PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CFTR	5	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vij N (2006), Ballar P (2010), Goldstein RF (2007), Goldstein RF (2007), Sun F (2006), Sun F (2006), Wang X (2006), Morito D (2008), Pankow S (2015)	9
SELENOS	0	VCP	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye Y (2004), Ye Y (2004), Wang Q (2008), Ballar P (2007), Ballar P (2007), Schulze A (2005), Zhong Y (2011), Zhong Y (2011), Christianson JC (2012), Liu Y (2014), Noda C (2014), Lee JH (2014), Mountassif D (2015)	13
DERL2	0	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lilley BN (2005), Huang CH (2013), Christianson JC (2012)	3
SPRTN	0	NPLOC4	4	affinity chromatography technology, affinity chromatography technology	Davis EJ (2012), Davis EJ (2012)	2
AMFR	2	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Morito D (2008), Ballar P (2007), Ye Y (2005), Zhong Y (2011)	4
DERL2	0	HERPUD1	2	affinity chromatography technology	Huang CH (2013)	1
VCP	6	FAF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, x-ray crystallography, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Haenzelmann P (2011), Song EJ (2005), Song EJ (2005), Shin HY (2010), Haenzelmann P (2011), Haenzelmann P (2011), Kang W (2011), Alexandru G (2012), Lee JJ (2013), Lee JJ (2013), Lee JJ (2013), Yu CC (2013), Baron Y (2014), Franz A (2016), Raman M (2015)	17
UBXN4	0	AMFR	2	affinity chromatography technology	Liang J (2006)	1
FAF1	1	NPLOC4	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Haenzelmann P (2011), Lee JJ (2013), Lee JJ (2013), Raman M (2015), Raman M (2015)	7
DERL2	0	FAF2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Greenblatt EJ (2011), Christianson JC (2012), Christianson JC (2012), Christianson JC (2012), Huttlin EL (2015), Raman M (2015), Huttlin EL (2017)	7
VCP	6	VCP	6	biochemical, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, biochemical, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, two hybrid	Wang Q (2003), Matsuoka S (2007), Vij N (2006), Niwa H (2012), Niwa H (2012), Mayr PS (1999), Yu CC (2013), Tang WK (2010), Song C (2007), Rolland T (2014)	10
UBQLN1	1	UBXN1	0	biochemical, two hybrid	Havugimana PC (2012), Rolland T (2014)	2
INSIG1	0	AMFR	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Song BL (2005), Lee JN (2006), Ikeda Y (2009), Jo Y (2011), Jo Y (2011), Song BL (2005), Song BL (2005)	7
HERPUD1	2	SELENOS	0	affinity chromatography technology, affinity chromatography technology	Schulze A (2005), Schulze A (2005)	2
VCP	6	IQGAP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Fogeron ML (2013), Itoh N (2017), Itoh N (2017), Itoh N (2017)	4
UBXN7	3	NPLOC4	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Raman M (2015)	3
VCPIP1	4	SVIP	1	affinity chromatography technology	Sowa ME (2009)	1
DERL2	0	UBXN4	0	affinity chromatography technology	Christianson JC (2012)	1
YOD1	0	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down	Ernst R (2009), Locke M (2014), Locke M (2014), Ernst R (2009), Ernst R (2009), Schimmack G (2017), Schimmack G (2017)	7
FAF2	4	UBXN7	3	affinity chromatography technology, affinity chromatography technology	Raman M (2015), Raman M (2015)	2
AMFR	2	UBC	7	pull down, pull down, imaging technique, affinity chromatography technology, enzymatic study, x-ray crystallography, pull down, x-ray crystallography, pull down, enzymatic study, enzymatic study, pull down, affinity chromatography technology	Zhong X (2004), Yang H (2010), Ying Z (2009), Jo Y (2011), Ye Y (2003), Xu Y (2012), Liu S (2012), Liu S (2012), Xu Y (2012), Morito D (2008), Flierman D (2006), Liu W (2014), Fang S (2001)	13
