PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBE2V2	0	UBC	7	x-ray crystallography, pull down, x-ray crystallography, x-ray crystallography, pull down	McKenna S (2003), McKenna S (2003), McKenna S (2003), Lewis MJ (2006), McKenna S (2001)	5
TRIM5	4	UBC	7	enzymatic study	Pertel T (2011)	1
USP34	7	UFM1	0	biochemical	Havugimana PC (2012)	1
UBE2V2	0	USP34	7	biochemical	Havugimana PC (2012)	1
HLTF	7	UBC	7	enzymatic study	Masuda Y (2012)	1
UBE2V2	0	SIAH1	2	two hybrid	Markson G (2009)	1
SSSCA1	0	UBXN1	0	biochemical	Havugimana PC (2012)	1
RPS21	0	UBE2V2	0	biochemical	Havugimana PC (2012)	1
RC3H1	6	RC3H2	5	affinity chromatography technology	Murakawa Y (2015)	1
UBE2V1	0	TRIM5	4	two hybrid	Markson G (2009)	1
TTC9C	2	UBE2V2	0	biochemical	Havugimana PC (2012)	1
UBE2V2	0	ZRANB2	0	biochemical	Havugimana PC (2012)	1
OTUB1	0	UBE2V2	0	pull down	Sato Y (2012)	1
UBE2V2	0	UBXN7	3	biochemical	Havugimana PC (2012)	1
TTC9C	2	UBE2V1	0	biochemical	Havugimana PC (2012)	1
USP9X	15	ZYX	2	biochemical	Havugimana PC (2012)	1
EGFR	5	MOB4	0	protein complementation assay	Deribe YL (2009)	1
UBXN7	3	USP9X	15	biochemical	Havugimana PC (2012)	1
TIGD6	0	ZRANB2	0	affinity chromatography technology	Hein MY (2015)	1
RAD23B	1	STUB1	4	biochemical	Havugimana PC (2012)	1
USP34	7	ZRANB2	0	biochemical	Havugimana PC (2012)	1
UBE2N	1	SIAH1	2	two hybrid	Markson G (2009)	1
BCL10	0	UBE2N	1	pull down	Zhou H (2004)	1
TTLL12	3	USP9X	15	biochemical	Havugimana PC (2012)	1
ATP6V1B2	3	ZPR1	1	biochemical	Havugimana PC (2012)	1
TRIM32	2	UBE2V2	0	two hybrid, two hybrid, affinity chromatography technology	Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011)	3
ATP6V1B2	3	ZFYVE19	0	biochemical	Havugimana PC (2012)	1
SEC23A	3	UBXN7	3	biochemical	Havugimana PC (2012)	1
UBE2L3	1	ZPR1	1	biochemical	Havugimana PC (2012)	1
TRAF2	1	UBC	7	enzymatic study, enzymatic study	Liu J (2011), Kanayama A (2004)	2
TTC9C	2	TTLL12	3	biochemical	Havugimana PC (2012)	1
UBE2V2	0	XIAP	0	two hybrid	Markson G (2009)	1
UBE2V2	0	TRIM5	4	two hybrid	Markson G (2009)	1
EGFR	5	USP9X	15	affinity chromatography technology	Foerster S (2013)	1
STUB1	4	UBE2L3	1	pull down	Hampe C (2006)	1
STUB1	4	TRAF2	1	affinity chromatography technology	Jang KW (2011)	1
SSSCA1	0	UBE2V2	0	biochemical	Havugimana PC (2012)	1
UBE2V1	0	UBE2V2	0	biochemical	Havugimana PC (2012)	1
RC3H1	6	UBE2V1	0	pull down	Zhang Q (2015)	1
UBE2L3	1	USP34	7	biochemical	Havugimana PC (2012)	1
UBE2V1	0	STUB1	4	pull down, pull down, pull down, biochemical, affinity chromatography technology, pull down	Zhang M (2005), Yang M (2011), Windheim M (2008), Havugimana PC (2012), Zhang M (2005), Zhang M (2005)	6
UBE2N	1	MKRN3	2	two hybrid	Markson G (2009)	1
XIAP	0	STUB1	4	pull down	Dogan T (2008)	1
UBXN1	0	UBC	7	pull down, pull down, affinity chromatography technology, pull down, pull down, pull down	Wu-Baer F (2010), Fenner BJ (2009), Alexandru G (2008), LaLonde DP (2011), McNeill H (2004), Zhang X (2017)	6
