PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PRKN	1	UBE2N	1	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Joch M (2007), Olzmann JA (2007), Chaugule VK (2011), Sha D (2010), Lim GG (2013), Durcan TM (2011), McKeon JE (2014), Sha D (2010)	8
UBE2V2	0	UBC	7	x-ray crystallography, pull down, x-ray crystallography, x-ray crystallography, pull down	McKenna S (2003), McKenna S (2003), McKenna S (2003), Lewis MJ (2006), McKenna S (2001)	5
UBC	7	UBE2C	1	affinity chromatography technology	Matsumoto M (2005)	1
TRIM5	4	UBC	7	enzymatic study	Pertel T (2011)	1
UBE2V2	0	USP34	7	biochemical	Havugimana PC (2012)	1
PSMB1	1	UBE4B	5	biochemical	Havugimana PC (2012)	1
RC3H2	5	TRIM8	6	two hybrid	Woodsmith J (2012)	1
YWHAQ	0	YWHAG	5	affinity chromatography technology, biochemical	Pozuelo-Rubio M (2010), Kristensen AR (2012)	2
SMURF1	4	UBE2D2	0	pull down, pull down	Kristariyanto YA (2015), Andrews PS (2010)	2
SFN	1	TRIM32	2	affinity chromatography technology, affinity chromatography technology	Benzinger A (2005), Ichimura T (2013)	2
PSMB1	1	HSD17B10	1	biochemical	Wan C (2015)	1
TRIM25	5	ZYX	2	affinity chromatography technology	Choudhury NR (2017)	1
RNF2	1	UBE2D2	0	enzymatic study, two hybrid, pull down	Lee SJ (2001), Markson G (2009), Dou H (2012)	3
PELI3	0	UBE2N	1	pull down	Yang S (2013)	1
ATP6V1B2	3	GMPPB	2	biochemical	Kristensen AR (2012)	1
TRAF6	0	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Muroi M (2011), Park S (2013), Sun L (2004), Kanayama A (2004), Sakamoto H (2015), Yu J (2016), Middleton AJ (2017)	7
RC3H1	6	RC3H2	5	affinity chromatography technology	Murakawa Y (2015)	1
PELI1	1	UBC	7	enzymatic study, enzymatic study	Smith H (2009), Smith H (2011)	2
UBE2V1	0	TRIM5	4	two hybrid	Markson G (2009)	1
TTC9C	2	UBE2V2	0	biochemical	Havugimana PC (2012)	1
TRAF2	1	TRAF3IP2	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Qian Y (2004), Sun D (2011)	3
UBE2V2	0	UBXN7	3	biochemical	Havugimana PC (2012)	1
UBE4B	5	UCHL3	1	biochemical	Havugimana PC (2012)	1
PELI1	1	BIRC3	1	affinity chromatography technology, pull down, pull down	Jeon YK (2016), Jeon YK (2016), Jeon YK (2016)	3
TTC9C	2	UBE2V1	0	biochemical	Havugimana PC (2012)	1
MAP3K1	4	UBE2K	0	enzymatic study	Charlaftis N (2014)	1
AHCYL1	2	ZYX	2	biochemical	Havugimana PC (2012)	1
HSD17B10	1	UCHL3	1	biochemical	Wan C (2015)	1
UBE2K	0	RNF2	1	two hybrid, pull down, affinity chromatography technology, two hybrid	Lee SJ (2001), Lee SJ (2001), Lee SJ (2001), Markson G (2009)	4
TRAF2	1	SMURF1	4	genetic interference	Li S (2010)	1
TRAF3IP2	0	TRAF6	0	enzymatic study, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Liu C (2009), Kanamori M (2002), Kanamori M (2002), Kanamori M (2002), Qian Y (2007), Qu F (2012), Wu NL (2014), Wu NL (2014), Rolland T (2014), Garg AV (2013), Sun D (2011), Yu H (2011)	12
TRIM25	5	USP34	7	affinity chromatography technology	Choudhury NR (2017)	1
UBE2D2	0	STUB1	4	pull down, pull down, biochemical, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down	Demand J (2001), Soss SE (2011), Shimura H (2004), Esser C (2005), Kalia LV (2011), Xie P (2009), Grelle G (2006), Westhoff B (2005), Hatakeyama S (2004), Dolan PJ (2010), Tsukahara F (2010), Chen Z (2013), Dreiseidler M (2012), Zhang H (2015), Liu X (2017), Liu X (2017), Blessing NA (2017)	17
HINT1	0	NME2	0	biochemical	Wan C (2015)	1
HINT1	0	NME1-NME2	0	biochemical	Wan C (2015)	1
BIRC2	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Silke J (2005), Rajalingam K (2006), Rajalingam K (2006), Oberoi-Khanuja TK (2012), Huttlin EL (2017)	5
UBE2V1	0	UGDH	0	biochemical	Havugimana PC (2012)	1
LDHB	4	NME2	0	biochemical	Wan C (2015)	1
AHCYL1	2	STUB1	4	biochemical	Havugimana PC (2012)	1
UBE2V1	0	MID1	1	two hybrid	Markson G (2009)	1
UBE2N	1	BIRC3	1	two hybrid, pull down, two hybrid	van Wijk SJ (2009), Wu CJ (2006), Schimmack G (2017)	3
AHCYL1	2	UBE2B	3	biochemical	Havugimana PC (2012)	1
AHCYL1	2	UBQLN1	1	biochemical	Havugimana PC (2012)	1
TRIM25	5	FAM168A	0	affinity chromatography technology	Choudhury NR (2017)	1
UBE2V1	0	CHORDC1	1	biochemical	Wan C (2015)	1
TRIM32	2	UBE2V2	0	two hybrid, two hybrid, affinity chromatography technology	Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011)	3
TRIM32	2	YWHAZ	1	affinity chromatography technology	Ichimura T (2013)	1
PSMB1	1	UBE2A	0	biochemical	Havugimana PC (2012)	1
TXN	1	UBE2V1	0	biochemical	Havugimana PC (2012)	1
UBE2D2	0	UBE2V1	0	biochemical	Havugimana PC (2012)	1
LDHB	4	YWHAZ	1	biochemical	Kristensen AR (2012)	1
UBE2D2	0	RNF185	1	two hybrid	Markson G (2009)	1
PELI1	1	UBE2D2	0	pull down	Smith H (2009)	1
TRAF2	1	UBC	7	enzymatic study, enzymatic study	Liu J (2011), Kanayama A (2004)	2