VCP	6	UFD1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Wang Q (2008), Ballar P (2007), Alexandru G (2008), Zhong X (2006), Fernandez-Saiz V (2010), Nagahama M (2009), Noguchi M (2005), Bruderer RM (2004), Bruderer RM (2004), Bruderer RM (2004), Erzurumlu Y (2013), Li JM (2013), Fogeron ML (2013), Haenzelmann P (2016), Haenzelmann P (2016), Haenzelmann P (2016), Raman M (2015), Raman M (2015), Mountassif D (2015), Wang T (2016), Guo X (2017)	21
FAF2	4	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Lee JN (2008), Alexandru G (2008), Alexandru G (2008), Mueller B (2008), Alexandru G (2012), Xu Y (2013), Christianson JC (2012), Besten Wd (2012), Madsen L (2014), Raman M (2015)	10
CAV1	0	UFD1	1	affinity chromatography technology	Chen SF (2013)	1
YOD1	0	DERL1	2	affinity chromatography technology	Ernst R (2009)	1
UBXN6	1	UBXN2A	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SIK2	2	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, biochemical, enzymatic study, affinity chromatography technology, biochemical	Yang FC (2013), Yang FC (2013), Yang FC (2013), Yang FC (2013), Yang FC (2013), Lee CW (2014), Lee CW (2014)	7
UBC	7	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhong X (2006), Dai RM (2001), Bish RA (2007), Lim JJ (2016), Zhang X (2017)	6
VCP	6	FAM104A	2	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Fogeron ML (2013), Rolland T (2014), Hein MY (2015), Huttlin EL (2017)	4
VCP	6	ASPSCR1	3	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Vinayagam A (2011), Alexandru G (2012), Yu CC (2013), Fogeron ML (2013), Rolland T (2014), Madsen L (2014), Madsen L (2014), Madsen L (2014), Madsen L (2014), Hein MY (2015), Raman M (2015), Huttlin EL (2017)	14
AMFR	2	FAF2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee JN (2008), Lee JN (2008), Alexandru G (2008), Wang Q (2011), Xu Y (2013), Wang Q (2011), Christianson JC (2012), Christianson JC (2012), Zhang T (2015)	9
UBXN1	0	UBC	7	pull down, pull down, affinity chromatography technology, pull down, pull down, pull down	Wu-Baer F (2010), Fenner BJ (2009), Alexandru G (2008), LaLonde DP (2011), McNeill H (2004), Zhang X (2017)	6
SYVN1	2	DERL1	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Schulze A (2005), Schulze A (2005), Ye Y (2005), Bernardi KM (2010), Huang CH (2013), van de Weijer ML (2014), Hosokawa N (2016)	7
HERPUD1	2	UBQLN1	1	affinity chromatography technology, affinity chromatography technology	Kim TY (2008), Kim TY (2008)	2
UBXN2B	2	ASPSCR1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Raman M (2015), Huttlin EL (2017)	3
NSFL1C	1	ASPSCR1	3	affinity chromatography technology, affinity chromatography technology	Raman M (2015), Huttlin EL (2017)	2
FAF1	1	VCPIP1	4	affinity chromatography technology	Alexandru G (2008)	1
VCP	6	UBXN2B	2	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Rolland T (2014), Huttlin EL (2015), Zhang X (2015), Raman M (2015), Raman M (2015), Huttlin EL (2017)	7
GZMK	0	UFD1	1	enzymatic study	Guo Y (2010)	1
RNF31	3	VCP	6	affinity chromatography technology, pull down, x-ray crystallography, unspecified method	Schaeffer V (2014), Schaeffer V (2014), Schaeffer V (2014), Elliott PR (2014)	4
UBQLN1	1	ATXN3	2	pull down	Heir R (2006)	1
SVIP	1	AMFR	2	biochemical, affinity chromatography technology	Ballar P (2007), Ballar P (2007)	2
UBXN7	3	VCPIP1	4	affinity chromatography technology	Raman M (2015)	1
VCP	6	UBXN2A	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Vinayagam A (2011), Fogeron ML (2013), Raman M (2015), Raman M (2015), Huttlin EL (2017)	6
UBXN1	0	VCPIP1	4	affinity chromatography technology	Alexandru G (2008)	1
INSIG1	0	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Lee JN (2008), Song BL (2005), Ikeda Y (2009), Song BL (2005)	4
HERPUD1	2	DERL1	2	biochemical, affinity chromatography technology	Schulze A (2005), Schulze A (2005)	2