UBC	7	STUB1	4	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Connell P (2001), Connell P (2001), Windheim M (2008), Zhang M (2005)	4
EGFR	5	XIAP	0	affinity chromatography technology	Yao Z (2017)	1
UBE2V1	0	UBXN7	3	biochemical	Havugimana PC (2012)	1
UBE2V2	0	ATP6V1B2	3	biochemical	Havugimana PC (2012)	1
TTC9C	2	ZRANB2	0	biochemical	Havugimana PC (2012)	1
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
UBE2V1	0	RNF2	1	two hybrid	Markson G (2009)	1
BCL10	0	TRAF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Yoneda T (2000), Yoneda T (2000), Yoneda T (2000), Yui D (2001), Rolland T (2014)	5
TRAF2	1	UBE2V2	0	pull down	Sasai M (2010)	1
TTLL12	3	UBE2V2	0	biochemical	Havugimana PC (2012)	1
HLTF	7	SHPRH	7	affinity chromatography technology	Lin JR (2011)	1
SSSCA1	0	UBE2V1	0	biochemical	Havugimana PC (2012)	1
TTLL12	3	UFM1	0	biochemical	Havugimana PC (2012)	1
TRAF2	1	XIAP	0	affinity chromatography technology	Vince JE (2009)	1
UFM1	0	USP9X	15	biochemical	Havugimana PC (2012)	1
UBE2V1	0	RNF144A	1	two hybrid	Markson G (2009)	1
CPLX1	0	UBE2V2	0	biochemical	Havugimana PC (2012)	1
TTC9C	2	ZFYVE19	0	biochemical	Havugimana PC (2012)	1
POLK	0	UBE2V2	0	affinity chromatography technology	Hein MY (2015)	1
UBXN1	0	USP9X	15	biochemical	Havugimana PC (2012)	1
UBE2L3	1	MKRN3	2	two hybrid	Markson G (2009)	1
CD2BP2	0	UBE2V2	0	biochemical	Havugimana PC (2012)	1
SSSCA1	0	USP34	7	biochemical	Havugimana PC (2012)	1
UBE2V2	0	VPS26A	0	biochemical	Havugimana PC (2012)	1
BCL10	0	UBE2V2	0	pull down	Zhou H (2004)	1
UBE2V2	0	UBE2B	3	biochemical	Havugimana PC (2012)	1
UBE2V2	0	ZPR1	1	biochemical	Havugimana PC (2012)	1
RC3H1	6	UBE2B	3	pull down	Zhang Q (2015)	1
RC3H2	5	UBC	7	enzymatic study	Zhang Q (2015)	1
UBC	7	RHOA	0	affinity chromatography technology	Huang G (2014)	1
UBXN1	0	UFM1	0	biochemical	Havugimana PC (2012)	1
UBE2V2	0	RNF144A	1	two hybrid	Markson G (2009)	1
UBE2V2	0	LRIF1	3	two hybrid	Stelzl U (2005)	1
TRIM32	2	TP53	0	affinity chromatography technology, affinity chromatography technology	Liu J (2014), Liu J (2014)	2
SEC23A	3	UBE2V2	0	biochemical	Havugimana PC (2012)	1
SSSCA1	0	USP9X	15	biochemical	Havugimana PC (2012)	1
UBE2V1	0	UBE2B	3	biochemical	Havugimana PC (2012)	1
UBC	7	UBE2B	3	affinity chromatography technology, affinity chromatography technology	Bish RA (2007), Hong JH (2015)	2
TP53	0	STUB1	4	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Muller P (2008), Stankiewicz M (2010), Tripathi V (2007), Tripathi V (2007), Esser C (2005), Lim JH (2011), Wang J (2011), Burch L (2004), Landre V (2013), Horikawa I (2014), Horikawa I (2014), Horikawa I (2014), Fraser JA (2015), Narayan V (2015), Yue X (2016), Parrales A (2016), Parrales A (2016)	17
RAD23B	1	UBXN7	3	biochemical	Havugimana PC (2012)	1
MUL1	1	UBE2V2	0	pull down	Ni G (2017)	1
SSSCA1	0	UBE2B	3	biochemical	Havugimana PC (2012)	1
SSSCA1	0	TTC9C	2	biochemical	Havugimana PC (2012)	1
