PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PACSIN2	0	WIPF1	0	affinity chromatography technology	Linkermann A (2009)	1
PRPF40A	5	WASL	2	pull down	Ingham RJ (2005)	1
SEC24C	2	SH3KBP1	1	biochemical	Wan C (2015)	1
WIPF1	0	ABI2	4	two hybrid	Rolland T (2014)	1
CDC42	3	WIPF1	0	pull down	Martinez-Quiles N (2001)	1
HCK	5	SH3KBP1	1	affinity chromatography technology	Narita T (2005)	1
PACSIN3	2	WIPF1	0	affinity chromatography technology	Linkermann A (2009)	1
PACSIN2	0	PACSIN1	0	two hybrid, two hybrid, pull down, pull down, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Modregger J (2000), Modregger J (2000), Modregger J (2000), Modregger J (2000), Bandyopadhyay S (2010), Rolland T (2014), Huttlin EL (2017)	8
ELAVL1	0	WASL	2	affinity chromatography technology	Abdelmohsen K (2009)	1
GAN	4	ACTG1	5	affinity chromatography technology	Johnson-Kerner BL (2015)	1
HCK	5	WIPF1	0	pull down	Scott MP (2002)	1
PACSIN3	2	WAS	0	affinity chromatography technology	Linkermann A (2009)	1
WAS	0	NCK2	2	affinity chromatography technology, two hybrid	Buvall L (2013), Rolland T (2014)	2
WIPF1	0	SEC24C	2	two hybrid	Rolland T (2014)	1
SH3KBP1	1	WASL	2	affinity chromatography technology	Havrylov S (2009)	1
WASL	2	GRB2	2	pull down, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Carlier MF (2000), Bandyopadhyay S (2010), Bisson N (2011), Rolland T (2014), Huttlin EL (2017)	5
PACSIN2	0	PACSIN3	2	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Modregger J (2000), Modregger J (2000), Modregger J (2000), Huttlin EL (2015), Huttlin EL (2017)	5
GRB2	2	SH3KBP1	1	pull down, pull down	Gout I (2000), Borinstein SC (2000)	2
ABI2	4	WASL	2	biochemical	Wan C (2015)	1
SH3KBP1	1	WIPF1	0	affinity chromatography technology	Havrylov S (2009)	1
ELAVL1	0	SH3KBP1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
GRB2	2	WAS	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Banin S (1996), She HY (1997), She HY (1997), She HY (1997)	4
GRB2	2	ACTG1	5	affinity chromatography technology, affinity chromatography technology	Blagoev B (2003), Li J (2013)	2
BAG3	4	WIPF1	0	affinity chromatography technology	Chen Y (2013)	1
APBB1	3	WAS	0	pull down	Ingham RJ (2005)	1
NCK1	0	GRB2	2	affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), de Castro RO (2012)	2
NCK2	2	NCK1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ITSN2	7	SH3KBP1	1	two hybrid	Wong KA (2012)	1
23380	0	WAS	0	affinity chromatography technology	Linkermann A (2009)	1
CTTN	1	WIPF1	0	two hybrid, pull down, affinity chromatography technology	Kinley AW (2003), Kinley AW (2003), Kinley AW (2003)	3
WAS	0	NCK1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Krause M (2000), Okabe S (2002), Rivero-Lezcano OM (1995), Rivero-Lezcano OM (1995), Buvall L (2013)	5
CTTN	1	WASL	2	affinity chromatography technology, far western blotting, affinity chromatography technology	Mizutani K (2002), Mizutani K (2002), Lynch DK (2003)	3
WASL	2	NCK1	0	far western blotting, pull down, affinity chromatography technology	Rohatgi R (2001), Rohatgi R (2001), Hein MY (2015)	3
ALAS1	2	WIPF1	0	two hybrid	Rolland T (2014)	1
PSTPIP1	3	WIPF1	0	affinity chromatography technology	Linkermann A (2009)	1
ELAVL1	0	CDC42	3	affinity chromatography technology	Abdelmohsen K (2009)	1
PACSIN2	0	WAS	0	affinity chromatography technology	Linkermann A (2009)	1
WASL	2	WIPF1	0	pull down, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology	Zettl M (2002), Martinez-Quiles N (2001), Martinez-Quiles N (2001), Martinez-Quiles N (2001), Rolland T (2014), Huttlin EL (2017)	6
WIPF1	0	FASTK	0	two hybrid	Rolland T (2014)	1