UBC	7	FAF2	4	affinity chromatography technology, affinity chromatography technology	Bish RA (2007), Alexandru G (2008)	2
AMFR	2	ATXN3	2	affinity chromatography technology, imaging technique	Ying Z (2009), Ying Z (2009)	2
UBXN7	3	ASPSCR1	3	affinity chromatography technology	Raman M (2015)	1
UBXN8	0	VCP	6	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Alexandru G (2008), Madsen L (2011), Madsen L (2011), Madsen L (2014), Raman M (2015)	5
CFTR	5	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sun F (2006), Sun F (2006), Younger JM (2006), Wang B (2008), Pankow S (2015)	5
CAV1	0	UBXN6	1	affinity chromatography technology, imaging technique	Kirchner P (2013), Kirchner P (2013)	2
ZFAND2B	1	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Glinka T (2014), Glinka T (2014), Glinka T (2014), Braunstein I (2015)	4
UBC	7	NPLOC4	4	affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Wang B (2003), Bish RA (2007), Kristariyanto YA (2015), Zhang X (2017)	5
UBXN7	3	NSFL1C	1	affinity chromatography technology, affinity chromatography technology	Raman M (2015), Raman M (2015)	2
SPRTN	0	NSFL1C	1	affinity chromatography technology, affinity chromatography technology	Davis EJ (2012), Davis EJ (2012)	2
IQGAP1	1	AKT1	1	affinity chromatography technology	Tekletsadik YK (2012)	1
AMFR	2	VCP	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, two hybrid, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhong X (2004), Zhong X (2004), Lee JN (2008), Cao J (2007), Ballar P (2007), Ballar P (2007), Ye Y (2005), Ye Y (2005), Zhong X (2004), Yang H (2010), Yang H (2010), Ballar P (2010), Jo Y (2011), St-Pierre P (2012), Grelle G (2006), Scheich C (2007), Ballar P (2006), Haenzelmann P (2011), Haenzelmann P (2011), Haenzelmann P (2011), Wang Q (2011), Yu CC (2013), Erzurumlu Y (2013), Liu S (2013), Wang Q (2011), Grelle G (2006), Grelle G (2006), Grelle G (2006), Grelle G (2006), Christianson JC (2012), Zhang T (2015), Khodayari N (2017)	32
UBC	7	CAV1	0	affinity chromatography technology, imaging technique	Luo X (2017), Luo X (2017)	2
GZMK	0	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Guo Y (2010), Guo Y (2010), Guo Y (2010), Guo Y (2010)	4
VCPIP1	4	UBXN2A	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Raman M (2015)	2
SELENOS	0	SYVN1	2	affinity chromatography technology, affinity chromatography technology	Ballar P (2007), Schulze A (2005)	2
UBXN6	1	VCPIP1	4	affinity chromatography technology	Alexandru G (2008)	1
NGLY1	0	DERL1	2	affinity chromatography technology, affinity chromatography technology, biochemical, pull down, biochemical	Katiyar S (2005), Katiyar S (2005), Katiyar S (2005), Katiyar S (2005), Katiyar S (2005)	5
CAV1	0	DERL1	2	affinity chromatography technology	Chen SF (2013)	1
UBC	7	ANKRD13A	1	affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Tanno H (2012), Zhang X (2017)	3
UBXN7	3	FAF1	1	affinity chromatography technology, affinity chromatography technology	Raman M (2015), Raman M (2015)	2
SELENOS	0	UFD1	1	affinity chromatography technology	Ye Y (2004)	1
CAV1	0	SELENOS	0	affinity chromatography technology	Chen SF (2013)	1
YOD1	0	FAF2	4	affinity chromatography technology	Ernst R (2009)	1
SPRTN	0	UBXN1	0	affinity chromatography technology	Ghosal G (2012)	1
FAF1	1	AMFR	2	affinity chromatography technology	Alexandru G (2008)	1
CFTR	5	UBXN1	0	affinity chromatography technology	Pankow S (2015)	1
UFD1	1	NPLOC4	4	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, x-ray crystallography, biochemical, affinity chromatography technology, affinity chromatography technology	Botta A (2001), Lass A (2008), Vong QP (2005), Bruderer RM (2004), Havugimana PC (2012), Li JM (2013), Pye VE (2007), Wan C (2015), Raman M (2015), Raman M (2015)	10