BIRC3	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006), Yang W (2014), Yang W (2014)	4
UBE2V2	0	XIAP	0	two hybrid	Markson G (2009)	1
SMURF1	4	UBC	7	affinity chromatography technology, enzymatic study, pull down	Xie Y (2013), Kristariyanto YA (2015), Zhang Y (2017)	3
UBE2V2	0	TRIM5	4	two hybrid	Markson G (2009)	1
RC3H2	5	UBE2D2	0	pull down	Zhang Q (2015)	1
AHCYL1	2	TAGLN2	0	biochemical	Havugimana PC (2012)	1
STUB1	4	TRAF2	1	affinity chromatography technology	Jang KW (2011)	1
MAP3K1	4	UBQLN1	1	enzymatic study	Charlaftis N (2014)	1
SSSCA1	0	UBE2V2	0	biochemical	Havugimana PC (2012)	1
UBE2V1	0	UBE2V2	0	biochemical	Havugimana PC (2012)	1
TRIM25	5	SFN	1	affinity chromatography technology	Urano T (2002)	1
RC3H1	6	UBE2V1	0	pull down	Zhang Q (2015)	1
UBE2V1	0	STUB1	4	pull down, pull down, pull down, biochemical, affinity chromatography technology, pull down	Zhang M (2005), Yang M (2011), Windheim M (2008), Havugimana PC (2012), Zhang M (2005), Zhang M (2005)	6
TRAF3IP2	0	UBC	7	enzymatic study	Liu C (2009)	1
PRKN	1	HSD17B10	1	pull down, enzymatic study, fluorescent resonance energy transfe	Bertolin G (2015), Bertolin G (2015), Bertolin G (2015)	3
UBE2N	1	MKRN3	2	two hybrid	Markson G (2009)	1
XIAP	0	STUB1	4	pull down	Dogan T (2008)	1
RHBDF2	5	UBE2N	1	affinity chromatography technology	Zhang Y (2018)	1
UBC	7	STUB1	4	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Connell P (2001), Connell P (2001), Windheim M (2008), Zhang M (2005)	4
UBXN7	3	BIRC2	1	affinity chromatography technology	Alexandru G (2008)	1
UBE2V1	0	UBXN7	3	biochemical	Havugimana PC (2012)	1
UBE2V2	0	ATP6V1B2	3	biochemical	Havugimana PC (2012)	1
PELI3	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Xiao H (2008), Jensen LE (2003), Jensen LE (2003), Butler MP (2005), Siednienko J (2012), Siednienko J (2012), Huoh YS (2014)	7
PRKN	1	NME2	0	affinity chromatography technology	Okatsu K (2012)	1
UBE2K	0	BIRC8	0	two hybrid	Markson G (2009)	1
UBE2V1	0	RNF2	1	two hybrid	Markson G (2009)	1
MID1	1	PSMB1	1	affinity chromatography technology	Gholkar AA (2016)	1
TRAF2	1	UBE2V2	0	pull down	Sasai M (2010)	1
UBE2D2	0	TRIM25	5	two hybrid, pull down, pull down, pull down, affinity chromatography technology	Markson G (2009), Nakajima A (2007), Ronchi VP (2012), Sanchez JG (2016), Choudhury NR (2017)	5
UBE4B	5	UBE2D2	0	pull down, pull down, pull down	Benirschke RC (2010), Wu H (2011), Buetow L (2015)	3
UBE2D2	0	RNF14	2	two hybrid	Markson G (2009)	1
SSSCA1	0	UBE2V1	0	biochemical	Havugimana PC (2012)	1
ATP6V1B2	3	ATP6V1F	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
PELI3	0	STUB1	4	affinity chromatography technology	Huttlin EL (2015)	1
TRAF2	1	XIAP	0	affinity chromatography technology	Vince JE (2009)	1
UBE2N	1	ARIH2	4	two hybrid, affinity chromatography technology, pull down	Marteijn JA (2009), Marteijn JA (2009), Marteijn JA (2009)	3
GMPPB	2	TXNDC5	5	two hybrid	Rolland T (2014)	1
PRKN	1	PSMB1	1	affinity chromatography technology	Sarraf SA (2013)	1
TGM2	2	TXNDC5	5	biochemical	Kristensen AR (2012)	1
TRAF6	0	UBOX5	4	two hybrid	Woodsmith J (2012)	1
UBE2K	0	UBC	7	enzymatic study, x-ray crystallography, x-ray crystallography, pull down, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Flierman D (2006), Ko S (2010), Wilson RC (2011), Wilson RC (2011), Wilson RC (2011), Sheng Y (2012), Raasi S (2005), Bishop N (2002), Rajsbaum R (2014), Chong RA (2014), Whitby FG (1998), Singh RK (2012), Cook BW (2015)	13
TRIM5	4	MAP3K1	4	affinity chromatography technology	Pertel T (2011)	1
UBE2V1	0	RNF144A	1	two hybrid	Markson G (2009)	1
TRIM25	5	ECHS1	2	affinity chromatography technology	Choudhury NR (2017)	1
TRAF6	0	XIAP	0	affinity chromatography technology, two hybrid, imaging technique	Sanna MG (2002), Woodsmith J (2012), Chen TC (2014)	3
USP34	7	UBQLN1	1	biochemical	Havugimana PC (2012)	1
G6PD	0	YWHAQ	0	biochemical	Kristensen AR (2012)	1
UCHL3	1	ZYX	2	biochemical	Havugimana PC (2012)	1
UBE2A	0	UBE2B	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hong JH (2015), Hong JH (2015), Huttlin EL (2017)	3
UBE2D2	0	RNF111	2	two hybrid, two hybrid, pull down, pull down, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Erker Y (2013), Wright JD (2016), Birkou M (2017), Birkou M (2017)	6
SSSCA1	0	UBQLN1	1	biochemical	Havugimana PC (2012)	1
UBE2V1	0	LDHB	4	biochemical	Kristensen AR (2012)	1
SOD1	0	LDHB	4	biochemical, affinity chromatography technology	Wan C (2015), Malty RH (2017)	2
SSSCA1	0	USP34	7	biochemical	Havugimana PC (2012)	1
UBE2V2	0	UBE2B	3	biochemical	Havugimana PC (2012)	1
RC3H1	6	UBE2A	0	pull down	Zhang Q (2015)	1
TRIM8	6	RNF111	2	two hybrid	Woodsmith J (2012)	1
UBE2K	0	MKRN3	2	two hybrid	Markson G (2009)	1
UBXN7	3	UCHL3	1	biochemical	Havugimana PC (2012)	1
UBE4B	5	ATP6V1F	1	biochemical	Havugimana PC (2012)	1