WIPF1	0	NCK1	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Anton IM (1998), Anton IM (1998), Hein MY (2015)	3
WASL	2	CDC42	3	pull down, pull down, two hybrid, pull down	Carlier MF (2000), Miki H (1998), Bandyopadhyay S (2010), Martinez-Quiles N (2001)	4
PACSIN2	0	WASL	2	pull down	Modregger J (2000)	1
NCK2	2	WIPF1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BAG3	4	GRB2	2	affinity chromatography technology, affinity chromatography technology	Chen Y (2013), Chen Y (2013)	2
CTTN	1	ACTG1	5	pull down	Uruno T (2001)	1
PACSIN3	2	WASL	2	pull down	Modregger J (2000)	1
WAS	0	ITSN2	7	two hybrid, affinity chromatography technology, pull down, two hybrid	McGavin MK (2001), McGavin MK (2001), McGavin MK (2001), Wong KA (2012)	4
WAS	0	WIPF1	0	two hybrid, affinity chromatography technology, pull down, two hybrid, two hybrid, two hybrid	Ramesh N (1997), Ramesh N (1997), Ramesh N (1997), Anton IM (1998), Wang J (2011), Rolland T (2014)	6
PRPF40A	5	WAS	0	pull down	Ingham RJ (2005)	1
CDC42	3	SEC24C	2	affinity chromatography technology	Hein MY (2015)	1
ITSN2	7	WIPF1	0	two hybrid	Wong KA (2012)	1
WIPF1	0	WWP2	7	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
PACSIN1	0	WIPF1	0	affinity chromatography technology	Linkermann A (2009)	1
ELAVL1	0	CTTN	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	GRB2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
NCK2	2	ABI2	4	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	4
APBB1	3	WASL	2	pull down	Ingham RJ (2005)	1
GRB2	2	CDC42	3	two hybrid	Vinayagam A (2011)	1
WBP4	0	WIPF1	0	pull down	Ingham RJ (2005)	1
PSTPIP1	3	WAS	0	affinity chromatography technology, pull down, affinity chromatography technology	Wu Y (1998), Wu Y (1998), Linkermann A (2009)	3
WIPF1	0	ACTG1	5	pull down	Martinez-Quiles N (2001)	1
CDC42	3	WAS	0	pull down, pull down, pull down, pull down, two hybrid, pull down, pull down, affinity chromatography technology, pull down	Tian L (2000), Kim AS (2000), Kolluri R (1996), Symons M (1996), Bandyopadhyay S (2010), Mott HR (1999), Owen D (2000), Edlund S (2004), Tetley GJN (2017)	9
PACSIN1	0	WASL	2	pull down	Modregger J (2000)	1
ELAVL1	0	WIPF1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
PACSIN1	0	WAS	0	affinity chromatography technology	Linkermann A (2009)	1
SUPT5H	2	WIPF1	0	affinity chromatography technology	Hein MY (2015)	1
WBP4	0	WAS	0	pull down	Ingham RJ (2005)	1
PSTPIP1	3	WASL	2	pull down	Tsujita K (2006)	1
HCK	5	WAS	0	pull down	Scott MP (2002)	1
SUPT5H	2	SEC24C	2	biochemical	Kristensen AR (2012)	1
ITSN2	7	WASL	2	two hybrid	Wong KA (2012)	1
PACSIN1	0	PACSIN3	2	two hybrid, pull down, pull down, two hybrid, two hybrid, affinity chromatography technology	Modregger J (2000), Modregger J (2000), Modregger J (2000), Modregger J (2000), Rolland T (2014), Huttlin EL (2017)	6
APBB1	3	WIPF1	0	pull down	Ingham RJ (2005)	1
PRPF40A	5	WIPF1	0	pull down	Ingham RJ (2005)	1
HOMER3	0	ABI2	4	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
GRB2	2	WIPF1	0	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Bandyopadhyay S (2010), Bisson N (2011), Wang J (2011), Huttlin EL (2017)	4
GRB2	2	CTTN	1	affinity chromatography technology	Brehme M (2009)	1
WIPF1	0	HOMER3	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
ACTG1	5	WASL	2	pull down, x-ray crystallography	Gaucher JF (2012), Gaucher JF (2012)	2
NCK2	2	WASL	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	3
23380	0	WIPF1	0	affinity chromatography technology	Linkermann A (2009)	1
GAN	4	WIPF1	0	affinity chromatography technology	Johnson-Kerner BL (2015)	1
23380	0	ITSN2	7	affinity chromatography technology	Linkermann A (2009)	1