UBQLN1	1	ZFAND2B	1	two hybrid	Rolland T (2014)	1
SPRTN	0	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique	Ghosal G (2012), Ghosal G (2012), Davis EJ (2012), Davis EJ (2012), Mosbech A (2012), Mosbech A (2012), Mosbech A (2012), Mosbech A (2012)	8
AMFR	2	HTT	14	affinity chromatography technology, pull down, pull down	Yang H (2010), Yang H (2010), Yang H (2010)	3
FAF2	4	CAV1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBXN6	1	ASPSCR1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haines DS (2012), Huttlin EL (2015), Raman M (2015), Huttlin EL (2017)	4
ZFAND2B	1	NPLOC4	4	affinity chromatography technology, affinity chromatography technology	Glinka T (2014), Glinka T (2014)	2
SVIP	1	SELENOS	0	affinity chromatography technology, affinity chromatography technology	Ballar P (2007), Ballar P (2007)	2
CFTR	5	DERL2	0	affinity chromatography technology	Pankow S (2015)	1
NGLY1	0	UBXN2B	2	two hybrid	Rolland T (2014)	1
HTT	14	UBQLN1	1	affinity chromatography technology	Wang H (2007)	1
UBQLN1	1	VCP	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lim PJ (2009), Yu CC (2013), Lim PJ (2009), Lim PJ (2009)	4
HERPUD1	2	VCP	6	biochemical, affinity chromatography technology, affinity chromatography technology, pull down	Schulze A (2005), Schulze A (2005), Schulze A (2005), Schulze A (2005)	4
VCPIP1	4	UBC	7	enzymatic study, enzymatic study, pull down	Totsukawa G (2013), Mevissen TE (2013), Kwasna D (2018)	3
UBXN2A	1	NSFL1C	1	affinity chromatography technology, affinity chromatography technology	Raman M (2015), Raman M (2015)	2
HERPUD1	2	SYVN1	2	biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Schulze A (2005), Schulze A (2005), Schulze A (2005), Schulze A (2005), Kny M (2011), Kny M (2011), Kny M (2011), Huang CH (2013), Zhang T (2015), Hosokawa N (2016), Schulz J (2017)	11
VCPKMT	2	VCP	6	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology	Cloutier P (2013), Cloutier P (2013), Cloutier P (2013), Huttlin EL (2017)	4
UBXN4	0	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Alexandru G (2008), Lim PJ (2009), Liang J (2006), Lim PJ (2009), Madsen L (2014), Raman M (2015)	6
VCP	6	NGLY1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down	McNeill H (2004), Allen MD (2006), Allen MD (2006), Christianson JC (2012), McNeill H (2004)	5
VCPIP1	4	NSFL1C	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Alexandru G (2008), Uchiyama K (2002), Raman M (2015)	4
CAV1	0	VCP	6	affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Kirchner P (2013), Kirchner P (2013), Chen SF (2013), Chen SF (2013)	4
SELENOS	0	UBXN8	0	affinity chromatography technology	Christianson JC (2012)	1
VCP	6	NFKBIA	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dai RM (1998), Dai RM (1998), Gao Y (2000), Hotta K (2013), Yu CC (2013), Li JM (2013), Li JM (2013), Schweitzer K (2016)	8
UBXN2B	2	FAF1	1	affinity chromatography technology	Raman M (2015)	1
VCP	6	UBXN7	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down	Alexandru G (2008), Alexandru G (2008), Alexandru G (2008), Alexandru G (2008), Alexandru G (2008), Besten Wd (2012), Raman M (2015), Li ZH (2017), Li ZH (2017)	9
UBXN8	0	NPLOC4	4	affinity chromatography technology	Alexandru G (2008)	1
RNF31	3	UBC	7	pull down, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down, enzymatic study, enzymatic study	Wauer T (2013), Fujita H (2014), Schaeffer V (2014), Tokunaga F (2011), Kirisako T (2006), Haas TL (2009), Emmerich CH (2013), Sakamoto H (2015), Lechtenberg BC (2016), Lechtenberg BC (2016), Stieglitz B (2012), Zhang X (2017), Kliza K (2017), Liu J (2017)	14
COPS5	0	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology	Cayli S (2009), Cayli S (2009), Cayli S (2009), Cayli S (2009), Bennett EJ (2010)	5