UBE2C	1	ATP6V1B2	3	biochemical	Havugimana PC (2012)	1
STUB1	4	TRAF6	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Yang M (2011), Yang M (2011), Wang S (2013), Li S (2014), Li S (2014), Li S (2014), Li S (2014)	7
RC3H1	6	UBE2B	3	pull down	Zhang Q (2015)	1
RC3H2	5	UBC	7	enzymatic study	Zhang Q (2015)	1
TRIM25	5	UBQLN1	1	affinity chromatography technology	Choudhury NR (2017)	1
HSD17B10	1	TAGLN2	0	biochemical, affinity chromatography technology	Wan C (2015), Malty RH (2017)	2
UCHL3	1	ATP6V1F	1	biochemical	Havugimana PC (2012)	1
UBE2V1	0	TGM2	2	biochemical	Kristensen AR (2012)	1
UBE2V1	0	G6PD	0	biochemical	Kristensen AR (2012)	1
TXN	1	TAGLN2	0	biochemical	Wan C (2015)	1
UBE2V1	0	ATP6V1F	1	biochemical	Havugimana PC (2012)	1
YWHAG	5	TXNDC5	5	biochemical	Kristensen AR (2012)	1
UBE2V2	0	RNF144A	1	two hybrid	Markson G (2009)	1
NME2	0	UBE2V1	0	biochemical	Wan C (2015)	1
SMURF1	4	UBE2K	0	enzymatic study	Andrews PS (2010)	1
NME2	0	TAGLN2	0	biochemical	Wan C (2015)	1
RAB7A	0	ATP6V1G1	1	affinity chromatography technology	Hein MY (2015)	1
UBE2V1	0	UBE2B	3	biochemical	Havugimana PC (2012)	1
SMURF1	4	UBXN7	3	enzymatic study	Andrews PS (2010)	1
UBC	7	UBE2B	3	affinity chromatography technology, affinity chromatography technology	Bish RA (2007), Hong JH (2015)	2
SSSCA1	0	UBE4B	5	biochemical	Havugimana PC (2012)	1
UBE2V1	0	RAB7A	0	biochemical	Wan C (2015)	1
UBE2V1	0	UBE4B	5	biochemical	Havugimana PC (2012)	1
AHCYL1	2	UCHL3	1	biochemical	Havugimana PC (2012)	1
BIRC3	1	DZIP3	6	two hybrid	Woodsmith J (2012)	1
TGM2	2	YWHAG	5	biochemical	Kristensen AR (2012)	1
ULK4	4	YWHAQ	0	two hybrid	Wang J (2011)	1
YWHAQ	0	TXNDC5	5	biochemical	Kristensen AR (2012)	1
SSSCA1	0	UBE2B	3	biochemical	Havugimana PC (2012)	1
SSSCA1	0	TTC9C	2	biochemical	Havugimana PC (2012)	1
IQCB1	3	TRIM32	2	affinity chromatography technology, affinity chromatography technology, pull down	Das A (2017), Das A (2017), Das A (2017)	3
SSSCA1	0	UBXN7	3	biochemical	Havugimana PC (2012)	1
BIRC8	0	XIAP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
YWHAZ	1	SFN	1	biochemical, affinity chromatography technology, affinity chromatography technology	Kristensen AR (2012), Huttlin EL (2015), Huttlin EL (2017)	3
UBE2D2	0	ARIH2	4	two hybrid	Markson G (2009)	1
TRAF2	1	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Li S (2011), Davies CC (2005), Relaix F (1998), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	7
TRIM25	5	HINT1	0	affinity chromatography technology	Choudhury NR (2017)	1
UBE2C	1	UBXN7	3	biochemical	Havugimana PC (2012)	1
SOD1	0	YWHAG	5	affinity chromatography technology	Malty RH (2017)	1
UBE2D2	0	RNF10	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Markson G (2009), Huttlin EL (2015), Huttlin EL (2017)	3
TRAF6	0	BIRC3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Goncharov T (2013), Harikumar KB (2014), Harikumar KB (2014)	4
YWHAG	5	SFN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Benzinger A (2005), Benzinger A (2005), Huttlin EL (2015), Huttlin EL (2017)	4
TRIM32	2	YWHAG	5	affinity chromatography technology	Ichimura T (2013)	1
UBE2V1	0	FAM168A	0	two hybrid	Rolland T (2014)	1
UBE2V1	0	RNF111	2	two hybrid	Markson G (2009)	1
TRIM25	5	STUB1	4	affinity chromatography technology	Choudhury NR (2017)	1
RC3H2	5	UBE2B	3	pull down	Zhang Q (2015)	1
UBE2V1	0	TXNDC5	5	biochemical	Kristensen AR (2012)	1
RNF185	1	UBQLN1	1	affinity chromatography technology	Iioka H (2007)	1
RNF5	0	RNF185	1	two hybrid	Rolland T (2014)	1
SSSCA1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
TAGLN2	0	UCHL3	1	biochemical	Wan C (2015)	1
AHCYL1	2	ATP6V1B2	3	biochemical	Havugimana PC (2012)	1
UBE2K	0	RNF111	2	two hybrid	Markson G (2009)	1
BIRC3	1	UBE2V1	0	pull down, pull down	Bertrand MJ (2008), Wu CJ (2006)	2
BIRC3	1	UBE2D2	0	x-ray crystallography, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down	Mace PD (2008), Mace PD (2008), Dynek JN (2010), Feltham R (2011), Dou H (2012), Li X (2002), Schumacher FR (2013), Choi JS (2014), Wu CJ (2006), Fang S (2001), Hu S (2003), Suzuki S (2017)	12
GMPPB	2	UBE2V1	0	biochemical	Wan C (2015)	1
UBE2K	0	DZIP3	6	two hybrid	Markson G (2009)	1
PRKN	1	STUB1	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Imai Y (2002), Imai Y (2002), Imai Y (2002), Imai Y (2003), Zhu X (2017)	5
TGM2	2	G6PD	0	biochemical	Kristensen AR (2012)	1
UBE2V1	0	ZNRF1	1	two hybrid	Markson G (2009)	1
UBE2V1	0	USP34	7	biochemical	Havugimana PC (2012)	1
UBE2N	1	DZIP3	6	two hybrid	Markson G (2009)	1
SMURF1	4	LDHB	4	affinity chromatography technology	Xie Y (2013)	1
TRIM25	5	RAB7A	0	affinity chromatography technology	Choudhury NR (2017)	1
UBE2K	0	UBE2N	1	biochemical	Wan C (2015)	1
TXN	1	HINT1	0	biochemical	Wan C (2015)	1