HLTF	7	UBE2N	1	affinity chromatography technology, pull down, pull down, enzymatic study	Unk I (2008), Unk I (2008), Masuda Y (2012), Masuda Y (2012)	4
SSSCA1	0	UBXN7	3	biochemical	Havugimana PC (2012)	1
RC3H1	6	ZRANB2	0	affinity chromatography technology	Murakawa Y (2015)	1
RNF8	2	UBC	7	enzymatic study, enzymatic study, enzymatic study	Feng L (2012), Hodge CD (2015), Ho YK (2015)	3
XIAP	0	UBE2L3	1	affinity chromatography technology	Hu S (2003)	1
SSSCA1	0	TTLL12	3	biochemical	Havugimana PC (2012)	1
RC3H2	5	UBE2B	3	pull down	Zhang Q (2015)	1
RHOA	0	UBE2V2	0	affinity chromatography technology	Hein MY (2015)	1
MALT1	1	USP9X	15	affinity chromatography technology	Park Y (2013)	1
OTUB1	0	UBE2N	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Nakada S (2010), Nakada S (2010), Sato Y (2012), Sato Y (2012), Sato Y (2012), Wiener R (2012), Herhaus L (2013), Herhaus L (2015), Scholz CC (2016), Boldt K (2016), Weber E (2017)	12
TRAF2	1	MUL1	1	affinity chromatography technology	Zemirli N (2014)	1
UBE2V1	0	ZNRF1	1	two hybrid	Markson G (2009)	1
UBE2V1	0	USP34	7	biochemical	Havugimana PC (2012)	1
TTLL12	3	UBXN7	3	biochemical	Havugimana PC (2012)	1
UBE2N	1	DZIP3	6	two hybrid	Markson G (2009)	1
TRIM32	2	UBC	7	enzymatic study, pull down	Streich FC (2013), Zhang X (2017)	2
UBE2V2	0	RNF2	1	two hybrid	Markson G (2009)	1
MALT1	1	UBE2N	1	pull down	Zhou H (2004)	1
SEC23A	3	UBE2B	3	biochemical	Havugimana PC (2012)	1
USP9X	15	ZFYVE19	0	biochemical	Havugimana PC (2012)	1
UBE2L3	1	UBE2B	3	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
RNF2	1	UBE2L3	1	pull down	Zaaroor-Regev D (2010)	1
SSSCA1	0	ZYX	2	biochemical	Havugimana PC (2012)	1
UBE2N	1	STUB1	4	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down	Zhang M (2005), Graf C (2010), Soss SE (2011), Huen MS (2008), Lim GG (2013), Taipale M (2014), Taipale M (2014), Zhu X (2014), Zhang M (2005), Zhang M (2005), Kim HT (2007), Blessing NA (2017)	12
MUL1	1	UBE2L3	1	two hybrid	Ambivero CT (2014)	1
UBE2V2	0	MKRN3	2	two hybrid	Markson G (2009)	1
UBE2N	1	RC3H2	5	two hybrid, pull down	Markson G (2009), Zhang Q (2015)	2
UBE2V1	0	UBC	7	pull down	McKenna S (2003)	1
SHPRH	7	UBE2V2	0	affinity chromatography technology, pull down	Unk I (2006), Unk I (2006)	2
UBE2B	3	UBXN7	3	biochemical	Havugimana PC (2012)	1
UBE2N	1	XIAP	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
HLTF	7	UBE2V2	0	affinity chromatography technology, pull down, pull down	Unk I (2008), Unk I (2008), Masuda Y (2012)	3
SSSCA1	0	VPS26A	0	biochemical	Havugimana PC (2012)	1
UBE2N	1	ZNRF1	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	van Wijk SJ (2009), Markson G (2009), Hoxhaj G (2012), Hoxhaj G (2012), Markson G (2009), Hoxhaj G (2012), Boldt K (2016)	7
MUL1	1	UBE2N	1	pull down	Ni G (2017)	1
STUB1	4	UBE2V2	0	biochemical	Havugimana PC (2012)	1
CPLX1	0	UBE2B	3	biochemical	Havugimana PC (2012)	1
UBE2V1	0	MKRN3	2	two hybrid	Markson G (2009)	1
UBE2N	1	RNF11	0	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology	van Wijk SJ (2009), Markson G (2009), Scheper J (2009), Colland F (2004), Poulsen SL (2013)	5