UBE4B	5	UBXN7	3	biochemical	Havugimana PC (2012)	1
VCPKMT	2	UBXN6	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cloutier P (2013), Huttlin EL (2015), Huttlin EL (2017)	3
NPLOC4	4	NFKBIA	0	affinity chromatography technology	Li JM (2013)	1
HTT	14	VCP	6	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Yang H (2010), Yu CC (2013), Fujita K (2013), Fujita K (2013)	4
VCP	6	SYVN1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, unspecified method, affinity chromatography technology, biochemical	Ballar P (2007), Schulze A (2005), Schulze A (2005), Schulze A (2005), Ye Y (2005), Ye Y (2005), Zhong X (2006), Fernandez-Saiz V (2010), Liu S (2013), Liu S (2013), Liu S (2013), Liu S (2013), Zhang T (2015), Hosokawa N (2016)	14
UBXN1	0	AMFR	2	affinity chromatography technology	Alexandru G (2008)	1
SELENOS	0	NPLOC4	4	affinity chromatography technology	Ballar P (2007)	1
UBXN4	0	UBXN6	1	affinity chromatography technology	Raman M (2015)	1
ZFAND2B	1	FAF2	4	affinity chromatography technology, affinity chromatography technology, biochemical	Glinka T (2014), Glinka T (2014), Glinka T (2014)	3
CFTR	5	ANKRD13A	1	affinity chromatography technology	Pankow S (2015)	1
SELENOS	0	AMFR	2	affinity chromatography technology, affinity chromatography technology	Ballar P (2007), Zhong Y (2011)	2
UBXN7	3	UFD1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Raman M (2015)	3
FAF2	4	NPLOC4	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Raman M (2015), Raman M (2015)	4
FAF2	4	INSIG1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Lee JN (2008), Lee JN (2008), Ikeda Y (2009), Kim H (2013)	4
UBXN1	0	UBE4B	5	affinity chromatography technology	Alexandru G (2008)	1
GZMK	0	NPLOC4	4	enzymatic study	Guo Y (2010)	1
ATXN3	2	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, biochemical, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doss-Pepe EW (2003), Wang Q (2008), Matsumoto M (2004), Matsumoto M (2004), Reina CP (2010), Zhong X (2006), Morreale G (2009), Fernandez-Saiz V (2010), Laco MN (2012), Laco MN (2012), Yu CC (2013), Liu S (2013), Yang H (2014), Yang H (2014), Yang H (2014), Liu H (2016), Pfeiffer A (2017), Tu Y (2017)	18
SPRTN	0	ATXN3	2	affinity chromatography technology	Mosbech A (2012)	1
SELENOS	0	FAF2	4	affinity chromatography technology, affinity chromatography technology	Christianson JC (2012), Christianson JC (2012)	2
ZFAND2B	1	UBC	7	affinity chromatography technology, pull down	Braunstein I (2015), Zhang X (2017)	2
SPRTN	0	UFD1	1	affinity chromatography technology, affinity chromatography technology	Davis EJ (2012), Davis EJ (2012)	2
VCPKMT	2	UBC	7	affinity chromatography technology	Cloutier P (2013)	1
NSFL1C	1	UBXN4	0	biochemical	Wan C (2015)	1
UBXN2B	2	FAM104A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Raman M (2015), Huttlin EL (2017)	3
CFTR	5	AMFR	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Morito D (2008), Ballar P (2010), Pankow S (2015)	3
NPLOC4	4	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Lass A (2008), Ballar P (2007), Alexandru G (2008), Alexandru G (2008), Fernandez-Saiz V (2010), Noguchi M (2005), Bruderer RM (2004), Bruderer RM (2004), Lee JJ (2013), Erzurumlu Y (2013), Raman M (2015), Raman M (2015), Mountassif D (2015), Wang T (2016), Guo X (2017)	15
FAF1	1	UBXN6	1	affinity chromatography technology	Raman M (2015)	1
SVIP	1	DERL1	2	biochemical, affinity chromatography technology	Ballar P (2007), Ballar P (2007)	2
ANKRD13A	1	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Burana D (2016), Burana D (2016), Burana D (2016), Burana D (2016)	4
VCPIP1	4	UFD1	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Raman M (2015)	2