TGM2	2	YWHAZ	1	biochemical	Kristensen AR (2012)	1
TXN	1	ATP6V1F	1	biochemical	Havugimana PC (2012)	1
TTC9C	2	UCHL3	1	biochemical	Havugimana PC (2012)	1
SOD1	0	UBE2V1	0	biochemical	Wan C (2015)	1
RNF185	1	UBC	7	affinity chromatography technology	Iioka H (2007)	1
RNF2	1	TRIM25	5	affinity chromatography technology	Cao Q (2014)	1
TRIM32	2	UBC	7	enzymatic study, pull down	Streich FC (2013), Zhang X (2017)	2
UBE2K	0	TRIM39	0	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
UBE2V2	0	RNF2	1	two hybrid	Markson G (2009)	1
RC3H1	6	UBE2D2	0	pull down	Zhang Q (2015)	1
ITPA	1	ECHS1	2	biochemical	Wan C (2015)	1
PSMB1	1	UBE2V1	0	biochemical	Havugimana PC (2012)	1
YWHAZ	1	YWHAG	5	biochemical, biochemical, affinity chromatography technology, fluorescent resonance energy transfe	Kristensen AR (2012), Wan C (2015), Hein MY (2015), Ivanov AA (2017)	4
UBE2V1	0	UCHL3	1	biochemical	Havugimana PC (2012)	1
SSSCA1	0	TAGLN2	0	biochemical	Havugimana PC (2012)	1
UBE2V1	0	YWHAQ	0	biochemical	Kristensen AR (2012)	1
TXN	1	UBE2K	0	biochemical	Havugimana PC (2012)	1
YWHAQ	0	SFN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pozuelo-Rubio M (2010), Huttlin EL (2015), Huttlin EL (2017)	3
RNF111	2	TTC9C	2	affinity chromatography technology	Huttlin EL (2017)	1
BIRC2	1	UBE2D2	0	two hybrid, pull down, pull down, pull down	Dynek JN (2010), Li X (2002), Feltham R (2011), Choi YE (2009)	4
TRAF2	1	MAP3K1	4	biochemical, affinity chromatography technology, affinity chromatography technology, enzymatic study, imaging technique	Baud V (1999), Baud V (1999), Wu Y (2006), Charlaftis N (2014), Chen TC (2014)	5
UBE2D2	0	TRIM8	6	two hybrid, pull down	Markson G (2009), Li Q (2011)	2
UBE4B	5	USP34	7	biochemical	Havugimana PC (2012)	1
UBE2V1	0	RNF10	0	two hybrid	Markson G (2009)	1
SSSCA1	0	ZYX	2	biochemical	Havugimana PC (2012)	1
UBE2C	1	TAGLN2	0	biochemical	Wan C (2015)	1
UBE2N	1	STUB1	4	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down	Zhang M (2005), Graf C (2010), Soss SE (2011), Huen MS (2008), Lim GG (2013), Taipale M (2014), Taipale M (2014), Zhu X (2014), Zhang M (2005), Zhang M (2005), Kim HT (2007), Blessing NA (2017)	12
UBE4B	5	UBXN7	3	biochemical	Havugimana PC (2012)	1
BIRC2	1	UBC	7	pull down, pull down, pull down, pull down, enzymatic study	Dynek JN (2010), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Komander D (2009), Sakamoto H (2015)	5
TTC9C	2	UBE4B	5	biochemical	Havugimana PC (2012)	1
AHCYL1	2	UBE2C	1	biochemical	Havugimana PC (2012)	1
ECHS1	2	TGM2	2	biochemical	Kristensen AR (2012)	1
UBE2V2	0	MKRN3	2	two hybrid	Markson G (2009)	1
UBE2D2	0	MKRN3	2	two hybrid	Markson G (2009)	1
G6PD	0	SFN	1	biochemical	Kristensen AR (2012)	1
UBE2N	1	RC3H2	5	two hybrid, pull down	Markson G (2009), Zhang Q (2015)	2
RNF111	2	UBXN7	3	affinity chromatography technology	Huttlin EL (2017)	1
TRIM8	6	MKRN3	2	two hybrid	Woodsmith J (2012)	1
UBE2V1	0	UBC	7	pull down	McKenna S (2003)	1
HSD17B10	1	UBE2V1	0	affinity chromatography technology	Malty RH (2017)	1
SSSCA1	0	TXN	1	biochemical	Havugimana PC (2012)	1
UBE2B	3	UBXN7	3	biochemical	Havugimana PC (2012)	1
PELI1	1	UBE2N	1	pull down	Smith H (2011)	1
HSD17B10	1	TRAF6	0	two hybrid	Narayan SB (2012)	1
UBE2C	1	ATP6V1F	1	biochemical	Havugimana PC (2012)	1
UBE2N	1	XIAP	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
BIRC3	1	TRAF2	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology	Uren AG (1996), Roy N (1997), Yoneda T (2000), Yoneda T (2000), Li X (2002), Behrends C (2010), Samuel T (2006), Vince JE (2009), Darding M (2011), Zheng C (2010), Zheng C (2010), Zheng C (2010), Zheng C (2010), Zheng C (2010), Rothe M (1995), Varfolomeev E (2006), Choudhary S (2013), Goncharov T (2013), Wang J (2011), Harikumar KB (2014), Shen RR (2012), Chen TC (2014), Akhtar N (2016)	23
UBE2N	1	ZNRF1	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	van Wijk SJ (2009), Markson G (2009), Hoxhaj G (2012), Hoxhaj G (2012), Markson G (2009), Hoxhaj G (2012), Boldt K (2016)	7
UBE2B	3	UBQLN1	1	biochemical	Havugimana PC (2012)	1
TRIM25	5	YWHAQ	0	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	UGDH	0	affinity chromatography technology	Choudhury NR (2017)	1
LDHB	4	YWHAQ	0	biochemical	Kristensen AR (2012)	1
ITPA	1	UBE2V1	0	biochemical	Wan C (2015)	1
UBE2D2	0	TRIM39	0	two hybrid, pull down	Markson G (2009), Woodsmith J (2012)	2
STUB1	4	UBE2V2	0	biochemical	Havugimana PC (2012)	1
TRIM25	5	BIRC2	1	affinity chromatography technology	Choudhury NR (2017)	1
YKT6	0	TAGLN2	0	biochemical	Wan C (2015)	1
UBE2V1	0	MKRN3	2	two hybrid	Markson G (2009)	1
UBE2V1	0	UBQLN1	1	two hybrid	Rolland T (2014)	1
LDHB	4	NME1-NME2	0	biochemical	Wan C (2015)	1
RC3H2	5	UBE2V1	0	pull down	Zhang Q (2015)	1
NME1-NME2	0	NME2	0	two hybrid	Wang J (2011)	1