UBXN1	0	ZPR1	1	biochemical	Havugimana PC (2012)	1
ZPR1	1	ZYX	2	biochemical	Havugimana PC (2012)	1
USP9X	15	UBC	7	unspecified method, pull down	Ernst A (2013), Kwasna D (2018)	2
RC3H2	5	UBE2V1	0	pull down	Zhang Q (2015)	1
UBC	7	UBE2N	1	affinity chromatography technology, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Matsumoto M (2005), Scheper J (2010), Wu PY (2003), McKenna S (2003), Wiener R (2012), Ye Y (2003), Bish RA (2007), Juang YC (2012), Pastushok L (2007), Singh RK (2012), McKenna S (2001), McKenna S (2001)	12
UBXN7	3	VPS26A	0	biochemical	Havugimana PC (2012)	1
TP53	0	UBE2N	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Laine A (2006), Laine A (2006), Laine A (2006), Topisirovic I (2009), Topisirovic I (2009)	5
SSSCA1	0	ZPR1	1	biochemical	Havugimana PC (2012)	1
RAD23B	1	UBE2V2	0	biochemical	Havugimana PC (2012)	1
MOB4	0	UBE2V2	0	two hybrid	Stelzl U (2005)	1
RNF2	1	OTUB1	0	affinity chromatography technology	Cao Q (2014)	1
TRIM5	4	MKRN3	2	two hybrid	Woodsmith J (2012)	1
UBXN7	3	ZYX	2	biochemical	Havugimana PC (2012)	1
UBXN1	0	ZFYVE19	0	biochemical	Havugimana PC (2012)	1
OTUB1	0	UBE2L3	1	affinity chromatography technology	Scholz CC (2016)	1
UBE2V2	0	UFM1	0	biochemical	Havugimana PC (2012)	1
RNF2	1	SIAH1	2	affinity chromatography technology	Woodsmith J (2012)	1
UBE2M	0	TP53	0	enzymatic study	Xirodimas DP (2004)	1
UFM1	0	ZPR1	1	biochemical	Havugimana PC (2012)	1
XIAP	0	UBC	7	x-ray crystallography, pull down, pull down, pull down	Tse MK (2011), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Nakatani Y (2012)	4
UBE2N	1	RNF8	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down, fluorescent resonance energy transfe, pull down, two hybrid	Markson G (2009), Bekker-Jensen S (2010), Lok GT (2011), Lok GT (2011), Campbell SJ (2012), Plans V (2006), Plans V (2006), Huen MS (2008), Zhang X (2013), Guerra-Rebollo M (2012), Zhao H (2014), Hodge CD (2015), Ho YK (2015), Weber E (2017), Weber E (2017), Schimmack G (2017)	16
UBE2N	1	TRIM5	4	two hybrid, pull down, x-ray crystallography	Markson G (2009), Yudina Z (2015), Yudina Z (2015)	3
UBE2L3	1	USP9X	15	biochemical	Havugimana PC (2012)	1
UBE2V2	0	USP9X	15	biochemical	Havugimana PC (2012)	1
RC3H1	6	UBE2V2	0	pull down	Zhang Q (2015)	1
RC3H1	6	CD2BP2	0	affinity chromatography technology	Murakawa Y (2015)	1
UBE2B	3	ZFYVE19	0	biochemical	Havugimana PC (2012)	1
UBE2M	0	UBE2V2	0	biochemical	Wan C (2015)	1
ZNRF1	1	UBC	7	enzymatic study	Hoxhaj G (2012)	1
UBC	7	UBE2L3	1	affinity chromatography technology	Bish RA (2007)	1
MUL1	1	UBC	7	enzymatic study	Braschi E (2009)	1
USP34	7	UBXN1	0	biochemical	Havugimana PC (2012)	1
EGFR	5	UBE2V2	0	protein complementation assay	Deribe YL (2009)	1
TTLL12	3	USP34	7	biochemical	Havugimana PC (2012)	1
UBE2V2	0	ZFYVE19	0	biochemical	Havugimana PC (2012)	1