YOD1	0	UBC	7	pull down, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study	Ernst R (2009), Mevissen TE (2013), Mevissen TE (2013), Ernst R (2009), Flierman D (2016)	5
AMFR	2	HERPUD1	2	enzymatic study, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, affinity chromatography technology	Li W (2007), David Y (2011), Yan L (2014), Yan L (2014), Wang Q (2011), Liu W (2014), Li W (2009), Li W (2009), Liu W (2014), Zhang T (2015)	10
UBC	7	ASPSCR1	3	affinity chromatography technology	Matsumoto M (2005)	1
VCPIP1	4	NPLOC4	4	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Raman M (2015)	2
SVIP	1	SYVN1	2	biochemical, affinity chromatography technology	Ballar P (2007), Ballar P (2007)	2
AMFR	2	UFD1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Cao J (2007), Cao J (2007), Cao J (2007), Cao J (2007)	4
FAF2	4	UFD1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Raman M (2015), Raman M (2015)	4
FAF1	1	ASPSCR1	3	affinity chromatography technology	Raman M (2015)	1
SELENOS	0	DERL2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lilley BN (2005), Huang CH (2013), Christianson JC (2012), Christianson JC (2012)	4
UBE4B	5	UBQLN1	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
AKT1	1	NFKBIA	0	affinity chromatography technology	Koul D (2001)	1
UBXN4	0	DERL1	2	affinity chromatography technology	Liang J (2006)	1
UBXN8	0	UFD1	1	affinity chromatography technology	Alexandru G (2008)	1
FAF1	1	UBC	7	pull down, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical	Song EJ (2005), Lee JJ (2012), Song J (2009), Song J (2009), Song J (2009), Lee JJ (2013), Lee JJ (2013), Nathan JA (2013), Baron Y (2014), Alexandru G (2008), Lee JJ (2012)	11
UBQLN1	1	NGLY1	0	two hybrid	Rolland T (2014)	1
SYVN1	2	FAF2	4	affinity chromatography technology	Zhang T (2015)	1
UBC	7	UBQLN1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, two hybrid, pull down, two hybrid, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Matsumoto M (2005), Ko HS (2004), Ko HS (2004), Sokratous K (2012), Raasi S (2005), Raasi S (2005), Massey LK (2004), Ko HS (2004), Ko HS (2004), Rolland T (2014), Castaneda CA (2013), Nakayasu ES (2013), Nakayasu ES (2013), Kristariyanto YA (2015), Kristariyanto YA (2015), Kurlawala Z (2017)	16
UBXN6	1	NSFL1C	1	affinity chromatography technology	Raman M (2015)	1
ASPSCR1	3	UFD1	1	affinity chromatography technology	Alexandru G (2008)	1
UBC	7	UFD1	1	pull down, x-ray crystallography, affinity chromatography technology, pull down	Nathan JA (2013), Park S (2005), Bish RA (2007), Zhang X (2017)	4
ZFAND2B	1	DERL1	2	affinity chromatography technology	Glinka T (2014)	1
UBQLN1	1	UBXN4	0	two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology	Lim PJ (2009), Lim PJ (2009), Lim PJ (2009), Rolland T (2014), Lim PJ (2009)	5
UBXN1	0	NPLOC4	4	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008)	2
UBE4B	5	VCP	6	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Matsumoto M (2004), Matsumoto M (2004), Boehm S (2011), Takahata M (2008), Morreale G (2009), Fernandez-Saiz V (2010), Fernandez-Saiz V (2010), Raman M (2015), Wang T (2016), Huttlin EL (2017)	10
DERL1	2	FAF2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Greenblatt EJ (2011), Suzuki M (2012), Suzuki M (2012), Xu Y (2013), Christianson JC (2012), Christianson JC (2012)	6
UBXN6	1	VCP	6	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kern M (2009), Kern M (2009), Kern M (2009), Stapf C (2011), Stapf C (2011), Stapf C (2011), Alexandru G (2008), Haenzelmann P (2011), Haenzelmann P (2011), Allen MD (2006), Nagahama M (2009), Nagahama M (2009), Alexandru G (2012), Haines DS (2012), Yu CC (2013), Huttlin EL (2015), Madsen L (2014), Trusch F (2015), Raman M (2015), Raman M (2015), Guo X (2017), Guo X (2017), Huttlin EL (2017)	23