UBC	7	UBE2N	1	affinity chromatography technology, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Matsumoto M (2005), Scheper J (2010), Wu PY (2003), McKenna S (2003), Wiener R (2012), Ye Y (2003), Bish RA (2007), Juang YC (2012), Pastushok L (2007), Singh RK (2012), McKenna S (2001), McKenna S (2001)	12
YWHAZ	1	UBC	7	affinity chromatography technology	Jin J (2004)	1
UCHL3	1	HINT1	0	biochemical	Wan C (2015)	1
TRIM25	5	YWHAZ	1	affinity chromatography technology	Choudhury NR (2017)	1
UBE2K	0	DTX3	4	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
UBE2D2	0	DTX3	4	two hybrid	Markson G (2009)	1
UBE2D2	0	ZNRF1	1	two hybrid, two hybrid, pull down	van Wijk SJ (2009), Markson G (2009), Markson G (2009)	3
UBE2V1	0	UBE2C	1	biochemical	Havugimana PC (2012)	1
G6PD	0	YWHAZ	1	biochemical	Kristensen AR (2012)	1
TRIM5	4	MKRN3	2	two hybrid	Woodsmith J (2012)	1
UBXN7	3	ZYX	2	biochemical	Havugimana PC (2012)	1
UBE2V1	0	YWHAZ	1	biochemical	Kristensen AR (2012)	1
PRKN	1	RAB7A	0	enzymatic study	Song P (2016)	1
RC3H2	5	UBE2K	0	pull down	Zhang Q (2015)	1
TRAF6	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Hinz M (2010)	2
SOD1	0	HINT1	0	affinity chromatography technology	Malty RH (2017)	1
RNF111	2	UBC	7	enzymatic study	Wright JD (2016)	1
XIAP	0	UBC	7	x-ray crystallography, pull down, pull down, pull down	Tse MK (2011), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Nakatani Y (2012)	4
SSSCA1	0	ATP6V1F	1	biochemical	Havugimana PC (2012)	1
TRIM25	5	UBE2V1	0	pull down	Sanchez JG (2016)	1
UBE2N	1	TRIM5	4	two hybrid, pull down, x-ray crystallography	Markson G (2009), Yudina Z (2015), Yudina Z (2015)	3
TRIM39	0	UBC	7	enzymatic study	Woodsmith J (2012)	1
RNF5	0	UBC	7	enzymatic study	Didier C (2003)	1
AHCYL1	2	USP34	7	biochemical	Havugimana PC (2012)	1
LDHB	4	G6PD	0	biochemical	Kristensen AR (2012)	1
TRAF2	1	PRKN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henn IH (2007), Henn IH (2007), Um JW (2012), Im E (2015)	4
PRKN	1	TXN	1	affinity chromatography technology	Zanon A (2013)	1
SMURF1	4	UBE2V1	0	enzymatic study	Andrews PS (2010)	1
UBE2V1	0	UBOX5	4	two hybrid	Markson G (2009)	1
HSD17B10	1	TRAF3IP2	0	two hybrid	Narayan SB (2012)	1
UBE2K	0	RNF144A	1	two hybrid	Markson G (2009)	1
RNF2	1	LDHB	4	affinity chromatography technology	Cao Q (2014)	1
TRIM39	0	UBE2N	1	pull down	Woodsmith J (2012)	1
PELI1	1	UBE2V1	0	pull down, pull down	Smith H (2011), Chang M (2009)	2
TXN	1	SOD1	0	biochemical	Wan C (2015)	1
RC3H1	6	UBE2V2	0	pull down	Zhang Q (2015)	1
SSSCA1	0	UCHL3	1	biochemical	Havugimana PC (2012)	1
UBE2B	3	UBE2C	1	biochemical	Havugimana PC (2012)	1
SSSCA1	0	UBE2C	1	biochemical	Havugimana PC (2012)	1
SOD1	0	YWHAQ	0	affinity chromatography technology	Malty RH (2017)	1
BIRC2	1	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006)	2
UBE2K	0	RNF185	1	two hybrid, affinity chromatography technology	Markson G (2009), Iioka H (2007)	2
ECHS1	2	YWHAQ	0	biochemical	Kristensen AR (2012)	1
UBE2D2	0	XIAP	0	two hybrid, two hybrid, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down	Markson G (2009), Dynek JN (2010), Nakatani Y (2012), Nakatani Y (2012), Markson G (2009), Fang S (2001), Hu S (2003), Buetow L (2015), Foglizzo M (2016), Edison N (2017)	10
USP34	7	UCHL3	1	biochemical	Havugimana PC (2012)	1
ZNRF1	1	UBC	7	enzymatic study	Hoxhaj G (2012)	1
AHCYL1	2	UBE2V1	0	biochemical	Havugimana PC (2012)	1
UBE2V1	0	RNF14	2	two hybrid	Markson G (2009)	1
UBE2D2	0	UBQLN1	1	biochemical	Havugimana PC (2012)	1
UBXN7	3	ATP6V1F	1	biochemical	Havugimana PC (2012)	1
UBE4B	5	UBQLN1	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
BIRC2	1	UBE2B	3	two hybrid	Dynek JN (2010)	1
PRKN	1	UBE2C	1	pull down	Kazlauskaite A (2014)	1
UBE2V1	0	ULK4	4	biochemical	Havugimana PC (2012)	1
HINT1	0	TAGLN2	0	biochemical	Wan C (2015)	1
TRAF6	0	UBE2V1	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Deng L (2000), Lamothe B (2007), Kanayama A (2004), Shi CS (2010), Xia ZP (2009), Yang WL (2009), Murata H (2013), Ning S (2008), Sun L (2004), Lin Y (2014)	10
TRIM32	2	YWHAQ	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ichimura T (2013), Ichimura T (2013), Ichimura T (2013)	3
UBE4B	5	STUB1	4	biochemical	Wan C (2015)	1
UBE2V1	0	ARIH2	4	two hybrid	Markson G (2009)	1
TRIM32	2	UBQLN1	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
RC3H2	5	UBE2V2	0	pull down	Zhang Q (2015)	1
RNF5	0	UBE2N	1	pull down	Tcherpakov M (2009)	1
RAB7A	0	ATP6V1B2	3	affinity chromatography technology	Hein MY (2015)	1
SOD1	0	STUB1	4	affinity chromatography technology, affinity chromatography technology	Choi JS (2004), Ishigaki S (2007)	2
TXN	1	UBE2D2	0	biochemical	Havugimana PC (2012)	1
UBE2V1	0	DTX3	4	two hybrid	Markson G (2009)	1
