography technology	Araujo SJ (2001)	1
ERCC4	2	MSH2	4	affinity chromatography technology, affinity chromatography technology	Lan L (2004), Lan L (2004)	2
MSH2	4	XPA	1	pull down	Zhao J (2009)	1
XPO1	8	XPA	1	affinity chromatography technology	Kirli K (2015)	1
ATR	6	XPC	1	imaging technique, affinity chromatography technology	Ray A (2009), Ray A (2013)	2
SPTA1	10	RPA2	0	affinity chromatography technology	Sridharan DM (2006)	1
XPO1	8	GPN1	2	affinity chromatography technology	Kirli K (2015)	1
SPTA1	10	XPA	1	affinity chromatography technology, affinity chromatography technology	Sridharan DM (2006), Sridharan DM (2006)	2
GTF2H1	0	ERCC1	1	affinity chromatography technology	Araujo SJ (2001)	1