AMFR	2	DERL2	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Morito D (2008), Zhong Y (2011), Huang CH (2013), Christianson JC (2012), Zhang T (2015)	5
NSFL1C	1	FAF1	1	affinity chromatography technology	Raman M (2015)	1
VCPIP1	4	FAF2	4	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Alexandru G (2008)	2
UBXN6	1	NPLOC4	4	affinity chromatography technology	Haines DS (2012)	1
FAM104A	2	NSFL1C	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Raman M (2015), Raman M (2015), Raman M (2015)	3
SVIP	1	VCP	6	biochemical, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, x-ray crystallography, pull down, unspecified method	Ballar P (2007), Ballar P (2007), Ballar P (2007), Wang Y (2011), Haenzelmann P (2011), Liu S (2013), Liu S (2013), Liu S (2013)	8
UBXN1	0	FAF1	1	affinity chromatography technology	Raman M (2015)	1
DERL2	0	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lilley BN (2005), Greenblatt EJ (2011), Huang CH (2013), Christianson JC (2012)	4
UBXN2A	1	ASPSCR1	3	affinity chromatography technology, affinity chromatography technology	Raman M (2015), Huttlin EL (2017)	2
ATXN3	2	UBC	7	pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, pull down, x-ray crystallography, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, x-ray crystallography, pull down, imaging technique, enzymatic study, pull down	Winborn BJ (2008), Mao Y (2005), Berke SJ (2005), Matsumoto M (2005), Bremm A (2010), Nicastro G (2010), Nicastro G (2010), Donaldson KM (2003), Chai Y (2004), Chai Y (2004), Nathan JA (2013), Seki T (2013), Yang H (2014), Yang H (2014), Blount JR (2014), Evers MM (2013), Weeks SD (2011), Donaldson KM (2003), Winborn BJ (2008), Faggiano S (2015), Wauer T (2015), Satoh T (2014), Satoh T (2014), Zhang X (2017), Toonen LJA (2017), Toonen LJA (2017), Kwasna D (2018)	27
AMFR	2	SYVN1	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Zhong Y (2011), Ballar P (2010), Zhang T (2015), Zhang T (2015), Zhang T (2015)	5
UBXN1	0	NSFL1C	1	biochemical	Kristensen AR (2012)	1
UBC	7	UBXN7	3	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Kelsall IR (2013), Alexandru G (2008), Besten Wd (2012), Besten Wd (2012)	4
CFTR	5	CAV1	0	affinity chromatography technology	Pankow S (2015)	1
UFD1	1	UBXN6	1	pull down	Nagahama M (2009)	1
UBXN1	0	FAF2	4	affinity chromatography technology	Raman M (2015)	1
VCP	6	UBXN1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), McNeill H (2004), LaLonde DP (2011), LaLonde DP (2011), LaLonde DP (2011), LaLonde DP (2011), Rolland T (2014), McNeill H (2004), Raman M (2015), Park ES (2017)	11
AKT1	1	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Vandermoere F (2006), Vandermoere F (2006), Vandermoere F (2006), Klein JB (2005), Klein JB (2005), Klein JB (2005), Yu CC (2013), Yu CC (2013)	8
CFTR	5	FAF2	4	affinity chromatography technology	Pankow S (2015)	1
NGLY1	0	NSFL1C	1	pull down	Allen MD (2006)	1
ATXN3	2	SYVN1	2	affinity chromatography technology	Bernardi KM (2013)	1
VCPIP1	4	UBXN2B	2	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Raman M (2015)	2
SYVN1	2	UBXN8	0	affinity chromatography technology	Madsen L (2011)	1
VCP	6	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography	Wang Q (2008), Ballar P (2007), Schulze A (2005), Schulze A (2005), Ye Y (2005), Lilley BN (2005), Greenblatt EJ (2011), Younger JM (2006), Christianson JC (2012), You H (2017), Lim JJ (2016), Lim JJ (2016)	12
UFD1	1	NFKBIA	0	affinity chromatography technology	Li JM (2013)	1
VCP	6	ANKZF1	2	unspecified method, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stapf C (2011), Stapf C (2011), Stapf C (2011), Haenzelmann P (2011), Haenzelmann P (2011)	5
SYVN1	2	HTT	14	imaging technique, affinity chromatography technology	Yang H (2007), Yang H (2007)	2