YWHAG	5	UBC	7	affinity chromatography technology	Jin J (2004)	1
UBE2K	0	RNF5	0	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
USP34	7	UBXN7	3	biochemical	Havugimana PC (2012)	1
UBE2V1	0	UBE2K	0	biochemical	Wan C (2015)	1
YWHAQ	0	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Pozuelo-Rubio M (2010), Kristensen AR (2012), Hein MY (2015)	3
YWHAQ	0	MAP3K1	4	affinity chromatography technology	Sun BK (2011)	1
TRAF6	0	UBE2N	1	genetic interference, pull down, two hybrid, biochemical, two hybrid, x-ray crystallography, two hybrid, enzymatic study, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, two hybrid	Deng L (2000), Deng L (2000), Markson G (2009), Yin Q (2009), Dynek JN (2010), Yin Q (2009), Yin Q (2009), Petroski MD (2007), Mercier P (2007), Lamothe B (2008), Kanayama A (2004), Murata H (2013), Ning S (2008), Markson G (2009), Lin Y (2014), Chen J (2015), Zhang J (2016), Boldt K (2016), Rezaeian AH (2017), Xing J (2016), Schimmack G (2017), Schimmack G (2017)	22
RNF2	1	UBC	7	enzymatic study	Woodsmith J (2012)	1
USP34	7	ATP6V1B2	3	biochemical	Havugimana PC (2012)	1
UBE2N	1	UBE2V1	0	biochemical, pull down, pull down, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, biochemical, pull down, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deng L (2000), Deng L (2000), Zhang M (2005), Andersen PL (2005), Andersen PL (2005), Scheper J (2010), Scheper J (2010), Scheper J (2010), Wooff J (2004), Plans V (2006), Huen MS (2008), Huen MS (2008), Havugimana PC (2012), Bohgaki M (2008), Petroski MD (2007), Sawasaki T (2008), Wan C (2015), Chen J (2015), Boldt K (2016), Zhang Y (2018)	20
IQCB1	3	UBE2V1	0	affinity chromatography technology	Sang L (2011)	1
ATP6V1B2	3	ZYX	2	biochemical	Havugimana PC (2012)	1
G6PD	0	YWHAG	5	biochemical	Kristensen AR (2012)	1
UBE2K	0	TRIM5	4	two hybrid	Markson G (2009)	1
SOD1	0	TAGLN2	0	biochemical, affinity chromatography technology	Wan C (2015), Malty RH (2017)	2
UBC	7	UBQLN1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, two hybrid, pull down, two hybrid, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Matsumoto M (2005), Ko HS (2004), Ko HS (2004), Sokratous K (2012), Raasi S (2005), Raasi S (2005), Massey LK (2004), Ko HS (2004), Ko HS (2004), Rolland T (2014), Castaneda CA (2013), Nakayasu ES (2013), Nakayasu ES (2013), Kristariyanto YA (2015), Kristariyanto YA (2015), Kurlawala Z (2017)	16
IQCB1	3	UBE2K	0	affinity chromatography technology	Sang L (2011)	1
TRIM32	2	UBE2D2	0	affinity chromatography technology, pull down, pull down	Napolitano LM (2011), Streich FC (2013), Mokhonova EI (2015)	3
ECHS1	2	AHCYL1	2	biochemical	Wan C (2015)	1
AHCYL1	2	UBE2D2	0	biochemical	Havugimana PC (2012)	1
PRKN	1	UBE2V1	0	pull down, pull down, pull down, affinity chromatography technology	Chaugule VK (2011), Durcan TM (2011), Sha D (2010), Sha D (2010)	4
UBE2V2	0	ZNRF1	1	two hybrid	Markson G (2009)	1
UBC	7	PSMB1	1	affinity chromatography technology	Matsumoto M (2005)	1
SOD1	0	YWHAZ	1	affinity chromatography technology	Malty RH (2017)	1
UBE2N	1	RNF111	2	affinity chromatography technology, pull down	Poulsen SL (2013), Wright JD (2016)	2
UBE2V1	0	TRIM32	2	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Markson G (2009), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011)	4
YKT6	0	UBE2V1	0	biochemical	Wan C (2015)	1
UBE2V1	0	YWHAG	5	biochemical	Kristensen AR (2012)	1
UBE2C	1	UBE4B	5	biochemical	Havugimana PC (2012)	1
UBE2V1	0	DZIP3	6	two hybrid	Markson G (2009)	1
UBQLN1	1	UCHL3	1	biochemical	Havugimana PC (2012)	1
UBE2V2	0	DZIP3	6	two hybrid	Markson G (2009)	1
XIAP	0	DTX3	4	two hybrid	Woodsmith J (2012)	1
LDHB	4	TXNDC5	5	biochemical	Kristensen AR (2012)	1
TGM2	2	YWHAQ	0	biochemical	Kristensen AR (2012)	1
UBE2A	0	XIAP	0	affinity chromatography technology	Hein MY (2015)	1
UBE2V1	0	ATP6V1G1	1	biochemical	Havugimana PC (2012)	1
BIRC3	1	TRIM32	2	affinity chromatography technology	Ryu YS (2011)	1
UBE2N	1	MID1	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Markson G (2009), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011)	4
RNF144A	1	UBC	7	enzymatic study	Michel MA (2017)	1
ECHS1	2	UBE2N	1	affinity chromatography technology	Boldt K (2016)	1
UBE2D2	0	MID1	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, pull down	Markson G (2009), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011), Watkins GR (2012), Du H (2014), Schweiger S (2014)	7
UBE2V1	0	BIRC8	0	two hybrid	Markson G (2009)	1
BIRC2	1	UBE2N	1	two hybrid	Schimmack G (2017)	1
NME1-NME2	0	TAGLN2	0	biochemical	Wan C (2015)	1
