Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
VASP rs10995 AG + GG hydrochlorothiazide efficacy yes The rs10995 G-allele was associated with better blood pressure response to hydrochlorothiazide versus noncarriers (delta systolic BP/delta diastolic BP: -12.3/-8.2 versus -6.8/-3.5 mm Hg, respectively, delta systolic BP P=3×10-4, delta diastolic BP P=5×10-5)". rs10995 G-allele was associated with increased mRNA expression of VASP (vasodilator-stimulated phosphoprotein). Genotypes AG + GG are associated with increased response to hydrochlorothiazide in people with Hypertension as compared to genotype AA. 28115488 1448568141