EGFR	5	TRAF2	1	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Tong J (2008), Puliyappadamba VT (2013), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
RAD23B	1	UFM1	0	biochemical	Havugimana PC (2012)	1
UBE2L3	1	UBXN7	3	biochemical	Havugimana PC (2012)	1
USP34	7	USP9X	15	biochemical	Havugimana PC (2012)	1
RC3H2	5	UBE2V2	0	pull down	Zhang Q (2015)	1
MOB4	0	LRIF1	3	two hybrid	Stelzl U (2005)	1
STUB1	4	MALT1	1	affinity chromatography technology	Wang S (2013)	1
USP34	7	UBXN7	3	biochemical	Havugimana PC (2012)	1
UBE2L3	1	UBE2V2	0	biochemical	Havugimana PC (2012)	1
RAD23B	1	UBE2N	1	biochemical	Wan C (2015)	1
UBE2B	3	TP53	0	affinity chromatography technology, affinity chromatography technology	Chen S (2012), Chen S (2012)	2
RNF2	1	UBC	7	enzymatic study	Woodsmith J (2012)	1
USP34	7	ATP6V1B2	3	biochemical	Havugimana PC (2012)	1
UBE2N	1	UBE2V1	0	biochemical, pull down, pull down, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, biochemical, pull down, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deng L (2000), Deng L (2000), Zhang M (2005), Andersen PL (2005), Andersen PL (2005), Scheper J (2010), Scheper J (2010), Scheper J (2010), Wooff J (2004), Plans V (2006), Huen MS (2008), Huen MS (2008), Havugimana PC (2012), Bohgaki M (2008), Petroski MD (2007), Sawasaki T (2008), Wan C (2015), Chen J (2015), Boldt K (2016), Zhang Y (2018)	20
TP53	0	UBE2V2	0	two hybrid	Daakour S (2016)	1
ATP6V1B2	3	ZYX	2	biochemical	Havugimana PC (2012)	1
UBXN7	3	ZRANB2	0	biochemical	Havugimana PC (2012)	1
UBC	7	RAD23B	1	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Ryu KS (2003), Chen L (2006), Nathan JA (2013), Nathan JA (2013), Nakayasu ES (2013), Nakayasu ES (2013), Kristariyanto YA (2015), Zhang X (2017)	9
UBE2L3	1	UFM1	0	biochemical	Wan C (2015)	1
UBXN7	3	UFM1	0	biochemical	Havugimana PC (2012)	1
UBE2V2	0	IGSF21	1	two hybrid	Stelzl U (2005)	1
UBE2V2	0	ZNRF1	1	two hybrid	Markson G (2009)	1
UBE2V1	0	TRIM32	2	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Markson G (2009), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011)	4
XIAP	0	BCL10	0	affinity chromatography technology	Hu S (2006)	1
RNF2	1	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Calao M (2012), Wen W (2013), Wen W (2013)	3
UBE2V1	0	DZIP3	6	two hybrid	Markson G (2009)	1
TP53	0	MUL1	1	affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study	Jung JH (2011), Jung JH (2011), Jung JH (2011), Jung JH (2011), Jung JH (2011)	5
UBE2V2	0	DZIP3	6	two hybrid	Markson G (2009)	1
SEC23A	3	TTLL12	3	biochemical	Havugimana PC (2012)	1
TTLL12	3	ZYX	2	biochemical	Havugimana PC (2012)	1
USP34	7	ZFYVE19	0	biochemical	Havugimana PC (2012)	1
RNF144A	1	UBC	7	enzymatic study	Michel MA (2017)	1
OTUB1	0	STUB1	4	affinity chromatography technology	Scholz CC (2016)	1
UBC	7	UBXN7	3	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Kelsall IR (2013), Alexandru G (2008), Besten Wd (2012), Besten Wd (2012)	4
MUL1	1	VPS26A	0	affinity chromatography technology	Braschi E (2010)	1