PRKN	1	UBC	7	enzymatic study, imaging technique, enzymatic study, fluorescent resonance energy transfe, pull down, pull down, pull down, pull down, x-ray crystallography, imaging technique, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, enzymatic study	Kondapalli C (2012), Kane LA (2014), Kane LA (2014), Koyano F (2014), Zheng X (2013), Shiba-Fukushima K (2014), Shiba-Fukushima K (2014), Kumar A (2015), Kumar A (2015), Okatsu K (2015), Okatsu K (2015), Okatsu K (2015), Yamano K (2015), Fiesel FC (2015), Ordureau A (2015), Kazlauskaite A (2015), Kazlauskaite A (2015), Kumar A (2017), Kliza K (2017)	19
UBC	7	UBXN7	3	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Kelsall IR (2013), Alexandru G (2008), Besten Wd (2012), Besten Wd (2012)	4
SMURF1	4	UBQLN1	1	enzymatic study	Andrews PS (2010)	1
YWHAQ	0	SMURF1	4	affinity chromatography technology	Ichimura T (2013)	1
PSMB1	1	POMP	1	two hybrid, two hybrid, biochemical, two hybrid, two hybrid, biochemical, affinity chromatography technology	Jayarapu K (2004), Jayarapu K (2007), Fricke B (2007), Fricke B (2007), Fricke B (2007), Wan C (2015), Huttlin EL (2017)	7
UBE2K	0	UBE2D2	0	biochemical	Wan C (2015)	1
RHBDF2	5	STUB1	4	affinity chromatography technology, enzymatic study	Zhang Y (2018), Zhang Y (2018)	2
TRIM25	5	RC3H2	5	affinity chromatography technology	Choudhury NR (2017)	1
PELI3	0	UBE2V1	0	pull down	Yang S (2013)	1
UBE2V1	0	TRIM8	6	two hybrid	Markson G (2009)	1
TRAF2	1	UBE2V1	0	pull down	Deng L (2000)	1
POMP	1	UBE2V1	0	biochemical	Havugimana PC (2012)	1
UBE2D2	0	UBXN7	3	biochemical	Havugimana PC (2012)	1
TRAF2	1	UBE2N	1	genetic interference, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Deng L (2000), Deng L (2000), Liu J (2011), Liu J (2011), Liu J (2011), Alvarez SE (2010), Sasai M (2010), Zhou AY (2013), Shen RR (2012)	9
XIAP	0	TRIM32	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Ryu YS (2011), Ryu YS (2011), Ryu YS (2011)	3
TRIM25	5	LDHB	4	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
XIAP	0	TRIM8	6	two hybrid	Woodsmith J (2012)	1
ECHS1	2	YWHAZ	1	biochemical	Kristensen AR (2012)	1
PRKN	1	UBE2K	0	pull down	Kazlauskaite A (2014)	1
TRIM25	5	TRIM8	6	two hybrid	Woodsmith J (2012)	1
UBE2D2	0	DZIP3	6	two hybrid, pull down	Markson G (2009), Zhou W (2008)	2
TRAF6	0	SMURF1	4	genetic interference	Li S (2010)	1
UBE2K	0	MID1	1	two hybrid	Markson G (2009)	1
UBE2N	1	TRIM25	5	two hybrid, pull down, x-ray crystallography, affinity chromatography technology	Markson G (2009), Sanchez JG (2016), Sanchez JG (2016), Choudhury NR (2017)	4
POMP	1	UBE2A	0	biochemical	Havugimana PC (2012)	1
SOD1	0	UBC	7	affinity chromatography technology	Urushitani M (2004)	1
UBE2A	0	UBC	7	affinity chromatography technology	Hong JH (2015)	1
ARIH2	4	UBC	7	enzymatic study	Marteijn JA (2009)	1
MID1	1	UBC	7	affinity chromatography technology, affinity chromatography technology	Trockenbacher A (2001), Trockenbacher A (2001)	2
NME1-NME2	0	UBE2V1	0	biochemical	Wan C (2015)	1
MAP3K1	4	UBE2V1	0	enzymatic study	Charlaftis N (2014)	1
TRAF3IP2	0	UBE2V1	0	pull down	Liu C (2009)	1
TRIM5	4	TRIM32	2	two hybrid	Woodsmith J (2012)	1
ZNRF1	1	YWHAQ	0	affinity chromatography technology, affinity chromatography technology	Hoxhaj G (2012), Hoxhaj G (2012)	2
UBE2V1	0	XIAP	0	two hybrid	Markson G (2009)	1
UBQLN1	1	ATP6V1B2	3	biochemical	Havugimana PC (2012)	1
SOD1	0	UBE2N	1	affinity chromatography technology	Malty RH (2017)	1
UBE2V1	0	RNF185	1	two hybrid	Markson G (2009)	1
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
UBE2D2	0	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
BIRC2	1	TRAF2	1	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Uren AG (1996), Roy N (1997), Shu HB (1996), Yoneda T (2000), Yoneda T (2000), Li X (2002), Li X (2002), Li X (2002), Behrends C (2010), Samuel T (2006), Samuel T (2006), Samuel T (2006), Silke J (2005), Wu CJ (2005), Vince JE (2009), Csomos RA (2009), Li S (2011), Darding M (2011), Sanjo H (2010), Mace PD (2010), Choi JW (2009), Kanno Y (2010), Jang HD (2001), Rothe M (1995), Rothe M (1995), Cartier J (2011), Varfolomeev E (2006), Varfolomeev E (2006), Shen RR (2012), Shen RR (2012), Goncharov T (2013), Wang J (2011), Marivin A (2013), Shen RR (2012), Park ES (2015), Wang YB (2015), Chen TC (2014), Petersen SL (2015), Huttlin EL (2017), Akhtar N (2016)	41
BIRC2	1	UBE2V1	0	pull down	Bertrand MJ (2008)	1
UBE2V1	0	UBE2A	0	biochemical	Havugimana PC (2012)	1
BIRC2	1	DZIP3	6	two hybrid	Woodsmith J (2012)	1
TRAF6	0	TRIM25	5	two hybrid	Woodsmith J (2012)	1
UBE2D2	0	UBOX5	4	two hybrid	Markson G (2009)	1
TRIM25	5	UBE4B	5	affinity chromatography technology	Choudhury NR (2017)	1
BIRC2	1	TRIM32	2	affinity chromatography technology	Ryu YS (2011)	1
UBE2D2	0	RNF5	0	two hybrid, pull down	Markson G (2009), Sakata E (2010)	2
UBE2V1	0	RNF5	0	two hybrid	Markson G (2009)	1
SOD1	0	NME1-NME2	0	biochemical	Wan C (2015)	1