UBXN1	0	UBXN7	3	affinity chromatography technology	Raman M (2015)	1
UBXN1	0	UFD1	1	affinity chromatography technology	Alexandru G (2008)	1
VCPKMT	2	ASPSCR1	3	affinity chromatography technology, pull down	Cloutier P (2013), Cloutier P (2013)	2
VCP	6	NSFL1C	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, unspecified method, two hybrid, affinity chromatography technology, two hybrid, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Uchiyama K (2003), Uchiyama K (2003), Alexandru G (2008), Alexandru G (2008), Vinayagam A (2011), Madsen L (2011), Fernandez-Saiz V (2010), Noguchi M (2005), Uchiyama K (2002), Uchiyama K (2002), Uchiyama K (2002), Alexandru G (2012), Fogeron ML (2013), Grelle G (2006), Grelle G (2006), Grelle G (2006), Rolland T (2014), Besten Wd (2012), Madsen L (2014), Zhang X (2015), Wan C (2015), Hein MY (2015), Raman M (2015), Raman M (2015), Wang T (2016), Guo X (2017), Park ES (2017), Huttlin EL (2017)	28
NGLY1	0	FAF1	1	pull down	Allen MD (2006)	1
UBXN7	3	AMFR	2	affinity chromatography technology	Alexandru G (2008)	1
NSFL1C	1	UFD1	1	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Wan C (2015), Raman M (2015), Raman M (2015)	4
HERPUD1	2	UBC	7	affinity chromatography technology	Sai X (2003)	1
AMFR	2	NPLOC4	4	affinity chromatography technology, affinity chromatography technology	Wang Q (2011), Wang Q (2011)	2
VCPIP1	4	VCP	6	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Totsukawa G (2011), Totsukawa G (2013), Totsukawa G (2013), Zhang X (2014), Raman M (2015)	6
SPRTN	0	UBC	7	pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down	Machida Y (2012), Machida Y (2012), Mosbech A (2012), Mosbech A (2012), Mosbech A (2012), Centore RC (2012), Davis EJ (2012)	7
UBC	7	NSFL1C	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Fenner BJ (2009), Shibata Y (2012), Alexandru G (2008), Raasi S (2005), Zhang X (2017)	5
ATXN3	2	UBE4B	5	pull down	Matsumoto M (2004)	1
NFKBIA	0	ATXN3	2	affinity chromatography technology	Hein MY (2015)	1
YOD1	0	SYVN1	2	affinity chromatography technology	Bernardi KM (2013)	1
UBXN6	1	FAM104A	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ASPSCR1	3	NPLOC4	4	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Raman M (2015)	2
SVIP	1	UFD1	1	biochemical	Ballar P (2007)	1
SELENOS	0	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye Y (2004), Ballar P (2007), Schulze A (2005), Ye Y (2005), Lilley BN (2005), Zhong Y (2011), Christianson JC (2012)	7
UBXN6	1	DERL1	2	pull down	Nagahama M (2009)	1
YOD1	0	UFD1	1	affinity chromatography technology	Ernst R (2009)	1
SVIP	1	NPLOC4	4	biochemical, affinity chromatography technology	Ballar P (2007), Ballar P (2007)	2
UBXN8	0	VCPIP1	4	affinity chromatography technology	Alexandru G (2008)	1
COPS5	0	UBC	7	affinity chromatography technology	Bennett EJ (2010)	1
ANKRD13A	1	CAV1	0	affinity chromatography technology, affinity chromatography technology	Burana D (2016), Burana D (2016)	2
SPRTN	0	VCPIP1	4	affinity chromatography technology	Ghosal G (2012)	1
FAF1	1	UFD1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Haenzelmann P (2011), Lee JJ (2013), Raman M (2015), Raman M (2015)	6
UBXN6	1	FAF2	4	affinity chromatography technology	Haines DS (2012)	1
YOD1	0	NPLOC4	4	affinity chromatography technology	Ernst R (2009)	1
YOD1	0	AMFR	2	affinity chromatography technology	Bernardi KM (2013)	1
DERL2	0	SYVN1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lilley BN (2005), Bernardi KM (2010), Huang CH (2013), Huang CH (2013), Huang CH (2013), Zhang T (2015)	6
NSFL1C	1	NPLOC4	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Raman M (2015), Raman M (2015)	4
ASPSCR1	3	VCPIP1	4	affinity chromatography technology	Alexandru G (2008)	1