RNF8	2	UBE2V2	0	pull down	Campbell SJ (2012)	1
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
BCL10	0	USP9X	15	affinity chromatography technology	Park Y (2013)	1
TRAF2	1	UBE2V1	0	pull down	Deng L (2000)	1
SEC23A	3	STUB1	4	biochemical	Havugimana PC (2012)	1
TRAF2	1	UBE2N	1	genetic interference, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Deng L (2000), Deng L (2000), Liu J (2011), Liu J (2011), Liu J (2011), Alvarez SE (2010), Sasai M (2010), Zhou AY (2013), Shen RR (2012)	9
XIAP	0	TRIM32	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Ryu YS (2011), Ryu YS (2011), Ryu YS (2011)	3
OTUB1	0	UBC	7	enzymatic study, enzymatic study, x-ray crystallography, unspecified method, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, enzymatic study, x-ray crystallography, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Wang T (2009), Bremm A (2010), Juang YC (2012), Ernst A (2013), Ernst A (2013), Nakasone MA (2013), Wiener R (2013), Edelmann MJ (2009), Bish RA (2007), Mevissen TE (2013), Juang YC (2012), Herhaus L (2013), Ernst A (2013), Herhaus L (2015), Herhaus L (2015), Herhaus L (2015), Wauer T (2015), Michel MA (2015), Kristariyanto YA (2015), Scholz CC (2016), Scholz CC (2016), Altun M (2015), Flierman D (2016), Castaneda CA (2016), Zhang X (2017), Kwasna D (2018)	26
UBE2B	3	ZRANB2	0	biochemical	Havugimana PC (2012)	1
UBE2L3	1	UBXN1	0	biochemical	Havugimana PC (2012)	1
TRIM5	4	TRIM32	2	two hybrid	Woodsmith J (2012)	1
UBE2V1	0	XIAP	0	two hybrid	Markson G (2009)	1
UBXN7	3	ZPR1	1	biochemical	Havugimana PC (2012)	1
EGFR	5	STUB1	4	protein complementation assay, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deribe YL (2009), Wang T (2014), Wang T (2014), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Chung C (2016), Chung C (2016)	8
UBXN1	0	UBXN7	3	affinity chromatography technology	Raman M (2015)	1
MALT1	1	TRAF2	1	pull down, affinity chromatography technology	Sun L (2004), Garrison JB (2009)	2
TP53	0	OTUB1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Sun XX (2011), Sun XX (2011), Sun XX (2011), Li Y (2014), Fernandez-Majada V (2016)	5
RAD23B	1	RPS21	0	biochemical	Havugimana PC (2012)	1
SIAH1	2	XIAP	0	affinity chromatography technology, affinity chromatography technology	Garrison JB (2011), Garrison JB (2011)	2
TIGD6	0	UBE2V2	0	affinity chromatography technology	Hein MY (2015)	1
MALT1	1	BCL10	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Uren AG (2000), Uren AG (2000), Uren AG (2000), Noels H (2009), Carvalho G (2010), Welteke V (2009), Oruganti SR (2011), Lucas PC (2001), Langel FD (2008), Langel FD (2008), Blonska M (2007), Oeckinghaus A (2007), Park Y (2013), Park Y (2013), Borthakur A (2013), Zhou H (2004), Zhou H (2004), Chen J (2015), Karim ZA (2015), Nie Z (2015), Eitelhuber AC (2011), Paul S (2012), Yang YK (2016), Liu Y (2012), Bidere N (2009), Bidere N (2009), Afonina IS (2016), Howes A (2016)	28
SEC23A	3	USP9X	15	biochemical	Havugimana PC (2012)	1