AHCYL1	2	SOD1	0	biochemical	Havugimana PC (2012)	1
BIRC3	1	UBC	7	pull down, pull down, enzymatic study	Gyrd-Hansen M (2008), Nakatani Y (2012), Sakamoto H (2015)	3
UBE2K	0	UBOX5	4	two hybrid	Markson G (2009)	1
UBE2V2	0	ZYX	2	biochemical	Havugimana PC (2012)	1
UBE2V1	0	TAGLN2	0	biochemical	Wan C (2015)	1
ZYX	2	UBE2N	1	affinity chromatography technology	Boldt K (2016)	1
PELI1	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jiang Z (2003), Jiang Z (2003), Choi KC (2006), Jensen LE (2003)	4
PRKN	1	UBE2A	0	pull down	Kazlauskaite A (2014)	1
RC3H1	6	UBE2N	1	pull down	Zhang Q (2015)	1
UBE2B	3	ATP6V1F	1	biochemical	Havugimana PC (2012)	1
UBE2V1	0	ZYX	2	biochemical	Havugimana PC (2012)	1
UBE2A	0	UBQLN1	1	biochemical	Havugimana PC (2012)	1
TRIM32	2	UBE2N	1	two hybrid, affinity chromatography technology, two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Saccone V (2008), Saccone V (2008), van Wijk SJ (2009), Markson G (2009), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011), Boldt K (2016)	8
SSSCA1	0	ATP6V1B2	3	biochemical	Havugimana PC (2012)	1
TRIM8	6	TRIM39	0	two hybrid	Woodsmith J (2012)	1
RNF2	1	TRAF2	1	affinity chromatography technology	Cao Q (2014)	1
TRIM25	5	UBC	7	enzymatic study	Sanchez JG (2016)	1
UCHL3	1	UBC	7	enzymatic study, enzymatic study, enzymatic study, x-ray crystallography, pull down, x-ray crystallography, pull down, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, pull down, pull down	Bremm A (2010), Boudreaux D (2012), Misaghi S (2005), Misaghi S (2005), Wilkinson KD (1999), Wilkinson KD (1999), Phillips AH (2013), Larsen CN (1998), Wada H (1998), Hemelaar J (2004), Altun M (2015), Flierman D (2016), Zhang X (2017), Kwasna D (2018), Lee YC (2017), Lee YC (2017), Hanpude P (2017)	17
AHCYL1	2	UBE4B	5	biochemical	Havugimana PC (2012)	1
UBC	7	USP34	7	pull down	Kwasna D (2018)	1
YWHAG	5	MAP3K1	4	affinity chromatography technology	Sun BK (2011)	1
UCHL3	1	XIAP	0	biochemical	Havugimana PC (2012)	1
UBE2D2	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
TRIM25	5	TAGLN2	0	affinity chromatography technology	Choudhury NR (2017)	1
UBE2D2	0	BIRC8	0	two hybrid	Markson G (2009)	1
TRIM25	5	RC3H1	6	affinity chromatography technology	Choudhury NR (2017)	1
UBE2B	3	ZYX	2	biochemical	Havugimana PC (2012)	1
RHBDF2	5	UBE2V1	0	affinity chromatography technology, affinity chromatography technology	Zhang Y (2018), Zhang Y (2018)	2
HINT1	0	UBE2V1	0	biochemical	Wan C (2015)	1
LDHB	4	YWHAG	5	biochemical	Kristensen AR (2012)	1
UBE2C	1	UBQLN1	1	biochemical	Havugimana PC (2012)	1
ECHS1	2	UBE2V1	0	biochemical	Kristensen AR (2012)	1
AHCYL1	2	TXN	1	biochemical	Havugimana PC (2012)	1
LDHB	4	UBE2N	1	biochemical	Wan C (2015)	1
UBE2V1	0	SFN	1	biochemical	Kristensen AR (2012)	1
TGM2	2	LDHB	4	biochemical	Kristensen AR (2012)	1
MAP3K1	4	UBXN7	3	enzymatic study	Charlaftis N (2014)	1
UBE2A	0	UCHL3	1	biochemical	Havugimana PC (2012)	1
AHCYL1	2	TTC9C	2	biochemical	Havugimana PC (2012)	1
UBE2C	1	USP34	7	biochemical	Havugimana PC (2012)	1
NME2	0	SOD1	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
UBE2N	1	BIRC8	0	two hybrid	Markson G (2009)	1
UBE2D2	0	TRIM5	4	two hybrid, pull down, pull down	Markson G (2009), Yamauchi K (2008), Xu L (2003)	3
PRKN	1	UBE2B	3	pull down	Kazlauskaite A (2014)	1
UBXN7	3	ATP6V1B2	3	biochemical	Havugimana PC (2012)	1
IQCB1	3	PSMB1	1	affinity chromatography technology	Sang L (2011)	1
TTC9C	2	UBE2C	1	biochemical	Havugimana PC (2012)	1
UBE2V2	0	UBE2N	1	pull down, two hybrid, x-ray crystallography, two hybrid, two hybrid, two hybrid, pull down, pull down, x-ray crystallography, affinity chromatography technology, pull down, two hybrid, pull down, pull down, affinity chromatography technology, two hybrid, pull down, biochemical, x-ray crystallography, pull down, affinity chromatography technology, pull down, x-ray crystallography, biochemical, x-ray crystallography, affinity chromatography technology	Andersen PL (2005), Andersen PL (2005), Markin CJ (2010), Wooff J (2004), Wooff J (2004), Plans V (2006), Wu PY (2003), McKenna S (2003), McKenna S (2003), Zou W (2005), Takeuchi T (2005), Pastushok L (2005), Pastushok L (2005), Pastushok L (2005), Huen MS (2008), Huen MS (2008), Ye Y (2003), Havugimana PC (2012), Moraes TF (2001), Pastushok L (2007), Zou W (2005), McKenna S (2001), Hodge CD (2015), Wan C (2015), Branigan E (2015), Boldt K (2016)	26
UBE2V1	0	TRIM39	0	two hybrid	Markson G (2009)	1
PRKN	1	UBE2D2	0	pull down, pull down, pull down, pull down, pull down, pull down	Joch M (2007), Imai Y (2002), Chaugule VK (2011), Durcan TM (2011), Caulfield TR (2014), Kazlauskaite A (2014)	6
SFN	1	MKRN3	2	two hybrid	Rolland T (2014)	1
UBE2V1	0	ATP6V1B2	3	biochemical	Havugimana PC (2012)	1