PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EP300	36	MAF	4	two hybrid, affinity chromatography technology, affinity chromatography technology	Chen Q (2002), Chen Q (2002), Chen Q (2002)	3
USF2	3	BIRC5	1	affinity chromatography technology	Ewing RM (2007)	1
BRCA1	7	VEGFA	3	genetic interference	Shen JP (2017)	1
EP300	36	BRCA1	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pao GM (2000), Pao GM (2000), Pao GM (2000), Pao GM (2000), Fan S (2002), Fan S (2002), Ma Y (2010), Subbaramaiah K (2011), Subbaramaiah K (2012)	9
EP300	36	FOSL2	2	enzymatic study	Wang WM (2011)	1
USF2	3	USF1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Viollet B (1996), Viollet B (1996), Crusselle-Davis VJ (2006), Giangrande PH (2004), Giangrande PH (2004), Huang S (2007), Huang S (2007), Li X (2011), Fujimori K (2008), Hein MY (2015), Huttlin EL (2017)	12
ADAMTS12	2	USF1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FOS	0	MAF	4	affinity chromatography technology, fluorescent resonance energy transfe	Annunziata CM (2011), Reinke AW (2013)	2
ADAMTS12	2	USF2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
USF2	3	EPAS1	6	affinity chromatography technology, affinity chromatography technology	Pawlus MR (2013), Pawlus MR (2013)	2
EP300	36	EPO	0	two hybrid	Wang J (2011)	1
NPM1	0	EPAS1	6	affinity chromatography technology	Chen R (2013)	1
USF2	3	S100A8	0	affinity chromatography technology	Ewing RM (2007)	1
BRCA1	7	RELA	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Benezra M (2003), Benezra M (2003), Benezra M (2003), Volcic M (2012)	4
RELA	1	USF2	3	two hybrid	Bandyopadhyay S (2010)	1
FOXJ2	3	USF2	3	affinity chromatography technology	Li X (2015)	1
USF2	3	HSPA4L	1	affinity chromatography technology	Ewing RM (2007)	1
NPM1	0	RELA	1	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Wang J (2011), Xu Y (2008), Xu Y (2008), Xu Y (2008)	4
FOSL2	2	USF2	3	affinity chromatography technology	Huttlin EL (2017)	1
PSG1	0	USF2	3	affinity chromatography technology	Huttlin EL (2015)	1
USF2	3	PTP4A2	1	affinity chromatography technology	Ewing RM (2007)	1
NPM1	0	BRCA1	7	affinity chromatography technology, affinity chromatography technology	Sato K (2004), Ertych N (2016)	2
PSG1	0	USF1	0	affinity chromatography technology	Huttlin EL (2015)	1
USF2	3	S100A9	0	affinity chromatography technology	Ewing RM (2007)	1
BRCA1	7	HSPA4L	1	affinity chromatography technology	Ertych N (2016)	1
PPARGC1A	3	RELA	1	affinity chromatography technology	Wang LH (2007)	1
EP300	36	FOS	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Wang WM (2011), Pekarsky Y (2008), Wang C (2001)	3
SERPINB3	0	SERPINB4	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
USF2	3	VEGFA	3	imaging technique	Pawlus MR (2013)	1
FOS	0	USF2	3	two hybrid	Rolland T (2014)	1
USF2	3	SERPINB3	0	affinity chromatography technology	Ewing RM (2007)	1
TFAP4	3	BRCA1	7	affinity chromatography technology	Ku WC (2009)	1
USF2	3	EPO	0	imaging technique	Pawlus MR (2013)	1
PPARGC1A	3	USF1	0	pull down	Moore ML (2003)	1
TFAP4	3	USF2	3	affinity chromatography technology, affinity chromatography technology	Ku WC (2009), Ku WC (2009)	2
FUS	0	RELA	1	affinity chromatography technology, pull down	Uranishi H (2001), Uranishi H (2001)	2
TFAP4	3	S100A8	0	affinity chromatography technology	Ku WC (2009)	1
EP300	36	EPAS1	6	pull down, affinity chromatography technology, affinity chromatography technology	Kung AL (2004), Steunou AL (2012), Chen R (2012)	3
PPARGC1A	3	EP300	36	affinity chromatography technology	Cooper MP (2006)	1
USF2	3	FUS	0	affinity chromatography technology	Ewing RM (2007)	1
USF2	3	SERPINE1	0	imaging technique	Pawlus MR (2013)	1
S100A9	0	S100A8	0	two hybrid, pull down	Bandyopadhyay S (2010), Vogl T (2004)	2
CCDC102B	0	USF2	3	affinity chromatography technology	Huttlin EL (2017)	1
USF2	3	TEAD2	2	two hybrid	Rolland T (2014)	1
BRCA1	7	FUS	0	affinity chromatography technology	Ertych N (2016)	1
USF2	3	BRCA1	7	affinity chromatography technology, affinity chromatography technology	Cable PL (2003), Cable PL (2003)	2
USF2	3	USF2	3	affinity chromatography technology, affinity chromatography technology, pull down	Ewing RM (2007), Viollet B (1996), Viollet B (1996)	3
EP300	36	RELA	1	enzymatic study, two hybrid, affinity chromatography technology, genetic interference, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kiernan R (2003), Gerritsen ME (1997), Gerritsen ME (1997), Gerritsen ME (1997), Gerritsen ME (1997), Hiroi M (2003), Nicot C (2001), Kim RH (2001), Hassa PO (2008), Hassa PO (2008), Hu J (2004), Naeaer AM (1999), Lee IT (2010), Nehra R (2010), Hsu HC (2007), Hsu HC (2007), Saha RN (2007), Saha RN (2007), Hassa PO (2003), Hassa PO (2003), Mendonca DB (2011), Chen W (2008), Chen LF (2002), OHara A (2014), Lu Y (2013), Lu Y (2013), Ren YB (2015), Chen LF (2005), Chen LF (2005), Chen LF (2005), Deng WG (2003)	31
MAF	4	USF2	3	pull down	Kurschner C (1997)	1
FOS	0	USF1	0	two hybrid	Rolland T (2014)	1
USF2	3	LZTS2	4	two hybrid	Rolland T (2014)	1
USF2	3	NPM1	0	affinity chromatography technology	Ewing RM (2007)	1
FUS	0	NPM1	0	affinity chromatography technology	Wang T (2014)	1
EP300	36	NPM1	0	enzymatic study	Swaminathan V (2005)	1
BRCA1	7	FOSL2	2	affinity chromatography technology	Hill SJ (2014)	1
EP300	36	USF2	3	two hybrid	Breen GA (1999)	1
USF2	3	SERPINB4	1	affinity chromatography technology	Ewing RM (2007)	1
RELA	1	FOS	0	two hybrid, genetic interference	Yang X (1999), Yang X (1999)	2
PPARGC1A	3	USF2	3	pull down, affinity chromatography technology	Moore ML (2003), Moore ML (2003)	2
USF1	0	EP300	36	affinity chromatography technology	Crusselle-Davis VJ (2007)	1