SSSCA1	0	ZRANB2	0	biochemical	Havugimana PC (2012)	1
UBE2V2	0	ZYX	2	biochemical	Havugimana PC (2012)	1
POLK	0	CD2BP2	0	affinity chromatography technology	Hein MY (2015)	1
OTUB1	0	RHOA	0	enzymatic study	Edelmann MJ (2010)	1
ZYX	2	UBE2N	1	affinity chromatography technology	Boldt K (2016)	1
SHPRH	7	UBE2N	1	affinity chromatography technology, pull down	Unk I (2006), Unk I (2006)	2
RC3H1	6	UBE2N	1	pull down	Zhang Q (2015)	1
UBE2B	3	USP9X	15	biochemical	Havugimana PC (2012)	1
UBE2V1	0	ZYX	2	biochemical	Havugimana PC (2012)	1
TRIM32	2	UBE2N	1	two hybrid, affinity chromatography technology, two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Saccone V (2008), Saccone V (2008), van Wijk SJ (2009), Markson G (2009), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011), Boldt K (2016)	8
UBE2L3	1	RNF144A	1	two hybrid, pull down	Markson G (2009), Ho SR (2014)	2
SSSCA1	0	ATP6V1B2	3	biochemical	Havugimana PC (2012)	1
UBE2V2	0	UBXN1	0	biochemical	Havugimana PC (2012)	1
RNF2	1	TRAF2	1	affinity chromatography technology	Cao Q (2014)	1
UBC	7	USP34	7	pull down	Kwasna D (2018)	1
TTLL12	3	ZRANB2	0	biochemical	Havugimana PC (2012)	1
UBXN7	3	ZFYVE19	0	biochemical	Havugimana PC (2012)	1
RNF11	0	UBC	7	two hybrid, two hybrid	Li H (2004), Colland F (2004)	2
UBE2B	3	ZYX	2	biochemical	Havugimana PC (2012)	1
TP53	0	EGFR	5	genetic interference, genetic interference	Xie L (2013), Ye H (2016)	2
RAD23B	1	ZYX	2	biochemical	Wan C (2015)	1
RNF11	0	UBE2V2	0	affinity chromatography technology	Poulsen SL (2013)	1
VPS26A	0	ZPR1	1	biochemical	Havugimana PC (2012)	1
TTLL12	3	UBE2B	3	biochemical	Havugimana PC (2012)	1
MALT1	1	UBE2V2	0	pull down	Zhou H (2004)	1
RC3H1	6	UBE2L3	1	pull down	Zhang Q (2015)	1
UBXN7	3	ATP6V1B2	3	biochemical	Havugimana PC (2012)	1
UBE2V2	0	UBE2N	1	pull down, two hybrid, x-ray crystallography, two hybrid, two hybrid, two hybrid, pull down, pull down, x-ray crystallography, affinity chromatography technology, pull down, two hybrid, pull down, pull down, affinity chromatography technology, two hybrid, pull down, biochemical, x-ray crystallography, pull down, affinity chromatography technology, pull down, x-ray crystallography, biochemical, x-ray crystallography, affinity chromatography technology	Andersen PL (2005), Andersen PL (2005), Markin CJ (2010), Wooff J (2004), Wooff J (2004), Plans V (2006), Wu PY (2003), McKenna S (2003), McKenna S (2003), Zou W (2005), Takeuchi T (2005), Pastushok L (2005), Pastushok L (2005), Pastushok L (2005), Huen MS (2008), Huen MS (2008), Ye Y (2003), Havugimana PC (2012), Moraes TF (2001), Pastushok L (2007), Zou W (2005), McKenna S (2001), Hodge CD (2015), Wan C (2015), Branigan E (2015), Boldt K (2016)	26
UBE2V1	0	ATP6V1B2	3	biochemical	Havugimana PC (2012)	1
EGFR	5	USP34	7	affinity chromatography technology	Yao Z (2017)	1
RNF8	2	BCL10	0	affinity chromatography technology	Zhao H (2014)	1
UFM1	0	ZFYVE19	0	biochemical	Havugimana PC (2012)	1